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Search Results: 1 - 10 of 596782 matches for " Miguel A Mendoza-Catalán "
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Nuclear expression of Rac1 in cervical premalignant lesions and cervical cancer cells
Miguel A Mendoza-Catalán, Gema R Cristóbal-Mondragón, Jesús Adame-Gómez, Heidi N del Valle-Flores, José Coppe, Laura Sierra-López, Mirna A Romero-Hernández, Luz del Carmen Alarcón-Romero, Berenice Illades-Aguiar, Eduardo Casta?eda-Saucedo
BMC Cancer , 2012, DOI: 10.1186/1471-2407-12-116
Abstract: Protein expression was analyzed by immunochemistry on 102 cervical paraffin-embedded biopsies: 20 without Squamous Intraepithelial Lesions (SIL), 51 Low- grade SIL, and 31 High-grade SIL; and in cervical cancer cell lines C33A and SiHa, and non-tumorigenic HaCat cells. Nuclear localization of Rac1 in HaCat, C33A and SiHa cells was assessed by cellular fractionation and Western blotting, in the presence or not of a chemical Rac1 inhibitor (NSC23766).Immunoreacivity for Rac1, RhoA, Tiam1 and beta-Pix was stronger in L-SIL and H-SIL, compared to samples without SIL, and it was significantly associated with the histological diagnosis. Nuclear expression of Rac1 was observed in 52.9% L-SIL and 48.4% H-SIL, but not in samples without SIL. Rac1 was found in the nucleus of C33A and SiHa cells but not in HaCat cells. Chemical inhibition of Rac1 resulted in reduced cell proliferation in HaCat, C33A and SiHa cells.Rac1 is expressed in the nucleus of epithelial cells in SILs and cervical cancer cell lines, and chemical inhibition of Rac1 reduces cellular proliferation. Further studies are needed to better understand the role of Rho-GTPases in cervical cancer progression.Cervical cancer is the second most common malignant neoplasia affecting woman worldwide. Infection with High-Risk Human Papillomavirus (HR-HPV) is considered the main risk factor for developing cervical cancer and its precursor lesions [1-3]. Development of cervical Low-grade Squamous Intraepithelial Lesions (L- SIL) and High-grade Squamous Intraepithelial Lesions (H-SIL), and progression to invasive carcinoma, are associated with alterations in the regulation of several cellular processes such as cell cycle progression, apoptosis, and DNA repair [2,4,5]. The HR-HPV oncoproteins E6 and E7 are responsible for many of these alterations, they act by binding to, and/or modifying the expression/activity of a growing number of cellular proteins [6], including p53 [7], pRb [8], p21 [9,10], and p27 [11,12]. Rho-GTPases
Genealogía de la noble mentira
Miguel Catalán
Amnis , 2004, DOI: 10.4000/amnis.399
Abstract: Cet article analyse la notion de noble mensonge que l’on retrouve tout au long de l’histoire chez de nombreux auteurs, de Platon dans la Republique à Leo Strauss, l’actuel inspirateur de la politique menée par les néo-conservateurs aux Etats-Unis. L’article trace une ligne de pensée qui traverse les principales écoles et les auteurs modernes qui ont justifié le mensonge politique. The notion of noble lie has a long history. It can be found from Plato’s Republic to Leo Strauss’opus, a contemporary thinker whose thought inspires the philosophical background of the North-American neo-conservatives, who control the present Republican administration. This article goes through and analyses the main modern schools and authors who have justified political lie, i.e. a specific lie by which the political authority deceives its own people. Partiendo de la noción de noble mentira que encontramos en República de Platón y desembocando en la figura de Leo Strauss, filósofo inspirador de los actuales políticos neo-conservadores norteamericanos en torno al partido republicano en el poder, este artículo traza una línea de pensamiento que recorre las principales escuelas y autores modernos que han justificado la mentira política, entendida como aquella mentira con que el gobernante enga a a sus gobernados.
