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Search Results: 1 - 10 of 403 matches for " Mick Rae "
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Waddlia chondrophila Infects and Multiplies in Ovine Trophoblast Cells Stimulating an Inflammatory Immune Response
Nick Wheelhouse, Christopher Coyle, Peter G. Barlow, Stephen Mitchell, Gilbert Greub, Tim Baszler, Mick T. Rae, David Longbottom
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0102386
Abstract: Background Waddlia chondrophila (W. chondrophila) is an emerging abortifacient organism which has been identified in the placentae of humans and cattle. The organism is a member of the order Chlamydiales, and shares many similarities at the genome level and in growth studies with other well-characterised zoonotic chlamydial abortifacients, such as Chlamydia abortus (C. abortus). This study investigates the growth of the organism and its effects upon pro-inflammatory cytokine expression in a ruminant placental cell line which we have previously utilised in a model of C. abortus pathogenicity. Methodology/Principal Findings Using qPCR, fluorescent immunocytochemistry and electron microscopy, we characterised the infection and growth of W. chondrophila within the ovine trophoblast AH-1 cell line. Inclusions were visible from 6 h post-infection (p.i.) and exponential growth of the organism could be observed over a 60 h time-course, with significant levels of host cell lysis being observed only after 36 h p.i. Expression of CXCL8, TNF-α, IL-1α and IL-1β were determined 24 h p.i. A statistically significant response in the expression of CXCL8, TNF-α and IL-1β could be observed following active infection with W. chondrophila. However a significant increase in IL-1β expression was also observed following the exposure of cells to UV-killed organisms, indicating the stimulation of multiple innate recognition pathways. Conclusions/Significance W. chondrophila infects and grows in the ruminant trophoblast AH-1 cell line exhibiting a complete chlamydial replicative cycle. Infection of the trophoblasts resulted in the expression of pro-inflammatory cytokines in a dose-dependent manner similar to that observed with C. abortus in previous studies, suggesting similarities in the pathogenesis of infection between the two organisms.
The Pancreas Is Altered by In Utero Androgen Exposure: Implications for Clinical Conditions Such as Polycystic Ovary Syndrome (PCOS)
Mick Rae, Cathal Grace, Kirsten Hogg, Lisa Marie Wilson, Sophie L. McHaffie, Seshadri Ramaswamy, Janis MacCallum, Fiona Connolly, Alan S. McNeilly, Colin Duncan
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0056263
Abstract: Using an ovine model of polycystic ovary syndrome (PCOS), (pregnant ewes injected with testosterone propionate (TP) (100 mg twice weekly) from day (d)62 to d102 of d147 gestation (maternal injection – MI-TP)), we previously reported female offspring with normal glucose tolerance but hyperinsulinemia. We therefore examined insulin signalling and pancreatic morphology in these offspring using quantitative (Q) RT-PCR and western blotting. In addition the fetal pancreatic responses to MI-TP, and androgenic and estrogenic contributions to such responses (direct fetal injection (FI) of TP (20 mg) or diethylstilbestrol (DES) (20 mg) at d62 and d82 gestation) were assessed at d90 gestation. Fetal plasma was assayed for insulin, testosterone and estradiol, pancreatic tissue was cultured, and expression of key β-cell developmental genes was assessed by QRT-PCR. In female d62MI-TP offspring insulin signalling was unaltered but there was a pancreatic phenotype with increased numbers of β-cells (P<0.05). The fetal pancreas expressed androgen receptors in islets and genes involved in β-cell development and function (PDX1, IGF1R, INSR and INS) were up-regulated in female fetuses after d62MI-TP treatment (P<0.05–0.01). In addition the d62MI-TP pancreas showed increased insulin secretion under euglycaemic conditions (P<0.05) in vitro. The same effects were not seen in the male fetal pancreas or when MI-TP was started at d30, before the male programming window. As d62MI-TP increased both fetal plasma testosterone (P<0.05) and estradiol concentrations (P<0.05) we assessed the relative contribution of androgens and estrogens. FI-TP (commencing d62) (not FI-DES treatment) caused elevated basal insulin secretion in vitro and the genes altered by d62MI-TP treatment were similarly altered by FI-TP but not FI-DES. In conclusion, androgen over-exposure alters fetal pancreatic development and β-cell numbers in offspring. These data suggest that that there may be a primary pancreatic phenotype in models of PCOS, and that there may be a distinct male and female pancreas.
Creativity: Cultural Capital in the Mathematics Classroom  [PDF]
Rae Ann Hirsh
Creative Education (CE) , 2010, DOI: 10.4236/ce.2010.13024
Abstract: Contemporary students face unique economic, environmental, and humanitarian challenges. The problem solving required to address these challenges requires solutions that have never been thought of before. In order to tackle these problems, teachers must challenge the traditional problem solving methodologies used in math classes and encourage new problem solving strategies through incorporation of the arts and facilitating of creative problem solving. This article will explore the research surrounding creativity, the arts, and creative problem solving and suggest future applications of creativity in the mathematics classroom.
Discursos de oprimidas: análisis crítico de los discursos de empleadas domésticas peruanas en Lima
Mick, Carola;
Papeles de población , 2010,
Abstract: this article is based on 32 interviews, in the capital of peru, lima, with domestic workers (all women) who migrated from other regions of the country. it analyzes their migration experiences taking into account their current situation, social and professional, as a social problem with a semiotic aspect. it investigates the language-power relationship from a critical discourse-analytical bottom-up-perspective, focusing on how domestic workers construct their identity and social reality, relating to basic ideological structures which define them as oppressed', and choosing different strategies in view of them. with a combination of the methods of conversation and discourse analysis while focusing on membership categorization processes, it shows how domestic workers transform ideologies in this process, contributing to social change and thus exercising influence and power in discourse.
