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Short-Term Effect of Pitavastatin Treatment on Glucose and Lipid Metabolism and Oxidative Stress in Fasting and Postprandial State Using a Test Meal in Japanese Men
Hirokazu Kakuda,Junji Kobayashi,Mio Nakato,Noboru Takekoshi
Cholesterol , 2013, DOI: 10.1155/2013/314170
Abstract: Introduction. The objective of this study was to clarify how pitavastatin affects glucose and lipid metabolism, renal function, and oxidative stress. Methods. Ten Japanese men (average age of 33.9 years) were orally administered 2?mg of pitavastatin for 4 weeks. Postprandial glucose, lipoprotein metabolism, and oxidative stress markers were evaluated at 0 and 4 weeks of pitavastatin treatment (2?mg once daily) with a test meal consisting of total calories: 460?kcal, carbohydrates: 56.5?g (226?kcal), protein: 18?g (72?kcal), lipids: 18?g (162?kcal), and NaCl: 1.6?g. Metabolic parameters were measured at 0, 60, and 120 minutes after test meal ingestion. Results. After administration of pitavastatin, serum total cholesterol, low-density lipoprotein cholesterol, apolipoprotein B, arachidonic acid, insulin, and adjusted urinary excretion of uric acid decreased, whereas creatinine clearance ( ) and uric acid clearance ( ) increased. And postprandial versus fasting urine 8-hydroxydeoxyguanosine remained unchanged, while postprandial versus fasting isoprostane decreased after pitavastatin treatment. Next, we compared postprandial glucose and lipid metabolism after test meal ingestion before and after pitavastatin administration. Incremental areas under the curve significantly decreased for triglycerides ( ) and remnant-like particle cholesterol ( ), while those for apolipoprotein E (apoE), glucose, insulin, and high-sensitivity C-reactive protein remained unchanged. Conclusion. Pitavastatin improves postprandial oxidative stress along with hyperlipidemia. 1. Introduction It has been generally recognized that postprandial hyperglycemia and hyperlipidemia are highly related to the development of atherosclerosis [1–5]. Hyperglycemia is known to damage vascular endothelial cells, increase oxidative stress, promote the expression of adhesion molecules, and inhibit Nitric Oxide (NO) production [6]. Remnant lipoprotein, an important component of postprandial hyperlipidemia, promotes foam cell formation of macrophages and proliferation of smooth muscle cells [7]. A very recent study on a large number of subjects demonstrated that remnant cholesterol was a causal risk factor for ischemic heart disease [8]. Lipid-lowering drugs, such as statins, fibrates, and ezetimibe are considered to be useful for the treatment of postprandial hyperlipidemia [9–15]. Pitavastatin, a member of the medication class of statins, has been available in the market in Japan since 2003. It has been well recognized that this statin is markedly effective in reducing low-density lipoprotein
Liquid Crystalline Behavior and Related Properties of Colloidal Systems of Inorganic Oxide Nanosheets
Teruyuki Nakato,Nobuyoshi Miyamoto
Materials , 2009, DOI: 10.3390/ma2041734
Abstract: Inorganic layered crystals exemplified by clay minerals can be exfoliated in solvents to form colloidal dispersions of extremely thin inorganic layers that are called nanosheets. The obtained “nanosheet colloids” form lyotropic liquid crystals because of the highly anisotropic shape of the nanosheets. This system is a rare example of liquid crystals consisting of inorganic crystalline mesogens. Nanosheet colloids of photocatalytically active semiconducting oxides can exhibit unusual photoresponses that are not observed for organic liquid crystals. This review summarizes experimental work on the phase behavior of the nanosheet colloids as well as photochemical reactions observed in the clay and semiconducting nanosheets system.
Cgaln: fast and space-efficient whole-genome alignment
Ryuichiro Nakato, Osamu Gotoh
BMC Bioinformatics , 2010, DOI: 10.1186/1471-2105-11-224
Abstract: We previously proposed the CGAT (Coarse-Grained AlignmenT) algorithm, which performs an alignment job in two steps: first at the block level and then at the nucleotide level. The former is "coarse-grained" alignment that can explore genomic rearrangements and reduce the sizes of the regions to be analyzed in the next step. The latter is detailed alignment within limited regions. In this paper, we present an update of the algorithm and the open-source program, Cgaln, that implements the algorithm. We compared the performance of Cgaln with those of other programs on whole genomic sequences of several bacteria and of some mammalian chromosome pairs. The results showed that Cgaln is several times faster and more memory-efficient than the best existing programs, while its sensitivity and accuracy are comparable to those of the best programs. Cgaln takes less than 13 hours to finish an alignment between the whole genomes of human and mouse in a single run on a conventional desktop computer with a single CPU and 2 GB memory.Cgaln is not only fast and memory efficient but also effective in coping with genomic rearrangements. Our results show that Cgaln is very effective for comparison of large genomes, especially of intact chromosomal sequences. We believe that Cgaln provides novel viewpoint for reducing computational complexity and will contribute to various fields of genome science.Sequence alignment is one of the most fundamental approaches in bioinformatics. It finds common subsequence patterns shared by the input sequences, and this information supports the identification of evolutionarily conserved genes or other functional regions, the prediction of 1-3D structures of proteins and RNAs, and the analysis of evolutionary relationships between the species [1]. With the rapid increase in genomic sequence data in recent years, there is great demand for alignment programs that can allow direct comparisons of whole genomic sequences. Cross-species genomic sequence compariso
Bifurcation Analysis of Reduced Network Model of Coupled Gaussian Maps for Associative Memory  [PDF]
Mio Kobayashi, Tetsuya Yoshinaga
International Journal of Modern Nonlinear Theory and Application (IJMNTA) , 2019, DOI: 10.4236/ijmnta.2019.81001
Abstract: This paper proposes an associative memory model based on a coupled system of Gaussian maps. A one-dimensional Gaussian map describes a discrete-time dynamical system, and the coupled system of Gaussian maps can generate various phenomena including asymmetric fixed and periodic points. The Gaussian associative memory can effectively recall one of the stored patterns, which were triggered by an input pattern by associating the asymmetric two-periodic points observed in the coupled system with the binary values of output patterns. To investigate the Gaussian associative memory model, we formed its reduced model and analyzed the bifurcation structure. Pseudo-patterns were observed for the proposed model along with other conventional associative memory models, and the obtained patterns were related to the high-order or quasi-periodic points and the chaotic trajectories. In this paper, the structure of the Gaussian associative memory and its reduced models are introduced as well as the results of the bifurcation analysis are presented. Furthermore, the output sequences obtained from simulation of the recalling process are presented. We discuss the mechanism and the characteristics of the Gaussian associative memory based on the results of the analysis and the simulations conducted.
