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Search Results: 1 - 10 of 2288 matches for " Milan ?iri? "
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Asthma Exacerbations and Viruses
Ivana Stankovi?,Zorica ?iri,Milan Radovi?
Acta Facultatis Medicae Naissensis , 2011,
Abstract: Acute exacerbations of asthma are the major cause of morbidity and mortali-ty of the disease and are difficult to prevent and treat. Asthma exacerbations are associated with several factors, including allergen exposure, air pollution and stress, but the major cause of exacerbations is respiratory virus infection. Respiratory viral infections cause >80% of asthma exacerbations in children and >50% in adults. The most prevalent viruses detected during exacerbations are the rhinoviruses. Respiratory viruses may induce asthma exacerbations through direct effects on their main target, airway epithelium, as well as via systemic immune reaction.
HISTOPATHOLOGICAL CHANGES IN THE SPLEEN OF RATS TREATED WITH MONOSODIUM GLUTAMATE
Milaniri,Sne?ana Ceki?,Voja Pavlovi?,Zorica Jovi?
Acta Facultatis Medicae Naissensis , 2005,
Abstract: Neonatal treatment of animals with monosodium glutamate (MSG) induces lesions of the arcuate, paraventricular and ventromedian nuclei of the hypothalamus. The aim of the study was to investigate the effect of MSG on the spleen of rats. Damage to these structures leads to functional disruption in the hypothalamic-pituitary-adrenocortical (HPA) axis. White Wister rats were used. The experimental group comprised 10 rats that underwent subcutaneous treatment with MSG (4 mg MSG per g/b.w.) on the 2nd, 4th, 6th, 8th, and 10th day of postnatal life. The control group consisted of 10 animals, as well. Four months after the treatment with MSG, the animals were sacrificed. Paraffin sections of the spleen tissue were stained using HE method. Macroscopically, the experimental animals displayed the atrophy of the spleen. Pathohistological changes in the spleen manifested as the atrophy of the while pulp. Germinate centers were missing. Follicles with preserved germinate centers were rare. In the red pulp of the spleen, there were morphologic elements of chronic delay, abundance of hemosiderophages and cell elements of hematopoiesis, especially megakaryocytes.
CHANGE OF THE ENZYME SDH ACTIVITY IN THE LIVER AND OF THE BIOCHEMICAL PARAMETERS IN THE BLOOD OF THE RATS TREATED WITH GENTAMICIN
Nenad Stojiljkovi?,Dragoljub Jovanovi?,Slavimir Veljkovi?,Milaniri
Acta Medica Medianae , 2002,
Abstract: The change of the enzyme SDH activity in the liver as well as the change of the biochemical parameters (sGOT, sGPT and bilirubins) in the blood of the rats treated with gentamicin. In the experimental group of animals treated with gentamicin (100 mg/kg TT/24 h) for eight days it was found that the highest SDH activity was in the peri venular zone of the acinus (+++), that the enzyme's reduced activity was in the intermediary zone (+) and that the SDH activity in the per portal zone of the acinus was just in traces (+). In the control group of animals treated with the physiological solution (1 ml/kg TT/24 h), the enzyme SDH activity was the most prominent in the perivenular zone of the acinus (+++), while in the intermediary and the periportal zone the enzyme's activity was preserved but somewhat weaker (++). The results of the comparative study of enzymohistochemical and biochemical changes confirm the existence of an important correlation between the gentamicin application and the observed changes.
THE EFFECTS OF ENALAPRIL ON UREA AND CREATININE SERUM CONCENTRATION AND PAS COLORING MORPHOLOGICAL CHANGES IN EXPERIMENTAL GENTAMICIN NEPHROTOXICITY
Milaniri,Slavimir Veljkovi?,Mirjana Radenkovi?,Sne?ana Ceki?
Acta Medica Medianae , 2003,
Abstract: The effects of Enalapril on glomerular changes and desquamation of tubular epithel in rats were analyzed in Gentamicin nephrotoxicity. It was detected necrosis and epithel desquamation of proximal tubules and degenerative changes in glomerular at animals treated by Gentamicin (100 mg/kg body mass/24 h). Nephron morphological changes were more intensive and extensive by simultaneous treatment of Gentamicin and Enalapril. In animals, treated by Gentamicin it appeared the increasing of urea (p<0,001) and creatinine (p<0,001) comparing to the control group. The combination of Enalapril and Gentamicin resulted bigger kidney damage then Gentamicin itself, so the level of urea concentration in serum (p<0,001) and creatinine concentration (p<0,05) was higher in the third experimental group. Our biochemical results are according to the PAS coloring morphological changes found in kidney. Consequently, our findings support hypothesis that Enalapril causes exacerbating of Gentamicin nephrotoxicity.
