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Search Results: 1 - 10 of 401702 matches for " Mihail M Protich "
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Incisional Atrial Tachycardia Masquerading As Counter-clockwise Atrial Flutter
Tchavdar N Shalganov,Mihail M Protich
Indian Pacing and Electrophysiology Journal , 2010,
Abstract: Forty-four-year-old male patient with surgical closure of ostium secundum type atrial septal defect at the age of 9 years had undergone radiofrequency catheter ablation of the cavotricuspid isthmus because of recurrent drug-resistant typical isthmus-dependent atrial flutter, with bi-directional isthmus block achieved. Only few days later he started to suffer again high-rate tachycardia. An atypical atrial flutter was diagnosed on ECG (Figure 1). This one proved to be drug-resistant as well and recurred promptly after cardioversion.
Cancer vaccines at an inflexion point: what next?
Adrian Bot, Mihail Obrocea, Francesco M Marincola
Journal of Translational Medicine , 2011, DOI: 10.1186/1479-5876-9-148
Abstract: It took more than a century after the first published description of cancer treatment through active immunotherapy by Coley [1], half a century since the formulation of the "cancer immunosurveillance" hypothesis by Burnet [2], and several decades since the discovery of dendritic cells by Steinman [3], MHC class I-restricted cytotoxic lymphocytes by Zinkernagel and Doherty [4] or tumor associated-antigens by Boon and Rosenberg [5,6], to finally witness the arrival of the first commercial veterinarian [7] and human [8] antigen-targeted therapeutic cancer vaccines.The mere subject of cancer vaccines could still trigger hot debates, finding its fervent opponents or its staunch supporters in the scientific and clinical community. As the arguments of the former are firmly anchored in the belief that the immune system has essentially evolved to ensure anti-microbial as opposed to anti-tumor monitoring, the latter segment of the scientific community sees the appealing and imminent possibility of translating the immunity's major features to groundbreaking therapies.The skepticism around immune interventions and in particular cancer vaccines had objective roots as key questions and hurdles needed to be tackled to fully unleash their potential in clinic: a) their indirect mechanism of action manifests through a rather subtle and sometimes delayed clinical benefit; b) the latter could be evident in most cases at cohort rather than patient's individual level; c) there are very few instances of objective, durable responses owing to poorly understood mechanistic circumstances; and d) the reliability of current immune correlates of clinical benefit was questionable despite significant progress in immunology. All these issues translated into an exceedingly difficult, risky and expensive process of developing such therapeutic agents. The decision-making for optimization, advancement to next stage or termination has been essentially deferred to large phase 2 or 3 clinical trials, unle
Theory of terahertz electric oscillations by supercooled superconductors
Todor M. Mishonov,Mihail T. Mishonov
Physics , 2005, DOI: 10.1088/0953-2048/18/11/017
Abstract: We predict that below T_c a regime of negative differential conductivity (NDC) can be reached. The superconductor should be supercooled to T
Simple model for the linear temperature dependence of the electrical resistivity of layered cuprates
Todor M. Mishonov,Mihail T. Mishonov
Physics , 2000, DOI: 10.1016/S0378-4371(99)00568-3
Abstract: The thermal fluctuations of the electric field between the CuO_2 planes of layered cuprates are considered as an origin of the electrical resistivity. The model evaluation employs a set of separate plane capacitors each having area equal to the squared in-plane lattice constant a_0^2. It is shown that the scattering of charge carriers by the fluctuation of electric charge in the conducting CuO_2 planes gives rise to the in-plane electrical resistivity rho_ab. Such a mechanism can be viewed as an analog of the Rayleigh's blue-sky law---the charge carriers are scattered by thermal fluctuations of electron density.
Perturbation analysis for the complex matrix equation Q ± AHXpA - X = 0
Juliana K. Boneva,Mihail M. Konstantinov,Petko H. Petkov
Surveys in Mathematics and its Applications , 2007,
Abstract: We study the sensitivity of the solution of a general type matrix equation Q ± AHXpA - X = 0. Local and nonlocal perturbation bounds are derived. The results are obtained using the technique of Lyapunov majorants and fixed point principles. A numerical example is given.
The Management of Mass Casualties in Case of Disasters
Dan M?N?STIREANU,Nicolae Steiner,Mihail P?SL?
Management in Health , 2010,
Abstract: The problems faced by the immediate management of dealing with a mass influx of victims refer mainly to politrauma and severe pathology and their consequences on increasing intensive care needs in the context of a large and sudden influx of victims in an infrastructure potentially affected by severe logistics and often unprepared. Emergency plans should be well designed and then tested as together with the immediate response plans they constitute the only solution to deal with a situation where faced with a lack of personnel and overall logistical shortcomings. WHO and DHA continue to be the best organisations that provide advice based on evidence and previous experience in international health issues and disaster management and humanitarian issues.Doctors, who are trained in disaster medicine, should achieve an adequate level of education and training in the unique principles and practices of the medical management of disaster and of massive inflows of victims and to play a key role in this area.