Reply
Mick Aston
Papers from the Institute of Archaeology , 2000, DOI: 10.5334/pia.151
Abstract:
Discursos de oprimidas: análisis crítico de los discursos de empleadas domésticas peruanas en Lima
Carola MICK
Papeles de población , 2010,
Abstract: Este estudio se realizó en la capital de Perú, Lima. Se efectuaron 32 entrevistas con trabajadoras del hogar peruanas migrantes de otras regiones del país en el a o 2005. Su experiencia migratoria fue analizada tomando en cuenta su precaria situación social y profesional actual como problema social con aspecto semiótico desde una perspectiva crítica. Combinando métodos del análisis de la conversación y del discurso, con enfoque en procesos conversacionales de categorización social, se investiga cómo las trabajadoras construyen a la vez su identidad y realidad social, haciendo referencia a estructuras ideológicas básicas y escogiendo estrategias discursivas individuales frente a ellas. En este proceso van transformando las estructuras, contribuyendo en diferentes medidas a posibles cambios sociales en su entorno y ejerciendo una cierta forma de influencia social y poder discursivo.
Den Vorv tern zum Ruhm – den Brüdern zur Ermutigung . Variationen zum Thema Grunwald/Tannenberg
Mick, Christoph
Zeitenblicke , 2004,
Abstract: Die Schlacht bei Tannenberg/Grunwald vom 15. Juli 1410 geh rt zu den wichtigsten polnischen Nationalmythen. Der Beitrag besch ftigt sich mit dem Grunwaldmythos, der nach 1870 einen enormen Bedeutungsgewinn erfuhr und zu einem beliebten Sujet der polnischen Malerei und Literatur wurde. Inszenierung und Funktionen der Fünfhundertjahrfeiern werden diskutiert, die vom 15.-17. Juli 1910 in Krakau stattfanden. 150.000 Menschen nahmen an dieser Feier teil und machten sie damit zur gr ten nationalen Kundgebung im geteilten Polen überhaupt. Diese Feiern wurden selbst zu einem Erinnerungsort und zu einem Bezugspunkt von Jubil umsfeiern. In Deutschland wurde der Sieg über die russischen Truppen bei Tannenberg im August 1914 mit der Schlacht von 1410 verknüpft. Der Sieg von 1914 spielte eine wichtige Rolle im Hindenburgkult, und das Nationaldenkmal Tannenberg wurde zum Ort gro er deutschnationaler und nationalsozialistischer Feiern. W hrend die Schlacht nach 1945 im deutschen kollektiven Ged chtnis keine Rolle mehr spielte, wurde der Nationalmythos in der Volksrepublik Polen modifiziert und dazu benutzt, das neue Regime in die polnische nationale Tradition einzubinden, das alte Feindbild Deutschland und die Freundschaft mit der Sowjetunion zu befestigen.
The association between ADHD and eating disorders/pathology in adolescents: A systematic review  [PDF]
Carol Curtin, Sherry L. Pagoto, Eric Mick
Open Journal of Epidemiology (OJEpi) , 2013, DOI: 10.4236/ojepi.2013.34028
Abstract: Background: Attention-Deficit/Hyperactivity Disorder (ADHD), one of the most common neurodevelopmental conditions of childhood, is associated with high rates of mood and behavioral disorders. Preliminary evidence suggests that ADHD may also be associated with eating disorders (ED) or eating pathology (EP). This systematic review synthesizes the extant published literature on this association among youth ages 12-21 years. Methods: Literature searches were performed using Medline, Ovid/Psych Info, Google Scholar, and via manual inspection of bibliographies. Cross-sectional, case-control, and prospective studies published in English with sample sizes larger than 50, participant ages 12-21 years, and assessed ADHD and ED or EP, were considered for review. Case reports, feeding, and drug studies were excluded. Results: Preliminary searches yielded 337 articles; eight articles met inclusion/exclusion criteria. Two studies documented an association between ADHD and ED, and three studies found an association between ADHD and EP. Youth with ADHD were nearly 3 to 6 times more likely to develop an ED than youth without ADHD, and were also more likely to have higher rates of EP, body dissatisfaction, and desire to lose weight/ drive for thinness. Impulsivity was predictive of EP, and ADHD youth with co-occurring mood/behavioral disorders and punitive parental relationships were at higher risk. Conclusions: Five of eight studies documented an association between ADHD and ED or EP in adolescents. Future research is needed to confirm and refine further these findings. The findings have clinical implications, including the inclusion of ED/EP in screening and anticipatory guidance efforts. Evaluating whether medical management of ADHD may be efficacious in preventing and/or treating ED/EP is also warranted.
Group breeding schemes in new-zealand
AL Rae
Genetics Selection Evolution , 1980, DOI: 10.1186/1297-9686-12-1-118b
Abstract:
From E-Learning to M-Learning - the use of Mixed Reality Games as a new Educational Paradigm
Rae Earnshaw
International Journal of Interactive Mobile Technologies (iJIM) , 2011, DOI: 10.3991/ijim.v5i2.1463
Abstract: This paper analyses different definitions of mobile learning which have been proposed by various researchers. The most distinctive features of mobile learning are extracted to propose a new definition for Mobile Educational Mixed Reality Games (MEMRG). A questionnaire and a quantifying scale are designed to assist the game developers in designing MEMRG. A new psycho-pedagogical approach to teaching is proposed for MEMRG. This methodology is based on the theme of ‘conversation’ between different actors of the learning community with the objective of building the architectural framework for MEMRG.
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