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Search Results: 1 - 10 of 37701 matches for " Michelle Zhou "
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Chromatin Regulation and Gene Centrality Are Essential for Controlling Fitness Pleiotropy in Yeast
Linqi Zhou,Xiaotu Ma,Michelle N. Arbeitman,Fengzhu Sun
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0008086
Abstract: There are a wide range of phenotypes that are due to loss-of-function or null mutations. Previously, the functions of gene products that distinguish essential from nonessential genes were characterized. However, the functions of products of non-essential genes that contribute to fitness remain minimally understood.
Anesthetic management for combined mitral valve replacement and aortic valve repair in a patient with osteogenesis imperfecta
Huang Jiapeng,Dinh Michelle,Kuchle Nicholas,Zhou Jing
Annals of Cardiac Anaesthesia , 2011,
Abstract: Osteogenesis imperfecta is a rare disorder of connective tissues and presents multiple challenges, including difficult airway, hyperthermia, coagulopathy and respiratory dysfunction, for anesthesiologists, especially during cardiac surgery. We present anesthetic management of a patient with osteogenesis impertecta during double valve surgery. Dexmedetomidine infusion minimized the risks of malignant hyperthermia. Glidescope and in-line stabilization facilitated endotracheal intubation and protected his oral structures and cervical spine. Transesophageal echocardiography (TEE) diagnosed a flail A3 segment and redundant left coronary cusp causing mitral and aortic regurgitation. The mitral valve was replaced and the aortic valve repaired. Coagulopathy was corrected according to comprehensive coagulation analysis. Glidescope, dexmedetomidine, coagulation analysis and TEE could facilitate anesthetic management in these patients.
TeV Observations of the Galactic Plane with HAWC and Joint Analysis of GeV Data from Fermi
Hao Zhou,C. Michelle Hui,Petra Huentemeyer,for the HAWC Collaboration
Physics , 2015,
Abstract: A number of Galactic sources emit GeV-TeV gamma rays that are produced through leptonic and/or hadronic mechanisms. Spectral analysis in this energy range is crucial in order to understand the emission mechanisms. The HAWC Gamma-Ray Observatory, with a large field of view and location at $19^\circ$ N latitude, is surveying the Galactic Plane from high Galactic longitudes down to near the Galactic Center. Data taken with partially-constructed HAWC array in 2013-2014 exhibit TeV gamma-ray emission along the Galactic Plane. A high-level analysis likelihood framework for HAWC, also presented at this meeting, has been developed concurrently with the Multi-Mission Maximum Likelihood (3ML) architecture to deconvolve the Galactic sources and to perform multi-instrument analysis. It has been tested on early HAWC data and the same method will be applied on HAWC data with the full array. I will present preliminary results on Galactic sources from TeV observations with HAWC and from joint analysis on Fermi and HAWC data in GeV-TeV energy range.
Who Will Retweet This? Automatically Identifying and Engaging Strangers on Twitter to Spread Information
Kyumin Lee,Jalal Mahmud,Jilin Chen,Michelle Zhou,Jeffrey Nichols
Computer Science , 2014,
Abstract: There has been much effort on studying how social media sites, such as Twitter, help propagate information in different situations, including spreading alerts and SOS messages in an emergency. However, existing work has not addressed how to actively identify and engage the right strangers at the right time on social media to help effectively propagate intended information within a desired time frame. To address this problem, we have developed two models: (i) a feature-based model that leverages peoples' exhibited social behavior, including the content of their tweets and social interactions, to characterize their willingness and readiness to propagate information on Twitter via the act of retweeting; and (ii) a wait-time model based on a user's previous retweeting wait times to predict her next retweeting time when asked. Based on these two models, we build a recommender system that predicts the likelihood of a stranger to retweet information when asked, within a specific time window, and recommends the top-N qualified strangers to engage with. Our experiments, including live studies in the real world, demonstrate the effectiveness of our work.
