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Search Results: 1 - 10 of 16935 matches for " Miguel Klünder-Klünder "
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Analysis of the contribution of FTO, NPC1, ENPP1, NEGR1, GNPDA2 and MC4R genes to obesity in Mexican children
Mejía-Benítez Aurora,Klünder-Klünder Miguel,Yengo Loic,Meyre David
BMC Medical Genetics , 2013, DOI: 10.1186/1471-2350-14-21
Abstract: Background Recent genome wide association studies (GWAS) and previous positional linkage studies have identified more than 50 single nucleotide polymorphisms (SNPs) associated with obesity, mostly in Europeans. We aimed to assess the contribution of some of these SNPs to obesity risk and to the variation of related metabolic traits, in Mexican children. Methods The association of six European obesity-related SNPs in or near FTO, NPC1, ENPP1, NEGR1, GNPDA2 and MC4R genes with risk of obesity was tested in 1,463 school-aged Mexican children (Ncases = 514; Ncontrols = 949). We also assessed effects of these SNPs on the variation of body mass index (BMI), fasting serum insulin levels, fasting plasma glucose levels, total cholesterol and triglyceride levels, in a subset of 1,171 nonobese Mexican children. Results We found a significant effect of GNPDA2 rs10938397 on risk of obesity (odds ratio [OR] = 1.30; P = 1.34 × 10-3). Furthermore, we found nominal associations between obesity risk or BMI variation and the following SNPs: ENPP1 rs7754561, MC4R rs17782313 and NEGR1 rs2815752. Importantly, the at-risk alleles of both MC4R rs17782313 and NPC1 rs1805081 showed significant effect on increased fasting glucose levels (β = 0.36 mmol/L; P = 1.47 × 10-3) and decreased fasting serum insulin levels (β = 0.10 μU/mL; P = 1.21 × 10-3), respectively. Conclusion Our present results suggest that some obesity-associated SNPs previously reported in Europeans also associate with risk of obesity, or metabolic quantitative traits, in Mexican children. Importantly, we found new associations between MC4R and fasting glucose levels, and between NPC1 and fasting insulin levels.
Adiponectin in eutrophic and obese children as a biomarker to predict metabolic syndrome and each of its components
Miguel Klünder-Klünder, Samuel Flores-Huerta, Rebeca García-Macedo, Jesús Peralta-Romero, Miguel Cruz
BMC Public Health , 2013, DOI: 10.1186/1471-2458-13-88
Abstract: A cross sectional study was conducted in 190 school-age children classified as obese and 196 classified as eutrophic. Adiponectin, glucose, insulin, high density lipoprotein cholesterol (HDL-C) and triglycerides were determined from a fasting blood sample. Height, weight, waist circumference, systolic and diastolic blood pressures (BP) were measured; MetS was evaluated with the IDF definition. The study groups were divided according to tertiles of adiponectin, using the higher concentration as a reference. Linear regression analysis was used to assess the association between adiponectin and components of the MetS. Finally, stepwise forward multiple logistic regression analysis controlling for age, gender, basal HOMA-IR values and BMI was performed to determine the odds ratio of developing MetS according to adiponectin tertiles.Anthropometric and metabolic measurements were statistically different between eutrophic and obese children with and without MetS (P <0.001). The prevalence of MetS in obese populations was 13%. Adiponectin concentrations were 15.5?±?6.1, 12.0?±?4.8, 12.4?±?4.9 and 9.4?±?2.8 μg/mL for eutrophic and obese subjects, obese without MetS, and obese with MetS, respectively (P <0.001). Obese children with low values of adiponectin exhibited a higher frequency of MetS components: abdominal obesity, 49%; high systolic BP, 3%; high diastolic BP, 2%; impaired fasting glucose, 17%; hypertriglyceridemia, 31%; and low HDL-C values, 42%. Adjusted odds ratio of presenting MetS according to adiponectin categories was 10.9 (95% CI 2.05; 48.16) when the first tertile was compared with the third.In this sample of eutrophic and obese Mexican children we found that adiponectin concentrations and MetS components have an inversely proportional relationship, which supports the idea that this hormone could be a biomarker for identifying individuals with risk of developing MetS.During the last three decades, obesity has emerged worldwide as an epidemic affecting all age
Insulin resistance and its association with the components of the metabolic syndrome among obese children and adolescents
Carlos Juárez-López, Miguel Klünder-Klünder, Patricia Medina-Bravo, Adrián Madrigal-Azcárate, Eliezer Mass-Díaz, Samuel Flores-Huerta
BMC Public Health , 2010, DOI: 10.1186/1471-2458-10-318