Mihail Iancu
Fruit Growing Research , 2012,
Abstract: The management and fertilization systems are particularly important owing to their influence both on tree behavior and soil properties as well. To highlight this influence of soil management systems (between tree rows and along the row) as well as N fertilization on some chemical components in soil, some investigations have been initiated since 1990 in a plum orchard established in 1984. The studies were performed on tipic planosol located on a flat land from the 3rd terrace of Doamnei river. The following experimental scheme was organized: A Factor – Soil sampling depth, with the graduations: a1 = 0-10 cm; a2 = 10-20 cm; B Factor = Soil management system, with the graduations: b1 = clean cultivation management of 1 cm wide stripe, along the tree row; b2 = the same management of another stripe like in b1 by mulching resulted from the grass mowing; C Factor = N rate, with the graduations: c1 = N0; c2 = N150; c3 = N100; c4 = N150; c5 = N200. The experiment was arranged in the field following the subdivided blocks method with the systematic design of A, B factors in 4 replications. The nitrogen was annually applied as ammonium azotate. P and K fertilization was evenly done over the whole acreage every 2-3 years. In 2011, after 22 years of B, C experimental factors involvement, pH values and P, K contents were registered. On an average, for the 3 soil management systems and 5 N fertilization levels on 0-10 cm versus 10-20 cm depth, pH value was significantly lower by 2.3% and P, K contents very significantly higher by 96% and 30.6% respectively. The soil management by mulching versus the other 2 management systems lead to a significant increase of P content by 48-78% and of K content by 42-62%. An increase of N rate versus to No treatment brought about a general decrease of pH values and certainly of P and K content. The data reported in this paper can be utilized for the selection of an adequate management system and of optimum N rates which are going to be applied in the plum orchards located on soil types with close properties to the experimental soil.
The Models of Inter-temporal Consume
Nora Mihail
Theoretical and Applied Economics , 2007,
Abstract: The articol presents a category of consumption models which shows the manner how theexpenses of consume in an economy are related to the available income achieved by this economy and theinterest rate from the financial market. Since the income as well as the expenses of consume are realizedin time, such dynamic models of consume are also referred to as models of inter-temporal consume,emphasizing therefore the fact that the available income achieved at a certain moment may be used forconsume at a future moment, whereas the decision of consume taken at a current moment may consider theincome that is to be achieved in the future.
Using the Agent-Based Modeling in Economic Field
Nora Mihail
Theoretical and Applied Economics , 2006,
Abstract: The last ten years of the XX century has been the witnesses of the apparition of a new scientific field, which is usually defined as the study of “Complex adaptive systems”. This field, generic named Complexity Sciences, shares its subject, the general proprieties of complex systems across traditional disciplinary boundaries, with cybernetics and general systems theory. But the development of Complexity Sciences approaches is determined by the extensive use of Agent-Based-Models (ABM) as a research tool and an emphasis on systems, such as markets, populations or ecologies, which are less integrated or “organized” than the ones, such as companies and economies, intensively studied by the traditional disciplines. For ABM, a complex system is a system of individual agents who have the freedom to act in ways that are not always totally predictable, and whose actions are interconnected such that one agent’s actions changes the context (environment) for other agents. These are many examples of such complex systems: the stock market, the human body immune system, a business organization, an institution, a work-team, a family etc.
Models of Macroeconomic Systems using Genetic Algorithms
Nora Mihail
Theoretical and Applied Economics , 2007,
Abstract: AG represents only one, it’s true that it is very fashionable today, of the new instruments which began to be used lately in the macroeconomic modelling. Here, it may also be mentioned the classification systems, the genetic programming, the models based on agents, the evolutionist games etc. The characteristics of all these methods consist in the effort to detect the internal dynamic processes of the modelled macroeconomic systems and not only the answer of these to external chocks and perturbations. Among these internal dynamic processes maybe the most interesting is that one of continuous adapting of the modelled macroeconomic system to the environment. In the macroeconomic environment are included different systems made of subsystems and heterogene agents and the decisions adopted by these affect both the systems as such and other subsystems and processes from the environment. This general independency, neglected several times in the macroeconomic modelling due to the lack of instruments and methods able to detect it, may be however approached with enough rigour resorting to new modelling methods as the one described in this chapter. In order to illustrate such a tendency, we shall present further on some of the most recent macroeconomic models which have been reformulated and studied using AG.
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