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Search Results: 1 - 10 of 8928 matches for " Miriam; Brown "
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Reversible Renal Insufficiency Secondary to Extrinsic Splenic Compression of the Kidney in a Patient with Chronic Lymphocytic Leukemia
Miriam Hadj-Moussa,James A. Brown
The Scientific World Journal , 2010, DOI: 10.1100/tsw.2010.74
Evaluating Cultural and Technical Obstacles in School-Based ICT Programs: An Analysis of Two Case Studies  [PDF]
Miriam Judge
Creative Education (CE) , 2013, DOI: 10.4236/ce.2013.49B006

The emergence of a knowledge-based economy has been identified as a central trend in modern economies as a result of the increasingly important role of information technology and learning in economic performance. In recognition of this most governments throughout the developed world have responded with a series of policy initiatives since the late 1990’s to either introduce or significantly increase information technology provision in schools to prepare students for life in the twenty first century. Ireland, with its growing reliance on the knowledge economy sector for employment and continued economic prosperity, developed its own policy initiative for computerizing the nations’ schools known as“Schools IT 2000: A Policy Framework for the New Millennium”. It was an ambitious programme with high expectations for the integration of ICT (Information and Communications Technology) in education. This paper examines two longitudinal educational ICT projects in Ireland in the first decade of the new millennium to query how far schools have travelled along the information superhighway and to ponder how well the catalytic capabilities of ICT have become embedded in the realities of classroom life and teachers pedagogic practices, with attendant implications for Ireland’s economic development.

Restricted Cell Surface Expression of Receptor Tyrosine Kinase ROR1 in Pediatric B-Lineage Acute Lymphoblastic Leukemia Suggests Targetability with Therapeutic Monoclonal Antibodies
Hema Dave, Miriam R. Anver, Donna O. Butcher, Patrick Brown, Javed Khan, Alan S. Wayne, Sivasubramanian Baskar, Christoph Rader
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0052655
Abstract: Background Despite high cure rates for pediatric B-lineage acute lymphoblastic leukemia (B-ALL), short-term and long-term toxicities and chemoresistance are shortcomings of standard chemotherapy. Immunotherapy and chemoimmunotherapy based on monoclonal antibodies (mAbs) that target cell surface antigens with restricted expression in pediatric B-ALL may offer the potential to reduce toxicities and prevent or overcome chemoresistance. The receptor tyrosine kinase ROR1 has emerged as a candidate for mAb targeting in select B-cell malignancies. Methodology and Principal Findings Using flow cytometry, Western blotting, immunohistochemistry, and confocal immunofluorescence microscopy, we analyzed the cell surface expression of ROR1 across major pediatric ALL subtypes represented by 14 cell lines and 56 primary blasts at diagnosis or relapse as well as in normal adult and pediatric tissues. Cell surface ROR1 expression was found in 45% of pediatric ALL patients, all of which were B-ALL, and was not limited to any particular genotype. All cell lines and primary blasts with E2A-PBX1 translocation and a portion of patients with other high risk genotypes, such as MLL rearrangement, expressed cell surface ROR1. Importantly, cell surface ROR1 expression was found in many of the pediatric B-ALL patients with multiply relapsed and refractory disease and normal karyotype or low risk cytogenetics, such as hyperdiploidy. Notably, cell surface ROR1 was virtually absent in normal adult and pediatric tissues. Conclusions and Significance Collectively, this study suggests that ROR1 merits preclinical and clinical investigations as a novel target for mAb-based therapies in pediatric B-ALL. We propose cell surface expression of ROR1 detected by flow cytometry as primary inclusion criterion for pediatric B-ALL patients in future clinical trials of ROR1-targeted therapies.
Excision margins in squamous cell carcinoma of the tongue: A retrospective audit and review of the literature  [PDF]
Miriam Thake, Athanasis Kalantzis
Open Journal of Stomatology (OJST) , 2013, DOI: 10.4236/ojst.2013.31013

The incidence of close and involved tongue resection margins for squamous cell carcinoma (SCC) were reviewed with the aim to identify any possible need for change in the surgical approach to glossectomies. The histopathological reports of 101 partial glossectomies for SCC between 2006 and 2012 were retrospectively reviewed. Results: Overall 52 (51.5%) patients had one or more close or involved margin and 9 (8.9%) had both close and involved margins. 42 (41.5%) patients had close margins and 11 (10.9%) had involved margins. The inferior/lateral muscoal margin was most frequently close/involved (32%) followed by deep margin (27%). The anterior margin was least close/involved (5%). The posterior and superior/medical margins were close/involved in 12% and 11% of cases respectively. Conclusions: 52.5% of patients had close or involved margins following surgery, potentially requiring further treatment to avoid an increased risk of tumour recurrence and the associated increase in morbidity and mortality. The inferior/lateral and deep margins were most frequently involved possible due to the anatomical difficulties visualising and dissecting these margins. The potential explanations for these disparities and possible solutions are discussed.