Prevalence of attention deficit hyperactivity disorder among children and adolescents in Spain: a systematic review and meta-analysis of epidemiological studies
Ferrán Catalá-López, Salvador Peiró, Manuel Ridao, Gabriel Sanfélix-Gimeno, Ricard Gènova-Maleras, Miguel A Catalá
BMC Psychiatry , 2012, DOI: 10.1186/1471-244x-12-168
Abstract: PubMed/MEDLINE, IME, IBECS and TESEO were comprehensively searched. Original reports were selected if they provided data on prevalence estimates of ADHD among people under 18 years old in Spain and were cross-sectional, observational epidemiological studies. Information from included studies was systematically extracted and evaluated. Overall pooled-prevalence estimates of ADHD were calculated using random-effects models. Sources of heterogeneity were explored by means sub-groups analyses and univariate meta-regressions.Fourteen epidemiological studies (13,026 subjects) were selected. The overall pooled-prevalence of ADHD was estimated at 6.8% [95% confidence interval (CI) 4.9 – 8.8%] representing 361,580 (95% CI 260,550 – 467,927) children and adolescents in the community. There was significant heterogeneity (P < 0.001), which was incompletely explained by subgroup analyses and meta-regressions.Our findings suggest that the prevalence of ADHD among children and adolescents in Spain is consistent with previous studies conducted in other countries and regions. This study represents a first step in estimating the national burden of ADHD that will be essential to building evidence-based programs and services.Attention deficit hyperactivity disorder (ADHD) can be defined as a condition starting in childhood, that comprises a persistent pattern of symptoms of hyperactivity, impulsiveness and/or lack of attention, more frequent and severe than usual for that age, and causing a significant impairment in school or work performance and in the activities of daily life. ADHD is a common neuropsychiatric disorder, with a high impact on the health system and the community in terms of economic costs, family stress, academic and vocational adversity and a clear negative effect on the self-esteem of the subject affected [1].Currently, there exist two diagnostic criteria in regular use to diagnose ADHD in children and adolescents, DSM-IV and ICD-10. Both classifications utilise list
Tendencias en la etiología de la meningitis bacteriana aguda en ni?os chilenos, período 1989-1998.: Impacto de la vacuna anti-H influenzae tipo b (Hib)
Díaz P,José Manuel; Catalán N,a; Urrutia L,María Teresa; Prado J,Valeria; Ledermann D,Walter; Mendoza N,Carmen; Topelberg V,Santiago;
Revista médica de Chile , 2001, DOI: 10.4067/S0034-98872001000700003
Abstract: background: acute bacterial meningitis still has a high mortality and rate of complications. aim: to assess the impact of anti h influenzae vaccination on the epidemiology of acute bacterial meningitis in chilean children. material and methods: a retrospective study of hospital discharge records of patients with acute bacterial meningitis. causative agents were studied globally, by hospital and by age group. the changes in etiology from 1989 to 1995 were also assessed. between 1996 and 1998, only those patients with acute bacterial meningitis caused by h influenzae were recollected. results: in the period prior to vaccination (1989-1995), 1000 cases were registered. the main causative agents were n meningitidis in 33.8%, h influenzas type b in 21.9% and s pneumoniae in 15.4%. the incidence of h influenzae decreased in the period from 36.4 to 9.9% (p<0.001) and the incidence of n meningitidis increased from 22.9 to 52.1% (p <0.001). the incidence of s pneumoniae did not change significantly. h influenzae predominated in children between 4 and 24 months of age and n meningitidis predominated in children over 25 months of age. in the period after the introduction of vaccination (1995-1998), there was a further decrease in the incidence of h influenzae from 10 to 2% (p <0.001). until 1997, there was a considerable increase in the incidence of n meningitidis, specially in children over 25 months of age. it declined in 1998 to 38%. conclusions: there was a reduction in the incidence of acute bacterial meningitis caused by h influenzae prior to the introduction of the vaccine against h influenzae type b. the decrease was more pronounced after the introduction of the vaccine (rev méd chile 2001; 129: 719-26)
Crystallographic Study of the TiO2 Obtained by Different Synthesis Methods  [PDF]
Fidel Alejandro Cortez-Lorenzo, Miguel Galván Ruiz, Rufino Nava Mendoza, Mario Enrique Rodriguez García, Rodrigo Rafael Velazquez Castillo
Journal of Materials Science and Chemical Engineering (MSCE) , 2013, DOI: 10.4236/msce.2013.16005

In this work, the crystal structure of titanium dioxide was studied, and the effect of the different synthesis routes on the microstructure and morphology of the nanostructures was analyzed. Samples characterization was carried out by X-ray diffraction by powders (XRD) to determine the different crystalline phases contented in the samples and using scanning electron microscopy (SEM), the morphology and topology of all samples were studied. XRD results were analyzed through Eva provided by Bruker to determine the average crystallite size. The results portrayed here showed that all the synthesis process produced anatase nanostructures with an average crystallite size smaller than 27 nm. Synthesized powders presented similar morphologies in all cases and they were homogeneous in their chemical composition.

