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Search Results: 1 - 10 of 32626 matches for " Mingyao Huang "
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Effects of Winter Harvesting and Salinity on the Structure of Regrowing Reed Stands  [PDF]
Mingyao Huang, Qiang Sheng, Jihua Wu, Xiaoyun Pan
American Journal of Plant Sciences (AJPS) , 2014, DOI: 10.4236/ajps.2014.521339
Abstract: Harvest and salinity are two important factors of the growth of common reed (Phragmites australis). We here examined the different impact of winter harvest treatment on the Phragmites australis between high and low salinity (mean soil electrical conductivity is 7.87 ms/cm and 0.91 ms/cm) areas in Dongtan wetland of Yangtze River estuary, China. We measured phenology, Shoot density, stem diameter and height, biomass (total, aboveground and belowground biomass) and spike weight. At high salinity areas, harvest significantly inhibited the individual growth of stem height yet enhanced ramet density, and consequently led to an insignificant change in aboveground biomass. The belowground parts of reed were significantly inhibited. The root shoot ratio and the proportion of asexual reproduction decreased significantly. At low salinity areas, however, winter harvest generally has no significant influence on reed growth. Our results suggest that the winter harvest management may cause a decline of reed populations in the long term under condition of high salinity; however winter harvesting can be suggested as a proper management for sustainable utilization of reed communities at low salinity areas.
Ventilator-induced lung injury and mechanotransduction: why should we care?
Mingyao Liu
Critical Care , 2007, DOI: 10.1186/cc6131
Abstract: As a professor in a clinical department, I am privileged to work with many clinician-investigator trainees. Recently, a new clinical research fellow told me that he had been reading many papers in order to decide which research project he should take. The more he reads, the more confused he feels. Many literatures sound contradictory. How to determine their clinical relevance is a challenge. In fact, this challenge is not only to new fellows, but also to experienced researchers.In this issue of Critical Care, Dr Li and Dr Quinn and their colleagues published a research article [1] exploring the molecular mechanisms of ventilator-induced lung injury (VILI). I would like to use this interesting article as an example, to lead readers who are not experts in this field through a translational process.Mechanical force-induced signal transduction (mechano-transduction) is responsible for many physiological processes in lung development [2], in maintaining lung functions [3], and in pathological conditions related to lung diseases, such as asthma, chronic obstructive pulmonary disease (COPD), and acute respiratory distress syndrome (ARDS), especially related to VILI [4]. However, very much like the routes in a city, both "good boys" and "bad boys" drive on the same streets. Many signal transduction pathways are shared by both the injury and repair processes.Neutrophil recruitment and activation is an important mechanism for lung tissue injury, which is mediated by a group of small molecules, namely chemokines, especially a subgroup of C-X-C chemokines. Interleukin-8 (IL-8) is the best example, which has been shown to be up-regulated by mechanical forces in human lung cells [5]. Rodents do not have the IL-8 gene, but produce macrophage inflammatory protein-2 (MIP-2) and other C-X-C chemokines. Mechanical stretch induced MIP-2 in rat lung cells [6]. Increased MIP-2 in murine lung was observed after high volume ventilation by Dr Li and co-workers [7]. They further questioned t
Roles of XB130, a novel adaptor protein, in cancer
Atsushi Shiozaki, Mingyao Liu
Journal of Clinical Bioinformatics , 2011, DOI: 10.1186/2043-9113-1-10
Abstract: Adaptor proteins are molecules of modular structures without enzymatic activity, composed of multiple protein-protein and/or protein-lipid interacting domains, through which they link signaling components to form macromolecular complexes and propagate cellular signals [1,2]. Depending on the functional role of the interacting partner and the specific biological event that is triggered by these interactions, adaptor proteins can participate in the regulation of different signaling pathways. A good example of how adaptor proteins are involved in signal transduction is the activation of c-Src protein-tyrosine kinases by adaptor proteins via protein-protein interactions. Adaptor proteins are also important to mediate signals initiated via receptor-tyrosine kinases in responses to extracellular stimuli [3,4], and together with non-receptor protein-tyrosine kinases to orchestrate the signal transduction elicited by either ligand receptor interactions or by cellular structure reorganization [5]. Further, a number of adaptor proteins have been demonstrated to regulate tumorigenesis. For example, actin filament associated protein (AFAP) is required