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Search Results: 1 - 10 of 3833 matches for " Milton Masahiro Kanashiro "
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INIBI O DA PRODU O DE óXIDO NíTRICO E EFEITO CITOTóXICO DE EXTRATO AQUOSO DE ANNONA MURICATA L.
Clara dos Reis Nunes,William Rodrigues Freitas,Thatiana Lopes Biá Ventura,Milton Masahiro Kanashiro
Perspectivas Online : Biológicas e Saúde , 2011,
Abstract: Annona muricata L. é conhecida na medicina popular por sua ampla variedade de efeitos medicinais. Atoxicidade de plantas da família Annonacea é ainda pouco estudada, principalmente em rela o aoscomponentes de seus frutos. A maioria dos trabalhos científicos realizados com estas plantas utilizaprincipalmente as folhas e aborda suas a es citotóxicas em ensaios biológicos in vitro enfatizando seusefeitos anti-tumorais. Nesse sentido, se observa uma alta prevalência do uso de Annona muricata L. emoncologia como tratamento coadjuvante, o que ressalta a importancia de se conhecer os possíveis efeitostóxicos relacionados ao seu uso. Como as propriedades biológicas de Annona muricata L. n o s ocompletamente conhecidas, o objetivo deste estudo foi investigar a capacidade inibitória da produ o deóxido nítrico em macrófagos e o potencial citotóxico do extrato aquoso oriundo da polpa dos frutos sobremacrófagos murinos RAW 264.7 e células tumorais U937 através do teste de libera o da enzimacitoplasmática lactato desidrogenase e do teste com 3-(4,5 dimetiltiazol-2-il)-2,5-difenil tetrazol. Nossosresultados mostram que a capacidade inibitória do extrato aquoso (500 μg/mL) na produ o de óxido nítrico(NO) em macrófagos RAW 264.7 estimulados por lipolissacarídeo (LPS) foi estatisticamente significante (p<0,05) quando comparado aos resultados obtidos em macrófagos controles, embora de forma n o expressiva.O extrato aquoso n o apresentou citotoxicidade para macrófagos RAW 264.7 e células leucêmicas U937,n o interferindo na viabilidade celular, o que sugere ausência de morte celular por necrose.
Metodología de Evaluación de los Pararrayos de Carburo de Silicio
Kanashiro,Arnaldo G; Zanotti Jr,Milton; Obase,Paulo F; Bacega,Wilson R;
Información tecnológica , 2010, DOI: 10.4067/S0718-07642010000300013
Abstract: this work presents results of a research project dveloped for determining the diagnostic of silicon carbide surge arresters. tests were performed in these arresters in the laboratory, considering the power frequency spark-over voltage and lightning spark-over voltage tests. the results were compared with values of leakage current, radio-influence voltage test and thermovision, obtained in the same surge arresters. it was observed a reasonable correlation between high values of the leakage current, considering the amplitude and the third harmonic component, and the presence of degradation in the surge arresters. therefore, it was concluded that leakage current measurements can provide important information about the stage of degradation of the surge arresters. measurements in the substations during several years could provide the identification, in case of leakage current variations, of deteriorated silicon carbide surge arresters.
Variabilidade no cpDNA em Manilkara huberi, espécie sob manejo sustentável na Amaz?nia brasileira
Azevedo, Vania Cristina Rennó;Kanashiro, Milton;Grattapaglia, Dario;Ciampi, Ana Yamaguishi;
Pesquisa Agropecuária Brasileira , 2008, DOI: 10.1590/S0100-204X2008000700010
Abstract: the objective of this work was to evaluate the existence of matrilineal genetic structure in ma?aranduba (manilkara huberi). evaluations were performed for 481 adult individuals of m. huberi, distributed in 200 hectares of a natural population in the floresta nacional do tapajós, belterra, pa, brazil, and 88 plantules, based on nine chloroplast microsatellite loci and, of 96 individuals, selected randomly in the 200 ha area, it was carried out the sequencing of three intergenic regions from the cpdna. no sequence polymorphism was detected. the analysis of the haplotypic variability showed a relatively low polymorphism, which resulted in 15 haplotypes, with total genetic diversity (ht) of 0.898. significant genetic structure until 250 m was detected, which indicates that seeds are restrictedly dispersed and confirms the pattern of spatial organization of the genetic variability, showed by the nuclear dna analysis. this indicates isolation by distance and the need of maintenance of primary forest large areas to allow the surviving of a greater number of subpopulations.
