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Search Results: 1 - 10 of 180544 matches for " Michael K. Tso "
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Acute Microvascular Changes after Subarachnoid Hemorrhage and Transient Global Cerebral Ischemia
Michael K. Tso,R. Loch Macdonald
Stroke Research and Treatment , 2013, DOI: 10.1155/2013/425281
Acute Microvascular Changes after Subarachnoid Hemorrhage and Transient Global Cerebral Ischemia
Michael K. Tso,R. Loch Macdonald
Stroke Research and Treatment , 2013, DOI: 10.1155/2013/425281
Abstract: Subarachnoid hemorrhage and transient global cerebral ischemia result in similar pathophysiological changes in the cerebral microcirculation. These changes include microvascular constriction, increased leukocyte-endothelial interactions, blood brain barrier disruption, and microthrombus formation. This paper will look at various animal and preclinical studies that investigate these various microvascular changes, perhaps providing insight in how these microvessels can be a therapeutic target in both subarachnoid hemorrhage and transient global cerebral ischemia. 1. Introduction Subarachnoid hemorrhage (SAH) is a type of hemorrhagic stroke, most commonly caused by a ruptured intracranial aneurysm. At the time of aneurysm rupture, blood pours into the subarachnoid space, and the intracranial pressure (ICP) inside the rigid calvarium increases sharply, causing a corresponding decrease in cerebral blood flow (CBF). The patient’s clinical presentation on arrival to the hospital can depend on the degree and duration of this initial global cerebral ischemia. Patients with aneurysmal SAH may develop angiographic vasospasm and delayed cerebral ischemia (DCI) with onset 3–12 days after the initial rupture [1]. DCI may or may not be accompanied by large artery vasospasm as seen with vascular imaging [2]. A multicenter randomized clinical trial has not shown improvement in neurologic outcome despite ameliorating the delayed large artery vasospasm [3]. Whether this is due to efficacy of rescue therapy in the placebo groups or drug toxicity abrogating beneficial effects in the clazosentan groups has not been resolved. Nevertheless, as a result of these results, research in SAH has also investigated early brain injury and acute microvascular changes [4]. Nimodipine, an L-type calcium channel antagonist, is the only pharmacologic agent that has been shown to consistently improve neurologic outcomes in clinical trials of patients with SAH [5]. Similarly, cardiac arrest (CA) results in global cerebral ischemia that is transient in clinically relevant cases, since if cardiac function is not restored, the situation is of pathological interest only. Other causes of transient global cerebral ischemia (tGCI) include asphyxia, shock, and complex cardiac surgery [6]. The clinical presentation depends on the duration of cardiac arrest and time to initiating cardiopulmonary resuscitation. After global cerebral ischemia from SAH or tGCI, a cascade of molecular events occurs, resulting in variable degrees of brain injury and cerebrovascular changes. Global cerebral ischemia in
Estimates of energy expenditure using the RT3 accelerometer in patients with systemic lupus erythematosus  [PDF]
Tim K. Tso, Wen-Nan Huang, Chen-Kang Chang
Health (Health) , 2010, DOI: 10.4236/health.2010.26089
Abstract: This study aimed to characterize energy expenditure patterns using the triaxial accelerometer and to identify the association of energy expenditure with clinical parameters in patients with systemic lupus erythematosus (SLE). Estimates of energy expenditures represented by total activity calorie (TA), physical activity calorie (PA), total activity calorie per body weight (TABW), and physical activity calorie per body weight (PABW) of 49 female SLE patients were assessed using the RT3 triaxial accelerometer (StayHealthy, Monrovia, CA) in a sevenday period. SLE patients in the highest body mass index (BMI) tertile showed significantly lower values of TABW compared to those in the lowest tertile, while SLE patients in the lowest TABW tertile showed significantly higher body weight, waist circumference, BMI, SLE disease activity index (SLEDAI), dosage of prednisone, and blood pressure. There was a high prevalence of metabolic syndrome and SLE patients with metabolic syndrome showed significantly lower TABW. In addition, both TABW and PABW significantly but negatively correlated with SLEDAI. In conclusion, the RT3 accelerometer is suitable for evaluating total and physical activity-related energy expenditure in patients with SLE. TABW measured by the triaxial accelerometer is inversely related with body weight status and disease activity in SLE patients. This suggests that estimates of energy expenditure by the tri-axial accelerometer may be applied in the management of SLE.
The association of circulating interleukin-18 with fasting insulin and weight loss in obese children  [PDF]
Tim K. Tso, Wen-Nan Huang, Chen-Kang Chang
Health (Health) , 2010, DOI: 10.4236/health.2010.27102
Abstract: Obesity is an independent risk factor for developing cardiovascular disease and increases insulin resistance in children. Interleukin (IL)-18 is a novel pro-inflammatory cytokine with potential atherogenetic properties. This study ai- med to identify circulating levels of IL-18 in obese children and examine the effects of combined nutritional education-physical activity course on circulating IL-18. Plasma IL-18, body mass index (BMI), fasting glucose and insulin, homeostasis model assessment insulin resistance (HOMA IR), lipid profile, uric acid, high- sensitive C-reactive protein (hs-CRP), and homocysteine were determined in 70 obese children aged 10-12 years before and after attending a 13-week weight reduction program, which included physical activities and nutritional education. Twenty-five age-matched non-obese children served as controls. At baseline, obese children had significantly higher levels of BMI, fasting insulin, HOMA IR, triglyceride (TG), uric acid, hs-CRP, and IL-18 but lower high-density lipoprotein-cholesterol (HDL-C) than non-obese children. Plasma IL-18 levels in obese children decreased significantly after the weight reduction program. At baseline, plasma IL-18 levels in obese children positively correlated with BMI, HOMA IR, insulin and TG but negatively correlated with HDL-C. There was a significant relationship between plasma IL-18 and BMI changes. Moreover, fasting insulin was responsible for IL-18 variability in obese children. These findings suggest that elevated plasma IL-18 levels in obese children are partly associated with parameters of obesity and insulin resistance, and are significantly affected by modest weight loss.
