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Search Results: 1 - 10 of 197842 matches for " Minguillón Constante "
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Curso Cero virtual de Matemáticas para estudiantes de Economía
Jarne Jarne, Gloria,Minguillón Constante, Ma Esperanza,Zabal Cortés, Ma Trinidad
Rect@ , 2009,
Abstract: RESUMEN El objetivo inicial de este trabajo ha sido intentar resolver los problemas que en el aprendizaje y en la labor docente generan las numerosas lagunas en los conocimientos matemáticos básicos con los que los estudiantes llegan a la universidad. Teniendo en cuenta que el actual proceso de convergencia hacia el Espacio Europeo de Educación Superior potencia la utilización de nuevas metodologías en la labor docente, hemos optado por el dise o de un curso virtual de nivelación con el que pretendemos que los estudiantes inicien sus estudios universitarios de carácter económico con un nivel adecuado en matemáticas y que dispongan de un material de consulta. Este curso se ha adaptado para su presentación en distintas plataformas tecnológicas: un sitio web de libre acceso, el Anillo Digital Docente de la Universidad de Zaragoza y el portal de acceso público Open CourseWare.ABSTRACT The initial objective of this work has been to try to solve problems in learning and teaching generated by the many gaps in basic maths skills with which students arrive at university. Given that the ongoing process of convergence towards the European Higher Education Area promotes the use of new methodologies in teaching, we have chosen to design an introductory online course to take the students to an adequate level to start their university economics studies. This course has been adapted to different technology platforms: a free access website, the Virtual Campus of the University of Zaragoza and the portal Open Courseware
Monograph 'Open educational resources'
Julià Minguillón
Revista de Universidad y Sociedad del Conocimiento , 2007,
Abstract: Open educational resources have been the subject of intense debate at an institutional level for a relatively short time, coinciding with the diffusion of diverse international experiences in this matter. This monograph presents various projects and proposals that address the issue from different approaches that are commonly employed within this ambit, combining methodological and technological aspects with examples of good practices that are introducing institutional policies in this direction within many organisations, both educational and from Public Administration.
Opera-Learning: Integración de estándares de distribución de contenidos multimedia y learning objects
M. Pascual,J. Minguillón
RED : Revista de Educación a Distancia , 2005,
Abstract: En este trabajo se describe una primera aproximaci′on a una integraci′on entre documentos conformes a est′andares de distribuci′on de contenidos multimedia como MPEG-7, y otros recursos dise nados usando est′andares de e-learning como LOM y, por extensi′on, SCORM. Como ejemplo, se presenta el proyecto Opera-Learning impulsado por el Gran Teatre del Liceu, dentro del cual se est′a llevando a cabo este trabajo, que tiene como objetivo la estructuraci′on de un curso sobre ′opera que combina unos contenidos fijos con otros variables en funci′on de la ′opera escogida. La necesidad de integrar el concepto de learning object reutilizable en el proceso de dise no del curso es evidente, dado la variabilidad de los contenidos del curso pero manteniendo a su vez, una estructura temporal y de dise no instruccional prefijados de antemano. Las posibilidades que ofrece el uso de learning objects reutilizables integrados en un documento conforme al est′andar MPEG-7 son amplias: desde la catalogaci′on e indexaci′on de los diferentes contenidos multimedia, hasta la descripci′on completa de cursos multimedia usando learning objects.