Low genetic diversity in Antarctic populations of the lichen-forming ascomycete Cetraria aculeata and its photobiont
Stephanie Domaschke,Fernando Fernández-Mendoza,Miguel A. García,María P. Martín
Polar Research , 2012, DOI: 10.3402/polar.v31i0.17353
Abstract: Lichens, symbiotic associations of fungi (mycobionts) and green algae or cyanobacteria (photobionts), are poikilohydric organisms that are particularly well adapted to withstand adverse environmental conditions. Terrestrial ecosystems of the Antarctic are therefore largely dominated by lichens. The effects of global climate change are especially pronounced in the maritime Antarctic and it may be assumed that the lichen vegetation will profoundly change in the future. The genetic diversity of populations is closely correlated to their ability to adapt to changing environmental conditions and to their future evolutionary potential. In this study, we present evidence for low genetic diversity in Antarctic mycobiont and photobiont populations of the widespread lichen Cetraria aculeata. We compared between 110 and 219 DNA sequences from each of three gene loci for each symbiont. A total of 222 individuals from three Antarctic and nine antiboreal, temperate and Arctic populations were investigated. The mycobiont diversity is highest in Arctic populations, while the photobionts are most diverse in temperate regions. Photobiont diversity decreases significantly towards the Antarctic but less markedly towards the Arctic, indicating that ecological factors play a minor role in determining the diversity of Antarctic photobiont populations. Richness estimators calculated for the four geographical regions suggest that the low genetic diversity of Antarctic populations is not a sampling artefact. Cetraria aculeata appears to have diversified in the Arctic and subsequently expanded its range into the Southern Hemisphere. The reduced genetic diversity in the Antarctic is most likely due to founder effects during long-distance colonization.
Physical Mathematical Evaluation of the Cardiac Dynamic Applying the Zipf-Mandelbrot Law  [PDF]
Javier Oswaldo Rodríguez, Signed Esperanza Prieto, Sandra Catalina Correa, Fernán Mendoza, Giora Weiz, María Yolanda Soracipa, Nelly Velásquez, Juan Mauricio Pardo, Miguel Martínez, Freddy Barrios
Journal of Modern Physics (JMP) , 2015, DOI: 10.4236/jmp.2015.613193
Abstract: Introduction: The law of Zipf-Mandelbrot is a power law, which has been observed in natural languages. A mathematical diagnosis of fetal cardiac dynamics has been developed with this law. Objective: To develop a methodology for diagnostic aid to assess the degree of complexity of adult cardiac dynamics by Zipf-Mandelbrot law. Methodology: A mathematical induction was done for this; two groups of Holter recordings were selected: 11 with normal diagnosis and 11 with acute disease of each group, one Holter of each group was chosen for the induction, the law of Zipf-Mandelbrot was applied to evaluate the degree of complexity of each Holter, searching similarities or differences between the dynamics. A blind study was done with 20 Holters calculating sensitivity, specificity and the coefficient kappa. Results: The complexity grade of a normal cardiac dynamics varied between 0.9483 and 0.7046, and for an acute dynamic between 0.6707 and 0.4228. Conclusions: A new physical mathematical methodology for diagnostic aid was developed; it showed that the degree of complexity of normal cardiac dynamics was higher than those with acute disease, showing quantitatively how cardiac dynamics can evolve to acute state.
