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Search Results: 1 - 10 of 3402 matches for " Minoru Kobayashi "
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Structure Analysis for Hydrate Models of Ethyleneimine Oligomer by Quantum Chemical Calculation  [PDF]
Minoru Kobayashi, Hisaya Sato
Pharmacology & Pharmacy (PP) , 2010, DOI: 10.4236/pp.2010.12009
Abstract: Structure analyses for hydrate models of ethyleneimine oligomer (5-mer as model of PEI) were investigated by quantum chemical calculations. Conformation energies and structures optimized for hydrate models of (ttt)5 and (tgt)5 conformers were examined. Hydrate ratio, h [h = H2O/N (mol)], was set from 0.5 to 2. In anhydrates, (tg+t)5 conformer was more stable (?1.8 kcal/m.u.) than (ttt)5. In hydrates, (ttt)5 conformers were more stable (?0.7 - ?4.3) than (tg+t)5. These results corresponded to experimental results that anhydrous linear PEI crystal changes from double helical to single planar chain in hydration process. Structures calculated for (ttt)5 agreed in those observed for hydrates of PEI. In all (tg+t)5 conformers, O???H bonds between waters were found with the decreases of N???H bonds between imino group and water. The O???H bonds in (tg+t)5 conformer resulted in its high chain torsion, and strongly related with instability and structure change (large swelling).
Inhibitory Actions of Tetrandrine on Tumor Necrosis Factor α-Induced NF-κB Activation in Neovascularization of Cultured Choroidal Explants  [PDF]
Minoru Kikuchi, Shusuke Kamimura, Tatsuo Takahashi, Nobuyoshi Hagino, Shinjiro Kobayashi, Masaaki Nomura
Chinese Medicine (CM) , 2010, DOI: 10.4236/cm.2010.13015
Abstract: Tetrandrine (1 μM), a bis-benzylisoquinoline alkaloid isolated from Stephania tetrandra S Moore, signifi-cantly decreased tumor necrosis factor alpha (TNFα; 10 ng/ml)-induced increase in the number of micro vessels that budded from cultured rat choroidal explants. Tetrandrine also decreased the TNFα-induced in-crease in the number of cells composing the microvessels. Ammonium pyrrolidine dithiocarbamate (APDC; 0.1-0.3 μM), an inhibitor of nuclear factor-κB (NF-κB), decreased the TNFα-induced increase in the number of microvessels in a concentration-dependent manner. TNFα increased the phosphorylation and degradation of inhibitor of NF-κB (IκBα), as well as increasing the DNA-binding activity of NF-κB in choroidal explants. TNF? induced an increase of vascular endothelial growth factor (VEGF)-A mRNA, but not VEGF-C mRNA or VEGF-D mRNA. TNFα-induced angiogenic action was inhibited by treatment of VEGF-A antibody in cultured choroidal capillaries. Tetrandrine inhibited the TNFα-induced increases of phosphorylation and degradation of IκBα, and reduced the TNFα-induced increase of DNA-binding activity of NF-κB in chor-oidal explants. In conclusion, tetrandrine inhibits TNFα-induced activation of NF-κB in the choroidal capil-laries via inhibition of TNFα-induced phosphorylation of IκBα.
Arterial pulsation on a human patient simulator improved students’ pulse assessment  [PDF]
Akihiro Takeuchi, Tomomi Kobayashi, Minoru Hirose, Takashi Masuda, Toshiro Sato, Noriaki Ikeda
Journal of Biomedical Science and Engineering (JBiSE) , 2012, DOI: 10.4236/jbise.2012.55036
Abstract: Even with basic cardiovascular lectures, undergraduates do not usually experience the reality of palpation and, therefore, cannot integrate their physiological knowledge. We created a pulse training scenario of human patient simulators (HPS) to recognize and assess the normal and arrhythmic pulse of the radial artery. All 25 participants were recruited as volunteers to the study from the School of Allied Health Sciences, Kitasato University. Participants received training in radial palpation of arrhythmias on HPS. The test scenario included 10 arrhythmic pulses combined with normal pulses and weak pulses. The average examination scores significantly improved, from 23.8 ± 2.8 of the pretest to 72.9 ± 3.4 of the posttest (mean and SE, N = 25, p < 0.00001). A questionnaire and general written comments for the palpation training were positive. The palpation training improved the participants’ assessment of radial pulses.
A New Paradigm of Designing Human Communication Tools: A Human Affordance Theory
Masayuki Ihara,,Minoru Kobayashi,Yoshinori Sakai
International Journal of Computer Science & Applications , 2009,
Instability of colliding metastable strings
Hiramatsu, Takashi;Eto, Minoru;Kamada, Kohei;Kobayashi, Tatsuo;Ookouchi, Yutaka
High Energy Physics - Phenomenology , 2013,
Abstract: We investigate the collision dynamics of two metastable strings which can be viewed as tube-like domain walls with winding numbers interpolating a false vacuum and a true vacuum. We find that depending on the relative angle and speed of two strings, instability of strings increases and the false vacuum is filled out by rapid expansion of the strings or of a remnant of the collision.