Abstract: An analytical, cross-sectional and population-based study was performed in forty-four public primary schools in Campeche City, Mexico. A total of 466 obese children and adolescents between 11-13 years of age were recruited. Fasting glucose and insulin concentrations, high density lipoprotein cholesterol, triglycerides, waist circumference, systolic and diastolic blood pressures were measured; insulin resistance and metabolic syndrome were also evaluated.Out of the total population studied, 69% presented low values of high density lipoprotein cholesterol, 49% suffered from abdominal obesity, 29% had hypertriglyceridemia, 8% presented high systolic and 13% high diastolic blood pressure, 4% showed impaired fasting glucose, 51% presented insulin resistance and 20% metabolic syndrome. In spite of being obese, 13% of the investigated population did not present any metabolic disorder. For each one of the components of the metabolic syndrome, when insulin resistance increased so did odds ratios as cardiometabolic risk factors.Regardless of age and gender an increased degree of insulin resistance is associated with a higher prevalence of disorders in each of the components of the metabolic syndrome and with a heightened risk of suffering metabolic syndrome among obese children and adolescents.The World Health Organization recognizes overweight and obesity in children and adolescents as worldwide public health problems. Mexico is one of the countries which suffer most from these.Indeed, according to Mexican National Health and Nutrition Surveys, in 1999 [1] the combined prevalence of overweight and obesity in school-age children was 18.6%; by 2006, such prevalence had increased to 26%, which represents an average increase of 1.1 percentage points per year [2].Insulin resistance (IR) is the primary metabolic disorder associated with obesity and is defined as a diminished ability of insulin to stimulate glucose uptake by skeletal muscle and adipose tissue, in addition to reduci
Análisis crítico del ACUERDO mediante el cual se establecen los lineamientos generales para el expendio o distribución de alimentos y bebidas en los establecimientos de consumo escolar de los planteles de educación básica
Flores Huerta, Samuel;Klünder Klünder, Miguel;Medina Bravo, Patricia;
Boletín médico del Hospital Infantil de México , 2011,
Abstract: this paper offers a critical analysis of the agreement under which the general guidelines to sell or distribute foods and beverages in elementary school cafeterias has been established. this is a legal instrument established by the ministry of public education and health to regulate that foods and beverages sold and consumed in school cafeterias will be healthful in order to reduce the high rates of overweight and obesity in school-aged children. all of the chapters in the agreement have been analyzed to determine their pertinence to overcome the problem of overweight and obesity: legal aspects, physical characteristics of the cafeteria, and the committees to determine the functions of the cafeteria. furthermore, analyses have been made of the scientific terms where the nutritional composition of the healthy products is defined. it is expected that foods and beverages sold in school cafeterias will be changed to healthful items over the next 3 years. a list of statements considered as strengths or weaknesses is presented as well as a table that includes several actions that could be undertaken by teachers, parents, students and school authorities within the school and the surroundings to reduce the problem of overweight and obesity in children.
Systematic Semiclassical Expansion for Harmonically Trapped Ideal Bose Gases
Ben Klünder,Axel Pelster
Physics , 2008, DOI: 10.1140/epjb/e2009-00112-9
Abstract: Using a field-theoretic approach, we systematically generalize the usual semiclassical approximation for a harmonically trapped ideal Bose gas in such a way that its range of applicability is essentially extended. With this we can analytically calculate thermodynamic properties even for small particle numbers. In particular, it now becomes possible to determine the critical temperature as well as the temperature dependence of both heat capacity and condensate fraction in low-dimensional traps, where the standard semiclassical approximation is not even applicable.
Stability of localized wave fronts in bistable systems
Steffen Rulands,Ben Klünder,Erwin Frey
Quantitative Biology , 2012, DOI: 10.1103/PhysRevLett.110.038102
Abstract: Localized wave fronts are a fundamental feature of biological systems from cell biology to ecology. Here, we study a broad class of bistable models subject to self-activation, degradation and spatially inhomogeneous activating agents. We determine the conditions under which wave-front localization is possible and analyze the stability thereof with respect to extrinsic perturbations and internal noise. It is found that stability is enhanced upon regulating a positional signal and, surprisingly, also for a low degree of binding cooperativity. We further show a contrasting impact of self-activation to the stability of these two sources of destabilization.
