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Search Results: 1 - 10 of 32342 matches for " Min Young Chung "
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The relationship between cardiovascular disease risk factors and gender  [PDF]
Chung-Min Cho, Young-Mi Lee
Health (Health) , 2012, DOI: 10.4236/health.2012.46051
Abstract: The purpose of this study was to investigate the relationship between three socioeconomic sta- tuses and five behavior-related cardiovascular risk factors by gender, based on data from the Third Korea National Health and Nutrition Examination III. Data from 4556 people were analyzed. The propensity toward obesity, hypercholesterolemia, and physical inactivity was significantly higher in women than in men. Hypertension and smoking were significantly more prevalent in men than in women. The differences in the prevalence of cardiovascular disease risk factors by gender is important and should be considered when developing programs to reduce the incidence of cardiovascular diseases.
A Retrospective Study of Directed Blood Donations in the Kasungu District of Malawi  [PDF]
David S. Chung, Fenjun Shen, Sumin Lee, Taekwon Kong, Jonathan Ko, Jin Young Choe, Sang Min Lee, George Talama
Open Journal of Blood Diseases (OJBD) , 2018, DOI: 10.4236/ojbd.2018.84008
Abstract: Since the discovery of blood circulation and transfusion, there has been an insatiable demand for voluntary blood donations throughout the world. However, gathering blood donors has never been easy because eligible donors constitute only a fraction of the general population and are often reluctant to donate. This is especially challenging in underprivileged countries of sub-Saharan Africa such as Malawi whose nationally run blood transfusion service struggles to maintain hospital blood banks. As a result, hospitals turn to their local communities for directed donations. A retrospective analysis from January 2014 to June 2016 of directed blood donor data from two hospitals in the Kasungu District of Malawi was conducted. The analysis of 2134 donations was carried out with respect to sex, age, hemoglobin concentration, blood group, and presence of transfusion-transmissible infections. On average, donors were 30 years of age and predominately male. Blood group O+ constituted more than half of all directed blood donations. Ultimately, about one third of donations were unable to be utilized for transfusion.
Performance Analysis of IEEE 802.11 DCF under Nonsaturation Condition
Yutae Lee,Min Young Chung,Tae-Jin Lee
Mathematical Problems in Engineering , 2008, DOI: 10.1155/2008/574197
Abstract: Carrier sense multiple access with collision avoidance (CSMA/CA) methods are considered to be attractive MAC protocols for wireless LANs. IEEE 802.11 distributed coordination function (DCF) is a random channel access scheme based on CSMA/CA method and the binary slotted exponential backoff procedure to reduce the packet collision. In this paper, we propose a new analytical model for a nonsaturated IEEE 802.11 DCF network and evaluate its performance. We verify our model using simulations and show that our results agree with the simulations.
Practical Approaches to Mitigation of Specimen Charging in High-Resolution Transmission Electron Microscopy
Young-Min Kim,Hu Young Jeong,Seong-Hyeon Hong,Sung-Yoon Chung
Journal of Analytical Science & Technology , 2010,
Abstract: Specimen charging that is associated with the electron bombardment on the sample is a practical hindrance to high-resolution transmission electron microscopy (HRTEM) analysis because it causes a severe loss of resolution in either diffraction or image data. Conductive thin film deposition on an insulating specimen has been proposed as an effective approach to the mitigation of the specimen charging; however, this method is generally not useful in HRTEM imaging of materials because the deposited film induces another artifact in the HRTEM image contrast. In this study, we propose practical methods to mitigate the specimen charging that takes place during the HRTEM of materials. For bulk-type specimens prepared by either an ion-thinning or focused-ion beam (FIB) process, a plasma cleaning treatment is significantly effective in eliminating the charging phenomenon. In the case of low-dimensional nanomaterials such as nanowires and nanoparticles, the plasma cleaning is not feasible; however, the charging effect can be effectively eliminated by adjusting the electron illumination condition. The proposed methods facilitate a decrease in the buildup of specimen charging, thereby enhancing the quality of high-resolution images significantly.