Pollination biology in Jacaranda copaia (Aubl.) D. Don. (Bignoniaceae) at the "Floresta Nacional do Tapajós", Central Amazon, Brazil
Maués, Márcia Motta;Oliveira, Paulo Eugênio A. M. de;Kanashiro, Milton;
Brazilian Journal of Botany , 2008, DOI: 10.1590/S0100-84042008000300015
Abstract: jacaranda copaia (aubl.) d. don is a pioneer tree widespread in the brazilian amazon, usually found colonizing forest gaps and altered areas, and the forest fragment edges. this study investigated aspects of the floral biology, breeding system and pollinators of j. copaia trees. flowering lasts from august to november, during the low rainfall period extending up to four weeks per tree and 3-4 months for the population as a whole, characterizing a cornucopia flowering pattern. the fruit set ends in the beginning of the rainy season, with wind dispersed winged seeds. fruit set from open pollination was 1.06% (n = 6,932). hand pollination using self-pollen (n = 2,099) did not set fruits. cross-pollination resulted in 6.54% fruit set (n = 2,524), representing six times more than the natural pollination rate (1.06%, n = 6,932). flowers excluded from insect visitation (automatic self-pollination) did not set fruits (n = 5,372). pollen tube growth down to ovary was detected under fluorescence microcoscopy in cross-pollinated and selfed pistils. the species is an obligate allogamous plant, with late-acting self-incompatibility system. approximately 40 species of native bees visited the flowers, but the main pollinators were medium-sized solitary bees as euglossa and centris species due to the compatibility between their body sizes with the corolla tube, direct contact with the reproductive structures and high frequency of visits.
Metodología de Evaluación de los Pararrayos de Carburo de Silicio Assessment Methodology of Silicon Carbide Surge Arresters
Arnaldo G Kanashiro,Milton Zanotti Jr,Paulo F Obase,Wilson R Bacega
Información Tecnológica , 2010,
Abstract: Este trabajo presenta los resultados de una investigación cuyo objetivo fue el diagnóstico de los pararrayos de carburo de silicio. En el laboratorio fueron realizados ensayos en pararrayos, siendo determinados los valores de tensión disruptiva en frecuencia industrial y de impulso atmosférico. Esos resultados fueron comparados con valores de la corriente de fuga, radiointerferencia y termovisión, obtenidos en mediciones en los mismos pararrayos. Se observó que valores más elevados de la corriente de fuga, en términos de amplitud y componente de tercer armónico, estaban asociados con una mayor degradación en esos pararrayos. Con base en esos resultados, se concluyó que la medición de la corriente de fuga puede proveer informaciones importantes sobre el estado de esos pararrayos. Mediciones del comportamiento de la corriente de fuga a lo largo de los a os en las suestaciones pueden ayudar a identificar los pararrayos más degradados. This work presents results of a research project dveloped for determining the diagnostic of silicon carbide surge arresters. Tests were performed in these arresters in the laboratory, considering the power frequency spark-over voltage and lightning spark-over voltage tests. The results were compared with values of leakage current, radio-influence voltage test and thermovision, obtained in the same surge arresters. It was observed a reasonable correlation between high values of the leakage current, considering the amplitude and the third harmonic component, and the presence of degradation in the surge arresters. Therefore, it was concluded that leakage current measurements can provide important information about the stage of degradation of the surge arresters. Measurements in the substations during several years could provide the identification, in case of leakage current variations, of deteriorated silicon carbide surge arresters.
Da antiga à nova Carta de Atenas em busca de um paradigma espacial de sustentabilidade
Milena Kanashiro
Desenvolvimento e Meio Ambiente , 2004,
Abstract: The visions of 1933 Athens Charter assumed a dogmatic character that is continually influencing our cities. The proposal of a functional city, as a critic of traditional spaces, was defined by its basic functions: dwelling, work (or production), recreation and transportation. Facing the existing obsolete urban tissue, a new order was imposed, having as result a homogeneous space, in formal terms. In the last decades the discussion of the concept of sustainable development has emerged aiming as maintaining life quality, ensuring continuous accessibility to the natural resources and avoiding the environmental damages. As a consequence, the 1998 Athens New Charter, resulting from the discussion of eleven countries of European Union witch defines an emergencies has emerged thematic. This paper deals with a brief panorama of the urban re-thinking, present the set of recommendations, expose the paradigm and outline considerations of the New Charter.