Review of Survey activities 2007: Laser ablation analysis of bivalve shells – archives of environmental information
Klünder, Maiken Hansen,Hippler, Dorothee,Witbaard, Rob,Frei, Dirk
Geological Survey of Denmark and Greenland Bulletin , 2008,
GDI-Mediated Cell Polarization in Yeast Provides Precise Spatial and Temporal Control of Cdc42 Signaling
Ben Klünder ,Tina Freisinger ,Roland Wedlich-S?ldner ,Erwin Frey
PLOS Computational Biology , 2013, DOI: 10.1371/journal.pcbi.1003396
Abstract: Cell polarization is a prerequisite for essential processes such as cell migration, proliferation or differentiation. The yeast Saccharomyces cerevisiae under control of the GTPase Cdc42 is able to polarize without the help of cytoskeletal structures and spatial cues through a pathway depending on its guanine nucleotide dissociation inhibitor (GDI) Rdi1. To develop a fundamental understanding of yeast polarization we establish a detailed mechanistic model of GDI-mediated polarization. We show that GDI-mediated polarization provides precise spatial and temporal control of Cdc42 signaling and give experimental evidence for our findings. Cell cycle induced changes of Cdc42 regulation enhance positive feedback loops of active Cdc42 production, and thereby allow simultaneous switch-like regulation of focused polarity and Cdc42 activation. This regulation drives the direct formation of a unique polarity cluster with characteristic narrowing dynamics, as opposed to the previously proposed competition between transient clusters. As the key components of the studied system are conserved among eukaryotes, we expect our findings also to apply to cell polarization in other organisms.
Cationic Lipid-Formulated DNA Vaccine against Hepatitis B Virus: Immunogenicity of MIDGE-Th1 Vectors Encoding Small and Large Surface Antigen in Comparison to a Licensed Protein Vaccine
Anne Endmann, Katharina Klünder, Kerstin Kapp, Oliver Riede, Detlef Oswald, Eduard G. Talman, Matthias Schroff, Christiane Kleuss, Marcel H. J. Ruiters, Christiane Juhls
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0101715
Abstract: Currently marketed vaccines against hepatitis B virus (HBV) based on the small (S) hepatitis B surface antigen (HBsAg) fail to induce a protective immune response in about 10% of vaccinees. DNA vaccination and the inclusion of PreS1 and PreS2 domains of HBsAg have been reported to represent feasible strategies to improve the efficacy of HBV vaccines. Here, we evaluated the immunogenicity of SAINT-18-formulated MIDGE-Th1 vectors encoding the S or the large (L) protein of HBsAg in mice and pigs. In both animal models, vectors encoding the secretion-competent S protein induced stronger humoral responses than vectors encoding the L protein, which was shown to be retained mainly intracellularly despite the presence of a heterologous secretion signal. In pigs, SAINT-18-formulated MIDGE-Th1 vectors encoding the S protein elicited an immune response of the same magnitude as the licensed protein vaccine Engerix-B, with S protein-specific antibody levels significantly higher than those considered protective in humans, and lasting for at least six months after the third immunization. Thus, our results provide not only the proof of concept for the SAINT-18-formulated MIDGE-Th1 vector approach but also confirm that with a cationic-lipid formulation, a DNA vaccine at a relatively low dose can elicit an immune response similar to a human dose of an aluminum hydroxide-adjuvanted protein vaccine in large animals.
Phase Measurement of Resonant Two-Photon Ionization in Helium
M. Swoboda,T. Fordell,K. Klünder,J. M. Dahlstr?m,M. Miranda,C. Buth,K. J. Schafer,J. Mauritsson,A. L'Huillier,M. Gisselbrecht
Physics , 2010, DOI: 10.1103/PhysRevLett.104.103003
Abstract: We study resonant two-color two-photon ionization of Helium via the 1s3p 1P1 state. The first color is the 15th harmonic of a tunable titanium sapphire laser, while the second color is the fundamental laser radiation. Our method uses phase-locked high-order harmonics to determine the {\it phase} of the two-photon process by interferometry. The measurement of the two-photon ionization phase variation as a function of detuning from the resonance and intensity of the dressing field allows us to determine the intensity dependence of the transition energy.
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