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Search Results: 1 - 10 of 11388 matches for " Miles Smith "
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hTERT Extends the Life of Human Fibroblasts without Compromising Type I Interferon Signaling
Miles C. Smith, Erica T. Goddard, Mirna Perusina Lanfranca, David J. Davido
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0058233
Abstract: Primary cells are often used to study viral replication and host-virus interactions as their antiviral pathways have not been altered or inactivated; however, their use is restricted by their short lifespan. Conventional methods to extend the life of primary cultures typically utilize viral oncogenes. Many of these oncogenes, however, perturb or inactivate cellular antiviral pathways, including the interferon (IFN) response. It has been previously shown that expression of the telomerase reverse transcriptase (TERT) gene extends the life of certain cell types. The effect that TERT expression has on the innate antiviral response to RNA- and DNA-containing viruses has not been examined. In the current study, we introduced the human TERT (hTERT) gene into a primary human embryonic lung (HEL-299) cell strain, which is known to respond to the type I IFN, IFN-β. We show that the resulting HEL-TERT cell line is capable of replicating beyond 100 population doublings without exhibiting signs of senescence. Treatment with IFN-β resulted in the upregulation of four model IFN stimulated genes (ISGs) in HEL-299 and HEL-TERT cells. Both cell lines supported the replication of herpes simplex virus type 1 (HSV-1) and vesicular stomatitis virus (VSV) and impaired the replication of both viruses upon IFN-β pretreatment. Introduction of the viral oncoprotein, simian virus 40 (SV40) large T-antigen, which is frequently used to immortalize cells, largely negated this effect. Taken together, our data indicate that expression of hTERT does not alter type 1 IFN signaling and/or the growth of two viruses, making this cell line a useful reagent for studying viral replication and virus-cell interactions.
Factors Associated with Women’s Chronic Disease Management: Associations of Healthcare Frustrations, Physician Support, and Self-Care Needs
Matthew Lee Smith,Marcia G. Ory,SangNam Ahn,Toni P. Miles
Journal of Aging Research , 2013, DOI: 10.1155/2013/982052
Abstract: Previous research emphasizes the importance of reducing healthcare frustrations and enhancing physician supports to help patients engage in recommended healthcare regimens. However, less is known about how these factors are associated with aging women’s knowledge about self-care behavior. This study examined the sociodemographics, health indicators, healthcare-related frustrations, and perceptions of physician support associated with middle-aged and older adult females’ self-reported need for help to learn how to take better care of their health. Data were analyzed from 287 females with one or more chronic conditions who completed The National Council on Aging (NCOA) Chronic Care Survey. A logistic regression model was developed. Women who were non-White ( , ) were more likely to need help learning how to better manage their health. Those who had some college education or more ( , ) and lower healthcare-related frustrations ( , ) and perceived to have more physician support ( , ) were less likely to need help learning how to better manage their health. Findings can inform the planning, implementation, assessment, and dissemination of evidence-based self-management programs for middle-aged and older women within and outside of clinical settings. 1. Introduction Over the next several decades, the number of Americans living to advanced ages will increase substantially. Although many individuals will age in relatively good health, a growing number will encounter challenges associated with the burdens of chronic conditions and associated disabilities [1–3]. This is especially so for the large numbers of women who will continue to outlive their male counterparts and likely live those additional years with chronic illnesses requiring day-to-day management [4, 5]. Further, with a dramatic increase of female “baby boomers” with obesity-related chronic conditions, accompanied by reduced fertility rates among this rapidly aging cohort, the additive or multiplicative effects of living with one or more chronic conditions are likely to result in a diminution of (1) individuals’ capacity to adequately care for themselves, (2) caregivers to serve as efficient resources, and (3) healthcare providers to give adequate attention and guidance to complex patients with multiple chronic conditions (MCCs) [6]. In line with the millions of older women struggling to manage the symptoms associated with chronic disease, there is growing recognition about the importance of self-care behavior, which is supported by strong epidemiological documentation regarding the positive
Improved limits on sterile neutrino dark matter from full-sky observations by the Fermi-GBM
Shunsaku Horiuchi,Kenny C. Y. Ng,Jennifer M. Gaskins,Miles Smith,Robert Preece
Physics , 2015,
Abstract: For the first time, we use the Gamma-ray Burst Monitor (GBM) on-board the Fermi satellite to search for sterile neutrino decay lines in the energy range 10-25 keV corresponding to sterile neutrino mass range 20-50 keV. This energy range has been out of reach of traditional X-ray satellites such as Chandra, Suzaku, XMM-Newton, and gamma-ray satellites such as INTEGRAL. Furthermore, the extremely wide field of view of the GBM opens a large fraction of the Milky Way dark matter halo to be probed. We start with 1601 days worth of GBM data, implement stringent data cuts, and perform two simple line search analyses on the reduced data: in the first, the line flux is limited without background modeling, and in the second, the background is modeled as a power-law. We find no significant excess lines in both our searches. We set new limits on sterile neutrino mixing angles, improving on previous limits by approximately an order of magnitude. Better understanding of detector and astrophysical backgrounds, as well as detector response, can further improve the limit.
