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Search Results: 1 - 10 of 42600 matches for " Minli Xu "
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A Novel Alignment-Free Method for Comparing Transcription Factor Binding Site Motifs
Minli Xu,Zhengchang Su
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0008797
Abstract: Transcription factor binding site (TFBS) motifs can be accurately represented by position frequency matrices (PFM) or other equivalent forms. We often need to compare TFBS motifs using their PFMs in order to search for similar motifs in a motif database, or cluster motifs according to their binding preference. The majority of current methods for motif comparison involve a similarity metric for column-to-column comparison and a method to find the optimal position alignment between the two compared motifs. In some applications, alignment-free methods might be preferred; however, few such methods with high accuracy have been described.
Computational prediction of cAMP receptor protein (CRP) binding sites in cyanobacterial genomes
Minli Xu, Zhengchang Su
BMC Genomics , 2009, DOI: 10.1186/1471-2164-10-23
Abstract: We have predicted and analyzed the CRP binding sites and regulons in 12 sequenced cyanobacterial genomes using a highly effective cis-regulatory binding site scanning algorithm. Our results show that cyanobacterial CRP binding sites are very similar to those in E. coli; however, the regulons are very different from that of E. coli. Furthermore, CRP regulons in different cyanobacterial species/ecotypes are also highly diversified, ranging from photosynthesis, carbon fixation and nitrogen assimilation, to chemotaxis and signal transduction. In addition, our prediction indicates that crp genes in modern cyanobacteria are likely inherited from a common ancestral gene in their last common ancestor, and have adapted various cellular functions in different environments, while some cyanobacteria lost their crp genes as well as CRP binding sites during the course of evolution.The CRP regulons in cyanobacteria are highly diversified, probably as a result of divergent evolution to adapt to various ecological niches. Cyanobacterial CRPs may function as lineage-specific regulators participating in various cellular processes, and are important in some lineages. However, they are dispensable in some other lineages. The loss of CRPs in these species leads to the rapid loss of their binding sites in the genomes.Cyclic AMP receptor protein (CRP), also known as catabolite gene activator protein (CAP), is an important transcriptional regulator widely distributed in a variety of bacterial groups [1,2]. The biological processes under the regulation of CRP are highly diverse, including energy metabolism [3,4], cell division and development [5], toxin production [1], competence development [6], quorum sensing [7] and cellular motility [8,9]. CRP belongs to the CRP/FNR transcription factor (TF) superfamily [10], which are generally believed to function as global regulators throughout the eubacteria [11]. Each member of the CRP/FNR superfamily contains an N-terminal effector binding domain a
Computational analysis of LexA regulons in Cyanobacteria
Shan Li, Minli Xu, Zhengchang Su
BMC Genomics , 2010, DOI: 10.1186/1471-2164-11-527
Abstract: Our analysis indicates that six of 33 sequenced cyanobacterial genomes do not harbor a lexA gene although they all encode the key SOS response genes, suggesting that LexA is not an indispensable transcription factor in these cyanobacteria, and that their SOS responses might be regulated by different mechanisms. Our phylogenetic analysis suggests that lexA was lost during the course of evolution in these six cyanobacterial genomes. For the 26 cyanobacterial genomes that encode a lexA gene, we have predicted their LexA-binding sites and regulons using an efficient binding site/regulon prediction algorithm that we developed previously. Our results show that LexA in most of these 26 genomes might still function as the transcriptional regulator of the SOS response genes as seen in E. coli and other organisms. Interestingly, putative LexA-binding sites were also found in some genomes for some key genes involved in a variety of other biological processes including photosynthesis, drug resistance, etc., suggesting that there is crosstalk between the SOS response and these biological processes. In particular, LexA in both Synechocystis sp. PCC6803 and Gloeobacter violaceus PCC7421 has largely diverged from those in other cyanobacteria in the sequence level. It is likely that LexA is no longer a regulator of the SOS response in Synechocystis sp. PCC6803.In most cyanobacterial genomes that we analyzed, LexA appears to function as the transcriptional regulator of the key SOS response genes. There are possible couplings between the SOS response and other biological processes. In some cyanobacteria, LexA has adapted distinct functions, and might no longer be a regulator of the SOS response system. In some other cyanobacteria, lexA appears to have been lost during the course of evolution. The loss of lexA in these genomes might lead to the degradation of its binding sites.The LexA protein was first characterized as the transcriptional regulator of the SOS response in Escherichia c
Coordinating Contracts for Two-Stage Fashion Supply Chain with Risk-Averse Retailer and Price-Dependent Demand
Minli Xu,Qiao Wang,Linhan Ouyang
Mathematical Problems in Engineering , 2013, DOI: 10.1155/2013/259164
Comparison of Supply Chain Contracts Based on Stackelberg Game and Nash bargaining Model with the Assumption of Risk Aversion

