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Search Results: 1 - 10 of 184605 matches for " Michael K. Henry "
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Study of localization in the quantum sawtooth map emulated on a quantum information processor
Michael K. Henry,Joseph Emerson,Rudy Martinez,David G. Cory
Physics , 2005, DOI: 10.1103/PhysRevA.74.062317
Abstract: Quantum computers will be unique tools for understanding complex quantum systems. We report an experimental implementation of a sensitive, quantum coherence-dependent localization phenomenon on a quantum information processor (QIP). The localization effect was studied by emulating the dynamics of the quantum sawtooth map in the perturbative regime on a three-qubit QIP. Our results show that the width of the probability distribution in momentum space remained essentially unchanged with successive iterations of the sawtooth map, a result that is consistent with localization. The height of the peak relative to the baseline of the probability distribution did change, a result that is consistent with our QIP being an ensemble of quantum systems with a distribution of errors over the ensemble. We further show that the previously measured distributions of control errors correctly account for the observed changes in the probability distribution.
The Concept of Oncoplastic Breast Surgery Applied in Surgery for a Giant Fibroadenoma  [PDF]
Michael Rose, Henry Svensson
Case Reports in Clinical Medicine (CRCM) , 2014, DOI: 10.4236/crcm.2014.34048
Abstract:

The treatment of a 40-year-old woman with a giant fibroadenoma in her left breast is presented. The fibroadenoma measured 14 × 5 × 3 cm and weighed 170 g. We demonstrate that the surgical strategy and the reconstructive techniques in oncoplastic breast cancer surgery successfully can be applied to the treatment of these rare benign tumours improving the cosmetic and functional outcome.

Connections between Floer-type invariants and Morse-type invariants of Legendrian knots
Michael Henry
Mathematics , 2009, DOI: 10.2140/pjm.2011.249.77
Abstract: We define an algebraic/combinatorial object on the front projection $\Sigma$ of a Legendrian knot called a Morse complex sequence, abbreviated MCS. This object is motivated by the theory of generating families and provides new connections between generating families, normal rulings, and augmentations of the Chekanov-Eliashberg DGA. In particular, we place an equivalence relation on the set of MCSs on $\Sigma$ and construct a surjective map from the equivalence classes to the set of chain homotopy classes of augmentations of $L_\Sigma$, where $L_\Sigma$ is the Ng resolution of $\Sigma$. In the case of Legendrian knot classes admitting representatives with two-bridge front projections, this map is bijective. We also exhibit two standard forms for MCSs and give explicit algorithms for finding these forms.
The complete chloroplast genome sequence of Citrus sinensis (L.) Osbeck var 'Ridge Pineapple': organization and phylogenetic relationships to other angiosperms
Michael G Bausher, Nameirakpam D Singh, Seung-Bum Lee, Robert K Jansen, Henry Daniell
BMC Plant Biology , 2006, DOI: 10.1186/1471-2229-6-21
Abstract: The complete chloroplast genome sequence of Citrus sinensis is 160,129 bp in length, and contains 133 genes (89 protein-coding, 4 rRNAs and 30 distinct tRNAs). Genome organization is very similar to the inferred ancestral angiosperm chloroplast genome. However, in Citrus the infA gene is absent. The inverted repeat region has expanded to duplicate rps19 and the first 84 amino acids of rpl22. The rpl22 gene in the IRb region has a nonsense mutation resulting in 9 stop codons. This was confirmed by PCR amplification and sequencing using primers that flank the IR/LSC boundaries. Repeat analysis identified 29 direct and inverted repeats 30 bp or longer with a sequence identity ≥ 90%. Comparison of protein-coding sequences with expressed sequence tags revealed six putative RNA edits, five of which resulted in non-synonymous modifications in petL, psbH, ycf2 and ndhA. Phylogenetic analyses using maximum parsimony (MP) and maximum likelihood (ML) methods of a dataset composed of 61 protein-coding genes for 30 taxa provide strong support for the monophyly of several major clades of angiosperms, including monocots, eudicots, rosids and asterids. The MP and ML trees are incongruent in three areas: the position of Amborella and Nymphaeales, relationship of the magnoliid genus Calycanthus, and the monophyly of the eurosid I clade. Both MP and ML trees provide strong support for the monophyly of eurosids II and for the placement of Citrus (Sapindales) sister to a clade including the Malvales/Brassicales.This is the first complete chloroplast genome sequence for a member of the Rutaceae and Sapindales. Expansion of the inverted repeat region to include rps19 and part of rpl22 and presence of two truncated copies of rpl22 is unusual among sequenced chloroplast genomes. Availability of a complete Citrus chloroplast genome sequence provides valuable information on intergenic spacer regions and endogenous regulatory sequences for chloroplast genetic engineering. Phylogenetic analyses
Fidelity enhancement by logical qubit encoding
Michael K. Henry,Chandrasekhar Ramanathan,Jonathan S. Hodges,Colm A. Ryan,Michael J. Ditty,Raymond Laflamme,David G. Cory
Physics , 2007, DOI: 10.1103/PhysRevLett.99.220501
Abstract: We demonstrate coherent control of two logical qubits encoded in a decoherence free subspace (DFS) of four dipolar-coupled protons in an NMR quantum information processor. A pseudo-pure fiducial state is created in the DFS, and a unitary logical qubit entangling operator evolves the system to a logical Bell state. The four-spin molecule is partially aligned by a liquid crystal solvent, which introduces strong dipolar couplings among the spins. Although the system Hamiltonian is never fully specified, we demonstrate high fidelity control over the logical degrees of freedom. In fact, the DFS encoding leads to higher fidelity control than is available in the full four-spin Hilbert space.