Persistence and adherence of solifenacin treatment for Japanese women with overactive bladder
Minoru Kobayashi,Akinori Nukui,Shinsuke Kurokawa,Tatsuo Morita
Urogynaecologia International Journal , 2012, DOI: 10.4081/uij.2012.e9
Abstract: Persistence and adherence of overactive bladder (OAB) medication have reported to be generally lower in real-world setting as compared with those in clinical trials. However, this information in Japanese population has not been well addressed. Medical records were reviewed for solifenacin as an initial treatment for 172 women with OAB symptom to examine medication persistence, switching, adherence, and the reasons for discontinuation. The associations between persistence and the reasons for discontinuation as well as concomitant conditions regarded as OAB-related risk factors were assessed. The 6-month and 1-year persistence rate of solifenacin were 39.8% and 27.8%, respectively. Consequently, 121 patients (70.3%) discontinued solifenacin, of whom 18 (14.9%) patients switched to other OAB drugs and 9 (7.4%) patients restarted solifenacin. Thus, the adherence rate was 66.8%. More women discontinued solifenacin owing to symptom resolution (41.3%) rather than unfavorable outcomes such as adverse effects (12.4%) and lack of efficacy (21.5%). However, such reason for discontinuation was not the determinant of persistence of solifenacin. There was a non-significant trend towards higher persistence for those with OAB-related risk factors. Japanese women discontinued solofenacin treatment with various reasons in real-world practice, resulting in much lower persistence as compared with clinical trials. A further prospective study in a larger cohort of patients is awaited to better assess their persistence and adherence and understand exact efficacy and tolerability of antimuscarinics for Japanese patients with OAB.
Ovarian Germline Stem Cells in the Teleost Fish, Medaka (Oryzias latipes)
Shuhei Nakamura, Kayo Kobayashi, Toshiya Nishimura, Minoru Tanaka
International Journal of Biological Sciences , 2011,
Abstract: In the mammalian testis germline stem cells keep producing many sperms, while there is no direct evidence for the presence of germline stem cells in the ovary. It is widely accepted in mammals that the mature oocytes are supplied from a pool of primordial follicles in the adult ovary. In other vertebrates, such as fish, however, there has been no investigation on the mechanism underlying the high egg-producing ability. In this review, we introduce the recently identified ovarian germline stem cells and the surrounding unique structure in teleost fish, medaka (Oryzias latipes) [Nakamura S et al. Science. 2010; 328: 1561-1563]. We also discuss about the expression and function of sox9 that characterizes this unique structure.
Spin-Glass-like Transition and Hall Resistivity of Y2-xBixIr2O7
Natsuki Aito,Minoru Soda,Yoshiaki Kobayashi,Masatoshi Sato
Physics , 2003, DOI: 10.1143/JPSJ.72.1226
Abstract: Various physical properties of the pyrochlore oxide Y2-xBixIr2O7 have been studied. The magnetizations M measured under the conditions of the zero-field-cooling(ZFC) and the field-cooling(FC) have different values below the temperature T=TG. The anomalous T-dependence of the electrical resistivities r and the thermoelectric powers S observed at around TG indicates that the behavior of the magnetization is due to the transition to the state with the spin freezing. In this spin-frozen state, the Hall resistivities rH measured with the ZFC and FC conditions are found to have different values, too, in the low temperature phase (T
Breakdown of Chemical Scaling for Pt-Doped CaFe2As2
Kazutaka Kudo,Masakazu Kobayashi,Satomi Kakiya,Masataka Danura,Minoru Nohara
Physics , 2012, DOI: 10.1143/JPSJ.81.035002
Abstract: We report a breakdown of the scaling of the antiferromagnetic transition temperature T_N on chemical doping for Pt-doped CaFe2As2. The substitution of Pt is ineffective in the reduction of antiferromagnetic ordering as well as in inducing superconductivity in Ca(Fe1-xPtx)2As2. The Pt-doped CaFe2As2 that does not exhibit superconductivity will, however, provide us an ideal opportunity to elucidate the role of chemical doping in the occurrence of superconductivity in iron-based materials.
Instability of colliding metastable strings
Takashi Hiramatsu,Minoru Eto,Kohei Kamada,Tatsuo Kobayashi,Yutaka Ookouchi
Physics , 2013, DOI: 10.1007/JHEP01(2014)165
Abstract: The breaking of $U(1)_R$ symmetry plays a crucial role in modeling the breaking of supersymmetry (SUSY). In the models that possess both SUSY preserving and SUSY breaking vacua, tube-like cosmic strings called R-tubes, whose surfaces are constituted by domain walls interpolating a false and a true vacuum with some winding numbers, can exist. Their (in)stability can strongly constrain SUSY breaking models theirselves. In the present study, we investigate the dynamical (in)stability of two colliding metastable tube-like strings by field-theoretic simulations. From them, we find that the strings become unstable, depending on the relative collision angle and speed of two strings, and the false vacuum is eventually filled out by the true vacuum owing to rapid expansion of the strings or unstable bubbles created as remnants of the collision.
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