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Search Results: 1 - 10 of 472368 matches for " Miguel García-Remesal "
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e-MIR2: a public online inventory of medical informatics resources
de la Calle Guillermo,García-Remesal Miguel,Nkumu-Mbomio Nelida,Kulikowski Casimir
BMC Medical Informatics and Decision Making , 2012, DOI: 10.1186/1472-6947-12-82
Abstract: Background Over the past years, the number of available informatics resources in medicine has grown exponentially. While specific inventories of such resources have already begun to be developed for Bioinformatics (BI), comparable inventories are as yet not available for the Medical Informatics (MI) field, so that locating and accessing them currently remains a difficult and time-consuming task. Description We have created a repository of MI resources from the scientific literature, providing free access to its contents through a web-based service. We define informatics resources as all those elements that constitute, serve to define or are used by informatics systems, ranging from architectures or development methodologies to terminologies, vocabularies, databases or tools. Relevant information describing the resources is automatically extracted from manuscripts published in top-ranked MI journals. We used a pattern matching approach to detect the resources’ names and their main features. Detected resources are classified according to three different criteria: functionality, resource type and domain. To facilitate these tasks, we have built three different classification schemas by following a novel approach based on folksonomies and social tagging. We adopted the terminology most frequently used by MI researchers in their publications to create the concepts and hierarchical relationships belonging to the classification schemas. The classification algorithm identifies the categories associated with resources and annotates them accordingly. The database is then populated with this data after manual curation and validation. Conclusions We have created an online repository of MI resources to assist researchers in locating and accessing the most suitable resources to perform specific tasks. The database contains 609 resources at the time of writing and is available at http://www.gib.fi.upm.es/eMIR2. We are continuing to expand the number of available resources by taking into account further publications as well as suggestions from users and resource developers.
BIRI: a new approach for automatically discovering and indexing available public bioinformatics resources from the literature
Guillermo de la Calle, Miguel García-Remesal, Stefano Chiesa, Diana de la Iglesia, Victor Maojo
BMC Bioinformatics , 2009, DOI: 10.1186/1471-2105-10-320
Abstract: We developed a web service to provide a set of high-level query primitives to access the index. The web service can be used by third-party web services or web-based applications. To test the web service, we created a pilot web application to access a preliminary knowledge base of resources. We tested our tool using an initial set of 400 abstracts. Almost 90% of the resources described in the abstracts were correctly classified. More than 500 descriptions of functionalities were extracted.These experiments suggest the feasibility of our approach for automatically discovering and indexing current and future bioinformatics resources. Given the domain-independent characteristics of this tool, it is currently being applied by the authors in other areas, such as medical nanoinformatics. BIRI is available at http://edelman.dia.fi.upm.es/biri/ webcite.The number of public online bioinformatics resources has grown exponentially over the past few years. Bioinformatics professionals can access and use a large number of resources for their research --including databases, tools and services. Discovering and accessing the appropriate bioinformatics resource for a specific research task has become increasingly important, as suggested in earlier reports [1].To address this issue, various significant projects and initiatives have been carried out, leading to several pioneering indexes of bioinformatics resources that are currently available over the Internet. For instance, BioPortal [2] is a web repository of biomedical ontology resources, developed at the National Center for Biomedical Ontology (NCBO) [3]. This application enables collaborative development of biomedical ontologies. BioPortal includes a service called Open Biomedical Resources (OBR) for annotating and indexing biomedical resources [4]. Resources are annotated using concepts from a domain ontology. The OBR service enables researchers to locate resources by specifying ontology concepts.Other examples of such indexes i
A method for automatically extracting infectious disease-related primers and probes from the literature
Miguel García-Remesal, Alejandro Cuevas, Victoria López-Alonso, Guillermo López-Campos, Guillermo de la Calle, Diana de la Iglesia, David Pérez-Rey, José Crespo, Fernando Martín-Sánchez, Víctor Maojo
BMC Bioinformatics , 2010, DOI: 10.1186/1471-2105-11-410