On the equivalence of game and denotational semantics for the probabilistic mu-calculus
Matteo Mio
Computer Science , 2012, DOI: 10.2168/LMCS-8(2:7)2012
Abstract: The probabilistic (or quantitative) modal mu-calculus is a fixed-point logic de- signed for expressing properties of probabilistic labeled transition systems (PLTS). Two semantics have been studied for this logic, both assigning to every process state a value in the interval [0,1] representing the probability that the property expressed by the formula holds at the state. One semantics is denotational and the other is a game semantics, specified in terms of two-player stochastic games. The two semantics have been proved to coincide on all finite PLTS's, but the equivalence of the two semantics on arbitrary models has been open in literature. In this paper we prove that the equivalence indeed holds for arbitrary infinite models, and thus our result strengthens the fruitful connection between denotational and game semantics. Our proof adapts the unraveling or unfolding method, a general proof technique for proving result of parity games by induction on their complexity.
Probabilistic modal μ-calculus with independent product
Matteo Mio
Computer Science , 2012, DOI: 10.2168/LMCS-8(4:18)2012
Abstract: The probabilistic modal {\mu}-calculus is a fixed-point logic designed for expressing properties of probabilistic labeled transition systems (PLTS's). Two equivalent semantics have been studied for this logic, both assigning to each state a value in the interval [0,1] representing the probability that the property expressed by the formula holds at the state. One semantics is denotational and the other is a game semantics, specified in terms of two-player stochastic parity games. A shortcoming of the probabilistic modal {\mu}-calculus is the lack of expressiveness required to encode other important temporal logics for PLTS's such as Probabilistic Computation Tree Logic (PCTL). To address this limitation we extend the logic with a new pair of operators: independent product and coproduct. The resulting logic, called probabilistic modal {\mu}-calculus with independent product, can encode many properties of interest and subsumes the qualitative fragment of PCTL. The main contribution of this paper is the definition of an appropriate game semantics for this extended probabilistic {\mu}-calculus. This relies on the definition of a new class of games which generalize standard two-player stochastic (parity) games by allowing a play to be split into concurrent subplays, each continuing their evolution independently. Our main technical result is the equivalence of the two semantics. The proof is carried out in ZFC set theory extended with Martin's Axiom at an uncountable cardinal.
Upper-Expectation Bisimilarity and Real-valued Modal Logics
Matteo Mio
Computer Science , 2013,
Abstract: Several notions of bisimulation relations for probabilistic non-deterministic transition systems have been considered in the literature. We consider a novel testing-based behavioral equivalence called upper-expectation bisimilarity and develop its theory using standard results from linear algebra and functional analysis. We show that, for a wide class of systems, our new notion coincides with Segala's convex bisimilarity. We develop logical characterizations in terms of expressive probabilistic modal mu-calculi and a novel real-valued modal logic. We prove that upper-expectation bisimilarity is a congruence for the wide family of process algebras specified following the probabilistic GSOS rule format.
O Estado Novo e as críticas a Machado de Assis na primeira metade dos anos 1940
Salla, Thiago Mio;
Machado de Assis em Linha , 2012, DOI: 10.1590/S1983-68212012000200008
Abstract: this article aims to analyse the treatment given by the brazilian estado novo (1937-1945) to machado de assis, after the official celebrations of the birth centenary of the author of dom casmurro, in 1939. if in the year of machado's centennial the government raised him to the status of the greatest brazilian writer, in the early 1940s, under the department of press and propaganda (dip), the tone was different: in the context of the prevalence of social and documentary conceptions of art, getúlio vargas himself, the ideologue cassiano ricardo and major estadonovista journals criticized the alleged absenteeism and lack of "local color" in the work of the founder of brazilian academy of letters.
Clothes Recommend Themselves: A New Approach to a Fashion Coordinate Support System
Mio Fukuda,Yoshio Nakatani
Lecture Notes in Engineering and Computer Science , 2011,
Book review: Buttle, F.: "Customer relationship management: concepts and tools"
Dario Mio?evi?
Tr?i?te/Market , 2007,
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