DIFFERENT EFFECTS OF THE ATROPINE UPON THE PENDULOUS MOVEMENTS OF THE PROXIMAL AND OF THE DISTAL COLON OF THE RABBIT
Mirjana Radenkovic,Slavimir Veljkovi?,Ranka Samrdzic,Milaniri
Acta Medica Medianae , 2000,
Abstract: The influence of the non-selective blocker of the muscarinic receptors, namely of the atropine (1,7 x10-10 - 5x10-7). upon thependulousmovements of the proximal and of the distal colon of the rabbit was studied. In the correct proportion to the concentration the atropine reduces the amplitude of both the proximal (r=0,98; P<0,001) and of the distal colon (r= 0,97; P < 0,001). On the basis of the ED50 values - that amount to 7,7 ± 0,03 x 10-7 M for the proximal colon and 3,5 ± 0,06 x 10-5 M for the distal colon, the atropine recluces for twenty times the amplitude of the pendulousmovements of the rabbit's distal colon. Likewise, it reduces for dozen times the frequency of the pendulous movements of the distal colon (ED50 = 5 ± 0,02 x 10-6M) with respect to the proximal one (ED50 = 4,7 ± 0,06 x I0-5M). The atropine does not change the tone of the proximal colon (average relaxation is 5,47 ± 2,32 %) while it induces the concentrically-dependent relaxation of the distal colon (maximal relaxation amounts to 38.03 + 8,34). The ED50 values for the atropine while affecting the distal colon tone is 1,7 ± 0,03 x 10-6M.
HISTOPATHOLOGIC CHANGES AT THE HYPOTHALAMIC, ADRENAL AND THYMIC NUCLEUS ARCUATUS IN RATS TREATED WITH MONOSODIUM GLUTAMATE
Sne?ana Ceki?,Milo? Filipovi?,Voja Pavlovi?,Milaniri
Acta Medica Medianae , 2005,
Abstract: The study consists of 100 patients who underwent surgery and were treated at the Surgical Clinic of Nis Clinical Centre. The patients were divided into two groups: the first one included 50 patients subjected to surgery with the use of the Shouldice operative technique (control group) and the second one included 50 patients who underwent surgery with the use of the Lichtenstein operative technique (experimental group). In these 100 patients, the pain score was examined on the basis of Visual Analogous Score (VAS) or using Verbal Pain Score (VPS). For statistical analysis we used the T – test for two large independent samples, which was later presented on graphs, tables and diagram. The pain score was observed from the first to the seventh day, and then on the tenth, fifteenth, twentieth, thirtieth, two months and one year after. The examination results showed a significantly lower pain score in patients who underwent surgery with the use of Lichtenstein technique.
Pulmonary rehabilitation in patients with chronic obstructive pulmonary disease
iri? Zorica,Stankovi? Ivana,Ran?i? Milan,Pej?i? Tatjana
Vojnosanitetski Pregled , 2008, DOI: 10.2298/vsp0807533c
Abstract: Background/Aim. Chronic obstructive pulmonary disease (COPD) irreversibly damages pulmonary function leading to disorder of arterial blood gases, arterial partial pressure of oxygen (PaO2) and arterial partial pressure of carbon dioxide (PaCO2), appearance of dyspnea, and decrease of physical condition. The aim of this study was to establish if medical treatment and respiratory rehabilitation in COPD used simultaneously lead to the greater improvement of PaO2, PaCO2 and physical condition and decreaseing dyspnea than medical treatment alone. Methods. A total of 60 patients divided into three groups according to the severity of obstruction (mild - I, severe - II, very severe - III) were tested. Each group had the two subgroups of patients - first one with those treated both with medical treatment and respiratory rehabilitation (A) and the second one with the patients treated only with medical treatment (B). The treatment took 21 days. The measurements of PaO2 and PaCO2) intensity of dyspnea at rest and exercise (10 - point Borg Category Scale), and physical capacity (Six-Minute Walk Test - 6MWT) were done on the first and on the last day of testing. Results. The results showed that all of the patients who were treated with the combination of medical treatment and respiratory rehabilitation had significantly higher increase in the values of PaO2 (I - p < 0.01; II - p < 0.05; III - p < 0.01), score of Borg's scale (I - p < 0.05, p < 0.001; II - p < 0.05, p < 0.001; III - p < 0.001, p < 0.001) and 6MWT (I - p < 0.001; II - p < 0.001; III - p < 0.001), and that statistically significant increase of the values of PaCO2 (p < 0.05) had only the patients with very severe COPD treated with the combination of drugs and respiratory rehabilitation. Conclusion. Based on the obtained results we conclude that using respiratory rehabilitation in combination with pharmacological treatment of COPD gives statistically higher improvement of values of PaO2 and PaCO2, and physical condition, and also leads to decrease of intensity of dyspnea than using just drug therapy.