A cidade e os sentidos: sentir a cidade
Milena Kanashiro
Desenvolvimento e Meio Ambiente , 2003,
Abstract: This article deals with the subject of the human sensorial perception related to the urban spaces. This is an attempt to contribute to the discussion of the senses and the perception of space qualities of builtenvironments.
Isolamento, identifica??o e avalia??o da atividade antileucêmica de alcaloides indólicos monoterpênicos de Tabernaemontana salzmannii A. DC., Apocynaceae
Figueiredo, Elaine R.;Vieira, Ivo J. C.;de Souza, Jucimar J.;Braz-Filho, Raimundo;Mathias, Leda;Kanashiro, Milton M.;C?rtes, Fernanda H.;
Revista Brasileira de Farmacognosia , 2010, DOI: 10.1590/S0102-695X2010000100016
Abstract: this work describes the isolation and structural determination of nine monoterpenic indole alkaloids from the root barks and leaves of tabernaemontana salzmannii. the alkaloids were identified by spectroscopic methods uni (nmr 1h, 13c, apt) and two-dimensional (1h-1h-cosy, 1h-1h-noesy, hmqc and hmbc) and mass spectra besides comparison with literature data. an in vitro screening was done with the isolated major alkaloids. among the nine alkaloids isolated, isovoacangine and voacangine alkaloids were able to induce apoptosis cell death in human leukemic cells line thp-1.
Isolamento, identifica??o e avalia??o da atividade antileucêmica de alcaloides indólicos monoterpênicos de Tabernaemontana salzmannii (A. DC.), Apocynaceae
Figueiredo, Elaine R.;Vieira, Ivo J. C.;Souza, Jucimar J. de;Braz-Filho, Raimundo;Mathias, Leda;Kanashiro, Milton M.;C?rtes, Fernanda H.;
Revista Brasileira de Farmacognosia , 2010, DOI: 10.1590/S0102-695X2010005000019
Abstract: this work describes the isolation and structural determination of nine monoterpenic indole alkaloids from the roots bark and leaves of tabernaemontana salzmannii. the alkaloids were identified by spectroscopic methods uni (nmr 1h, 13c, apt) and two-dimensional (1h-1h-cosy, 1h-1h-noesy, hmqc and hmbc) and mass spectra besides comparison with literature data. an in vitro screening was done with the isolated major alkaloids. among the nine alkaloids isolated, isovoacangine and voacangine alkaloids were able to induce apoptosis cell death in human leukemic cells line thp-1.
Lepidotrichilins A and B, New Protolimonoids with Cytotoxic Activity from Trichilia Lepidota (Meliaceae)
Wagner da S. Terra,Ivo J. C. Vieira,Raimundo Braz-Filho,William R. de Freitas,Milton M. Kanashiro,Maria Concei?o M. Torres
Molecules , 2013, DOI: 10.3390/molecules181012180
Abstract: Two novel protolimonoids, named lepidotrichilins A ( 1) and B ( 2), four known protolimonoids, 21,23-epoxy-7α-21α-dihydroxyapotirucalla-14,24-dien-3-one ( 3), 21,23-epoxy-7α-21β-dihydroxyapotiru-calla-14,24-dien-3-one ( 4), dysorone D ( 5), deoxy-flindissone ( 6), and the two steroids β-sitosterol ( 7) and stigmasterol ( 8) were identified in leaves of Trichilia lepidota subsp. schumanniana (Harms) T.D. Pennington. From wood the coumarin scopoletin ( 9) was isolated. The structures were established by NMR (1D 1H and 13C-NMR and 2D 1H- 1H COSY, HMQC and HMBC), mass spectroscopy and infrared (IR) spectral data. The hexane and methanol extracts of the leaves, the protolimonoids lepidotrichilins A ( 1) and B ( 2) (IC 50 42.7 μg mL ?1) and the protolimonoid deoxy-flindissone ( 6; IC 50 9.3 μgmL ?1) exhibited significant cytotoxic activity against the MOLT-4 and U937 leukemic cell lines.
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