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Search Results: 1 - 10 of 45005 matches for " Michael Ware "
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An Evaluation of Link Neighborhood Lexical Signatures to Rediscover Missing Web Pages
Jeb Ware,Martin Klein,Michael L. Nelson
Computer Science , 2011,
Abstract: For discovering the new URI of a missing web page, lexical signatures, which consist of a small number of words chosen to represent the "aboutness" of a page, have been previously proposed. However, prior methods relied on computing the lexical signature before the page was lost, or using cached or archived versions of the page to calculate a lexical signature. We demonstrate a system of constructing a lexical signature for a page from its link neighborhood, that is the "backlinks", or pages that link to the missing page. After testing various methods, we show that one can construct a lexical signature for a missing web page using only ten backlink pages. Further, we show that only the first level of backlinks are useful in this effort. The text that the backlinks use to point to the missing page is used as input for the creation of a four-word lexical signature. That lexical signature is shown to successfully find the target URI in over half of the test cases.
Coupling Efficiencies in Single Photon On-Demand Sources
Stefania Castelletto,I. P. Degiovanni,Michael Ware,Alan Migdall
Physics , 2003, DOI: 10.1117/12.504773
Abstract: Many quantum computation and communication schemes require, or would significantly benefit from, true sources of single photon on-demand (SPOD). Unfortunately, such sources do not exist. It is becoming increasingly clear that coupling photons out of a SPOD source will be a limiting factor in many SPOD implementations. In particular, coupling these source outputs into optical fibers (usually single mode fibers) is often the preferred method for handling this light. We investigate the practical limits to this coupling as relates to parametric downconversion, an important starting point for many SPOD schemes. We also explored whether it is possible to optimize the engineering of the downconversion sources to improve on this coupling. We present our latest results in this area.
Chrysotype: Photography in nanoparticle gold
Mike Ware
Gold Bulletin , 2006, DOI: 10.1007/BF03215540
Abstract: The printing of photographs in pure gold, rather than the ubiquitous medium of silver, was first achieved in 1842 by Sir John Herschel, but his innovative ‘chrysotype’ process was soon consigned to obscurity, owing to its expense and uncertain chemistry. In the 1980s some modern coordination chemistry of gold was applied to overcome the inherent problems, enabling an economic, controllable gold-printing process of high quality, which offers unique benefits for specialised artistic and archival photographic purposes. The colour of the gold image depends on the dimensions of the nanoparticles, which are controlled by the parameters of the photochemical process.
Paige Ware
Language Learning and Technology , 2005,
Abstract: This qualitative study explores the factors that contributed to limited interactional involvement in a telecollaborative project linking two groups of participants: 12 advanced-level students of English in northeastern Germany and 9 advanced-level students of German in the southwestern United States. Drawing on data from online transcripts, interviews, and questionnaires, I examine the tensions that arise when students' attempts at communicating online result in missed opportunities for engaging with their online partners. I report on the results of a discourse analysis of the online transcripts and rely on extensive interview and survey data to examine which factors made it difficult for students to maintain sustained interpersonal involvement in the online discourse. I document three main contextual tensions that arose from the different socially and culturally situated attitudes, beliefs, and expectations that informed students' communicative choices in the online discourse. I address the pedagogical implications of each of these three tensions. The findings suggest that research needs to focus not only on how students jointly construct online discourse, but how they co-construe the context for their participation. The paper concludes by addressing the implications of these findings for future research promoting language and culture learning online.
Anti-Memorials and the Art of Forgetting: Critical Reflections on a Memorial Design Practice
SueAnne Ware
Public History Review , 2008,
Abstract: Andreas Huyssen writes, ‘Remembrance as a vital human activity shapes our links to the past, and the ways we remember define us in the present. As individuals and societies, we need the past to construct and to anchor our identities and to nurture a vision of the future.’ Memory is continually affected by a complex spectrum of states such as forgetting, denial, repression, trauma, recounting and reconsidering, stimulated by equally complex changes in context and changes over time. The apprehension and reflective comprehension of landscape is similarly beset by such complexities. Just as the nature and qualities of memory comprise inherently fading, shifting and fleeting impressions of things which are themselves ever-changing, an understanding of a landscape, as well as the landscape itself, is a constantly evolving, emerging response to both immense and intimate influences. There is an incongruity between the inherent changeability of both landscapes and memories, and the conventional, formal strategies of commemoration that typify the constructed landscape memorial. The design work presented in this paper brings together such explorations of memory and landscape by examining the ‘memorial’. This article examines two projects. One concerns the fate of illegal refugees travelling to Australia: The SIEVX Memorial Project. The other, An Anti-Memorial to Heroin Overdose Victims, was designed by the author as part of the 2001 Melbourne Festival.
