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Radiation effects on skeletal muscle
Mihaela Jurdana
Radiology and Oncology , 2008, DOI: 10.2478/v10019-007-0034-5
Abstract: Background. Adult skeletal muscle is considered resistant to ionizing radiation unless higher doses of radiation are applied; a fact that is attributed to the low number of radiosensitive proliferating cells in adulthood. However, developing skeletal muscles are highly sensitive to ionizing radiation, thus radiotherapy in childhood may induce muscular atrophy. Radiation affects muscle satellite cells by impairing their activation, proliferation and differentiation, as well as neuromuscular junction, by influencing the ionic membrane permeability affecting the Na+/K+ pump. It also prevents muscle growth during development and after injury. Conclusions. The results of the investigation performed after radiation point to the occurrence of a significant change in muscle satellite cell activity. Inhibitors of some proteins such as cytokines in muscle satellite cells could provide a therapeutic benefit in diseases for which muscle mass is limiting, improve response to cancer therapy, and increase life span in patients with cachexia.
Hyperhomocysteinemia and the role of B vitamins in cancer
Nadja Plazar, Mihaela Jurdana
Radiology and Oncology , 2010, DOI: 10.2478/v10019-010-0022-z
Abstract: Background. Patients suffering from malignancies have increased complications due to corresponding cardiovascular diseases and risk factor for the development of venous thromboembolism. Epidemiological studies have shown that increased homocysteine plasma concentration (hyperhomocysteinemia) is related to a higher risk of coronary heart disease, stroke, peripheral vascular disease and malignancies. Homocysteine (tHcy) is an intermediate sulfurcontaining amino acid produced from methionine during processing of dietary proteins. The plasma homocysteine levels are strongly influenced by diet, as well as by genetic factors. Folic acid, vitamins B6 and B12 are dietary components which influence the plasma homocysteine levels the most. Several studies have found that high blood levels of B vitamins are related to the integrity and function of DNA, and, are at least related to lower concentration of homocysteine. Folate depletion has been found to change DNA methylation and DNA synthesis in both animal and human studies. Because of this critical role of folate, most studies including homocysteine have focused on these two actions. Conclusions. Hyperhomocysteinemia proves to be the most common condition highly associated with both venous and arterial thrombosis in many cancer patients, while the associated pathophysiology has not been precisely established yet. Therefore, of current interest is the possible role of folate metabolism developing into a cancer initiating hyperhomocysteinemia. This review will discuss this possibility.
The past photometric history of the FU Ori-type young eruptive star 2MASS J06593158-0405277 = V960 Mon
R. Jurdana-Sepic,U. Munari
Physics , 2015, DOI: 10.1016/j.newast.2015.08.001
Abstract: The known FU Ori-type young eruptive stars are exceedingly rare (a dozen or so confirmed objects) and 2MASS J06593158-0405277, with its 2014 outburst, is likely the latest addition to the family. All members have displayed just one such eruption in their recorded history, an event lasting for decades. To test the FU Ori nature of 2MASS J06593158-0405277, we have reconstructed its photometric history by measuring its brightness on Harvard photographic plates spanning the time interval 1899-1989. No previous large amplitude eruption similar to that initiated in 2014 has been found, as in bona fide FU Ori-type objects. The median value of the brightness in quiescence of 2MASS J06593158-0405277 is B=15.5, with the time interval 1935-1950 characterized by a large variability (~1 mag amplitude) that contrasts with the remarkable photometric stability displayed at later epochs. The variability during 1935-1950 can either be ascribed to some T Tau like activity of 2MASS J06593158-0405277 itself or to the also young and fainter star 2MASS J06593168-0405224 that lies 5 arcsec to the north and forms an unresolved pair at the astrometric scale of Harvard photographic plates.
Symbiotic stars on Asiago archive plates. II
Ulisse Munari,Rajka Jurdana-Sepic
Physics , 2002, DOI: 10.1051/0004-6361:20020201
Abstract: The Asiago photographic archive has been searched for plates containing the symbiotic stars Hen 2-468, QW Sge, LT Del, V407 Cyg, K 3-9, V335 Vul, FG Ser and Draco C-1. A total of 635 plates imaging the program stars have been found and the brightness estimated using the Henden & Munari (2000) UBVRI photometric sequences. These historical data have allowed for the first time the determination of the orbital periods of Hen 2-468 (774 days) and QW Sge (390.5 days), a significant improvement in the orbital period of LT Del (465.6 days) and for V407 Cyg an evaluation of the Mira's pulsation period and complex lightcurve shape in the red (R and I bands). Some previously unknown outbursts have been discovered too. (Paper I: Munari et al. 2001, A&A 370, 503)
Outburst evolution, historic light curve and a flash-ionized nebula around the WZ Sge-type object PNV J03093063+2638031
U. Munari,R. Jurdana-Sepic,P. Ochner,G. Cherini
Physics , 2015, DOI: 10.1051/0004-6361/201526789
Abstract: We have monitored the 2014 superoutburst of the WZ Sge-type transient PNV J03093063+2638031 for more than four months, from V=11.0 maximum brightness down to V=18.4 mag, close to quiescence value, by obtaining BVRI photometry and low resolution fluxed spectroscopy. The evolution was normal and no late-time `echo' outbursts were observed. The absolute integrated flux of emission lines kept declining along the superoutburst, and their increasing contrast with the underlying continuum was simply the result of the faster decline of the continuum compared to the emission lines. Inspection of historical Harvard plates covering the 1899-1981 period did not reveal previous outbursts, neither `normal' nor 'super'. We discovered an extended emission nebula (radius ~1 arcmin) around PNV J03093063+2638031, that became visible for a few months as the result of photo-ionization from the superoutburst of the central star. It is not present on Palomar I and II sky survey images and it quickly disappeared when the outburst was over. From the rate at wich the inization front swept through the nebula, we derive a distance of ~120 pc to the system. The nebula is density bounded with an outer radius of 0.03 pc, and the absolute magnitude of the central star in quiescence is M(V)~14.2 mag. The electron density in the nebula is estimated to be 10(+5) cm(-3) from the observed recombination time scale. Given the considerable substructures seen across the nebula, a low filling factor is inferred. Similar nebulae have not been reported for other WZ Sge objects and the challenges posed to models are considered.