Optimizing The Selection of Strangers To Answer Questions in Social Media
Jalal Mahmud,Michelle Zhou,Nimrod Megiddo,Jeffrey Nichols,Clemens Drews
Computer Science , 2014,
Abstract: Millions of people express themselves on public social media, such as Twitter. Through their posts, these people may reveal themselves as potentially valuable sources of information. For example, real-time information about an event might be collected through asking questions of people who tweet about being at the event location. In this paper, we explore how to model and select users to target with questions so as to improve answering performance while managing the load on people who must be asked. We first present a feature-based model that leverages users exhibited social behavior, including the content of their tweets and social interactions, to characterize their willingness and readiness to respond to questions on Twitter. We then use the model to predict the likelihood for people to answer questions. To support real-world information collection applications, we present an optimization-based approach that selects a proper set of strangers to answer questions while achieving a set of application-dependent objectives, such as achieving a desired number of answers and minimizing the number of questions to be sent. Our cross-validation experiments using multiple real-world data sets demonstrate the effectiveness of our work.
Health Promotion in Cardiac Rehabilitation Patients through the Use of a High-Intensity Interval Training Protocol  [PDF]
Michelle Tinkham
World Journal of Cardiovascular Diseases (WJCD) , 2014, DOI: 10.4236/wjcd.2014.410059
Abstract: According to the American Heart Association’s (AHA) recent statistical update, over 2150 Americans die each day from cardiovascular disease (CVD), which equals approximately 1 death every 40 seconds; many of which were under the age of 65 years old [1]. In 2009, 386,324 people, 1 in 6 Americans, died as a result of coronary artery disease (CAD) alone [1]. They also estimate 150,000 people have “silent” heart attacks each year [1]. Even though the number of cardiovascular disease deaths has declined in the last 10 years, they still accounted for 32.3% of American deaths [1]. As a result, the AHA updated their 2020 goals to improve the nation’s cardiovascular health by 20% [1]. One of these methods is through the use of cardiac rehabilitation. Cardiac rehabilitation (CR) is a health promotion strategy to help return cardiac patients to their previous level of functioning, increase health, decrease comorbidities and promote education and lifestyle change. For select patients, another alternative exercise plan may exist to gain even better results. High intensity interval training (HIIT) has shown positive training results for athletes and many studies show that it may also be an effective exercise modality for many cardiac patients instead of the traditional circuit training method. This article will review current literature on the effects of HIIT on CR patients as well as a sample HIIT protocol for instituting this treatment with appropriate patients.
Emotionally Competent Behaviors and Nurse Bullying: Is There a Direct Link?  [PDF]
Michelle Doas
Open Journal of Psychiatry (OJPsych) , 2015, DOI: 10.4236/ojpsych.2015.51008
Abstract: An abundance of literature spanning many years depicts the devastating effects of nurse bullying within the profession. The evidence suggests that bullying in general is a deliberate act aimed at another person. Conceptualizing nurse bullying appears to be a key ingredient in creating both awareness and preventative strategies. Emotional competence includes a set of behaviors which are unique to each individual. These behaviors according to Goldman (1995) include, but are not limited to emotional self-assessment, accurate self-assurance, self-confidence, emotional self-control, and empathy. The majority of researchers agree that emotionally competent behaviors are impacted by both positive and negative interactions and experiences. Thus, it is hypothesized that emotionally competent behaviors are continually cultivated throughout one’s life based upon lived experiences. This article assesses direct relationships between implementation of emotionally competent behaviors as a means of combatting nurse bullying within the profession. Creating awareness of these two areas can be initial steps in cultivating the needed tools and supportive interventions to assist nurses from novice to expert to professionally mentor and role model for generations to come.
Are We Losing the Art of Actively Listening to Our Patients? Connecting the Art of Active Listening with Emotionally Competent Behaviors  [PDF]
Michelle Doas
Open Journal of Nursing (OJN) , 2015, DOI: 10.4236/ojn.2015.56060
Abstract: Active listening is an essential communication technique that requires the listener to focus and provide feedback on what is heard. The ability to listen actively demonstrates sincerity, and assumes that nothing is being shrugged or taken for granted. As a result, active listeners strive to improve professional and personal relationships, decrease misinterpretation of information, strengthen compliance, and foster understanding. Likewise, active listening can foster trust, mutual respect, and patient compliance. This paper will explore vital connections between active listening and displaying emotionally competent behaviors. Additionally, analysis of a case study as a means of strengthening these connections while improving patient outcomes will be assessed.
