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Search Results: 1 - 10 of 247922 matches for " Michael L. Bledsoe "
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Thyroxine and Free Thyroxine Levels in Workers Occupationally Exposed to Inorganic Lead
Michael L. Bledsoe, Lynne E. Pinkerton, Sharon Silver, James A. Deddens and Raymond E. Biagini
Environmental Health Insights , 2012, DOI: 10.4137/EHI.S7193
Abstract: Background: The effects of lead exposure on thyroid function are unclear. Methods: Serum thyroxine (T4) was evaluated among 137 lead-exposed workers and 83 non-exposed workers. Free thyroxine (FT4) was evaluated among a subset of these workers. Exposure metrics included blood lead level (BLL), which reflects recent exposure, zinc protoporphyrin (ZPP), a marker of intermediate-duration lead exposure, exposure duration, and estimated cumulative exposure. Multiple linear regression results were adjusted for age, race, and current smoking status. Results: Mean BLLs were 38.9 μg/dL in lead exposed workers and 2.1 μg/dL in non-exposed workers. The adjusted mean T4 and FT4 concentrations among exposed and non-exposed workers were similar. While T4 was not significantly related to any of the exposure metrics, FT4 was inversely related to the logged values of both exposure duration and cumulative exposure, but not to ZPP or BLL. Conclusions: The findings suggest that FT4 levels may be related to long-term lead exposure.
Thyroxine and Free Thyroxine Levels in Workers Occupationally Exposed to Inorganic Lead
Michael L. Bledsoe,Lynne E. Pinkerton,Sharon Silver,James A. Deddens
Environmental Health Insights , 2011,
Stability of the inverse resonance problem for Jacobi operators
Matthew Bledsoe
Physics , 2012,
Abstract: When the coefficients of a Jacobi operator are finitely supported perturbations of the 1 and 0 sequences, respectively, the left reflection coefficient is a rational function whose poles inside, respectively outside, the unit disk correspond to eigenvalues and resonances. By including the zeros of the reflection coefficient, we have a set of data that determines the Jacobi coefficients up to a translation as long as there is at most one half-bound state. We prove that the coefficients of two Jacobi operators are pointwise close assuming that the zeros and poles of their left reflection coefficients are $\eps$-close in some disk centered at the origin.
Stability of the inverse resonance problem on the line
Matthew Bledsoe
Physics , 2012, DOI: 10.1088/0266-5611/28/10/105003
Abstract: In the absence of a half-bound state, a compactly supported potential of a Schr\"odinger operator on the line is determined up to a translation by the zeros and poles of the meropmorphically continued left (or right) reflection coefficient. The poles are the eigenvalues and resonances, while the zeros also are physically relevant. We prove that all compactly supported potentials (without half-bound states) that have reflection coefficients whose zeros and poles are $\eps$-close in some disk centered at the origin are also close (in a suitable sense). In addition, we prove stability of small perturbations of the zero potential (which has a half-bound state) from only the eigenvalues and resonances of the perturbation.
Elliott Bledsoe,Jessica Coates
PLATFORM : Journal of Media and Communication , 2010,
EDITORIAL: A Creative Commons Special Issue: Yes, We’re Open!
Elliott Bledsoe,Jessica Coates
PLATFORM : Journal of Media and Communication , 2010,
Reproduction at the Margins: Migration and Legitimacy in the New Europe
Bledsoe Caroline H.
Demographic Research , 2004,
Abstract: One of the most compelling demographic questions in contemporary Europe has been whether immigrant populations will bring their youthful age pyramids to help support Europe's subfertile, aging populations. But how do immigrants envision their own reproductive life trajectories across vast, ambiguous political boundaries whose seismic shifts can threaten their security? This paper reviews some recent literature from demography, anthropology, and the media as well as several case studies to suggest that for immigrant families at the political margins of Europe, especially those from developing countries, the most pressing fertility question is not numbers of children. It is instead the legitimacy that children may provide in their families' efforts to gain work, social security, and rights to settle. This implies that the reproductive practices adopted by immigrants in Europe may derive less from traditions in their home countries than from efforts to adapt to new rules of "belonging" in Europe. Indeed, what seem very striking in the light of conspicuously low and increasingly non-marital fertility in mainstream Western Europe are the increasing demands placed on immigrants to pursue legitimacy in their reproductive lives. The paper concludes that levels of fertility among immigrants are unlikely to assimilate to the national norms until people's status becomes more secure. Finally, just as we can no longer rest on conventional notions of reproductive practices in the developing world, it is increasingly impossible to draw general conclusions about fertility in Europe without keeping the developing world in view.
A Case Study and Meta-Analysis of Type 2 Diabetes Research  [PDF]
Michael L. Gracia
Advances in Anthropology (AA) , 2013, DOI: 10.4236/aa.2013.32013

In the last decade, a new wave of inspired research surrounding a transcription factor’s role in blood-sugar homeostasis has emerged. Transcription Factor 7-like 2 (TCF7L2 or TCF4), a member of the Wnt signaling pathway, is intimately involved in suppressing glucagon synthesis. It also may affect β-cell function. Regiospecific trends concerning the selection of its molecular variants, their dependency on environmental and behavioral changes, and their relative associations with type 2 diabetes (T2D) have become well documented. This dynamic and nuanced understanding of one T2D risk factor should be desired in all other phases of study. An open and incorporative mindset such as this can revitalize the research field.

Medical Image Acquisition and Processing: Clinical Validation  [PDF]
Michael L. Goris
Open Journal of Medical Imaging (OJMI) , 2014, DOI: 10.4236/ojmi.2014.44028
Abstract: The validation of medical imaging (processing and acquisition) can be achieved in multiple ways, somewhat influenced by the context. There are three traps to avoid: First reliance on ground truth requires the knowledge of it before the end of the trial, second comparison to gold standards cannot show improvement and finally one needs to deal with confirmation bias. In this paper we discuss those topics and alternative validation schemes.
The Specificity of a Diagnostic FDG-PET Study Is a Function of the Patient and the Location  [PDF]
Michael L. Goris
Open Journal of Medical Imaging (OJMI) , 2018, DOI: 10.4236/ojmi.2018.84013
Abstract: The present paper is based on the observations that 1) there is reported variation in the specificities according to the type of tumor targeted (target) by FDG PET and 2) that while one can posit that the sensitivity of the tracer depends on the avidity for glucose and the plasma supply of the target, even so that the targeting cannot influence the avidity of unrelated tissues or lesions. The hypothesis to be tested is twofold: 1) patients imaged for different types of lesions could have a different prevalence of FDG avid tissues or lesions different from the target and 2) that the target lesions could be generally located in body location (sites) more likely to contain unrelated foci of increased uptake. Variance analysis shows that the sensitivity varies according to the target (p = 0.022), but not according to the location (p = 0.34); the specificity varies with the location (p = 0.0012) and the target (p = 0.05). Specificities are significantly different in different primary targets and target locations. The former is assumed to be due to different comorbidities in patients with different targets, the latter to the different locations of unrelated glucose avid organs or structures. Conclusion: When specificities are recorded or defined, the patient population characteristics and the organ or pathology of the false positives should also be described.
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