Bisimulations for fuzzy automata
Miroslav ?iri,Jelena Ignjatovi?,Nada Damljanovi?,Milan Ba?i?
Computer Science , 2011,
Abstract: Bisimulations have been widely used in many areas of computer science to model equivalence between various systems, and to reduce the number of states of these systems, whereas uniform fuzzy relations have recently been introduced as a means to model the fuzzy equivalence between elements of two possible different sets. Here we use the conjunction of these two concepts as a powerful tool in the study of equivalence between fuzzy automata. We prove that a uniform fuzzy relation between fuzzy automata $\cal A$ and $\cal B$ is a forward bisimulation if and only if its kernel and co-kernel are forward bisimulation fuzzy equivalences on $\cal A$ and $\cal B$ and there is a special isomorphism between factor fuzzy automata with respect to these fuzzy equivalences. As a consequence we get that fuzzy automata $\cal A$ and $\cal B$ are UFB-equivalent, i.e., there is a uniform forward bisimulation between them, if and only if there is a special isomorphism between the factor fuzzy automata of $\cal A$ and $\cal B$ with respect to their greatest forward bisimulation fuzzy equivalences. This result reduces the problem of testing UFB-equivalence to the problem of testing isomorphism of fuzzy automata, which is closely related to the well-known graph isomorphism problem. We prove some similar results for backward-forward bisimulations, and we point to fundamental differences. Because of the duality with the studied concepts, backward and forward-backward bisimulations are not considered separately. Finally, we give a comprehensive overview of various concepts on deterministic, nondeterministic, fuzzy, and weighted automata, which are related to bisimulations.
Nondeterministic automata: equivalence, bisimulations, and uniform relations
Miroslav ?iri,Jelena Ignjatovi?,Milan Ba?i?,Ivana Jan?i?
Computer Science , 2011,
Abstract: In this paper we study the equivalence of nondeterministic automata pairing the concept of a bisimulation with the recently introduced concept of a uniform relation. In this symbiosis, uniform relations serve as equivalence relations which relate states of two possibly different nondeterministic automata, and bisimulations ensure compatibility with the transitions, initial and terminal states of these automata. We define six types of bisimulations, but due to the duality we discuss three of them: forward, backward-forward, and weak forward bisimulations. For each od these three types of bisimulations we provide a procedure which decides whether there is a bisimulation of this type between two automata, and when it exists, the same procedure computes the greatest one. We also show that there is a uniform forward bisimulation between two automata if and only if the factor automata with respect to the greatest forward bisimulation equivalences on these automata are isomorphic. We prove a similar theorem for weak forward bisimulations, using the concept of a weak forward isomorphism instead of an isomorphism. We also give examples that explain the relationships between the considered types of bisimulations.
TROPONINS, EXCERSISE TESTS AND CORONAROGRAPHY ASSESSMENT OF THE SEVERITY IN ACUTE CORONARY SYNDROME
Sne?ana ?iri? Zdravkovi?,Milan Pavlovi?,Svetlana Petrovi? Nagorni,Goran Kora?evi?
Acta Medica Medianae , 2012,
Abstract: Dispite the advances in diagnostics and treatment in acute coronary syndrome (ACS), there is still a problem of undesirable events after ACS, which increases the chance of mortality by 10%. Verification of patient who may be candidates for these undesirable events is the basis for the prevention, treatment and decrease in mortality. One of the strategies which gives good results is a combination of monitoring of troponine levels, symptom-limited exercise tests and coronarography. The correlation of cardiac markers values in acute coronary syndrome and severity of coronary disease is estimated by exercise stress tests and coronarography, as well as by impact of the markers on therapy choice. The study enrolled 450 patients. Laboratory analysis involved troponin T and I (TnT, TnI), myoglobin, CK-MB and CK-MB mass. Ergometric and invasive examinations were done at the end of hospitalisation. There is a significant relation in positive exercise stress tests in troponin-positive patients, which is statistically significant. Analysis of exercise stress test showed statistically significant increase of positive findings in troponin-positive ones (p<0.05). Out of 104 coronarographies in the group with two diseased coronary vessels, there were 46,4% of Tn-positive, compared to 29% of troponin-negative patients, which can also be seen in the group with ≥3 diseased coronary vessels (3,2 vs 14,8%). Out of 104 coronarographied patients, 29 (8,1%) underwent PTCA, and 25 (7%) ACBG. Statistically significance occurred in choosing patients for PTCA in comparison to Tn status (p<0.05), which was not the case in the group selected for ACBG. In our research, a good diagnostic and prognostic troponin value was established and confirmed by statistically significant correlation of troponin values and exercise stress tests findings on discharge. They were a reliable indicator of degree and severity of coronarographic finding, as well as a guideline in choosing invasive strategy treatment.
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