Perfiles toxicológicos de contaminantes químicos peligrosos
Torres Rodríguez,Marina T; García Melián,Maricel; Hernández,María Teresa; Sardi?as Pe?a,Olivia; Martínez Varona,Miriam; Brown,Luis Alberto;
Revista Cubana de Higiene y Epidemiolog?-a , 2002,
Abstract: con el objetivo de complementar adecuadamente y sustentar el desarrollo de trabajos de investigación y de servicios en el área de toxicología ambiental, en la evaluación de riesgos por exposición a sustancias y desechos químicos así como en estudios de impacto ambiental de proyectos de desarrollo que involucren la emisión de contaminantes químicos al ambiente, se elaboró en el instituto nacional de higiene, epidemiología y microbiología, la documentación para obtener una información suficiente acerca de las características físico-químicas y toxicológicas de siete contaminantes de interés en el país: cadmio, cromo, plomo, mercurio, lindano, clordano y aldicarb. en el trabajo se presentan los criterios de selección de los contaminantes así como los aspectos informativos contemplados en los perfiles y se se?alan las fuentes de información principales.
Influence of deficit irrigation on nutrient indices in wine grape (Vitis vinifera L.)  [PDF]
Krista Shellie, Brad Brown
Agricultural Sciences (AS) , 2012, DOI: 10.4236/as.2012.32031
Abstract: Deficit irrigation is widely used in wine grape production (Vitis vinifera L.) to meet wine quality goals yet its influence on tissue nutrient indices has not been well studied. The objective of this research was to determine whether response to water deficit compromised the prescriptive usefulness of tissue nutrient analyses. Tissue macro and micronutrient composition at bloom and veraison were evaluated over multiple seasons in nine wine grape cultivars grown under well-watered or deficit-irrigated conditions. Deficit-irrigated vines sampled at veraison had 2 to 12-fold higher petiole nitrate-nitrogen concentration, 6% lower blade nitrogen concentration and 13% lower blade copper concentration compared to well-watered vines. Water deficit influenced blade potassium concentration at veraison differently according to cultivar and was lower (cv. Malbec, Petite syrah, Viognier, Lemberger and Sangiovese), higher (cv. Merlot, Cabernet franc and Cabernet Sauvignon) or similar (cv. Grenache) to well-watered vines. Results from this study indicate that nutrient analysis of petiole or blade tissue sampled at veraison has limited diagnostic and prescriptive usefulness when vines are grown under a water deficit.
Locke’s Solid Souls  [PDF]
D. Kenneth Brown
Open Journal of Philosophy (OJPP) , 2012, DOI: 10.4236/ojpp.2012.24034
Abstract: John Locke holds that matter is solid, the soul thinks, and for all we know the soul may be a material substance divinely endowed with a power to think. Though he openly admits to nothing stronger than the bare possibility of thinking matter, Locke grants that what thinks in us occupies a definite spatial location to the exclusion of other souls. Solidity is the quality that prevents other things from occupying a spatial location. Locke’s general criterion for identity is spatiotemporal exclusion of other things of the same kind. To meet these conditions for identity, souls must be solid. Although Locke refuses to declare that souls really are material things, taking the solidity of souls to be a condition for their identity is consistent with the following of Locke’s other important commitments: (1) nominalism about the essences by which substances are classified, (2) agnosticism about the underlying reality of what supports such “nominal essences,” and (3) the identity of persons is distinct from the identity of any substance. Locke ignores the implication that souls are solid because the solidity of souls is irrelevant to those three aims. Nevertheless he could allow for the solidity of souls without giving up on any of his other important and explicitly held commitments. There is therefore no need for Locke’s commentators to refrain from employing solidity in their accounts of Locke’s general criterion for identity from fear of attributing to Locke the position that souls would be solid.
Ambivalence and obesity stigma in decisions about weight management: A qualitative study  [PDF]
Ian Brown, Alex McClimens
Health (Health) , 2012, DOI: 10.4236/health.2012.412A224
