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Search Results: 1 - 10 of 743 matches for " Miki Hashizume "
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Disruption of cerebellar microzonal organization in GluD2 (GluRδ2) knockout mouse
Miki Hashizume,Taisuke Miyazaki,Kenji Sakimura,Masahiko Watanabe,Kazuo Kitamura,Masanobu Kano
Frontiers in Neural Circuits , 2013, DOI: 10.3389/fncir.2013.00130
Abstract: Cerebellar cortex has an elaborate rostrocaudal organization comprised of numerous microzones. Purkinje cells (PCs) in the same microzone show synchronous activity of complex spikes (CSs) evoked by excitatory inputs from climbing fibers (CFs) that arise from neurons in the inferior olive (IO). The synchronous CS activity is considered to depend on electrical coupling among IO neurons and anatomical organization of the olivo-cerebellar projection. To determine how the CF–PC wiring contributes to the formation of microzone, we examined the synchronous CS activities between neighboring PCs in the glutamate receptor δ2 knockout (GluD2 KO) mouse in which exuberant surplus CFs make ectopic innervations onto distal dendrites of PCs. We performed in vivo two-photon calcium imaging for PC populations to detect CF inputs. Neighboring PCs in GluD2 KO mice showed higher synchrony of calcium transients than those in wild-type (control) mice. Moreover, the synchrony in GluD2 KO mice hardly declined with mediolateral separation between PCs up to ~200 μm, which was in marked contrast to the falloff of the synchrony in control mice. The enhanced synchrony was only partially affected by the blockade of gap junctional coupling. On the other hand, transverse CF collaterals in GluD2 KO mice extended beyond the border of microzone and formed locally clustered ectopic synapses onto dendrites of neighboring PCs. Furthermore, PCs in GluD2 KO mice exhibited clustered firing (Cf), the characteristic CF response that was not found in PCs of wild-type mice. Importantly, Cf was often associated with localized calcium transients in distal dendrites of PCs, which are likely to contribute to the enhanced synchrony of calcium signals in GluD2 KO mice. Thus, our results indicate that CF signals in GluD2 KO mice propagate across multiple microzones, and that proper formation of longitudinal olivo-cerebellar projection is essential for the spatiotemporal organization of CS activity in the cerebellum.
Effect of Individual Differences in Construal Level on Procrastination: Moderating Role of Intelligence Theories  [PDF]
Miki Terada
Psychology (PSYCH) , 2017, DOI: 10.4236/psych.2017.84032
Abstract: The relationship between individual differences in construal level and self-control, including procrastination was investigated by examining the following hypotheses. 1) People with high level of construal would procrastinate less when learning a task than those with low level of construal; and 2) theories of intelligence would moderate the effect of construal level on procrastination. These hypotheses were tested by using survey data. Results indicated that people with a low construal level procrastinated more. Results also indicated the moderating role of intelligence theories on the relationship between Behavior Identification Form (BIF) score and procrastination. This study is expected to expand our understanding of construal level theory and individual differences. The findings are also expected to clarify the relationship between construal level and procrastination.
Remarks on the abundance conjecture
Kenta Hashizume
Mathematics , 2015,
Abstract: We prove the abundance theorem for log canonical $n$-folds such that the boundary divisor is big assuming the abundance conjecture for log canonical $(n-1)$-folds. We also discuss the log minimal model program for log canonical $4$-folds.
Finite generation of adjoint ring for log surfaces
Kenta Hashizume
Mathematics , 2015,
Abstract: We prove the finite generation of the adjoint ring for $\mathbb{Q}$-factorial log surfaces over any algebraically closed field.
A Parallel Circuit Simulator for Iterative Power Grids Optimization System  [PDF]
Taiki Hashizume, Masaya Yoshikawa, Masahiro Fukui
Circuits and Systems (CS) , 2012, DOI: 10.4236/cs.2012.32020
Abstract: This paper discusses a high efficient parallel circuit simulator for iterative power grid optimization. The simulator is implemented by FPGA. We focus particularly on the following points: 1) Selection of the analysis method for power grid optimization, the proposed simulator introduces hardware-oriented fixed point arithmetic instead of floating point arithmetic. It accomplishes the high accuracy by selecting appropriate time step of the simulation; 2) The simulator achieves high speed simulation by developing dedicated hardware and adopting parallel processing. Experiments prove that the proposed simulator using 80 MHz FPGA and eight parallel processing achieves 35 times faster simulation than software processing with 2.8 GHz CPU while maintaining almost same accuracy in comparison with SPICE simulation.
Functionally Incremental Sentence Processing and Reanalysis Difficulty in Head-Final Agglutinative Language  [PDF]
Shingo Tokimoto, Miki Uetsuki
Open Journal of Modern Linguistics (OJML) , 2015, DOI: 10.4236/ojml.2015.51003
Abstract: This paper quantitatively expresses the degrees of processing difficulties caused by syntactically different reanalyses in Japanese sentences by questionnaire and self-paced reading experiments with non-syntactic factors strictly controlled. We propose the functionally incremental processing for Japanese sentences and we demonstrate that our hypothesis is effective to explain the degree of the processing difficulty in various sentence types. The peculiarity of Japanese processing and the relevance of our results to the human sentence processing model are discussed.