Comprehensive Analysis of Gene-Environmental Interactions with Temporal Gene Expression Profiles in Pseudomonas aeruginosa
Kangmin Duan, William M. McCullough, Michael G. Surette, Tony Ware, Jiuzhou Song
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0035993
Abstract: To explore gene-environment interactions, based on temporal gene expression information, we analyzed gene and treatment information intensively and inferred interaction networks accordingly. The main idea is that gene expression reflects the response of genes to environmental factors, assuming that variations of gene expression occur under different conditions. Then we classified experimental conditions into several subgroups based on the similarity of temporal gene expression profiles. This procedure is useful because it allows us to combine diverse gene expression data as they become available, and, especially, allowing us to lay the regulatory relationships on a concrete biological basis. By estimating the activation points, we can visualize the gene behavior, and obtain a consensus gene activation order, and hence describe conditional regulatory relationships. The estimation of activation points and building of synthetic genetic networks may result in important new insights in the ongoing endeavor to understand the complex network of gene regulation.
Health-related productivity losses increase when the health condition is co-morbid with psychological distress: findings from a large cross-sectional sample of working Australians
Libby Holden, Paul A Scuffham, Michael F Hilton, Robert S Ware, Nerina Vecchio, Harvey A Whiteford
BMC Public Health , 2011, DOI: 10.1186/1471-2458-11-417
Abstract: We used the cross-sectional data set from the Australian Work Outcomes Research Cost-benefit (WORC) study to explore the impacts of health conditions with and without co-morbid psychological distress, compared to those with neither condition, in a sample of approximately 78,000 working Australians. The World Health Organisation Health and Performance Questionnaire was used which provided data on demographic characteristics, health condition and working conditions. Data were analysed using negative binomial logistic regression and multinomial logistic regression models for absenteeism and presenteeism respectively.For both absenteeism and presenteeism productivity measures there was a greater risk of productivity loss associated when health conditions were co-morbid with psychological distress. For some conditions this risk was much greater for those with co-morbid psychological distress compared to those without.Co-morbid psychological distress demonstrates an increased risk of productivity loss for a range of health conditions. These findings highlight the need for further research to determine whether co-morbid psychological distress potentially exacerbates lost productivity.Health related productivity loss is a concern to researchers, policy makers and industry. There is a growing body of evidence regarding the impact of health conditions on work performance [1-9]. It has been repeatedly found that health conditions increase work-related absences (absenteeism) and/or decrease productivity while at work (presenteeism), creating a substantial economic burden on industry [1-11]. Studies that have considered presenteeism have found it accounts for a greater proportion of the productivity loss than absenteeism [11,12]. For example the associated absenteeism by chronic condition ranged from 0.9 to 5.9 hours in a 4-week period, whereas on-the-job work impairment ranged from a 17.8% to 36.4% decrement in ability to function at work. The total cost of chronic conditions w
Biomarkers of inflammation, coagulation and fibrinolysis predict mortality in acute lung injury
Dana McClintock, Hanjing Zhuo, Nancy Wickersham, Michael A Matthay, Lorraine B Ware
Critical Care , 2008, DOI: 10.1186/cc6846
Abstract: Plasma samples and ventilator data were prospectively collected from 50 patients with early ALI. Plasma biomarkers of inflammation (IL-6, IL-8, intercellular adhesion molecule 1), of coagulation (thrombomodulin, protein C) and of fibrinolysis (plasminogen activator inhibitor 1) were measured by ELISA. Biomarker levels were compared between survivors (n = 29) and non-survivors (n = 21) using Mann–Whitney analysis.The tidal volume for the study group was 6.6 ± 1.1 ml/kg predicted body weight and the plateau pressure was 25 ± 7 cmH2O (mean ± standard deviation), consistent with lung-protective ventilation. All markers except IL-6 were significantly different between survivors and nonsurvivors. Nonsurvivors had more abnormal values. Three biomarkers – IL-8, intercellular adhesion molecule 1 and protein C – remained significantly different by multivariate analysis that included age, gender, Simplified Acute Physiology Score II and all biomarkers that were significant on bivariate analysis. Higher levels of IL-8 and intercellular adhesion molecule 1 were independently predictive of worse outcomes (odds ratio = 2.0 and 5.8, respectively; P = 0.04 for both). Lower levels of protein C were independently associated with an increased risk of death (odds ratio = 0.5), a result that nearly reached statistical significance (P = 0.06).Despite lung-protective ventilation, abnormalities in plasma levels of markers of inflammation, coagulation and fibrinolysis predict mortality in ALI patients, indicating more severe activation of these biologic pathways in nonsurvivors.Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are common causes of acute respiratory failure with a high mortality rate despite decades of research into these conditions [1]. Many studies have implicated activation of inflammation and derangement of the coagulation and fibrinolytic pathways in patients with ALI/ARDS. A number of biomarkers of inflammation are associated with poor clinical outc
Successful surgical treatment of a giant coronary artery aneurysm presenting with recurrent profuse haemoptysis
Opoku-Ware Mensah, Philip AR Hayward, Michael Koeppe, Christof Huth
Journal of Cardiothoracic Surgery , 2008, DOI: 10.1186/1749-8090-3-36
Abstract: Coronary artery aneurysm is a clinical entity, which is found rarely during coronary angiography. Most patients have typical coronary artery disease symptoms. We present here a case of a giant coronary artery aneurysm of the LAD presenting with recurrent profuse haemoptysis.A 72-year old man, previously well, was admitted to a regional hospital with fever, recurrent bloody sputum, weight loss and left sided chest pain of 4 weeks duration. A chest radiograph showed a mass at the left hilum thought to be a neoplasm (see figure 1). A misdiagnosis of haematemesis led to an upper gastrointestinal endoscopy showing oesophagitis. He developed respiratory failure requiring ventilation. A subsequent bronchoscopy excluded a central bronchial tumour, confirmed by histopathologic examination of biopsies. He was transferred to a specialist centre where a CT and MRT scans of the thorax showed the mass to be infiltrating the left upper lobe and was suspicious for an aneurysm of a coronary artery (see figure 2). Transthoracic echocardiography and MRI confirmed this impression and he proceeded to coronary angiography, which demonstrated a giant aneurysm from the LAD (figure 3). He developed cardiovascular instability and proceeded emergently to surgery.The procedure was performed using right atrial to aortic cardiopulmonary bypass via median sternotomy and opening of the anterior pericardium. The aneurysm was adherent to the left anterolateral pericardial aspect and was not disturbed until cardioplegic arrest was achieved, to avoid distal embolization in a beating heart. After achieving myocardial arrest the dissection was completed, revealing the aneurysm to have entry and exit openings into the proximal and mid LAD (see figure 4), and there was compression of the left upper lobe with airway inflammation rather than invasion. The adherent pericardium was removed together with the aneurysm and a large quantity of thrombus, leaving a significant pericardial defect requiring Supple-Gu
CD8 T Cell Memory to a Viral Pathogen Requires Trans Cosignaling between HVEM and BTLA
Rachel Flynn, Tarun Hutchinson, Kenneth M. Murphy, Carl F. Ware, Michael Croft, Shahram Salek-Ardakani
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0077991
Abstract: Defining the molecular interactions required to program activated CD8 T cells to survive and become memory cells may allow us to understand how to augment anti-viral immunity. HVEM (herpes virus entry mediator) is a member of the tumor necrosis factor receptor (TNFR) family that interacts with ligands in the TNF family, LIGHT and Lymphotoxin-α, and in the Ig family, B and T lymphocyte attenuator (BTLA) and CD160. The Ig family members initiate inhibitory signaling when engaged with HVEM, but may also activate survival gene expression. Using a model of vaccinia virus infection, we made the unexpected finding that deficiency in HVEM or BTLA profoundly impaired effector CD8 T cell survival and development of protective immune memory. Mixed adoptive transfer experiments indicated that BTLA expressed in CD8α+ dendritic cells functions as a trans-activating ligand that delivers positive co-signals through HVEM expressed in T cells. Our data demonstrate a critical role of HVEM-BTLA bidirectional cosignaling system in antiviral defenses by driving the differentiation of memory CD8 T cells.
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