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Search Results: 1 - 10 of 47533 matches for " Min Jung Lee "
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Development of the Guideline for HIV Testing in South Korea with Low Prevalence of HIV-1 Infection Based on the Expert Consensus  [PDF]
Hee Jung Choi, Kyoung Ae Kong, Jung Won Min, Hun-Jae Lee, Hae-Sook Park
World Journal of AIDS (WJA) , 2011, DOI: 10.4236/wja.2011.14023
Abstract: Purpose: This study was conducted to develop a guideline for HIV testing in South Korea where the HIV prevalence is very low. It is necessary to make the recommendations presented here based on the epidemiology of opportunistic infection and cancer in the community. Methods: The development of a guideline for HIV testing was conducted using literature reviews and the agreement of Korean experts for HIV patients using a two-round Delphi consensus technique. Each expert was asked to independently answer to each item related to HIV risk. Ten experts participated in the two-round survey. Results: The individual items were determined based on the following categories: high risk behavior, symptom and diseases, colo-rectal diseases, uro-genital diseases and gynecology, skin and oral diseases. The final guideline consisted of 4-scale agreement rating (strongly recommended, recommended, not routinely recommended, no recommendation for routine provision). Discussion: We have developed the guideline for HIV testing in a country where the HIV prevalence is low based on a systematic investigation and expert consensus.
Cyanidine-3-O-Galactoside Enriched Aronia melanocarpa Extract Inhibits Adipogenesis and Lipogenesis via Down-Regulation of Adipogenic Transcription Factors and Their Target Genes in 3T3-L1 Cells  [PDF]
Su-Min Lim, Jae In Jung, Nam Young Kim, Jung-Shik Bae, Hyun Sook Lee, Eun Ji Kim
Food and Nutrition Sciences (FNS) , 2019, DOI: 10.4236/fns.2019.102011
Abstract: Aronia melamocarpa (AM) is a rich source of anthocyanins, which are known to help prevent obesity. The cyanidine-3-O-galactoside enriched AM extract (AM-Ex) containing more cyanidine-3-O-galactoside than conventional AM extract was recently developed. The objective of this study was to examine the effect of AM-Ex on adipogenesis and its action mechanisms in vitro using 3T3-L1 adipocytes. To examine the anti-obesity effect of AM-Ex, 3T3-L1 cells were induced adipocyte differentiation and incubated with various concentration of AM-Ex. Lipid accumulation, cellular triglyceride content, mRNA expression of transcription factors and adipogenic genes were analyzed. Treatment with 100 - 400 μg/mL of AM-Ex resulted in a dose-dependent decrease in adipocyte differentiation and triglyceride accumulation. mRNA expression of adipogenic transcription factors, such as peroxisome proliferator-activated receptor gamma, CCAAT/enhancer binding protein α, sterol regulatory element-binding protein 1 were decreased. The level of gene expression of adipogenesis and lipogenesis-related genes, such as adipocyte protein 2, lipoprotein lipase, acetyl-CoA carboxylase, ATP-citrate lyase and fatty acid synthase were decreased. These results suggest that AM-Ex alleviated risk factors related to obesity by modulating multiple pathways associated with adipogenesis.
Bis[μ-4-(1H-imidazol-3-ium-1-yl)benzoato-κ2O:O′]bis[(methanol)tris(nitrato-κ2O,O′)terbium(III)]
Yeong-Min Jung,Soon W. Lee
Acta Crystallographica Section E , 2011, DOI: 10.1107/s1600536811002443
Abstract: In the centrosymmetric dinuclear title complex, [Tb2(NO3)6(C10H8N2O2)2(CH3OH)2], the Tb atoms are bridged by the carboxylate groups of the two 4-(1H-imidazol-3-ium-1-yl)benzoate (iba) ligands. The iba ligand adopts a zwitterionic form with a protonated imidazole group. The Tb atom adopts a distorted tricapped trigonal–prismatic coordination geometry and is coordinated by six O atoms of three chelating nitrate ions, one O atom of the methanol molecule and two O atoms of two iba ligands. The intramolecular Tb...Tb separation is 5.1419 (3) . O—H...O and N—H...O hydrogen bonds connect complex molecules into a two-dimensional network.
Quantification of HBsAg: Basic virology for clinical practice
Jung Min Lee, Sang Hoon Ahn
World Journal of Gastroenterology , 2011,
Abstract: Hepatitis B surface antigen (HBsAg) is produced and secreted through a complex mechanism that is still not fully understood. In clinical fields, HBsAg has long served as a qualitative diagnostic marker for hepatitis B virus infection. Notably, advances have been made in the development of quantitative HBsAg assays, which have allowed viral replication monitoring, and there is an opportunity to make maximal use of quantitative HBsAg to elucidate its role in clinical fields. Yet, it needs to be underscored that a further understanding of HBsAg, not only from clinical point of view but also from a virologic point of view, would enable us to deepen our insights, so that we could more widely expand and apply its utility. It is also important to be familiar with HBsAg variants and their clinical consequences in terms of immune escape mutants, issues resulting from overlap with corresponding mutation in the P gene, and detection problems for the HBsAg variants. In this article, we review current concepts and issues on the quantification of HBsAg titers with respect to their biologic nature, method principles, and clinically relevant topics.
