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Search Results: 1 - 10 of 160035 matches for " Michael T. Lucenko "
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Mechanism of Cell Cycle Asynchrony within the Animal Organism
Michael T. Lucenko, PhD, ScD
International Journal of BioMedicine , 2013,
Abstract: Every organism is composed of multi-cellular systems. Each of these cells, from the time of birth until death, often plays a polyfunctional role. Obviously, this cycle must include periods of intense work and leisure. In other words, the organ cell masses are able to perform the asynchronous mechanism of cell cycle. The implementation of such a mechanism is regulated by the cell’s gene apparatus which receives the signal from the cytosol of the functioning cell; it also performs the reverse inclusion of the cells doing the work after the rest interval. The aim of this study was to show the presence of a daily regulation of the cell apparatus of any organ, using the liver as an example. This phenomenon is the obligatory mechanism developed over the course of a long evolution and explains the lifetime of the multicellular organ system.
The Effect of Human Herpes Virus Infections on the Stages of Gestation
Michael T. Lucenko, PhD, ScD
International Journal of BioMedicine , 2012,
Abstract: Human herpes virus (HHV) infections are dangerous during the early stages of pregnancy. Circulatory disorders of theendometrium from the uterine arteries pose a threat to the implantation of the embryo and the formation of the structure of chorionic villi. Oxygenation of the placental blood gets disrupted.
Lipid Transport through the Fetoplacental Barrier by the Fatty Acid-Binding Proteins in Pregnant Women with Herpes Virus Infection in the third Trimester
Michael T. Lucenko, PhD, ScD,Irina A. Andrievskaya, PhD, ScD,Natalia A. Ishutina, PhD
International Journal of BioMedicine , 2012,
Abstract: In this study, the transport of the long chain polyunsaturated fatty acids (LCPUFAs) from the lacunar blood through the syncytiotrophoblast of the placental villi to the fetal cord blood via a saturable protein-mediated mechanism by the heart-type fatty acid-binding proteins (H-FABPs) has been examined. Exacerbation of the herpes simplex viruses (HSV-1) in the third trimester of gestation reduces the delivery of the fatty acid-binding proteins to the syncytiotrophoblast. During exacerbation of the HSV-1 infection, the selective transfer of the LCPUFAs across the syncytiotrophoblast basal plasma membrane into the fetal cord blood was observed. The supply of anti-inflammatory ω-3 PUFAs was reduced; however, the inflow of inflammatory arachidonic acid and other ω-6 PUFAs into the fetal blood was increased.
Simulation in Residency Training: A Review  [PDF]
Michael T. Flannery, Sharon Zahorsky
Creative Education (CE) , 2014, DOI: 10.4236/ce.2014.51007
Abstract:

Background: Simulation suddenly came into the limelight of regulation a few years ago when the Accreditation Council on Graduate Medical Education (ACGME) recommended simulation training without specifics. That left internal medicine program directors confused as they tried to figure out what was best for their residents. Summary: The author’s review discusses the many issues and unanswered questions regarding simulation training. It appears clear to this faculty member that residents enjoy the additional training to make them more comfortable doing procedures related to their training. A few studies mention longevity in retention of skills learned over time and very few discuss the numbers of procedures to attain competency and outcome improvements if they occur. Conclusion: This leaves several areas that need further study on the effects of simulation training in residency and meeting the needs of post-graduate descriptions via surveys following training. What kind of procedures and clinical scenarios (codes, medical dilemmas, ethical/communication issues), how often/how many, timing and appropriate measurements especially if focusing on improved patient outcomes. This narrative summary utilized a review focusing on simulation, internal medicine and various simulation outcomes.

A Novel Knee Orthosis in the Treatment of Patellofemoral Pain Syndrome  [PDF]
Michael J. Khadavi, Y. T. Chen, Michael Fredericson
Open Journal of Therapy and Rehabilitation (OJTR) , 2015, DOI: 10.4236/ojtr.2015.32008
Abstract: Context: Patellofemoral Pain (PFPS) accounts for up to 25% of knee injuries in sports medicine clinics, with up to 91% of symptoms unresolved after conservative treatment at 5 years. The variability of response to treatment reflects its multi-factorial biomechanical etiologies. Bracing has been utilized to modify patellofemoral kinematics, generally by increasing patellofemoral contact area. The DJO Reaction orthosis is unique in its shock-absorbing elastomeric design, which is created to dissipate peak stress and enhance patellar tracking. Objective: To assess whether the DJO Reaction Brace reduces pain and improves functional outcomes in patients with chronic PFPS. Design: Cohort Series. Setting: Academic Sports Medicine Clinic. Patients: Twenty-two individuals between 18 and 40 years old with chronic patellofemoral pain have failed conservative treatment. Intervention: DJO Reaction Brace. Main Outcome Measures: Kujala Anterior Knee Pain Scale, Knee Injury and Osteoarthritis Outcome Score. Results: Seven males and 10 females with an age range of 19 - 39 years old complete the study. At an average follow-up time of 55 days, the Kujala score significantly improves by 9.8%, and KOOS Scores increase by the following statistically significant amounts: symptom 3.2%, pain 10.7%, sports and recreation 12.9%, quality of life 20.2%. Conclusion: The DJO Reaction orthosis reduces knee pain, increases function, and enhances quality of life with individuals with PFPS and is effective in the conservative care of patellofemoral pain syndrome.