电力系统自动化 , 2002,
Abstract: Powersystemtransientstabilityassessment(TSA)basedonpatternrecognitiontechniquescanusuallybetreatedasatwopatternclassificationproblem.Theclassificationqualityispracticallydeterminedbyseparabilityoftheinputspacerepresentedbytheinputfeatures.ThispaperpresentsanapproachforseparabilityassessmentoftheinputspacesforTSA,throughrecognizingthe“inconsistentcases”ofanygivensampleset.Theinconsistentcasesinthispaperdenotethesamplesthatlieintheregionsoccupieddominantlybytheotherclassinaninputspace.Throughdefiningagroupofhypercubicregions,theinconsistentcasescanbeautomaticallysortedoutbyaprocessofdatamining.Aseparabilityindexdefinedbasedontheamountoftheinconsistentcasesinthesamplesetencapsulatestheknowledgerequiredforenhancingstabilityclassification.Thenumericalresultsforthe10unit39busNewEnglandpowersystemshowtheeffectivenessoftheproposedapproachinseparabilityassessmentoftwopatterninputspacesforTSA.Theproposedapproachisapplicableforfeatureselectionprocedureandimprovingclassifierdesign.
Adult Medication-Free Schizophrenic Patients Exhibit Long-Chain Omega-3 Fatty Acid Deficiency: Implications for Cardiovascular Disease Risk
Robert K. McNamara,Ronald Jandacek,Therese Rider,Patrick Tso
Cardiovascular Psychiatry and Neurology , 2013, DOI: 10.1155/2013/796462
Stable Coulomb bubbles ?
L. G. Moretto,K. Tso,G. J. Wozniak
Physics , 1996, DOI: 10.1103/PhysRevLett.78.824
Abstract: Coulomb bubbles, though stable against monopole displacement, are unstable at least with respect to quadrupole and octupole distortions. We show that there exists a temperature at which the pressure of the vapor filling the bubble stabilizes all the radial modes. In extremely thin bubbles, the crispation modes become unstable due to the surface-surface interaction.
Aβ-Like Peptide Displayed on Bacteriophage T7 Catalyzes Chromate and Uranyl Reduction  [PDF]
Hongjun Jin, Chiann-Tso Lin, Jianying Shang, Michael J. Wilkins, Yingbin Liu, Wei Gong, Weiping Xu, Thomas C. Squier, Philip E. Long
Journal of Environmental Protection (JEP) , 2013, DOI: 10.4236/jep.2013.48100

In order to discover genes capable of catalyzing the reductive immobilization of toxic chromate and uranyl ions, we have created a T7 bacteriophage library containing cDNA from environmental microbes (i.e., Geobacter sulfurreducens and Shewanella oneidensis MR-1) that are known to mediate the reduction of chromate and uranyl ions. After three rounds of screening, ten bacteriophage mutants were found to mediate the NADH-dependent reduction of chromate and uranyl ions whose cDNA encodes polypeptide chains ranging 14 to 73 amino acids in length. All identified sequences contain disordered structural motifs similar to the β-amyloid peptide (Aβ) known to promote aggregation and formation of high-affinity metal binding sites. Confirmation of this structural similarity involved phage display of the 42 amino-acid Aβ-peptides that have been found to catalyze the NADH-dependent reduction of both chromate and uranyl ions. Transmission electron microscopy (TEM) and X-ray absorption near edge structure (XANES) measurements confirm that reduced uranium is present on the surface of bacteriophage expressing the Aβ-peptide. The surface-displayed Aβ-like peptide on bacteriophage has

Scaling Laws and Transient Times in 3He Induced Nuclear Fission
Th. Rubehn,K. X. Jing,L. G. Moretto,L. Phair,K. Tso,G. J. Wozniak
Physics , 1996, DOI: 10.1103/PhysRevC.54.3062
Abstract: Fission excitation functions of compound nuclei in a mass region where shell effects are expected to be very strong are shown to scale exactly according to the transition state prediction once these shell effects are accounted for. The fact that no deviations from the transition state method have been observed within the experimentally investigated excitation energy regime allows one to assign an upper limit for the transient time of 10 zs.
The Role of Phase Space in Complex Fragment Emission from Low to Intermediate Energies
L. G. Moretto,R. Ghetti,K. X. Jing,L. Phair,K. Tso,G. J. Wozniak
Physics , 1996,
Abstract: The experimental emission probabilities of complex fragments by low energy compound nuclei and their dependence upon energy and atomic number are compared to the transition state rates. Intermediate-mass-fragment multiplicity distributions for a variety of reactions at intermediate energies are shown to be binomial and thus reducible at all measured transverse energies. From these distributions a single binary event probability can be extracted which has a thermal dependence. A strong thermal signature is also found in the charge distributions. The n-fold charge distributions are reducible to the 1-fold charge distributions through a simple scaling dictated by fold number and charge conservation.
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