Beyond Breast and Ovarian Cancers: PARP Inhibitors for BRCA Mutation-Associated and BRCA-Like Solid Tumors
Elise C. Kohn,Jung-Min Lee
Frontiers in Oncology , 2014, DOI: 10.3389/fonc.2014.00042
Abstract: Poly(ADP-ribose) polymerase inhibitors (PARPi) have shown clinical activity in patients with germline BRCA1/2 mutation (gBRCAm)-associated breast and ovarian cancers. Accumulating evidence suggests that PARPi may have a wider application in the treatment of cancers defective in DNA damage repair pathways, such as prostate, lung, endometrial, and pancreatic cancers. Several PARPi are currently in phase I/II clinical investigation, as single-agents and/or combination therapy in these solid tumors. Understanding more about the molecular abnormalities involved in BRCA-like phenotype in solid tumors beyond breast and ovarian cancers, exploring novel therapeutic trial strategies and drug combinations, and defining potential predictive biomarkers are critical to expanding the scope of PARPi therapy. This will improve clinical outcome in advanced solid tumors. Here, we briefly review the preclinical data and clinical development of PARPi, and discuss its future development in solid tumors beyond gBRCAm-associated breast and ovarian cancers.
Distributed and Parallel Path Query Processing for Semantic Sensor Networks
Sung-Jae Jung,Dong-Min Seo,Seungwoo Lee,Hwan-Min Kim,Hanmin Jung
International Journal of Distributed Sensor Networks , 2014, DOI: 10.1155/2014/438626
Abstract: As the sensor networks are broadly used in diverse range of applications, Semantic Web technologies have been adopted as a means to manage the huge amount of heterogeneous sensor nodes and their observation data. Large amount of sensor data are annotated with spatial, temporal, and thematic semantic metadata. As a consequence, efficient query processing over large RDF graph is becoming more important in retrieving contextual information from semantic sensor data. In this paper we propose a novel path querying scheme which uses RDF schema information. By utilizing the class path expressions precalculated from RDF schema, the graph search space is significantly reduced. Compared with the conventional BFS algorithm, the proposed algorithm (bidirectional BFS combined with class path lookup approach) achieves performance improvement by 3 orders of magnitude. Additionally, we show that the proposed algorithm is efficiently parallelizable, and thus, the proposed algorithm returns graph search results within a reasonable response time on even much larger RDF graph. 1. Introduction Sensor networks are used in wide range of applications such as weather monitoring, environmental monitoring, military surveillance, medical science for patient health care, and biochemical detection [1–3]. As sensors have been increasingly adopted by a diverse array of disciplines [4–6], heterogeneous standards based on different hardwares, softwares, and protocols have been introduced. As a consequence, Semantic Web technologies have been proposed as a means to manage the huge amount of heterogeneous sensor nodes and their observation data [2, 3]. The combination of sensor networks and ontologies can bring significantly added value to intelligently process the raw data into meaningful information [7]. By annotating sensor data with spatial, temporal, and thematic semantic metadata, one can retrieve contextual information from the annotated sensor data [3]. This study aims to introduce a novel path querying scheme which can efficiently extract situational knowledge from semantically annotated sensor data. In the field of generic Semantic Web technology, several relationship finding services have been proposed. Microsoft coauthor path (http://academic.research.microsoft.com/VisualExplorer), Relfinder [8], and OntoRelfinder [9] are the examples of relationship finding services which retrieve relationships between two given objects of interest from Resource Description Framework (RDF) graph. RDF is a language for representing information about resources in the World Wide Web. By
Neural activity in mediodorsal nucleus of thalamus in rats performing a working memory task
Jihyero Han,Ji Hyun Lee,Min Jung Kim,Min Whan Jung
Frontiers in Neural Circuits , 2013, DOI: 10.3389/fncir.2013.00128
Abstract: The neural circuit consisting of mediodorsal nucleus (MDN) of thalamus and prefrontal cortex (PFC) has been implicated in working memory. In order to investigate whether and how the rodent MDN processes working memory-related signals, we recorded activity of single neurons from the MDN in rats performing a delayed spatial alternation task. The MDN conveyed significant neural signals for the animal's previously chosen goal (retrospective information) in the early delay period, but the signals deteriorated gradually over time so that they became weak toward the end of the delay period. Neural signals for the animal's upcoming goal choice (prospective information) were even weaker than those for the previously chosen goal. These results are in contrast to the finding in monkeys that both MDN and PFC persistently maintain task-related neural signals throughout delay period. Our results do not support sustained MDN-PFC interactions as a general mechanism for mediating working memory across different behavioral tasks and/or animal species.
