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Search Results: 1 - 10 of 44867 matches for " Michael Jerin "
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Age Differences in Long Term Outcomes of Coronary Patients Treated with Drug Eluting Stents at a Tertiary Medical Center
Nicolas W. Shammas,Gail A. Shammas,Peter Sharis,Michael Jerin
Journal of Aging Research , 2013, DOI: 10.1155/2013/471026
Abstract: We evaluate differences in outcomes in younger (<65 years) and older (≥65 years) patients for target lesion failure (TLF) at 2-year follow-up in an unselected consecutive series of patients treated with the everolimus- (EES) and paclitaxel-eluting (PES) stents at a tertiary medical center. 348 consecutive patients (younger 150; older 198) stented with the EES and PES were retrospectively analyzed. The primary endpoint was TLF (composite endpoint of cardiac death, non fatal myocardial infarction due to index vessel and target lesion revascularization (TLR)). At 2 years follow up, younger versus older patients had the following outcomes respectively: TLF 27.7% versus 25.5% ( ), TLR 24.8% versus 21.4% ( ), cardiac death 3.4% versus 2.5% ( ) and definite and probable stent thrombosis (2.0% versus 1.0%). Multivariate analysis showed that renal failure (odds ratio: 2.55, ), number of stents per patient (odds ratio: 1.60, ) and younger age (odds ratio: 0.97; ), but not gender, diabetes or type of DES stent (EES versus PES) predicted TLF. We conclude that older age was not a predictor of TLF at 2-year follow-up after adjusting for renal insufficiency, number of stents used per patient, gender, diabetes and type of DES used. 1. Introduction There is a relative paucity of data on clinical outcomes of elderly patients undergoing contemporary percutaneous coronary interventions (PCIs) with drug eluting stents (DESs). Elderly patients have been frequently excluded from randomized clinical trials because of multiple comorbidities making available data on DES difficult to generalize to older patients [1]. Several reports indicated that older age (>65 years old and particularly >75 years old) is an independent predictor of adverse events after percutaneous coronary interventions (PCIs) with higher inhospital vascular complications and cardiac death [2, 3] and higher long term cardiac mortality [4]. Other reports suggested that older age, after adjusting for various clinical and procedural variables, does not appear to independently predict adverse early or late outcomes after PCI [5, 6]. The paclitaxel-eluting stent (PES) Taxus Liberte (Boston Scientific, Natick, MA, USA) and the everolimus-eluting stent (EES) Xience (or Promus) (Abbott Laboratories, Abbott Park, IL, USA) are drug eluting stents (DESs) that showed lower TVR than bare metal stents (BMSs) irrespective of age, although higher mortality and myocardial infarction seem to increase with higher age groups [7]. In this report, we examine our own data for differences between younger (<65 years) and older (≥65
Caffeinium bisulfate monohydrate
C. Vincent Jerin,S. Athimoolam
Acta Crystallographica Section E , 2011, DOI: 10.1107/s1600536811031540
Abstract: In the title compound (systematic name: 1,3,7-trimethyl-2,6-dioxo-7H-purin-9-ium hydrogen sulfate monohydrate), C8H11N4O2+·HSO4 ·H2O, the crystal packing is stabilized through N—H...O and O—H...O hydrogen bonds.
Effect of meloxicam and meloxicam with misoprostol on serum prostaglandins and gastrointestinal permeability in healthy beagle dogs
Ro?kar Tina,Nemec Svete Alenka,Jerin A.,Butinar J.
Acta Veterinaria , 2011, DOI: 10.2298/avb1101033r
Abstract: The aim of the present study was to investigate the effect of meloxicam and meloxicam with misoprostol on prostaglandin E2 (PGE2) and prostaglandin I2 (PGI2) serum concentration, as well as on gastrointestinal permeability. NSAIDs, such as meloxicam, have gastrointestinal side effects, which are due to prostaglandins depletion and topical damage. Seven adult beagle dogs were included in the study. Three different 20 days long treatments were carried out (placebo, meloxicam and meloxicam with misoprostol). The same seven dogs participated in all three treatments. On days 1 to 10 the dogs received placebo, meloxicam or meloxicam together with misoprostol PO. Dogs were than monitored from day 11 to 20. Samples for serum PGE2 and PGI2 concentration and plasma lactulose, mannitol and sucrose concentration determination were drawn on day 0, 2, 6, 11 and 20. Lactulose/mannitol (L/M) index was calculated. Treatment with meloxicam and meloxicam with misoprostol resulted in lower PGE2 and PGI2 serum concentrations in comparison to the placebo. L/M index and sucrose plasma concentration were increased in both groups in comparison to the placebo. According to the results of the study, meloxicam has altered gastrointestinal permeability and depleted prostaglandins production. Misoprostol was shown to be an effective preventing treatment.