Background: Many adults do not take up weight management interventions even after apparently deciding to do so. Further research about decision making prior to the intervention would be useful. This paper presents a qualitative study exploring the process of decision making and the influences of obesity stigma. Methods: A pragmatic qualitative methodology, conducting indepth interviews with 52 participants all with BMI > 30 kg/m2 and experience of efforts at weight management. Equal numbers of men and women with mean age 56.9 years completed interviews. Inductive analyses proceeded through systematic steps over a series of iterations. Findings: Decision making is difficult in the context of on-going mixed feelings over a long time. Thoughts and feelings become ingrained with habits and it is hard to separate out what is needed to think through a good decision. Thinking about weight brings a large volume of thoughts and feelings and apparent options or action choices. The volume of thoughts makes decisions difficult but, in the context of obesity stigma, many of the thoughts are negative. A variable sensitivity to these stigma-related thoughts adds further ambivalence and inhibition for taking deciions. The need for further thinking does not stand out in the context of the emotional resolving of thoughts about personal responsibility arising from obesity stigma. Conclusions: Obesity stigma contributes to a deeper ambivalence in the decision process and hence difficulty in decision making about weight management. Decision aid interventions and training of health care staff in communication skills for shared decision making are needed.
Assessing the Sensitivity of Climate Change Targets to Policies of Land Use, Energy Demand, Low Carbon Energy and Population Growth  [PDF]
Douglas Crawford-Brown
Journal of Environmental Protection (JEP) , 2012, DOI: 10.4236/jep.2012.312178
Abstract: A reduced scale model of the coupled carbon cycle, population dynamics, energy system and land use characteristics is used to assess the sensitivity of atmospheric carbon to a variety of policies. Policies simulated include reduction of the rate of growth of the population; reduction of the rate of conversion of forested land to cropland; reduction in per capita energy demand in developed nations; reduction in per capita energy demand in developing nations; reduction in the carbon intensity of energy production in developed nations; and reduction in the carbon intensity of energy production in developing nations. For each policy, both the time to onset of the policy and the fractional annual rate of change in the associated model variable are established. Using as a measure of sensitivity the extension in years required for atmospheric carbon to reach the policy ceiling of 1160 BMT, achieved at a policy that introduces a rate of change in each affected model variable of 0.05 per year (a 5% change per year), then the policies in decreasing order of sensitivity are: Developing nations per capita growth (17 years), Developing nations carbon intensity (17 years), Population control (11 years), Developed nations carbon intensity (2.9 years), Developed nations per capita growth (2.8 years) and Land use (1.3 years). These values are all approximately doubled when population is stabilised first. An analysis of the model results also shows a convergence of the developed and developing nations per capita carbon emissions by 2100 when a portfolio of policies is selected to prevent a doubling of the pre-industrial revolution level of atmospheric carbon at any point in the future, consistent with a principle of “contract and converge”.
Qualitative studies of obesity: A review of methodology  [PDF]
Ian Brown, Jill Gould
Health (Health) , 2013, DOI: 10.4236/health.2013.58A3010

BACKGROUND: There is a developing interest in qualitative research to understand the perspectives and experiences of people living with obesity. However, obesity is a stigmatised condition associated with negative stereotypes. Social contexts emphasizing large body size as a problem, including research interviews, may amplify obesity stigma. This study reviews the methodology employed by qualitative studies in which study participants were obese and data collection involved face-to-face interviews. METHODS: Database searches identified qualitative studies meeting inclusion criteria from 1995 to 2012. Following screening and appraisal data were systematically extracted and analyzed from 31 studies. RESULTS: The studies included 1206 participants with a mean age of 44 years and mean BMI of37 kg/m2. Women (78.8%) outnumbered men (21.2%) by four to one. Socio-economic background was not consistently reported. The studies employed similar, typically pragmatic, qualitative methodologies, providing rich textual data on the experience of obesity derived from face-to-face interviews. The majority considered quality issues in data collection, analyses and generalizability of findings. However, the studies were weak as regards researcher reflexivity in relation to interviewer characteristics and obesity stigma. CONCLUSIONS: The impact of obesity stigma has not been attended to in the qualitative research. Clear information about study

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