for actin stress fiber formation and cell adhesion, and is critical for tumorigenic growth in prostate cancer [6,7]. Tyrosine kinase substrate 5 is a scaffolding adaptor protein with five Src homology (SH) 3 domains, co-localizes to podosomes and regulates migration and invasion of different human cancer cells [8,9]. These findings support a broader investigation of adaptor proteins on tumorigenesis and their potentiality as diagnostic biomarkers and therapeutic targets of cancer.During our studies aimed at the characterization of the AFAP [10-12], we cloned a novel 130 kDa protein, referred to as XB130 [13]. Our studies have indeed indicated that XB130 plays, as an adaptor, important roles in the regulation of signal transduction, cell proliferation, survival, motility and invasion [13-16]. In this review, we focus on studies rel
Novel Miniaturized Bandpass Filters Using Spiral-Shaped Resonators and Window Feed Structures
Gaole Dai;Mingyao Xia
PIER , 2010, DOI: 10.2528/PIER09120401
Abstract: In this paper, we present a new class of miniaturized microstrip bandpass filters with low-insertion loss, sharp-rejection and narrow-band performance. The proposed filters are composed of two spiral-shaped resonators and rectangle window feed structures. Both back-to-back and interdigital combinations of the resonators are adopted to obtain the miniaturized filter size. Compared to the traditional square loop bandpass filter, the sizes are reduced by 82% and 80%. It is also found that there is a pair of transmission zeros located on each side of the passbands, resulting in high selectivity. To validate the proposed idea, two demonstration filters with back-to-back and interdigital spiral-shaped resonators are implemented. The measured results exhibit good agreement with the full-wave simulation results.
Research on the Lean Process Reengineering Based on Value Stream Mapping for Chinese Enterprises
Bo MENG,Mingyao Dong
Management Science and Engineering , 2012, DOI: 10.3968/j.mse.1913035x20120602.3696
Abstract: Under current economic environment, each enterprise faces serious situation. Especially in China, material and labor costs keep increasing for several years and put a great burden on Chinese enterprises. The paper puts forward a set of steps for Chinese enterprises to realize lean value stream so that to reduce costs, increase efficiency and improve product quality. We also propose suggestions for them to implement value stream mapping successfully. Key words: Chinese enterprises; Value stream mapping; Lean value stream; Process reengineering
Research on the Construction of a New-Type Bank-Enterprise Relation in China
Bo MENG,Mingyao DONG
International Business and Management , 2012, DOI: 10.3968/j.ibm.1923842820120402.1030
Abstract: Many Chinese enterprises face financing difficulties under current economic situation especially small and middle sized enterprises, the paper analyzes the problems of bank-enterprise relation in China, puts forward a new close bank-enterprise relation model that will benefit both banks and enterprise in reference to typical bank-enterprise relation models in the world, which is different from the host bank system in existence and the close bank-enterprise relation model prevails in western countries. The paper also gives some suggestions to construct such relation model. Key words: Bank-enterprise relation in China; Long-term cooperation; New-type close bank-enterprise relation
A Natural Small Molecule Harmine Inhibits Angiogenesis and Suppresses Tumour Growth through Activation of p53 in Endothelial Cells
Fujun Dai, Yihua Chen, Yajuan Song, Li Huang, Dong Zhai, Yanmin Dong, Li Lai, Tao Zhang, Dali Li, Xiufeng Pang, Mingyao Liu, Zhengfang Yi
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0052162
Abstract: Activation of p53 effectively inhibits tumor angiogenesis that is necessary for tumor growth and metastasis. Reactivation of the p53 by small molecules has emerged as a promising new strategy for cancer therapy. Several classes of small-molecules that activate the p53 pathway have been discovered using various approaches. Here, we identified harmine (β-carboline alkaloid) as a novel activator of p53 signaling involved in inhibition of angiogenesis and tumor growth. Harmine induced p53 phosphorylation and disrupted the p53-MDM2 interaction. Harmine also prevented p53 degradation in the presence of cycloheximide and activated nuclear accumulation of p53 followed by increasing its transcriptional activity in endothelial cells. Moreover, harmine not only induced endothelial cell cycle arrest and apoptosis, but also suppressed endothelial cell migration and tube formation as well as induction of neovascularity in a mouse corneal micropocket assay. Finally, harmine inhibited tumor growth by reducing tumor angiogenesis, as demonstrated by a xenograft tumor model. Our results suggested a novel mechanism and bioactivity of harmine, which inhibited tumor growth by activating the p53 signaling pathway and blocking angiogenesis in endothelial cells.