Rejection Sensitivity, Self-Efficacy, and Learning Strategy: Mediating and Moderating the Role of Basic Needs Satisfaction  [PDF]
Miki Terada, Taishi Kawamoto
Psychology (PSYCH) , 2017, DOI: 10.4236/psych.2017.83028
Abstract: Rejection sensitive people often experience interpersonal difficulties, resulting in dissatisfaction with their need for relatedness. However, whether they are satisfied with their autonomy and competence, or experience difficulties from these factors other than in interpersonal relationships, remains largely unexplored. This study examined the influence of rejection sensitivity and need satisfaction (autonomy, competence, and relatedness) on learning strategy and self-efficacy. We found that competence satisfaction mediates the relationship between rejection sensitivity and self-efficacy. In addition, hierarchical regression analysis revealed a significant three-way interaction of rejection sensitivity, autonomy, and competence satisfaction with learning strategy. Competence satisfaction has a positive effect when individuals have low rejection sensitivity and are satisfied with autonomy need, whereas autonomy satisfaction has a positive effect when individuals have high rejection sensitivity and are dissatisfied with their competence levels. This suggests that autonomy and competence satisfaction levels are important for the understanding of psychological difficulties in rejection sensitive individuals.
The Correlation between Sexuality and Family Functioning among Patients with Inflammatory Bowel Disease in Japan  [PDF]
Yoshiko Miki, Naohiro Hohashi
Open Journal of Nursing (OJN) , 2018, DOI: 10.4236/ojn.2018.810054
Abstract: Purpose: The objective of this study was to examine the correlation between the sexuality of patients with Inflammatory Bowel Disease and family functioning. Methods: The study took the form of a self-administered questionnaire survey, utilizing the Sexuality Satisfaction Index for IBD (SEXSI-IBD) for measuring sexuality and the Survey of Family Environment Survey of Family Environment (SFE) for measuring family functioning. SEXSI-IBD consists of 28 items and five domains, and SFE consists of 30 items and five domains. The participants were recruited at 15 self-help groups and 14 hospitals. Results: Of 146 participants, 48.6% were male and 52.4% female, with an average age of 41.1 years. A significant correlation was observed between the item average score of SEXSI-IBD and Overall Satisfaction Score (OSS) of SFE. Significant correlations were observed in two domains of the SEXSI-IBD, “Daily interaction” and “Sexual communication,” and in all five domains of the SFE. In particular, for “Daily interaction,” the strongest correlation was observed in the SFE’s “Macro system” and “Family internal environment system.” A correlation was observed between the “Physical contact importance” in SEXSI-IBD and the “Macro system” in the OSS of the SFE. Conclusions: Sexuality correlates with family functioning not only in the family internal environment system but also in the family external environment system. Through an approach aimed at elevating the degree of satisfaction for sexuality, it becomes possible to improve family functioning and realize a sense of family well-being.
Distributed Intelligent Lighting System by Performing New Model for Illuminance and Color Temperature in the Workplace  [PDF]
Mohammed Hajjaj, Mitsunori Miki
Intelligent Control and Automation (ICA) , 2019, DOI: 10.4236/ica.2019.101001
Abstract: A new approach has been proposed to improve the performance of the in-telligent lighting system by estimating personal illuminance and desired color temperature at the workplace. We are considering the problem of using the sensing devices manually for the intelligent lighting system. The lighting control system has not become useful without sensing devices to measure the provided illuminance and color temperature. In this paper, we have used the property of light for the color temperature to estimate the level of color temperature for each user at the workplace. The new method will give personal illuminance for each user at the workplace and decrease the power consumption of the environment as well. As a result, the proposed method of the intelligent lighting system has realized the target of illuminance and color temperature for each user at the workplace by adapting dimming levels using illuminance sensing information for each user. Thus, the energy of the workplace has reduced by using a distributed luminance to realize the target for each user.
The Roles of Interleukin-6 in the Pathogenesis of Rheumatoid Arthritis
Misato Hashizume,Masahiko Mihara
Arthritis , 2011, DOI: 10.1155/2011/765624
Abstract: Several clinical studies have demonstrated that the humanized anti-interleukin-6 (IL-6) receptor antibody tocilizumab (TCZ) improves clinical symptoms and prevents progression of joint destruction in rheumatoid arthritis (RA). However, the precise mechanism by which IL-6 blockade leads to the improvement of RA is not well understood. IL-6 promotes synovitis by inducing neovascularization, infiltration of inflammatory cells, and synovial hyperplasia. IL-6 causes bone resorption by inducing osteoclast formation via the induction of RANKL in synovial cells, and cartilage degeneration by producing matrix metalloproteinases (MMPs) in synovial cells and chondrocytes. Moreover, IL-6 is involved in autoimmunity by altering the balance between Th17 cells and Treg. IL-6 also acts on changing lipid concentrations in blood and on inducing the production of hepcidin which causes iron-deficient anemia. In conclusion, IL-6 is a major player in the pathogenesis of RA, and current evidence indicates that the blockade of IL-6 is a beneficial therapy for RA patients.
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