CD91-Dependent Modulation of Immune Responses by Heat Shock Proteins: A Role in Autoimmunity
Robert J. Binder,Yu Jerry Zhou,Michelle N. Messmer,Sudesh Pawaria
Autoimmune Diseases , 2012, DOI: 10.1155/2012/863041
Abstract: Heat shock proteins (HSPs) have been known for decades for their ability to protect cells under stressful conditions. In the 1980s a new role was ascribed for several HSPs given their ability to elicit specific immune responses in the setting of cancer and infectious disease. These immune responses have primarily been harnessed for the immunotherapy of cancer in the clinical setting. However, because of the ability of HSPs to prime diverse immune responses, they have also been used for modulation of immune responses during autoimmunity. The apparent dichotomy of immune responses elicited by HSPs is discussed here on a molecular and cellular level. The potential clinical application of HSP-mediated immune responses for therapy of autoimmune diseases is reviewed. 1. Introduction: HSPs in Immunity Expression of HSPs is generally upregulated in cells in response to a variety of stressful conditions including nonphysiological temperature, nutrient deprivation, and hypoxia [1]. It is the inherent chaperoning function of HSPs that allows them to provide their cytoprotective function in assisting correct protein/polypeptide folding and preventing further protein denaturation. It has become evident over the past two decades that the chaperoning function of HSPs also plays a key role in several processes during the development of immune responses [2]. Within the cell, several HSPs act as chaperones of peptides that are ultimately presented by MHC I and MHC II molecules. Thus, the HSPs in the cytosol and in the endoplasmic reticulum form a relay line for the transport of peptides from their formation by the proteasome to the MHC I heavy chain (HC). This is discussed in the next subheading. As the HSPs are some of the most abundant proteins in cells, their liberation into the extracellular environment has been shown to be a key indicator of loss of cellular integrity and they are rapidly recognized by the cellular sentinels of the immune system. Such recognition allows for cross-priming of the potential antigens that the HSPs chaperone. The efficiency of this pathway predicted a cell surface receptor on the cross-presenting cells and that receptor has now been shown to be CD91. These events are discussed in the next two subheadings. The isolation of HSPs (and the associated peptides) from tumor cells or cells infected with pathogens therefore provides a single entity that primes immune responses specific for the chaperoned peptides and thus for the cell that harbored these antigens. This application has been tested in a vast number of rodent models of cancer and
Large-Scale Conformational Changes of Trypanosoma cruzi Proline Racemase Predicted by Accelerated Molecular Dynamics Simulation
César Augusto F. de Oliveira ,Barry J. Grant ,Michelle Zhou ,J. Andrew McCammon
PLOS Computational Biology , 2011, DOI: 10.1371/journal.pcbi.1002178
Abstract: Chagas' disease, caused by the protozoan parasite Trypanosoma cruzi (T. cruzi), is a life-threatening illness affecting 11–18 million people. Currently available treatments are limited, with unacceptable efficacy and safety profiles. Recent studies have revealed an essential T. cruzi proline racemase enzyme (TcPR) as an attractive candidate for improved chemotherapeutic intervention. Conformational changes associated with substrate binding to TcPR are believed to expose critical residues that elicit a host mitogenic B-cell response, a process contributing to parasite persistence and immune system evasion. Characterization of the conformational states of TcPR requires access to long-time-scale motions that are currently inaccessible by standard molecular dynamics simulations. Here we describe advanced accelerated molecular dynamics that extend the effective simulation time and capture large-scale motions of functional relevance. Conservation and fragment mapping analyses identified potential conformational epitopes located in the vicinity of newly identified transient binding pockets. The newly identified open TcPR conformations revealed by this study along with knowledge of the closed to open interconversion mechanism advances our understanding of TcPR function. The results and the strategy adopted in this work constitute an important step toward the rationalization of the molecular basis behind the mitogenic B-cell response of TcPR and provide new insights for future structure-based drug discovery.
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