Portulaca oleracea Ameliorates Diabetic Vascular Inflammation and Endothelial Dysfunction in db/db Mice
An Sook Lee,Yun Jung Lee,So Min Lee,Jung Joo Yoon,Jin Sook Kim,Dae Gill Kang,Ho Sub Lee
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/741824
Abstract: Type 2 diabetes is associated with significantly accelerated rates of micro- and macrovascular complications such as diabetic vascular inflammation and endothelial dysfunction. In the present study, we investigated the protective effect of the aqueous extract of Portulaca oleracea L. (AP), an edible plant used as a folk medicine, on diabetic vascular complications. The db/db mice were treated with AP (300 mg/kg/day, p.o.) for 10 weeks, and AP treatment markedly lowered blood glucose, plasma triglyceride, plasma level of LDL-cholesterol, and systolic blood pressure in diabetic db/db mice. Furthermore, AP significantly increased plasma level of HDL-cholesterol and insulin level. The impairment of ACh- and SNP-induced vascular relaxation of aortic rings were ameliorated by AP treatment in diabetic db/db mice. This study also showed that overexpression of VCAM-1, ICAM-1, E-selectin, MMP-2, and ET-1 were observed in aortic tissues of untreated db/db mice, which were significantly suppressed by treatment with AP. We also found that the insulin immunoreactivity of the pancreatic islets remarkably increased in AP treated db/db mice compared with untreated db/db mice. Taken together, AP suppresses hyperglycemia and diabetic vascular inflammation, and prevents the development of diabetic endothelial dysfunction for the development of diabetes and its vascular complications.
Do Quantity and Quality of Irradiance Influence Migration Behavior Motile Cells of the Green Alga, Ulva fasciata?  [PDF]
Hyun-Woung Shin, Han Seong Lee, Sang Mok Jung, Min Kyu Choo, Ji Young Cho, Kwang Soo Lee, Celia M. Smith
Open Journal of Marine Science (OJMS) , 2014, DOI: 10.4236/ojms.2014.44028
Abstract: Motile cells of the green alga, Ulva fasciata respond to the quantity and quality of irradiance simultaneously. The specific responses of motile cell types (gametes and spores) by irradiance influence migration behavior in coastal water environment. Gametes maximally aggregated at the highest white light intensity (250 μmol·m-2·s-1), while spores maximally aggregated in the dark (0 μmol m-2·s-1) of this study. Gametes maximally aggregated in green irradiance over blue, red and dark while spore maximally aggregated in the dark. The results of quantity are spectral responses are likely to be underline the ecological success and physiological strategies in varied irradiance environments includes: 1) gametes respond to specific quantities and spectral irradiance; 2) spores respond negatively to quantity and quality of irradiance to enhance the probability of finding substratum; and 3) populations of adults that come from these motile cells behaviors. The specific quantities and spectral qualities of irradiance responses show specific ecological migration that can be attributed to photosynthesis under limiting irradiance in coastal waters for the motile cells of U. fasciata.
Noninvasive Prenatal Testing for Fetal Chromosomal Abnormalities Using Massively Parallel Sequencing: Clinical Experience from 7910 Korean Pregnancies  [PDF]
Seon Young Yun, Hyuk Jung Kwon, Amit Goyal, Katiyar P. Shashank, Heesu Im, Joungsu Joo, Jin-Sik Bae, Min Seob Lee, Sunghoon Lee
Open Journal of Genetics (OJGen) , 2018, DOI: 10.4236/ojgen.2018.83005
Abstract: Objective: The purpose of this study is to review the clinical experience and performance of noninvasive prenatal testing (NIPT) method, using cell-free DNAto detect chromosomes 21, 18, 13, X, and Y abnormalities in over 7910 clinical samples from South Korean population. Method: Pregnant women between 1st of November 2015 to 18th of February 2018, with obstetric clinical findings participated in the study. NIPT was performed based on masivelly parallel sequencing with 0.3× low coverage paired-end sequencing using cell-free DNA in maternal plasma. Further invasive prenatal testing was recommended for pregnant women with positive NIPT results. Results: Of the total 7910 participants, 7890 (99.75%) were tested for NIPT and the remaining 20 (0.25%) were below the Quality Control (QC) standards. T13, T18, XXX, XXY and XYY had 100% of sensitivity, specificity, positive predictive values (PPV) and accuracy. The overall sensitivity was 100% and specificity, PPV and accuracy of all chromosomal abnormalities with further validation were 99.92%, 94.25%, and, 99.92% respectively. Conclusion: Our NIPT results showed high positive predictive value for the detection of autosomal trisomies and sex chromosome aneuploidies in
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