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Search Results: 1 - 10 of 760 matches for " Miklos Toth "
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Maternal Genetic Mutations as Gestational and Early Life Influences in Producing Psychiatric Disease-Like Phenotypes in Mice
Georgia Gleason,Miklos Toth
Frontiers in Psychiatry , 2011, DOI: 10.3389/fpsyt.2011.00025
Abstract: Risk factors for psychiatric disorders have traditionally been classified as genetic or environmental. Risk (candidate) genes, although typically possessing small effects, represent a clear starting point to elucidate downstream cellular/molecular pathways of disease. Environmental effects, especially during development, can also lead to altered behavior and increased risk for disease. An important environmental factor is the mother, demonstrated by the negative effects elicited by maternal gestational stress and altered maternal care. These maternal effects can also have a genetic basis (e.g., maternal genetic variability and mutations). The focus of this review is “maternal genotype effects” that influence the emotional development of the offspring resulting in life-long psychiatric disease-like phenotypes. We have recently found that genetic inactivation of the serotonin 1A receptor (5-HT1AR) and the fmr1 gene (encoding the fragile X mental retardation protein) in mouse dams results in psychiatric disease-like phenotypes in their genetically unaffected offspring. 5-HT1AR deficiency in dams results in anxiety and increased stress responsiveness in their offspring. Offspring of 5-HT1AR deficient dams display altered development of the hippocampus, which could be linked to their anxiety-like phenotype. Maternal inactivation of fmr1, like its inactivation in the offspring, results in a hyperactivity-like condition and is associated with receptor alterations in the striatum. These data indicate a high sensitivity of the offspring to maternal mutations and suggest that maternal genotype effects can increase the impact of genetic risk factors in a population by increasing the risk of the genetically normal offspring as well as by enhancing the effects of offspring mutations.
Modeling Flocks and Prices: Jumping Particles with an Attractive Interaction
Marton Balazs,Miklos Z. Racz,Balint Toth
Mathematics , 2011, DOI: 10.1214/12-AIHP512
Abstract: We introduce and investigate a new model of a finite number of particles jumping forward on the real line. The jump lengths are independent of everything, but the jump rate of each particle depends on the relative position of the particle compared to the center of mass of the system. The rates are higher for those left behind, and lower for those ahead of the center of mass, providing an attractive interaction keeping the particles together. We prove that in the fluid limit, as the number of particles goes to infinity, the evolution of the system is described by a mean field equation that exhibits traveling wave solutions. A connection to extreme value statistics is also provided.
Modeling Flocks and Prices: Jumping Particles with an Attractive Interaction (shortened version)
Marton Balazs,Miklos Z. Racz,Balint Toth
Mathematics , 2011, DOI: 10.1214/12-AIHP512
Abstract: We introduce and investigate a new model of a finite number of particles jumping forward on the real line. The jump lengths are independent of everything, but the jump rate of each particle depends on the relative position of the particle compared to the center of mass of the system. The rates are higher for those left behind, and lower for those ahead of the center of mass, providing an attractive interaction keeping the particles together. We prove that in the fluid limit, as the number of particles goes to infinity, the evolution of the system is described by a mean field equation that exhibits traveling wave solutions. A connection to extreme value statistics is also provided.
Ser80Ile mutation and a concurrent Pro25Leu variant of the VHL gene in an extended Hungarian von Hippel-Lindau family
Attila Patocs, Peter Gergics, Katalin Balogh, Miklos Toth, Ferenc Fazakas, Istvan Liko, Karoly Racz
BMC Medical Genetics , 2008, DOI: 10.1186/1471-2350-9-29
Abstract: Von Hippel-Lindau disease (VHL) (OMIM nr. 193300) is a rare autosomal dominant multi-organ disease caused by molecular abnormalities of the VHL tumor suppressor gene [1]. Patients with VHL are at risk for development of retinal, cerebellar, spinal, pancreatic and renal hemangioblastomas, pulmonary and liver hemangiomas, clear-cell renal carcinomas, pheochromocytomas, endolymphatic sac tumors, multiple renal, epididymal and pancreatic cysts, cystadenomas of the epididymis and of the broad ligament, and pancreatic islet cell tumors [1-3]. Based on the presence or absence of pheochromocytoma, two main subtypes of the VHL disease have been identified. Patients with VHL type 1 are at risk to develop renal cell carcinoma and hemangioblastoma but predominantly without pheochromocytoma, while those with VHL type 2 may have all manifestations of the disease predominantly including pheochromocytoma. VHL type 2 has been subdivided into subtype 2A and 2B, with a low and high risk of renal cell carcinoma, respectively, whereas subtype 2C is a pheochromocytoma-only phenotype. The prevalence of the VHL disease varies between 1:39,000 in Germany and 1:53,000 in East Anglia [4,5]. Manifestations of the disease show variable expression and several patients may have only one manifestation [4].The human VHL gene maps to chromosome 3p25-26 [1]. As predicted by Knudson's two-hit model, tumor development requires inactivation of both copies; the first hit, the germline mutation or deletion is followed by somatic alterations usually detected as loss of heterozygosity. The VHL gene has two translational initiation sites separated by 53 codons. Of the two proteins encoded by the VHL gene, the larger one contains 213 amino acids (pVHL30), whereas the shorter protein consists of 160 amino acids (pVHL18). Both proteins are functionally active and they share the same mechanism of tumor suppressor activity [6-8]. The VHL proteins form a multimeric complex with Elongin B, Elongin C, Cul2 and Rbx1.