Symbiotic stars on Asiago archive plates. I
U. Munari,R. Jurdana-Sepic,D. Moro
Physics , 2001, DOI: 10.1051/0004-6361:20010256
Abstract: The rich plate archive of the Asiago observatory has been searched for plates containing the symbiotic stars AS 323, Ap 3-1, CM Aql, V1413 Aql (=AS 338), V443 Her, V627 Cas (=AS 501) and V919 Sgr. The program objects have been found on 602 plates, where their brightness has been estimated against the UBVRI photometric sequences calibrated by Henden and Munari (2000, A&AS 143, 343). AS 323 is probably eclipsing, with a preliminary P=197.6 day period. If confirmed, it would be the shortest orbital period known among symbiotic stars. CM Aql does not seem to undergo a series of outbursts, its lightcurve being instead modulated by a large amplitude sinusoidal variation with a P~1058 day period. V627 Cas presents a secular trend in agreement with the possible post-AGB nature of its cool component.
Cryptanalysis of the Double-Moduli Cryptosystem  [PDF]
Sonia Mihaela Bogos, Serge Vaudenay
Int'l J. of Communications, Network and System Sciences (IJCNS) , 2012, DOI: 10.4236/ijcns.2012.512088
Abstract: In this article we present a lattice attack done on a NTRU-like scheme introduced by Verkhovsky in [1]. We show how, based on the relation between the public and private key, we can construct an attack which allows any passive adversary to decrypt the encrypted messages. We explain, step by step, how an attacker can construct an equivalent private key and guess what the original plaintext was. Our attack is efficient and provides good experimental results.
Tumor Microenvironment in the Brain
Mihaela Lorger
Cancers , 2012, DOI: 10.3390/cancers4010218
Abstract: In addition to malignant cancer cells, tumors contain a variety of different stromal cells that constitute the tumor microenvironment. Some of these cell types provide crucial support for tumor growth, while others have been suggested to actually inhibit tumor progression. The composition of tumor microenvironment varies depending on the tumor site. The brain in particular consists of numerous specialized cell types such as microglia, astrocytes, and brain endothelial cells. In addition to these brain-resident cells, primary and metastatic brain tumors have also been shown to be infiltrated by different populations of bone marrow-derived cells. The role of different cell types that constitute tumor microenvironment in the progression of brain malignancies is only poorly understood. Tumor microenvironment has been shown to be a promising therapeutic target and diagnostic marker in extracranial malignancies. A better understanding of tumor microenvironment in the brain would therefore be expected to contribute to the development of improved therapies for brain tumors that are urgently required due to a poor availability of treatments for these malignancies. This review summarizes some of the known interactions between brain tumors and different stromal cells, and also discusses potential therapeutic approaches within this context.
The Human Transcriptome: An Unfinished Story
Mihaela Pertea
Genes , 2012, DOI: 10.3390/genes3030344
Abstract: Despite recent technological advances, the study of the human transcriptome is still in its early stages. Here we provide an overview of the complex human transcriptomic landscape, present the bioinformatics challenges posed by the vast quantities of transcriptomic data, and discuss some of the studies that have tried to determine how much of the human genome is transcribed. Recent evidence has suggested that more than 90% of the human genome is transcribed into RNA. However, this view has been strongly contested by groups of scientists who argued that many of the observed transcripts are simply the result of transcriptional noise. In this review, we conclude that the full extent of transcription remains an open question that will not be fully addressed until we decipher the complete range and biological diversity of the transcribed genomic sequences.
Judicial review and transitional justice: reflective judgment in three contexts
Mihaela Mihai
Papeles del CEIC , 2010,
Abstract: Este artículo busca examinar las vías a través de las cuales las cortes de revisión constitucional han intentado discernir con sentimientos públicos dentro de sociedades emergentes de una situación de opresión y conflicto de alta escala. Un análisis comparativo de decisiones de revisión judicial de la Hungría post–comunista, de la Sudáfrica post–Apartheid y de la Argentina post–dictadura como casos que muestran como los jueces han, con mayor o menor éxito, reconocido y engranado pedagógicamente sentimientos sociales negativos de resentimiento e indignación hacia antiguos víctimarios y beneficiarios de violencia. Así, el artículo espera cimentar el camino para investigaciones de mayor envergadura sobre uno de las dimensiones más descuidadas de sociedades post–confictuales: la influencia pública. / This article seeks to examine the ways in which courts of constitutional review have tried to deal with public sentiments within societies emerging from large–scale oppression and conflict. A comparative analysis of judicial review decisions from post–communist Hungary, post–Apartheid South Africa and post–dictatorial Argentina is meant to show–case how judges have,more or less successfully, recognised and pedagogically engaged social negative feelings of resentment and indignation towards former victimisers and beneficiaries of violence. Thus, the article hopes to pave the way for more in–depth research on one of the most neglecteddimensions of post–conflict societies: public affect.
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