JIAN Huiyun
,XU Minli

- , 2016,
Abstract: 摘要 以批发价契约与回购契约为例,分析与比较风险规避型供应链分别采取Stackelberg博弈和Nash讨价还价博弈时的最优化决策,探讨供应链主导方如何根据合作伙伴的风险规避水平选择契约与博弈机制。研究表明,当零售商与供应商风险规避水平相同时,供应链的最优选择是采用Nash讨价还价博弈的批发价契约或者回购契约,二者等价;当零售商与供应商风险规避水平比较接近时,采用Nash讨价还价博弈下的回购契约要优于相同博弈机制下的批发价契约;当零售商与供应商风险规避水平相差较大时,供应商不会选择Nash讨价还价博弈下的任一契约,而是选择Stackelberg博弈下的回购契约。与风险中性假设下的结论相比,风险规避下的研究结论更符合供应链管理实践
Foreign Present Condition of the Science and Technology Project Evaluation and Development Trend Research
Minli Jin
International Journal of Business and Management , 2009, DOI: 10.5539/ijbm.v3n8p123
Abstract: The science and technology project evaluation is science and technology evaluation of importance constitute part, push national science and technology business to develop continuously and healthily, promote science and technology resources excellent turn to install, suggest a high-tech management important means and guarantee of the level. This text carried on for the abroad in advance national way of doing with evaluation of the science and technology project analytical, put forward evaluating to our country science and technology project according to its evaluation characteristics and the development trend of apocalypse.
Remanufacturing Decision Based on Brand Advantage and Cost Difference

XU Minli
,ZHANG Xuan,JIAN Huiyun

- , 2016,
Abstract: 摘要 考虑消费者对新产品和再制造产品的不同偏好,以及原制造商(OEM)的品牌优势,利用博弈论研究3种情形下的生产决策,分析OEM授权或自行再制造应满足的条件。研究结果表明,在不同竞争环境下,OEM产品和第三方再制造产品的最优定价和最优产量受双方的生产成本、消费者对再制造产品的认知及OEM品牌优势的影响。OEM品牌优势越小、第三方的再制造成本越低、OEM再制造的成本越高,以及消费者对再制造产品的认知越高,更愿意授权;而第三方再制造商只有在获得授权后所节约的成本超过某临界值时,才会愿意接受OEM授权。OEM的品牌优势越大、消费者对再制造产品的认知较低时,第三方再制造商更愿意接受OEM授权。OEM只有在自己再制造的成本较低且有利润时才愿意生产再制造产品,其品牌优势越高、消费者对再制造产品的认知越高,以及第三方再制造成本越高,OEM更愿意自行生产再制造产品
Performance Evaluation of Marine Industries Based on Eco-economy
Minli Gong,Yanqing Qi
International Journal of Online Engineering (iJOE) , 2013, DOI: 10.3991/ijoe.v9is2.2603
Abstract: An assessment framework is made to evaluate the performance factors of marine industries from the perspective of eco-economics by means of the AHP and the Delphi methods. Results are as follows: Performance assessment index of marine industries is decided by ecological performance, economic performance and social performance with ecological index taking priority over economic index; the efficiency of economy output and value-creating are preferred in the pursuit of low energy-consuming and less polluting marine industries; and in the near future, marine industries will make the greatest contribution to employment.
Design and development of highway tunnel maintenanceand management system
Ge Minli, Sun Lu
- , 2015, DOI: 10.3969/j.issn.1003-7985.2015.01.023
Abstract: In order to solve the urgent problem of how to manage and sustain highway tunnels with advanced information technology with the background of the rapid development in the modern traffic, and achieve the cost-effectiveness optimal principle objectives under the premise of guaranteeing a smooth flow of traffic; a highway tunnel maintenance and management system framework and the key modules were proposed. First, the determined highway tunnel condition assessment index system was established according to the result of expert consulting forms. Secondly, the tunnel diseases, the corresponding maintenance measurements, and many-to-many relationship between diseases and maintenance measurements were introduced. Then, three kinds of 0-1 integer programming models were built according to different tunnel operators’ needs in the optimization decision module. Finally, the further development and implementation of the system was prospected. The research results can provide references to tunnel researchers and managers.
Effects of Encapsulated Propolis on Blood Glycemic Control, Lipid Metabolism, and Insulin Resistance in Type 2 Diabetes Mellitus Rats
Yajing Li,Minli Chen,Hongzhuan Xuan,Fuliang Hu
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/981896
Abstract: The present study investigates the encapsulated propolis on blood glycemic control, lipid metabolism, and insulin resistance in type 2 diabetes mellitus (T2DM) rats. The animal characteristics and biological assays of body weight, fasting blood glucose (FBG), fasting serum insulin (FINS), insulin act index (IAI), triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were measured and euglycemic hyperinsulinemic glucose clamp technique were used to determine these effects. Our findings show that oral administration of encapsulated propolis can significantly inhibit the increasing of FBG and TG in T2DM rats and can improve IAI and M value in euglycemic hyperinsulinemic clamp experiment. There was no significant effects on body weight, TC, HDL-C, and LDL-C in T2DM rats treated with encapsulated propolis. In conclusion, the results indicate that encapsulated propolis can control blood glucose, modulate lipid metabolism, and improve the insulin sensitivity in T2DM rats.
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