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Search Results: 1 - 10 of 399455 matches for " Miranda Ana L. P. "
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The role of videolaparoscopy in the diagnostic and therapeutic approach of nonpalpable testis
Bittencourt Daniel G,Miranda Márcio L,Moreira Ana P.P,Miyabara Shoji
International braz j urol , 2003,
Abstract: OBJECTIVE: Evaluate the results from the first 5 years of experience with laparoscopy for diagnosis and treatment of nonpalpable testes. MATERIALS AND METHODS: Medical records of 51 patients submitted to laparoscopic testicular exploration, during a 5-year period, were retrospectively analyzed. Patients' mean age was 65.7 months (median = 48) on the first procedure. The youngest patient was 10 months and the oldest was 14 years old on the first surgery. Twenty-four (47%) patients presented nonpalpable testes bilaterally, 7 (14%) only at the right side and 20 (39%) at the left, totaling 75 testicular units assessed. Patients who had their testes palpated after anesthetic induction were excluded from the study, and in all other cases, surgical management was based on the testicular position and viability. During the post-operative follow-up, surgical success was classified as palpable testis in scrotal sac, with adequate consistency and volume. RESULTS: Nine (12%) testes were not localized, but their vessels and deferent duct were atrophic. Two (3%) testes were intra-abdominal and atrophic, and 2 (3%) gonads, in the same patient, had a dysmorphic aspect. Nineteen (25%) testicular units were located close to the internal inguinal ring (peeping testes) and, in 22 (29%) units, the spermatic vessels and deferent duct penetrated the internal inguinal ring. Eight (10%) testes were located at a distance of less than 2 cm from the internal inguinal ring and 13 (17%) at a distance greater than 2 cm. The 2 intra-abdominal atrophic testes were removed. Inguinotomy was performed in a total of 41 (54%) cases, reaching a surgical success of 89%. Laparoscopic orchiopexy in one stage, without vascular ligation, was performed in 9 (12%) testes, which presented a distance of less than 2 cm from the internal inguinal ring, also with a surgical success index of 89%. Orchiopexy in 2 stages, with ligation of the spermatic vessels, was performed in 13 (17%) testicular units located at a distance greater than 2 cm from the internal inguinal ring, reaching 77% of good results. CONCLUSION: Videolaparoscopy is a safe and effective method for diagnosis and treatment of nonpalpable testis.
The synthesis of new isochromanylacetylarylhydrazones designed as probable non-addictive analgesic agents
Santos, Margareth R?se L.;Barreiro, Eliezer J.;Braz-Filho, Raimundo;Miranda, Ana Luisa P.;
Journal of the Brazilian Chemical Society , 1997, DOI: 10.1590/S0103-50531997000500007
Abstract: the synthesis and pharmacological profile as analgesic and anti-inflammatory agents of new isochromanylacetylarylhydrazone derivatives (3) are described in this paper. the synthetic route used in this work to construct the heterocyclic six member ring explored a lewis acid-catalyzed cyclization process as the key step, which represents a modified friedel-crafts reaction. these new derivatives (3) were obtained in ca. 85 % overall yields from the starting material safrole (4), an abundant natural product isolated from sassafras oil. the nmr spectral analysis of these new derivatives indicated, at the c=n double bond level, the diastereomeric nature in a 70:30 ratio, where the major compound is the (e)-isomer. the results obtained from the pharmacological evaluation of (3) using the carrageenan-induced rat paw edema test and the acetic acid solution-induced constrictions in mouse test, indicated the pharmacophoric nature of the acylarylhydrazone moiety to the analgesic activity observed in this series.the role of the aryl substituents in the bioactivity seems to indicate that the presence of hydrophobic groups may improve the analgesic profile. these new isochromanylacetylarylhydrazone derivatives (3) represent a new class of non-addictive analgesic agents.
A química medicinal de N-acilidrazonas: novos compostos-protótipos de fármacos analgésicos, antiinflamatórios e anti-trombóticos
Barreiro, Eliezer J.;Fraga, Carlos A. M.;Miranda, Ana L. P.;Rodrigues, Carlos R.;
Química Nova , 2002, DOI: 10.1590/S0100-40422002000100022
Abstract: in this article are described new bioactive n-acylhydrazone (nah) derivatives, structurally designed as optimization of aryl hydrazones precursors planned by molecular hybridization of two 5-lipoxigenase inhibitors, e.g. cbs-1108 and bw-755c. the analgesic, antiedematogenic and anti-platelet aggregating profile of several isosteric compounds was investigated by using classic pharmacological assays in vivo and ex-vivo, allowing to identify new potent peripheric analgesic lead, a new anti-inflammatory and an antithrombotic agent. during this study was discovered dozen of active nah compounds clarifying the structure-activity relationship for this series of nah derivatives, indicating the pharmacophore character of the n-acylhydrazone functionality.