Metodología fiable para definir el estado límite de descompresión en puentes de hormigón pretensado
Crespo Minguillón, César
Informes de la Construccion , 1997,
Abstract:
Fossil versus contemporary sources of fine elemental and organic carbonaceous particulate matter during the DAURE campaign in Northeast Spain
M. C. Minguillón,N. Perron,X. Querol,S. Szidat
Atmospheric Chemistry and Physics (ACP) & Discussions (ACPD) , 2011, DOI: 10.5194/acp-11-12067-2011
Abstract: We present results from the international field campaign DAURE (Determination of the sources of atmospheric Aerosols in Urban and Rural Environments in the Western Mediterranean), with the objective of apportioning the sources of fine carbonaceous aerosols. Submicron fine particulate matter (PM1) samples were collected during February–March 2009 and July 2009 at an urban background site in Barcelona (BCN) and at a forested regional background site in Montseny (MSY). We present radiocarbon (14C) analysis for elemental and organic carbon (EC and OC) and source apportionment for these data. We combine the results with those from component analysis of aerosol mass spectrometer (AMS) measurements, and compare to levoglucosan-based estimates of biomass burning OC, source apportionment of filter data with inorganic composition + EC + OC, submicron bulk potassium (K) concentrations, and gaseous acetonitrile concentrations. At BCN, 87 % and 91 % of the EC on average, in winter and summer, respectively, had a fossil origin, whereas at MSY these fractions were 66 % and 79 %. The contribution of fossil sources to organic carbon (OC) at BCN was 40 % and 48 %, in winter and summer, respectively, and 31 % and 25 % at MSY. The combination of results obtained using the 14C technique, AMS data, and the correlations between fossil OC and fossil EC imply that the fossil OC at Barcelona is ~47 % primary whereas at MSY the fossil OC is mainly secondary (~85 %). Day-to-day variation in total carbonaceous aerosol loading and the relative contributions of different sources predominantly depended on the meteorological transport conditions. The estimated biogenic secondary OC at MSY only increased by ~40 % compared to the order-of-magnitude increase observed for biogenic volatile organic compounds (VOCs) between winter and summer, which highlights the uncertainties in the estimation of that component. Biomass burning contributions estimated using the 14C technique ranged from similar to slightly higher than when estimated using other techniques, and the different estimations were highly or moderately correlated. Differences can be explained by the contribution of secondary organic matter (not included in the primary biomass burning source estimates), and/or by an overestimation of the biomass burning OC contribution by the 14C technique if the estimated biomass burning EC/OC ratio used for the calculations is too high for this region. Acetonitrile concentrations correlate well with the biomass burning EC determined by 14C. K is a noisy tracer for biomass burning.
Genesis and evolution of the Evx and Mox genes and the extended Hox and ParaHox gene clusters
Carolina Minguillón, Jordi Garcia-Fernàndez
Genome Biology , 2003, DOI: 10.1186/gb-2003-4-2-r12
Abstract: We claim that neither Mox nor Evx is a Hox or ParaHox gene. We propose a scenario that reconciles phylogeny with linkage data, in which an Evx/Mox ancestor gene linked to a ProtoHox cluster was involved in a segmental tandem duplication event that generated an array of all Hox-like genes, referred to as the 'coupled' cluster. A chromosomal breakage within this cluster explains the current composition of the extended Hox cluster (with Evx, Hox and Mox genes) and the ParaHox cluster.Most studies dealing with the origin and evolution of Hox and ParaHox clusters have not included the Hox-related genes Mox and Evx. Our phylogenetic analyses and the available linkage data in mammalian genomes support an evolutionary scenario in which an ancestor of Evx and Mox was linked to the ProtoHox cluster, and that a tandem duplication of a large genomic region early in metazoan evolution generated the Hox and ParaHox clusters, plus the cluster-neighbors Evx and Mox. The large 'coupled' Hox-like cluster EvxHox/MoxParaHox was subsequently broken, thus grouping the Mox and Evx genes to the Hox clusters, and isolating the ParaHox cluster.Homeobox genes have