Proteomic Validation of Multifunctional Molecules in Mesenchymal Stem Cells Derived from Human Bone Marrow, Umbilical Cord Blood and Peripheral Blood
Jumi Kim, Jeong Min Shin, Young Joo Jeon, Hyung Min Chung, Jung-Il Chae
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0032350
Abstract: Mesenchymal stem cells (MSCs) are one of the most attractive therapeutic resources in clinical application owing to their multipotent capability, which means that cells can differentiate into various mesenchymal tissues such as bone, cartilage, fat, tendon, muscle and marrow stroma. Depending on the cellular source, MSCs exhibit different application potentials according to their different in vivo functions, despite similar phenotypic and cytological characteristics. To understand the different molecular conditions that govern the different application or differentiation potential of each MSC according to cellular source, we generated a proteome reference map of MSCs obtained from bone marrow (BM), umbilical cord blood (CB) and peripheral blood (PB). We identified approximately 30 differentially regulated (or expressed) proteins. Most up-regulated proteins show a cytoskeletal and antioxidant or detoxification role according to their functional involvement. Additionally, these proteins are involved in the increase of cell viability, engraftment and migration in pathological conditions in vivo. In summary, we examined differentially expressed key regulatory factors of MSCs obtained from several cellular sources, demonstrated their differentially expressed proteome profiles and discussed their functional role in specific pathological conditions. With respect to the field of cell therapy, it may be particularly crucial to determine the most suitable cell sources according to target disease.
Efficient Generation of Virus-Free iPS Cells Using Liposomal Magnetofection
Hyo Young Park, Eun Hyung Noh, Hyung-Min Chung, Man-Jong Kang, Eun Young Kim, Se Pill Park
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0045812
Abstract: The generation of induced pluripotent stem (iPS) cells is a powerful tool in regenerative medicine, and advances in nanotechnology clearly have great potential to enhance stem cell research. Here, we introduce a liposomal magnetofection (LMF) method for iPS cell generation. Efficient conditions for generating virus-free iPS cells from mouse embryonic fibroblast (MEF) cells were determined through the use of different concentrations of CombiMag nanoparticle-DNA(pCX-OKS-2A and pCX-cMyc)-lipoplexes and either one or two cycles of the LMF procedure. The cells were prepared in a short reprogramming time period (≤8 days, 0.032–0.040%). Among the seven LMF-iPS cell lines examined, two were confirmed to be integration-free, and an integration-free LMF-iPS cell line was produced under the least toxic conditions (single LMF cycle with a half-dose of plasmid). This cell line also displayed in vitro/in vivo pluripotency, including teratoma formation and chimeric mouse production. In addition, the safety of CombiMag-DNA lipoplexes for the transfection of MEF cells was confirmed through lactate dehydrogenase activity assay and transmission electron microscopy. These results demonstrated that the LMF method is simple, effective, and safe. LMF may represent a superior technique for the generation of virus-free or integration-free iPS cell lines that could lead to enhanced stem cell therapy in the future.
Effects of Methamphetamine on Single Unit Activity in Rat Medial Prefrontal Cortex In Vivo
Jinhwa Jang,Hee-Jin Ha,Yun Bok Kim,Young-Ki Chung,Min Whan Jung
Neural Plasticity , 2007, DOI: 10.1155/2007/29821
Abstract: To investigate how neuronal activity in the prefrontal cortex changes in an animal model of schizophrenia, we recorded single unit activity in the medial prefrontal cortex of urethane-anesthetized and awake rats following methamphetamine (MA) administration. Systemic MA injection (4 mg/kg, IP) induced inconsistent changes, that is, both enhancement and reduction, in unit discharge rate, with a subset of neurons transiently (<30 min) elevating their activities. The direction of firing rate change was poorly predicted by the mean firing rate or the degree of burst firing during the baseline period. Also, simultaneously recorded units showed opposite directions of firing rate change, indicating that recording location is a poor predictor of the direction of firing rate change. These results raise the possibility that systemic MA injection induces random bidirectional changes in prefrontal cortical unit activity, which may underlie some of MA-induced psychotic symptoms.