A framework for power analysis using a structural equation modelling procedure
Jeremy Miles
BMC Medical Research Methodology , 2003, DOI: 10.1186/1471-2288-3-27
Abstract: Satorra and Saris developed a method for estimating the power of the likelihood ratio test for structural equation models. Whilst the Satorra and Saris approach is familiar to researchers who use the structural equation modelling approach, it is less well known amongst other researchers. The SEM approach can be equivalent to other multivariate statistical tests, and therefore the Satorra and Saris approach to power analysis can be used.The covariance matrix, along with a vector of means, relating to the alternative hypothesis is generated. This represents the hypothesised population effects. A model (representing the null hypothesis) is then tested in a structural equation model, using the population parameters as input. An analysis based on the chi-square of this model can provide estimates of the sample size required for different levels of power to reject the null hypothesis.The SEM based power analysis approach may prove useful for researchers designing research in the health and medical spheres.Structural equation modelling (SEM) was developed from work in econometrics (simultaneous equation models; see for example Wansbeek and Meijer [2]) and latent variable models from factor analysis [3,4]. Structural equation modelling is an enormously flexible technique – it is possible to use a structural equation modelling approach to carry out direct equivalents of many analyses, including (but not limited to): ANOVA, correlation, ANCOVA, multiple regression, multivariate analysis of variance, and multivariate regression. This flexibility will be exploited in the approach set out in this article.A necessarily very brief introduction to the logic of structural equation modelling is presented here – for a more thorough introduction to the basics of structural equation modelling the reader is directed towards one of the many good introductory texts, (Steiger has recently reviewed several such texts [5]). For more details on the statistical and mathematical aspects of struc
Yao bride-exchange, matrifiliation and adoption
Douglas Miles
Bijdragen tot de Taal-, Land- en Volkenkunde , 1972,
Abstract:
Effect of Tire Pressure on Efficiency
Miles Mullins
Undergraduate Journal of Mathematical Modeling : One + Two , 2010, DOI: 10.5038/2326-3652.2.2.7
Abstract: Many people ignore tire pressure in their day-to-day lives. In a country striving for maximum efficiency, neglecting to maintain correct tire pressure can noticeably affect the amount of horsepower required to overcome the drag forces due to tire/roadway friction. In order to quantify these horsepower changes, 21 test trials were conducted by allowing a test vehicle to coast from 50 mph down to 20 mph at pressures ranging from 50 psi to 20 psi. After compiling the results, it was shown that lower tire pressures increased the horsepower necessary to propel the automobile.
A Life of Music Therapy: Working Together and in Isolation
Louise Miles
Voices: A World Forum for Music Therapy , 2007,
Abstract:
THE ‘SOCIAL MODEL OF DISABILITY’ MET A NARRATIVE OF (IN)CREDULITY: A REVIEW
M Miles
Disability, CBR & Inclusive Development , 2011, DOI: 10.5463/dcid.v22i1.14
Abstract: The article reviews components and recent discussion of the ‘Social Model of Disability’, with special focus on two books, Disability Rights and Wrongs by Tom Shakespeare, and The Social Model: Europe and the Majority World edited by Colin Barnes and Geof Mercer. The ‘Social Model’ calls for close and sceptical scrutiny, as it has become one of the most influential metanarratives in campaigns and publications of the ‘Disability Movement’, while tending to overlook the complexities experienced by many disabled people and their relatives. Some components of a Social Model appear in historical literature of Asia and the Middle East, lending credibility to its ongoing life as an interesting idea. Yet current anglophone advocacy of the model makes assumptions of universality that are questionable in the socio-economic situations experienced by much of the global population having disabilities. A calmer and better informed discussion of the model’s merits and flaws would contribute to greater understanding of global disability. DOI 10.5463/DCID.v22i1.14
Review: Joseph Cowen and Popular Radicalism on Tynside, 1829-1900, by Joan Allen
Miles Taylor
Journal of Historical Biography , 2008,
Abstract:
Ead McTaggart: Using VBA to Automate EAD Container List Tagging
Randall Miles
Code4Lib Journal , 2009,
Abstract: Faced with the prospect of converting 200-page container lists to Encoded Archival Description (EAD), the author programmed a Microsoft Access database using Visual Basic for Applications (VBA) to automatically insert the necessary EAD tags and their attributes. Some work is still required to ensure that the container list is properly formatted before importing into the database. Once formatted, the database, named Ead McTaggart, will convert a 7,000 line Microsoft Excel container list, where each line represents a series, sub-series, or folder title, into a properly tagged EAD container list in about five minutes. As written, Ead McTaggart will handle up to six component levels, but can be modified to handle more. Although many institutions use Archivists' Toolkit or Archon for this functionality, many libraries and archives who have not implemented those tools will find that EAD McTaggert minimizes the work of converting existing container lists to EAD finding aids with a low time investment for implementation.
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