A química medicinal de N-acilidrazonas: novos compostos-protótipos de fármacos analgésicos, antiinflamatórios e anti-trombóticos
Barreiro Eliezer J.,Fraga Carlos A. M.,Miranda Ana L. P.,Rodrigues Carlos R.
Química Nova , 2002,
Abstract: In this article are described new bioactive N-acylhydrazone (NAH) derivatives, structurally designed as optimization of aryl hydrazones precursors planned by molecular hybridization of two 5-lipoxigenase inhibitors, e.g. CBS-1108 and BW-755c. The analgesic, antiedematogenic and anti-platelet aggregating profile of several isosteric compounds was investigated by using classic pharmacological assays in vivo and ex-vivo, allowing to identify new potent peripheric analgesic lead, a new anti-inflammatory and an antithrombotic agent. During this study was discovered dozen of active NAH compounds clarifying the structure-activity relationship for this series of NAH derivatives, indicating the pharmacophore character of the N-acylhydrazone functionality.
Identification of impact aroma compounds in Eugenia uniflora L. (Brazilian Pitanga) leaf essential oil
Melo, Rosineia M.;Corrêa, Vivian F. S.;Amorim, Ana Carolina L.;Miranda, Ana Luisa P.;Rezende, Claudia M.;
Journal of the Brazilian Chemical Society , 2007, DOI: 10.1590/S0103-50532007000100020
Abstract: the leaf essential oil of eugenia uniflora l. (myrtaceae) was extracted by clevenger apparatus and analysed by gas chromatography-mass spectrometry (gc-ms). the leaves were collected and immediately extracted for five consecutive days at 9:00 am and 2:00 pm. no variance in the oil yields were observed in the period. furanodiene and its rearrangement product, furanoelemene (or curzerene, 50.2%), b-elemene (5.9%) and a-cadinol (4.7%) were identified as the most abundant compounds. gc-olfatometry (gc-o) associated to aroma extract dilution analysis (aeda) allowed the identification of nine active aroma compounds, where furanodiene (along with furanoelemene, fd 1024), b-elemene (fd 256) and (e,e)-germacrone (fd 256) were characterized as the main impact aroma compounds in the odor of this essential oil. those substances were collected through a sniffing port adapted on the gc allowing to obtain a typical essence of pitanga as indicated by comparative olfatometric analysis.
The role of videolaparoscopy in the diagnostic and therapeutic approach of nonpalpable testis
Bittencourt, Daniel G;Miranda, Márcio L;Moreira, Ana P.P;Miyabara, Shoji;Bustorff-Silva, J.M;
International braz j urol , 2003, DOI: 10.1590/S1677-55382003000400011
Abstract: objective: evaluate the results from the first 5 years of experience with laparoscopy for diagnosis and treatment of nonpalpable testes. materials and methods: medical records of 51 patients submitted to laparoscopic testicular exploration, during a 5-year period, were retrospectively analyzed. patients' mean age was 65.7 months (median = 48) on the first procedure. the youngest patient was 10 months and the oldest was 14 years old on the first surgery. twenty-four (47%) patients presented nonpalpable testes bilaterally, 7 (14%) only at the right side and 20 (39%) at the left, totaling 75 testicular units assessed. patients who had their testes palpated after anesthetic induction were excluded from the study, and in all other cases, surgical management was based on the testicular position and viability. during the post-operative follow-up, surgical success was classified as palpable testis in scrotal sac, with adequate consistency and volume. results: nine (12%) testes were not localized, but their vessels and deferent duct were atrophic. two (3%) testes were intra-abdominal and atrophic, and 2 (3%) gonads, in the same patient, had a dysmorphic aspect. nineteen (25%) testicular units were located close to the internal inguinal ring (peeping testes) and, in 22 (29%) units, the spermatic vessels and deferent duct penetrated the internal inguinal ring. eight (10%) testes were located at a distance of less than 2 cm from the internal inguinal ring and 13 (17%) at a distance greater than 2 cm. the 2 intra-abdominal atrophic testes were removed. inguinotomy was performed in a total of 41 (54%) cases, reaching a surgical success of 89%. laparoscopic orchiopexy in one stage, without vascular ligation, was performed in 9 (12%) testes, which presented a distance of less than 2 cm from the internal inguinal ring, also with a surgical success index of 89%. orchiopexy in 2 stages, with ligation of the spermatic vessels, was performed in 13 (17%) testicular units located at a dis
New antithrombotic aryl-sulfonylthiosemicarbazide derivatives synthesized from natural safrole
Lima, Lídia M.;Ormelli, Claudia B.;Fraga, Carlos A.M.;Miranda, Ana L.P.;Barreiro, Eliezer J.;
Journal of the Brazilian Chemical Society , 1999, DOI: 10.1590/S0103-50531999000500013
Abstract: as part of a research program aiming at the synthesis and pharmacological evaluation of novel lead-compounds exploring brazilian abundant natural products, we describe herein the synthesis and the antithrombotic profile of new aryl-sulfonylsemicarbazides and aryl-sulfonylthiosemicarbazides (10a-d). the new derivatives, designed with basis on the molecular hybridization concept, were prepared in good yields from natural safrole (9), isolated from sassafras oil. the anti-aggregating activity of these new derivatives (10a-d) on platelet aggregation induced by adp, collagen, arachidonic acid and u-46619, indicates an important antithrombotic profile for the 6-methyl-3,4-methylenedioxyphenyl-sulfonyl-n-phenylthiosemicarbazide derivative (10d), acting at the arachidonic acid cascade and representing a new lead-compound with antithrombotic activity.