Incidence and clinicopathologic behavior of uterine cervical carcinoma in renal transplant recipients
Sung Taek Park, Min Jong Song, Jong Sup Park, Soo Young Hur, Chung Won Lee
World Journal of Surgical Oncology , 2011, DOI: 10.1186/1477-7819-9-72
Abstract: Among 453 women receiving renal transplantation from January 1990 to December 2008, 5 patients were diagnosed with cervical carcinoma. Medical records of these 5 patients were retrospectively reviewed, and clinicopathologic data were collected and analyzed.The incidence of cervical carcinoma in renal transplant recipients was 58.1 out of 100,000 per year, which is 3.5 times higher than in the general Korean population. The mean interval between the time of renal transplantation and the time of cervical carcinoma diagnosis was 80.7 months. After a median follow-up of 96.2 months, there was no recurrence of the disease or death. In 4 patients who were positive from human papillomavirus in situ hybridization (HPV ISH), high or probably high risk HPV DNA was detected in all. Punctate staining of HPV ISH was detected in 3 out of 4 patients.Higher incidence of cervical carcinoma is expected in renal transplant recipients, so appropriate surveillance is needed to ensure early detection and treatment of cervical carcinoma.Recent advancements in immunosuppressive therapy have reduced cases of acute rejection and improved the long-term survival rate of grafts in organ transplant patients. Long-term use of immunosuppressants has likewise increased the incidence of infectious diseases, autoimmune diseases, and malignancy in organ transplant patients.Particularly, the incidence of malignancy was reported to be 2-31% in patients who had received renal transplants [1-6], and was also reported to be a major cause of one-third of cases of post-organ transplant death [7]. Possible mechanisms by which immunosuppressants increase malignant carcinoma include the increased chances of infection with such oncogenic viruses as the human papillomavirus (HPV), DNA damage due to the immunosuppresant, increased carcinogenicity of carcinogens due to the immunosuppressant, and immunologic tolerance to oncocyte due to immunosuppresion [8,9].HPV is known as the major cause of cervical carcinoma and
Guest Editorial
Min Young Chung,Jae-Hyun Kim,Masato Oguchi,Jeng-Shyang Pan
Journal of Networks , 2010, DOI: 10.4304/jnw.5.3.265-266
Abstract: This special issue comprises of 10 selected papers from the 3rd International Conference on Ubiquitous Information Management and Communication (ICUIMC 2009). From 358 papers submitted in the conference, 106 papers were selected for presentation. Among them, ten qualified papers have been selected as the papers for this special issue, which deal with state-of-the-art communication technology. Sensor network is vulnerable to hostile environments. Thus, 3 papers focus on security issues in wireless sensor network. Also, energy consumption is an important problem in sensor network, which is considered in this issue: "Environment-based selection method for en-route filtering scheme using fuzzy logic" by Sang Jin Lee, Hae Young Lee, Tae Ho Cho, adopts the fuzzy logic to determine the threshold to filter false reports in wireless sensor networks. "Light weight key renewals for clustered sensor networks" by Gicheol Wang, Seunghae Kim, Daewook Kang, Deokjai Choi and Gihwan Cho, proposed a lightweight key renewal scheme, which removes the compromised nodes by reforming clusters. In a cluster, each member uses a pair-wise key to communicate with its cluster head. "An isolation intrusion detection system for hierarchical wireless sensor networks" by Rung-Ching Chen, Chia-Fen Hsieh and Yu
Increased Expression of Neurotrophin 4 Following Focal Cerebral Ischemia in Adult Rat Brain with Treadmill Exercise
Jin-Young Chung, Min-Wook Kim, Moon-Suk Bang, Manho Kim
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0052461
Abstract: Neurotrophin 4 (NT-4) belongs to the family of neurotrophic factors, and it interacts with the tyrosine kinase B (trkB) receptor. NT-4 has neuroprotective effects following cerebral ischemia. Its role might be similar to brain-derived neurotrophic factor (BDNF), because both interact with trkB. Exercise also improves neural function by increasing neurotrophic factors. However, expression profiles of NT-4 in the brain during exercise are unknown. Here, we assessed the expressions of NT-4 and its receptor, trkB, following cerebral ischemia and hypothesized that exercise changes the expressions of NT-4 and trkB. Results showed that in a permanent middle cerebral artery occlusion rat model, ischemia decreased NT-4 and trkB expression. Immunohistochemistry showed their immunoreactivities around the region of the ischemic area. Treadmill exercise changed the expression of NT-4, which increased in the contralateral hemisphere in rats with ischemic injury. TrkB also showed similar patterns to its neurotophins. The change in NT-4 suggested that exercise might have primed NT4 production so that further injury causes slightly greater increases in NT4 compared with non-exercise controls.
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