Riemann and Euler Sum Investigation in an Introductory Calculus Class  [PDF]
Michael M. Henry, Dennis M. Cates
Open Journal of Discrete Mathematics (OJDM) , 2011, DOI: 10.4236/ojdm.2011.12007
Abstract: This paper provides a detailed outline of a mathematical research exploration for use in an introductory high school or college Calculus class and is directed toward teachers of such courses. The discovery is accomplished by introducing a novel method to generate a polynomial expression for each of the Euler sums, ΣNk=0kn,n∈Z+ . The described method flows simply from initial discussions of the Riemann sum definition of a definite integral and is readily accessible to all new calculus students. Students investigate the Bernoulli numbers and the interesting connections with Pascal's Triangle. Advice is offered throughout as to how the project can be assigned to students and offers multiple suggestions for additional exploration for any motivated student.
Sever’s Disease: An Underdiagnosed Foot Injury in the Pediatric Emergency Department  [PDF]
Michael Marchick, Henry Young, Mathew F. Ryan
Open Journal of Emergency Medicine (OJEM) , 2015, DOI: 10.4236/ojem.2015.34007
Abstract: Sever’s disease—also known as calcaneal apophysitis—is a common cause of heel pain in pediatric patients typically aged 7 - 14 years old. Sever’s disease can be painful and limit a child’s function as well as participation in physical activity. Herein, we described a case of delayed presentation of chronic Sever’s disease in a child who had been experiencing heel pain for over one year which worsened substantially when the child began to participate in sports. This is important for the emergency medicine physician because Sever’s disease represents an underdiagnosed cause of foot and heel pain in the pediatric patient and may be often missed. We describe the diagnosis and treatment options of Sever’s disease as well as associated controversies, e.g., whether activity is indeed the cause of Sever’s disease and whether imaging is needed for a diagnosis.
A Randomized Controlled Trial of Glucose versus Amylase Resistant Starch Hypo-Osmolar Oral Rehydration Solution for Adult Acute Dehydrating Diarrhea
Balakrishnan S. Ramakrishna, Venkataraman Subramanian, Vivek Mohan, Bendon K. Sebastian, Graeme P. Young, Michael J. Farthing, Henry J. Binder
PLOS ONE , 2008, DOI: 10.1371/journal.pone.0001587
Abstract: Background Reduction of gross diarrhea rate in excess of that seen over time with intravenous therapy and appropriate antibiotics is not usually achieved by oral glucose-electrolyte rehydration therapy for cholera and cholera-like diarrheas. Methodology and Principal Findings This prospective randomized clinical trial at a tertiary referral hospital in southern India was undertaken to determine whether amylase resistant starch, substituting for glucose in hypo-osmolar oral rehydration solution, would reduce diarrhea duration and weight in adults with acute severe dehydrating diarrhea. 50 adult males with severe watery diarrhea of less than three days' duration and moderate to severe dehydration were randomized to receive hypo-osmolar ORS (HO-ORS) or HO-ORS in which amylase resistant high amylose maize starch 50g/L substituted for glucose (HAMS-ORS). All remaining therapy followed standard protocol. Duration of diarrhea (ORS commencement to first formed stool) in hours was significantly shorter with HAMS-ORS (median 19, IQR 10-28) compared to HO-ORS (median 42, IQR 24-50) (Bonferroni adjusted P, Padj<0.001). Survival analysis (Kaplan-Meier) showed faster recovery from diarrhea in the HAMS-ORS group (P<0.001, log rank test). Total diarrhea fecal weight in grams (median, IQR) was not significantly lower in the HAMS-ORS group (2190, 1160-5635) compared to HO-ORS (5210, 2095-12190) (Padj = 0.08). However, stool weight at 13-24 hours (280, 0-965 vs. 1360, 405-2985) and 25–48 hours (0, 0-360 vs. 1080, 55-3485) were significantly lower in HAMS-ORS compared to HO-ORS group (Padj = 0.048 and P = 0.012, respectively). ORS intake after first 24 hours was lower in the HAMS-ORS group. Subgroup analysis of patients with culture isolates of Vibrio cholerae indicated similar significant differences between the treatment groups. Conclusions Compared to HO-ORS, HAMS-ORS reduced diarrhea duration by 55% and significantly reduced fecal weight after the first 12 hours of ORS therapy in adults with cholera-like diarrhea. Trial Registration Current Controlled Trials ISRCTN72841333