Los efectos de la política monetaria en el producto y los precios en México: un análisis econométrico
Luis Miguel Galindo,Horacio Catalán
Economía, sociedad y territorio , 2005,
Abstract: El objetivo de este trabajo es analizar los efectos de la política monetaria en el producto y los precios en la economía mexicana utilizando diversas técnicas econométricas. Los principales resultados obtenidos indican que existe una estrecha relación entre los agregados monetarios, la tasa de interés, los precios y el producto. Sin embargo, estas relaciones son complejas, adquieren diversas formas y tienen una dimensión temporal importante. El conjunto de los resultados sugiereque existe una asociación entre los agregados monetarios y la trayectoria de precios, pero ello no excluye la presencia simultánea de una relación peque a pero significativa entre los agregados monetarios, la tasa de interés y el producto. Se observa además que las relaciones entre estas variables rechazan la hipótesis de exogeneidad y por tanto una relación de causalidad unidireccional.
Las brechas de precios interna y externa en México: un análisis mediante la ecuación cuantitativa
Horacio Catalán,Luis Miguel Galindo
Análisis Económico , 2008,
Abstract: El presente artículo analiza las brechas de precios doméstica y externa utilizando como base al modelo P* para la economía mexicana. Las estimaciones se realizan considerando un tipo de cambio controlado y fluctuación en bandas para el periodo 1980-1994, en contraste con un tipo de cambio flexible y un esquema de metas de inflación para 1995-2006. Los principales resultados obtenidos indican que durante el primer periodo la brecha de precios doméstica tenía un mayor poder explicativo sobre la inflación, en cambio, durante el segundo la brecha de precios externa adquiere mayor poder explicativo. En este sentido, los shocks externos que afecten los costos internacionales tendrán un impacto positivo sobre la inflación doméstica, esta situación modifica las expectativas de los agentes generando presiones inflacionarias. Lo anterior puede obligar al banco central a ajustar su objetivo de inflación afectando negativamente su credibilidad la cual es fundamental en un esquema de metas de inflación.
Multiple Sclerosis Risk Variant HLA-DRB1*1501 Associates with High Expression of DRB1 Gene in Different Human Populations
Antonio Alcina, María del Mar Abad-Grau, María Fedetz, Guillermo Izquierdo, Miguel Lucas, óscar Fernández, Dorothy Ndagire, Antonio Catalá-Rabasa, Agustín Ruiz, Javier Gayán, Concepción Delgado, Carmen Arnal, Fuencisla Matesanz
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0029819
Abstract: The human leukocyte antigen (HLA) DRB1*1501 has been consistently associated with multiple sclerosis (MS) in nearly all populations tested. This points to a specific antigen presentation as the pathogenic mechanism though this does not fully explain the disease association. The identification of expression quantitative trait loci (eQTL) for genes in the HLA locus poses the question of the role of gene expression in MS susceptibility. We analyzed the eQTLs in the HLA region with respect to MS-associated HLA-variants obtained from genome-wide association studies (GWAS). We found that the Tag of DRB1*1501, rs3135388 A allele, correlated with high expression of DRB1, DRB5 and DQB1 genes in a Caucasian population. In quantitative terms, the MS-risk AA genotype carriers of rs3135388 were associated with 15.7-, 5.2- and 8.3-fold higher expression of DQB1, DRB5 and DRB1, respectively, than the non-risk GG carriers. The haplotype analysis of expression-associated variants in a Spanish MS cohort revealed that high expression of DRB1 and DQB1 alone did not contribute to the disease. However, in Caucasian, Asian and African American populations, the DRB1*1501 allele was always highly expressed. In other immune related diseases such as type 1 diabetes, inflammatory bowel disease, ulcerative colitis, asthma and IgA deficiency, the best GWAS-associated HLA SNPs were also eQTLs for different HLA Class II genes. Our data suggest that the DR/DQ expression levels, together with specific structural properties of alleles, seem to be the causal effect in MS and in other immunopathologies rather than specific antigen presentation alone.
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