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Search Results: 1 - 10 of 226910 matches for " Michelle R. Rebello "
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Ryanodine Receptors Selectively Interact with L Type Calcium Channels in Mouse Taste Cells
Michelle R. Rebello, Amanda B. Maliphol, Kathryn F. Medler
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0068174
Abstract: Introduction We reported that ryanodine receptors are expressed in two different types of mammalian peripheral taste receptor cells: Type II and Type III cells. Type II cells lack voltage-gated calcium channels (VGCCs) and chemical synapses. In these cells, ryanodine receptors contribute to the taste-evoked calcium signals that are initiated by opening inositol trisphosphate receptors located on internal calcium stores. In Type III cells that do have VGCCs and chemical synapses, ryanodine receptors contribute to the depolarization-dependent calcium influx. Methodology/Principal Findings The goal of this study was to establish if there was selectivity in the type of VGCC that is associated with the ryanodine receptor in the Type III taste cells or if the ryanodine receptor opens irrespective of the calcium channels involved. We also wished to determine if the ryanodine receptors and VGCCs require a physical linkage to interact or are simply functionally associated with each other. Using calcium imaging and pharmacological inhibitors, we found that ryanodine receptors are selectively associated with L type VGCCs but likely not through a physical linkage. Conclusions/Significance Taste cells are able to undergo calcium induced calcium release through ryanodine receptors to increase the initial calcium influx signal and provide a larger calcium response than would otherwise occur when L type channels are activated in Type III taste cells.
Taste Quality and Intensity of 100 Stimuli as Reported by Rats: The Taste–Location Association Task
Shree Hari Gautam,Michelle R. Rebello,Justus V. Verhagen
Frontiers in Behavioral Neuroscience , 2012, DOI: 10.3389/fnbeh.2012.00019
Abstract: The interpretation of neural activity related to sensory stimulation requires an understanding of the subject’s perception of the stimulation. Previous methods used to evaluate the perception of chemosensory stimuli by rodents have distinct limitations. We developed a novel behavioral paradigm, the taste–location association task, to complement these methods. First we tested if rats are able to learn associations between five basic taste stimuli and their spatial locations. This spatial task was based on four prototypical tastants and water. All four rats trained to perform the task reached levels of performance well above chance. Control trials demonstrated that the rats used only taste cues. Further, the learned stimulus set was resistant to interference, allowing for generalization experiments performed subsequently. We tested the rats’ gustatory generalizations of 100 tastants to the five trained stimuli, both regarding their taste qualities as well as intensity ratings. The taste profiles generated by these experiments contribute to the understanding of how perception of the specific taste stimuli relate to the perception of the five basic taste qualities in intact behaving rats. In this large taste space we found that intensity plays a major role. Furthermore, umami stimuli were not reported as being similar to other basic tastants. Our new paradigm enables neurophysiological studies of taste-based learning and memory in awake, freely moving animals.
Expression of GABAergic Receptors in Mouse Taste Receptor Cells
Margaret R. Starostik,Michelle R. Rebello,Kellie A. Cotter,Akos Kulik,Kathryn F. Medler
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0013639
Abstract: Multiple excitatory neurotransmitters have been identified in the mammalian taste transduction, with few studies focused on inhibitory neurotransmitters. Since the synthetic enzyme glutamate decarboxylase (GAD) for gamma-aminobutyric acid (GABA) is expressed in a subset of mouse taste cells, we hypothesized that other components of the GABA signaling pathway are likely expressed in this system. GABA signaling is initiated by the activation of either ionotropic receptors (GABAA and GABAC) or metabotropic receptors (GABAB) while it is terminated by the re-uptake of GABA through transporters (GATs).
Perception of Odors Linked to Precise Timing in the Olfactory System
Michelle R. Rebello,Thomas S. McTavish,David C. Willhite,Shaina M. Short,Gordon M. Shepherd,Justus V. Verhagen
PLOS Biology , 2014, DOI: 10.1371/journal.pbio.1002021
Abstract: While the timing of neuronal activity in the olfactory bulb (OB) relative to sniffing has been the object of many studies, the behavioral relevance of timing information generated by patterned activation within the bulbar response has not been explored. Here we show, using sniff-triggered, dynamic, 2-D, optogenetic stimulation of mitral/tufted cells, that virtual odors that differ by as little as 13 ms are distinguishable by mice. Further, mice are capable of discriminating a virtual odor movie based on an optically imaged OB odor response versus the same virtual odor devoid of temporal dynamics—independently of the sniff-phase. Together with studies showing the behavioral relevance of graded glomerular responses and the response timing relative to odor sampling, these results imply that the mammalian olfactory system is capable of very high transient information transmission rates.