Abstract: We tested our approach using a test set composed of 297 manuscripts. The extracted sequences and their organism/gene annotations were manually evaluated by a panel of molecular biologists. The results of the evaluation show that our approach is suitable for automatically extracting DNA sequences, achieving precision/recall rates of 97.98% and 95.77%, respectively. In addition, 76.66% of the detected sequences were correctly annotated with their organism name. The system also provided correct gene-related information for 46.18% of the sequences assigned a correct organism name.We believe that the proposed method can facilitate routine tasks for biomedical researchers using molecular methods to diagnose and prescribe different infectious diseases. In addition, the proposed method can be expanded to detect and extract other biological sequences from the literature. The extracted information can also be used to readily update available primer/probe databases or to create new databases from scratch.Molecular technologies are used in routine clinical practice to identify microorganisms, and evaluate the presence of virulence factors, antibiotic resistance determinants and host-microbe interactions [1]. For instance, numerous nucleic acid assays have been developed [2] using hybridization or DNA extension techniques that include a wide range of technologies, such as polymerase chain reaction (PCR) methods [3], gene and whole genome sequencing [4,5], Luminex [6] and microarray analysis [7].There is a wide range of technologies that provide specific short base sequences of DNA as probes — used to detect the complementary base sequence of interest—or as primers—that guide the DNA amplification process—used for different purposes. Primers and probes are the main components of nucleic acid-based detection systems and have been the subject of multiple studies. Therefore, different software programs have been developed to design these specific sequences of primers and probes mini
Miguel García Bustamante
Tabula Rasa , 2003,
Miguel García Bustamante
Tabula Rasa , 2004,
Duplex est liber: La clerecía, el mester y la historicidad de la escritura Juan García única. Cuando los libros eran Libros. Cuatro claves de una escritura “a sílabas contadas”. Granada: Comares (De guante blanco), 2011, 270 págs.
Miguel ángel García
Impossibilia : Revista Internacional de Estudios Literarios , 2011,
Laura sin aura. La literatura después de la literatura
Miguel ángel García
álabe , 2012,
Dios problemático?
García Baró, Miguel
Arbor : Ciencia, Pensamiento y Cultura , 2002,
Abstract: Not available El final de la modernidad, ya con dos siglos de historia, es, desde el punto de vista de la religión y su filosofía, sobre todo la gran cuestión abierta de cómo pueda continuar la empresa de la emancipación del hombre después del fracaso del idealismo absoluto y de sus secuelas. Se trata de un tiempo que ha sido comparado con justicia al de una segunda inocencia , donde importa esencialmente afrontar en toda su amplitud y seriedad el problema del mal y la posibilidad de una esperanza realmente dirigida a la salvación de Dios, y no a cualquier objetivo intramundano.
Algunas reflexiones sobre innovación docente en el marco del Proyecto Bolonia
Valero García, Miguel
Arbor : Ciencia, Pensamiento y Cultura , 2011, DOI: 10.3989/arbor.2011.extra-3n3134
Abstract: This paper presents some thoughts built near 10 years of experimentation in teaching innovation stimulated by the process of building the European Higher Education Area. Some of these thoughts have to do with how much of the faculty who has embarked on the adventure is experiencing the process of teaching innovation. Other thoughts relate to how the institution is facilitating (or rather should facilitate) the process of change. En este artículo se presentan algunas reflexiones que se alimentan en cerca ya de 10 a os de experimentación en materia de innovación docente estimulada por el proceso de construcción del Espacio Europeo de Educación Superior. Algunas de estas reflexiones tienen que ver con la forma en que una buena parte del profesorado que se ha embarcado en la aventura está viviendo el proceso de innovación docente. Otras reflexiones tienen que ver con la forma en que la institución está facilitando (o más bien debería facilitar) este proceso de cambio.
Propagation and Confinement of Electric Field Waves along One-Dimensional Porous Silicon Hybrid Periodic/Quasiperiodic Structure  [PDF]
José Escorcia-García, Miguel Eduardo Mora-Ramos
Optics and Photonics Journal (OPJ) , 2013, DOI: 10.4236/opj.2013.32A001

Selective spatial confinement of the electric field intensity is theoretically obtained for the light propagation along hybrid structures conformed by periodic and Fibonacci quasiperiodic dielectric multilayers. Sandwich-like configurations featuring periodic-quasiperiodic-periodic as well as quasiperiodic-periodic-quasiperiodic designs exhibit spatial localization of a large percent of the optical signal within specific zones of the hybrid system. Such a feature might be of interest in the pursuing of lasing devices based on porous silicon. It is found that the electric field confinement does not only depend on the quality of the defect or a particular transmission mode observed in the reflectivity spectra. We show that it is possible to enhance the electric field confinement solely varying the angle of incidence. The possibility of realizing finite photonic crystals with reduced size and very well defined band gap by means of a quasiperiodic-periodic-quasiperiodic hybrid multilayer is also revealed.

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