Effectiveness of different trap design in mass trapping of Bothynoderes punctiventris Germar
Siv?ev Ivan L.,Toth Miklos,Toma?ev Ivan,Ujvary Istvan
Zbornik Matice Srpske za Prirodne Nauke , 2006, DOI: 10.2298/zmspn0610205s
Abstract: The discovery of an aggregation attractant for Bothynoderes punctiventris Germ. raised several questions for possible improvements of IPM of Bothynoderes punctiventris in sugar beet. First results on exploration of possibilities for its use for monitoring purposes as well as for mass trapping of adults of the pest are described in this paper. Trap design effectiveness was evaluated in the overwintering fields of sugar beet weevil for two years in localities in Serbia and Hungary. Among trap designs tested it was proved that baited CSALOMON TAL trap design was optimal.
Pheromone races of Cydia splendana (Lepidoptera, Tortricidae) overlap in host plant association and geographic distribution
Marie Bengtsson,Anne Boutitie,Julia Jósvai,Miklos Toth,Stefanos Andreadis,C. Rikard Unelius,Peter Witzgall
Frontiers in Ecology and Evolution , 2014, DOI: 10.3389/fevo.2014.00046
Abstract: Identification of the sex pheromone of Cydia splendana (Lepidoptera, Tortricidae) by pheromone gland analysis followed by field trapping with synthetic compounds shows the occurrence of two pheromone races. Acorn moth females from Sweden, where oak Quercus robur is the only host plant, use a blend of the E,Z and E,E isomers of 8,10-dodecadien-1-yl acetate. In Central and Southern Europe, where C. splendana feeds on chestnut Castanea sativa and several species of oak, males respond to another isomer blend, E,E and Z,E. The distribution of the two pheromone races of C. splendana overlaps in Northern France, where they share oak as plant host. Differences in sex communication signals between these populations of C. splendana corroborate the role of specific mate recognition in speciation events.
CREDIT LEVEL INFLUENCING FACTORS AT HUNGARIAN FARMS
Toth Kristof,Toth Jozsef
Annals of the University of Oradea : Economic Science , 2012,
Abstract: In this paper we estimate the impact of different factors on creditability of agricultural farms. According to the literature the collateral (tangible assets), the farm size, productivity, and subsidies should have significant effects on farm loans. We use data from the Hungarian Farm Accountancy Data Network to test our two hypotheses and theoretical assumptions for the period 2001-2010. Because of using panel data, we do our estimations using fixed effects econometrics model to test our assumptions. The results indicate that the chosen factors have significant influence on total liabilities and short- and long-term loans as well. With specially interest of subsidies the growing level of supports decrease the need of other financial tools. At output factors (inclusive farm size) have significant and positive effect, same as collateral (tangible assets).
Phenomenological theory of two-dimensional quantum liquids
Miklos Gulacsi
Physics , 1996, DOI: 10.1080/01418639608240360
Abstract: A phenomenological theory is presented for two-dimensional quantum liquids in terms of the Fermi surface geometry. It is shown that there is a one-to-one correspondence between the properties of an interacting electron system and its corresponding Fermi surface. By doing this, the concept of Fermi surface is generalized to include different topologies. It is shown that for a Fermi liquid the corresponding Fermi surface is rough. In the presence of a condensate, the Fermi surface is faceted, while for a ferromagnetc instability, the Fermi surface becomes a frozen solid. I also determine the surface tension, the step free energy, low lying excitations and other surface and transport properties of the Fermi surface. The different transitions between these phases are also determined. A non-Fermi liquid phase is shown to be a pre-roughening state of the Fermi surface, the properties of which are briefly analyzed.
Quark Matter 95: Concluding Remarks
Miklos Gyulassy
Physics , 1995, DOI: 10.1016/0375-9474(95)00251-U
Abstract: Highlights of Quark Matter 95 are discussed.
The QGP Discovered at RHIC
Miklos Gyulassy
Physics , 2004,
Abstract: Three empirical lines of evidence from RHIC have converged and point to the discovery of a strongly coupled Quark Gluon Plasma. The evidence includes (1) bulk collective elliptic flow and (2) jet quenching and mono-jet production, observed in Au+Au collisions at 200 AGeV, and (3) a critical control experiment using D+Au at 200 AGeV.
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