crucial roles during embryogenesis and have been deeply studied from the point of view of the evolution of development. Changes in their number and regulation may have been instrumental in body-plan evolution and diversification [1]. Whether the physical linkage of many homeobox genes is maintained by regulatory constraints or is simply a reflection of their evolutionary origin by tandem gene duplication has not yet been fully elucidated. The clustering of the Antennapedia superclass of homeobox genes in contemporary genomes is proposed to be the outcome of tandem gene duplication and cluster duplications from an ancestral UrArcheHox gene during metazoan evolution [2,3]. However, genome rearrangements, clade-specific duplications and gene losses obscure the complete evolutionary chronicle.The analysis of the human genome led Pollard
Personalización del proceso de aprendizaje usando learning objects reutilizables
J. Minguillón,E. Mor,F. Santanach,L. Guárdia
RED : Revista de Educación a Distancia , 2005,
Abstract: En este artículo se describe el dise o de una plataforma de e-learning que integra el uso de learning objects (objetos de aprendizaje) reutilizables como elementos básicos para la construcción de itinerarios que permiten la personalización del proceso de aprendizaje en función de las características especiales de cada curso y de cada perfil de estudiante. El objetivo es describir las características deseadas de tal plataforma y las problemáticas que se presentan cuando se integran diferentes tecnologías, especialmente el salto existente entre las definiciones de metadatos proporcionadas por los estándares de marcado de objetos de aprendizaje, y la aplicación de un modelo de dise o instruccional adecuado a este nuevo escenario. La plataforma propuesta apuesta por el uso del estándard SCORM y, por extensión, del estándar LOM para el marcado de los objetos de aprendizaje, teniendo en cuenta que el objetivo central es el seguimiento del proceso de aprendizaje y la personalización del mismo.
PM speciation and sources in Mexico during the MILAGRO-2006 Campaign
X. Querol,J. Pey,M. C. Minguillón,N. Pérez
Atmospheric Chemistry and Physics Discussions , 2007,
Abstract: Levels of PM10, PM2.5 and PM1 and chemical speciation of PM10 and PM2.5 were measured during the MILAGRO campaign (1 to 31 March 2006, but extended in some cases until 6 April) at four urban, one suburban, two rural, two rural background sites with different degree of industrial influence in the Mexico City Metropolitan Area (MCMA) and adjacent regions. PM10 and PM2.5 daily levels varied between 50–56 μg/m3 and 24–46 μg/m3 at the urban sites, 22–35 μg/m3 and 13–25 μg/m3 at the rural sites, and 75 μg/m3 and 31 $mu $g/m3 at the industrial hotspot, respectively; lower than those recorded at some Asian mega-cities and similar to those recorded at other South American cities. At the urban sites, hourly PM2.5 and PM1 concentrations showed a marked impact of road traffic emissions (at rush hours), with levels of coarse PM remaining elevated during daytime. At the suburban and rural sites, different PM daily patterns were registered according to the influence of the pollution plume from MCMA and also on local soil resuspension. The speciation studies showed that mineral matter accounted for 25–27% of bulk PM10 at the urban sites and a higher proportion (up to 43%) at the suburban and rural sites. This pattern is repeated in PM2.5, with 15% at urban and 28% at suburban and rural sites. Carbonaceous compounds accounted for a similar proportion at the urban sites (24–32% in PM10, and up to 37% in PM2.5), markedly reduced at the suburban and rural sites (17% in PM10, and 23–38% in PM2.5). The secondary inorganic aerosols accounted for 10–20% of bulk PM10 at urban, suburban, rural and industrial sites, with a higher proportion (40%) at the industrial background site. A relatively high proportion of nitrate in rural sites was present in the coarse fraction. Typically anthropogenic elements (As, Cr, Zn, Cu, Pb, Sn, Sb, Ba, among others) showed considerably high levels at the urban sites; however levels of particulate Hg and crustal trace elements (Rb, Ti, La, Sc, Ga) were generally higher at the suburban site. Principal component analysis identified three common factors: crustal, regional background and road traffic. Moreover, some specific factors were obtained for each site.