Prolyl-4-Hydroxylase 3 (PHD3) Expression Is Downregulated during Epithelial-to-Mesenchymal Transition
Trenton L. Place, Jones T. Nauseef, Maina K. Peterson, Michael D. Henry, James J. Mezhir, Frederick E. Domann
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0083021
Abstract: Prolyl-4-hydroxylation by the intracellular prolyl-4-hydroxylase enzymes (PHD1-3) serves as a master regulator of environmental oxygen sensing. The activity of these enzymes is tightly tied to tumorigenesis, as they regulate cell metabolism and angiogenesis through their control of hypoxia-inducible factor (HIF) stability. PHD3 specifically, is gaining attention for its broad function and rapidly accumulating array of non-HIF target proteins. Data from several recent studies suggest a role for PHD3 in the regulation of cell morphology and cell migration. In this study, we aimed to investigate this role by closely examining the relationship between PHD3 expression and epithelial-to-mesenchymal transition (EMT); a transcriptional program that plays a major role in controlling cell morphology and migratory capacity. Using human pancreatic ductal adenocarcinoma (PDA) cell lines and Madin-Darby Canine Kidney (MDCK) cells, we examined the correlation between several markers of EMT and PHD3 expression. We demonstrated that loss of PHD3 expression in PDA cell lines is highly correlated with a mesenchymal-like morphology and an increase in cell migratory capacity. We also found that induction of EMT in MDCK cells resulted in the specific downregulation of PHD3, whereas the expression of the other HIF-PHD enzymes was not affected. The results of this study clearly support a model by which the basal expression and hypoxic induction of PHD3 is suppressed by the EMT transcriptional program. This may be a novel mechanism by which migratory or metastasizing cells alter signaling through specific pathways that are sensitive to regulation by O2. The identification of downstream pathways that are affected by the suppression of PHD3 expression during EMT may provide important insight into the crosstalk between O2 and the migratory and metastatic potential of tumor cells.
Cost Analysis of a Nucleic Acid Amplification Test in the Diagnosis of Pulmonary Tuberculosis at an Urban Hospital with a High Prevalence of TB/HIV
Max W. Adelman, Ekaterina Kurbatova, Yun F. Wang, Michael K. Leonard, Nancy White, Deborah A. McFarland, Henry M. Blumberg
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0100649
Abstract: Introduction The Centers for Disease Control and Prevention has recommended using a nucleic acid amplification test (NAAT) for diagnosing pulmonary tuberculosis (TB) but there is a lack of data on NAAT cost-effectiveness. Methods We conducted a prospective cohort study that included all patients with an AFB smear-positive respiratory specimen at Grady Memorial Hospital in Atlanta, GA, USA between January 2002 and June 2008. We determined the sensitivity, specificity, and positive and negative predictive value of a commercially available and FDA-approved NAAT (amplified MTD, Gen-Probe) compared to the gold standard of culture. A cost analysis was performed and included costs related to laboratory tests, hospital charges, anti-TB medications, and contact investigations. Average cost per patient was calculated under two conditions: (1) using a NAAT on all AFB smear-postive respiratory specimens and (2) not using a NAAT. One-way sensitivity analyses were conducted to determine sensitivity of cost difference to reasonable ranges of model inputs. Results During a 6 1/2 year study period, there were 1,009 patients with an AFB smear-positive respiratory specimen at our public urban hospital. We found the NAAT to be highly sensitive (99.6%) and specific (99.1%) on AFB smear-positive specimens compared to culture. Overall, the positive predictive value (PPV) of an AFB smear-positive respiratory specimen for culture-confirmed TB was 27%. The PPV of an AFB smear-positive respiratory specimen for culture-confirmed TB was significantly higher for HIV-uninfected persons compared to those who were HIV-seropositive (152/271 [56%] vs. 85/445 [19%]; RR = 2.94, 95% CI 2.36–3.65, p<0.001). The cost savings of using the NAAT was $2,003 per AFB smear-positive case. Conclusions Routine use of the NAAT on AFB smear-positive respiratory specimens was highly cost-saving in our setting at a U.S. urban public hospital with a high prevalence of TB and HIV because of the low PPV of an AFB smear for culture-confirmed TB.
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