New antithrombotic aryl-sulfonylthiosemicarbazide derivatives synthesized from natural safrole
Lima Lídia M.,Ormelli Claudia B.,Fraga Carlos A.M.,Miranda Ana L.P.
Journal of the Brazilian Chemical Society , 1999,
Abstract: As part of a research program aiming at the synthesis and pharmacological evaluation of novel lead-compounds exploring Brazilian abundant natural products, we describe herein the synthesis and the antithrombotic profile of new aryl-sulfonylsemicarbazides and aryl-sulfonylthiosemicarbazides (10a-d). The new derivatives, designed with basis on the molecular hybridization concept, were prepared in good yields from natural safrole (9), isolated from sassafras oil. The anti-aggregating activity of these new derivatives (10a-d) on platelet aggregation induced by ADP, collagen, arachidonic acid and U-46619, indicates an important antithrombotic profile for the 6-methyl-3,4-methylenedioxyphenyl-sulfonyl-N-phenylthiosemicarbazide derivative (10d), acting at the arachidonic acid cascade and representing a new lead-compound with antithrombotic activity.
Screening of the odour-activity and bioactivity of the essential oils of leaves and flowers of Hyptis Passerina Mart. from the Brazilian Cerrado
Zellner, Barbara D.;Amorim, Ana Carolina L.;Miranda, Ana Luisa P. de;Alves, Ruy J. V.;Barbosa, Jussara P.;Costa, Gisela L. da;Rezende, Claudia M.;
Journal of the Brazilian Chemical Society , 2009, DOI: 10.1590/S0103-50532009000200018
Abstract: the chemical profile of the essential oils obtained from the leaves and flowers of hyptis passerina mart., a rare species of the brazilian cerrado, has been determined for the first time. analyses by gc-ms showed sesquiterpenes as major compounds. β-epi-acorenol (35.7% and 32.8%, respectively from leaf and flower essential oils), was isolated and identified by 1d and 2d nmr. the flower-derived oil presented a higher concentration of hydrocarbon and oxygenated monoterpenes, while the leaf-oil was richer in diterpenes. the global odour impressions of both oils were given by direct analysis and gc-ms-o and were characterized as herbaceous with tea notes, and green, cooked and woody impressions for leaf-oil; herbaceous, with spicy, woody and minty notes for flower-oil. β-epi-acorenol, spathulenol, β-caryophyllene, and caryophyllene oxide were relevant for the odour-activity of both oils, as well as minor constituents, such as linalool. the antimicrobial activity was investigated by means of agar diffusion disc method and contact bioautography, against gram-positive and negative bacteria and yeast. both oils presented to be bioactive against the tested microorganisms with significant inhibition level.
Synthesis and Biological Activity of 6-Selenocaffeine: Potential Modulator of Chemotherapeutic Drugs in Breast Cancer Cells
Inês L. Martins,Joana P. Miranda,Nuno G. Oliveira,Ana S. Fernandes,Sandrina Gon?alves,Alexandra M. M. Antunes
Molecules , 2013, DOI: 10.3390/molecules18055251
Abstract: We report the development of a new microwave-based synthetic methodology mediated by Woollins’ reagent that allowed an efficient conversion of caffeine into 6-selenocaffeine. A preliminary evaluation on the modulation of antioxidant activity upon selenation of caffeine, using the DPPH assay, indicated a mild antioxidant activity for 6-selenocaffeine, contrasting with caffeine, that exhibited no antioxidant activity under the same experimental conditions. Interestingly, whereas 6-selenocaffeine has revealed to have a low cytotoxic potential in both MCF10A and MCF-7 breast cells (24 h, up to 100 μM, MTT assay), a differential effect was observed when used in combination with the anticancer agents doxorubicin and oxaliplatin in MCF-7 breast cancer cells. The co-treatment of doxorubicin (1 μM) and 6-selenocaffeine (100 μM) resulted in a slight decrease in cellular viability when compared to doxorubicin (1 μM) alone. Conversely, the seleno-caffeine derivative at the same concentration markedly increased the viability of oxaliplatin (100 μM)-treated cells ( p < 0.01). Overall, this work highlights an emerging methodology to synthesize organoselenium compounds and points out the differential roles of 6-selenocaffeine in the modulation of the cytotoxicity of anticancer agents.
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