Finite $p$-groups with a minimal non-abelian subgroup of index $p$ (III)
Haipeng Qu,Mingyao Xu,Lijian An
Mathematics , 2013,
Abstract: In this paper, we finished the classification of three-generator finite $p$-groups $G$ such that $\Phi(G)\le Z(G)$. This paper is a part of classification of finite $p$-groups with a minimal non-abelian subgroup of index $p$, and partly solved a problem proposed by Y. Berkovich.
Hydroxyl radical induced structural changes of collagen
Helan Xiao,Guoping Cai,Mingyao Liu
Spectroscopy: An International Journal , 2007, DOI: 10.1155/2007/496174
Abstract: Extracellular matrix (ECM) plays an important role in cell differentiation, growth, migration and apoptosis. Collagen is the most abundant protein family in vivo, but its function has still not been clearly defined yet. Reactive oxygen species (ROS) have a central role in oxidative cell stress. Electron spin resonance (ESR) spectroscopy indicates that type I collagen could uniquely scavenge hydroxyl radicals in dose- and time-dependent manner; whereas BSA and gelatin (a denatured collagen) have no such an effect. However, the mechanism by which type I collagen scavenges hydroxyl radicals is different from that of GSH, a well-known free radical scavenger. Using a new method, two-dimensional FTIR correlation analysis, for the first time, we show that the order of functional group changes of type I collagen in this process is amide I earlier than amide II than amide III than –CH– than ν(C=O). The results indicates that the structure of the main chain of collagen changed first, followed by more residue group ν(C=O) exposed to hydroxyl radicals. The reaction with the carbonyl group in collagen causes the hydroxyl free radicals to be scavenged. Therefore, ECM can effectively scavenge ROS under normal physiological conditions. When the proteins of ECM were denatured in the same way as gelatin, they lost their function as a free radical scavenger. All of these results provide new insight into therapy or prevention of oxidative stress, apoptosis and ageing.
GENIE: a software package for gene-gene interaction analysis in genetic association studies using multiple GPU or CPU cores
Satish Chikkagoudar, Kai Wang, Mingyao Li
BMC Research Notes , 2011, DOI: 10.1186/1756-0500-4-158
Abstract: Here we present a novel software package GENIE, which utilizes the power of multiple GPU or CPU processor cores to parallelize the interaction analysis. GENIE reads an entire genetic association study dataset into memory and partitions the dataset into fragments with non-overlapping sets of SNPs. For each fragment, GENIE analyzes: 1) the interaction of SNPs within it in parallel, and 2) the interaction between the SNPs of the current fragment and other fragments in parallel. We tested GENIE on a large-scale candidate gene study on high-density lipoprotein cholesterol. Using an NVIDIA Tesla C1060 graphics card, the GPU mode of GENIE achieves a speedup of 27 times over its single-core CPU mode run.GENIE is open-source, economical, user-friendly, and scalable. Since the computing power and memory capacity of graphics cards are increasing rapidly while their cost is going down, we anticipate that GENIE will achieve greater speedups with faster GPU cards. Documentation, source code, and precompiled binaries can be downloaded from http://www.cceb.upenn.edu/~mli/software/GENIE/ webcite.The advent of high-throughput genotyping technologies has made it possible to study human genetic variation on a genome-wide scale. Recent years have seen an explosion of results generated from genome-wide association studies (GWAS). Most GWAS focus on single marker-based analysis in which each marker is analyzed individually, ignoring the dependence or interactions between markers. Although this approach has led to the discovery of disease susceptibility genes for many diseases, the identified markers often only explain a small fraction of the phenotypic variation, suggesting a large number of disease variants are yet to be discovered. It is becoming increasingly evident that gene-gene interactions play an important role in the etiology of complex diseases and traits [1-3], and likely explain some fraction of the "missing heritability". Gene-gene interaction is often studied using a regress
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