Analysis of the transcriptional activity of endogenous NFAT5 in primary cells using transgenic NFAT-luciferase reporter mice
Beatriz Morancho, Jordi Minguillón, Jeffery D Molkentin, Cristina López-Rodríguez, Jose Aramburu
BMC Molecular Biology , 2008, DOI: 10.1186/1471-2199-9-13
Abstract: The 9xNFAT-Luc reporter was activated by hypertonicity in an NFAT5-dependent manner in different types of non-transformed transgenic cells: lymphocytes, macrophages and fibroblasts. Activation of this reporter by the phorbol ester PMA plus ionomycin was independent of NFAT5 and mediated by NFATc proteins. Transcriptional activation of NFAT5 in T lymphocytes was detected at hypertonic conditions of 360–380 mOsm/kg (isotonic conditions being 300 mOsm/kg) and strongly induced at 400 mOsm/kg. Such levels have been recorded in plasma in patients with osmoregulatory disorders and in mice deficient in aquaporins and vasopressin receptor. The hypertonicity threshold required to activate NFAT5 was higher in bone marrow-derived macrophages (430 mOsm/kg) and embryonic fibroblasts (480 mOsm/kg). Activation of the 9xNFAT-Luc reporter by hypertonicity in lymphocytes was insensitive to the ERK inhibitor PD98059, partially inhibited by the PI3-kinase inhibitor wortmannin (0.5 μM) and the PKA inhibitor H89, and substantially downregulated by p38 inhibitors (SB203580 and SB202190) and by inhibition of PI3-kinase-related kinases with 25 μM LY294002. Sensitivity of the reporter to FK506 varied among cell types and was greater in primary T cells than in fibroblasts and macrophages.Our results indicate that NFAT5 is a sensitive responder to pathologic increases in extracellular tonicity in T lymphocytes. Activation of NFAT5 by hypertonicity in lymphocytes was mediated by a combination of signaling pathways that differed from those required in other cell types. We propose that the 9xNFAT-Luc transgenic mouse model might be useful to study the physiopathological regulation of both NFAT5 and NFATc factors in primary cells.NFAT5/TonEBP belongs to the Rel family of transcription factors, which also comprises NF-κB and the calcineurin-dependent NFATc proteins (NFAT1/NFATc2, NFAT2/NFATc1, NFAT3/NFATc4, NFAT4/NFATc3) [1,2]. Rel proteins have in common a conserved DNA binding domain, but do not d
No more than 14: the end of the amphioxus Hox cluster
Minguillón Carolina,Gardenyes Josep,Serra Elisa,Castro L. Filipe C.
International Journal of Biological Sciences , 2005,
Abstract: The Hox gene cluster has been a key paradigm for a generation of developmental and evolutionary biologists. Since its discovery in the mid-1980's, the identification, genomic organization, expression, colinearity, and regulation of Hox genes have been immediate targets for study in any new model organism, and metazoan genome projects always refer to the structure of the particular Hox cluster(s). Since the early 1990's, it has been dogma that vertebrate Hox clusters are composed of thirteen paralogous groups. Nonetheless, we showed that in the otherwise prototypical cephalochordate amphioxus (Branchiostoma floridae), the Hox cluster contains a fourteenth Hox gene, and very recently, a 14th Hox paralogous group has been found in the coelacanth and the horn shark, suggesting that the amphioxus cluster was anticipating the finding of Hox 14 in some vertebrate lineages. In view of the pivotal place that amphioxus occupies in vertebrate evolution, we thought it of considerable interest to establish the limits of its Hox gene cluster, namely resolution of whether more Hox genes are present in the amphioxus cluster (e.g., Hox 15). Using two strategies, here we report the completion and characterization of the Hox gene content of the single amphioxus Hox cluster, which encompasses 650 kb from Hox1 to Evx. Our data have important implications for the primordial Hox gene cluster of chordates: the prototypical nature of the single amphioxus Hox cluster makes it unlikely that additional paralogous groups will be found in any chordate lineage. We suggest that 14 is the end.
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