Influence of length and measurement geometry on magnetoimpedance in La0.7Sr0.3MnO3
A. Rebello,R. Mahendiran
Physics , 2009, DOI: 10.1063/1.3293292
Abstract: We show that ac magnetoresistance at room temperature in La0.7Sr0.3MnO3 is extremely high (= 47% in H = 100 mT, f = 3-5 MHz), and magnetic field dependence of reactance exhibits a double peak behavior. However, magnitudes of the ac magnetoresistance and magnetoreactance for a fixed length of the sample (li) decrease with decreasing separation (lv) between voltage probes unlike the dc magnetoresistance. On the contrary, change in li has a negligible influence on magnetoimpedance when lv is fixed. Our results indicate that high frequency electrical transport is sensitive to local variations in the magnetic permeability.
Current driven discontinuous insulator-metal transition and colossal low-field magnetoresistance in Sm0.6Sr0.4MnO3
A. Rebello,R. Mahendiran
Physics , 2009,
Abstract: It is shown that with increasing magnitude of current (I), resistivity of Sm0.6Sr0.4MnO3 transforms from a smooth to a discontinuous insulator-metal transition which is also accompanied by an abrupt decrease in temperature of the sample. We report colossal low-field magnetoresistance under a high current bias (-99% at H = 0.5 T and 70 K) and electroresistance (-8000 % at H = 0 T and 60 K) for I = 11 mA. We interpret our observations in terms of current induced supercooling of the high temperature paramagnetic phase and enlargement of volume fraction of the ferromagnetic phase under a magnetic field.
Negative differential resistance and pulsed current induced multi-level resistivity switching in charge ordered and disordered manganites
A. Rebello,R. Mahendiran
Physics , 2008,
Abstract: We have investigated direct and pulsed current induced electroresistance in two manganites with different electronic and magnetic ground states: charge-orbital ordered 50 % Ca doped NdMnO3 and 50 % Mn doped LaNiO3. It has been shown that negative differential resistance observed at high current density in these compounds is related to Joule heating. However, bi-level and multi-level resistivity switching induced by variations in pulse width and pulse period at low current density can not be attributable to Joule heating alone. We discuss possible origins.
Pulse width controlled resistivity switching at room temperature in Bi0.8Sr0.2MnO3
A. Rebello,R. Mahendiran
Physics , 2009, DOI: 10.1063/1.3093673
Abstract: We report pulsed as well as direct current/voltage induced electroresistance in Bi0.8Sr0.2MnO3 at room temperature. It is shown that bi-level and multi-level resistivity switching can be induced by a sequence of pulses of varying pulse width at fixed voltage amplitude. Resistivity increases abruptly (= 55 % at 300 K) upon reducing pulse width from 100 ms to 25 ms for a fixed electric field (E = 2 V/cm2) of 200 ms pulse period. The resistivity switching is accompanied by a periodic change in temperature which alone can not explain the magnitude of the resistivity change.
Magnetothermal cooling with a phase separated manganite
A. Rebello,R. Mahendiran
Physics , 2009, DOI: 10.1063/1.3272270
Abstract: We show that temperature of a current (I = 20 mA) carrying manganite (Nd0.5Ca0.5Mn0.93Ni0.07O3) in presence of a magnetic field (H) decreases abruptly as much as deltaT = 45 K (7 K) accompanied by a step like decrease in magnetoresistance at a critical value of H when the base temperature is 40 K (100 K). The magnitude of deltaT and the position of magnetoresistance step decrease towards lower H with decreasing amplitude of the current. We discuss possible origins of the current and magnetic- field driven temperature change which may find applications in magnetothermal refrigeration besides magnetocaloric effect.
Composition dependence of magnetocaloric effect in Sm1-xSrxMnO3 (x = 0.3-0.5)
A. Rebello,R. Mahendiran
Physics , 2008, DOI: 10.1063/1.3040698
Abstract: We investigated magnetic and magnetocaloric properties in Sm1-xSrxMnO3 (x = 0.30-0.5). We report a magnetic field driven first-order metamagnetic transition in the paramagnetic state in x = 0.4 and 0.5 and a second-order transition in x = 0.3. The highest magnetic entropy (-Sm = 6.2 J/kgK for H = 5 T at T = 125 K) that occurs in x = 0.4 is associated with the metamagnetic transition resulting from the field-induced growth and coalescence of ferromagnetic nano clusters preexisting in the paramagnetic state. Our results suggest that manganites with intrinsic nanoscale phase separation can be exploited for magnetic refrigeration.
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