A Transient but Protracted Geomagnetic Anomaly in the Sudbury Basin Following Two Near-Contiguous Intense Geomagnetic Storms  [PDF]
Michael A Persinger, Blake T Dotta
International Journal of Geosciences (IJG) , 2011, DOI: 10.4236/ijg.2011.23038
Abstract: During the maintained quiescence between solar cycle 23 and 24, two unusually intense (K-indices = 7) global geomagnetic disturbances separated by 6 days occurred. They were followed by a protracted increase of between 150 and 200 nT in the vertical component of our local magnetic field (Sudbury, Ontario). The duration of the variation anomaly was unusually long, about 3 weeks, before returning to baseline following a one week period of below average intensity characterized by approximately 50 min periodicities. We suggest this anomaly supports previous research that specific temporal patterns of increased global geomagnetic activity when matched with local impedance/reluctance of ore bodies created the condition for remarkable transient changes in the surface static intensity of magnetic fields.
“Doubling” of local photon emissions when two simultaneous, spatially-separated, chemiluminescent reactions share the same magnetic field configurations  [PDF]
Blake T. Dotta, Michael A. Persinger
Journal of Biophysical Chemistry (JBPC) , 2012, DOI: 10.4236/jbpc.2012.31009
Abstract: The aim of the present experiments was to discern if the “entanglement”-like photon emissions from pairs of cell cultures or human brains separated by significant distances but sharing the same circling magnetic field could be demonstrated with a classic chemiluminescent reaction produced by hydrogen peroxide and hypochlorite. Simultaneous injection of the same amount of peroxide into a local dish (above a photomultiplier tube) and a dish 10 m away in a closed chamber produced a “doubling” of the durations of the photon spikes only when the two reactions were placed in the center of separate spaces around each of which magnetic fields were generated as accelerating group velocities containing decreasing phase modulations followed by decelerating group velocities embedded with increasing phase modulations. The duration of this “entanglement” was about 8 min. These results suggest that separate distances behave as if they were “the same space” if they are exposed to the same precise temporal configuration of magnetic fields with specific angular velocities.
Invertible Bloom Lookup Tables
Michael T. Goodrich,Michael Mitzenmacher
Computer Science , 2011,
Abstract: We present a version of the Bloom filter data structure that supports not only the insertion, deletion, and lookup of key-value pairs, but also allows a complete listing of its contents with high probability, as long the number of key-value pairs is below a designed threshold. Our structure allows the number of key-value pairs to greatly exceed this threshold during normal operation. Exceeding the threshold simply temporarily prevents content listing and reduces the probability of a successful lookup. If later entries are deleted to return the structure below the threshold, everything again functions appropriately. We also show that simple variations of our structure are robust to certain standard errors, such as the deletion of a key without a corresponding insertion or the insertion of two distinct values for a key. The properties of our structure make it suitable for several applications, including database and networking applications that we highlight.
Anonymous Card Shuffling and its Applications to Parallel Mixnets
Michael T. Goodrich,Michael Mitzenmacher
Computer Science , 2012,
Abstract: We study the question of how to shuffle $n$ cards when faced with an opponent who knows the initial position of all the cards {\em and} can track every card when permuted, {\em except} when one takes $K< n$ cards at a time and shuffles them in a private buffer "behind your back," which we call {\em buffer shuffling}. The problem arises naturally in the context of parallel mixnet servers as well as other security applications. Our analysis is based on related analyses of load-balancing processes. We include extensions to variations that involve corrupted servers and adversarially injected messages, which correspond to an opponent who can peek at some shuffles in the buffer and who can mark some number of the cards. In addition, our analysis makes novel use of a sum-of-squares metric for anonymity, which leads to improved performance bounds for parallel mixnets and can also be used to bound well-known existing anonymity measures.
Privacy-Preserving Access of Outsourced Data via Oblivious RAM Simulation
Michael T. Goodrich,Michael Mitzenmacher
Computer Science , 2010,
Abstract: Suppose a client, Alice, has outsourced her data to an external storage provider, Bob, because he has capacity for her massive data set, of size n, whereas her private storage is much smaller--say, of size O(n^{1/r}), for some constant r > 1. Alice trusts Bob to maintain her data, but she would like to keep its contents private. She can encrypt her data, of course, but she also wishes to keep her access patterns hidden from Bob as well. We describe schemes for the oblivious RAM simulation problem with a small logarithmic or polylogarithmic amortized increase in access times, with a very high probability of success, while keeping the external storage to be of size O(n). To achieve this, our algorithmic contributions include a parallel MapReduce cuckoo-hashing algorithm and an external-memory dataoblivious sorting algorithm.
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