Outcomes of patients treated with the everolimus-eluting stent versus the zotarolimus-eluting stent in a consecutive cohort of patients at a tertiary medical center
Shammas NW,Shammas GA,Nader E,Jerin M
Vascular Health and Risk Management , 2012,
Abstract: Nicolas W Shammas, Gail A Shammas, Elie Nader, Michael Jerin, Luay Mrad, Peter Marogil, Courtney Henn, Alex Dvorak, Archana Chintalapani, Susan MerinerMidwest Cardiovascular Research Foundation, Davenport, IA, USABackground: In this study we compared the outcomes of the everolimus-eluting stent (EES) versus the zotarolimus-eluting stent (ZES) in patients treated at a tertiary medical center, with up to one year of follow-up.Methods: Unselected consecutive patients were retrospectively recruited following stenting with the ZES (n = 197) or EES (n = 190). The first 100 consecutive patients in each cohort underwent syntax scoring. The primary endpoint of the study was target vessel failure, defined as the combined endpoint of cardiac death, non-fatal myocardial infarction, or target vessel revascularization. Secondary endpoints included target lesion revascularization, target lesion failure, acute stent thrombosis, total death, cardiac death, and non-fatal myocardial infarction.Results: The two groups were similar, including for Syntax scores (19.6 ± 12.8 versus 20.6 ± 13.6), number of stents per patient (2.9 ± 1.9 versus 2.9 ± 2.1), and cardiovascular risk factors. By one year, the primary outcome occurred in 20.8% EES versus 26.7% ZES (P = 0.19) patients. The secondary endpoints were as follows: target lesion revascularization (8.9% versus 20.6%, P = 0.003), target vessel revascularization (18.9% versus 25.6%, P = 0.142), definite and probable stent thrombosis (0% versus 2.5%), non-fatal myocardial infarction (2.7% versus 3.6%), and mortality (3.2% versus 5.1%) for the EES versus the ZES, respectively.Conclusion: EES had similar target vessel failure to ZES, but superior target lesion revascularization and target lesion failure at one year of follow-up in an unselected cohort of patients.Keywords: coronary stent, drug eluting stent, zotarolimus, everolimus, outcome, target lesion revascularization, stent thrombosis
Integrated Layout Design Approach for Cellular Manufacturing System Environment
I. Jerin Leno,S. Saravanasankar,S.G. Ponnambalam
Journal of Applied Sciences , 2012,
Abstract: Traditionally, the design of physical layout of the manufacturing system, I/O station location determination and subsequently the design of Material Handling System (MHS) is being carried out in isolation. In this work an attempt is made to concurrently design 1. Cell System Layout (CSL) or Inter-cell layout, 2. Determining optimum location of input, output (I/O) stations of each cell and 3.The flow path of the MHS using a Genetic Algorithm based methodology for a Cellular Manufacturing System (CMS) environment under open field configuration. The proposed algorithm is employed to optimize one of the classical objective namely Total Material Handling Cost (TMHC). The algorithm is tested on four different bench mark layouts and with different initial problem data sets. It is found that the proposed algorithm is able to produce satisfactory solutions consistently within a reasonable computational limit.
Active Timing Based Approach for Tracking Anonymous Peer-to-peer Network in VoIP
Karthikeyan.C,Karthikeyan.V,Jerin Sajeev.C.R,,Merlin Moses.M
International Journal of Soft Computing & Engineering , 2013,
Abstract: Peer-to-peer VoIP calls are popular due to theirlow cost and convenience. When these calls are encrypted andanonymized the network becomes a secured one. Tracing of theanonymous VoIP call users are important and the tracedinformation about them should be sent to the server to knowhow long the users are in communication.The key challenge in tracking encrypted VoIP calls acrossanonymous communication system is to identify the correlationbetween the VoIP flows of the caller and the callee. Since all thetraffic of the peer-to-peer VoIP calls are encrypted, the best wayto track anonymous VoIP calls across the internet is using theActive timing based correlation. It is done by embedding aunique watermark into the inter-packet timing domain. Theanalysis shows that it only takes several milliseconds timeadjustment to make normal VoIP flows highly unique and theembedded delay value could be preserved across the low latencyanonymizing network. In this proposal, tracking of anonymousVoIP calls across internet was successfully achieved by usingactive time based correlation method and the resultsdemonstrate that tracing of anonymous peer-to-peer VoIP callson the internet is feasible and low latency anonymizing networksare susceptible to timing attacks.
Exercise-Induced Changes in Iron Status and Hepcidin Response in Female Runners
Irena Auersperger, Branko ?kof, Bojan Lesko?ek, Bojan Knap, Ale? Jerin, Mitja Lainscak
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0058090
Abstract: Background and Aims Exercise-induced iron deficiency is a common finding in endurance athletes. It has been suggested recently that hepcidin may be an important mediator in this process. Objective To determine hepcidin levels and markers of iron status during long-term exercise training in female runners with depleted and normal iron stores. Methods Fourteen runners were divided into two groups according to iron status. Blood samples were taken during a period of eight weeks at baseline, after training and after ten days’ recovery phase. Results Of 14 runners, 7 were iron deficient at baseline and 10 after training. Hepcidin was lower at recovery compared with baseline (p<0.05). The mean cell haemoglobin content, haemoglobin content per reticulocyte and total iron binding capacity all decreased, whereas soluble transferrin receptor and hypochromic red cells increased after training and recovery (p<0.05 for all). Conclusion The prevalence of depleted iron stores was 71% at the end of the training phase. Hepcidin and iron stores decreased during long-term running training and did not recover after ten days, regardless of baseline iron status.
Outcomes of patients treated with the everolimus-eluting stent versus the zotarolimus-eluting stent in a consecutive cohort of patients at a tertiary medical center
Shammas NW, Shammas GA , Nader E, Jerin M, Mrad L, Marogil P, Henn C, Dvorak A, Chintalapani A, Meriner S
Vascular Health and Risk Management , 2012, DOI: http://dx.doi.org/10.2147/VHRM.S30122
Abstract: tcomes of patients treated with the everolimus-eluting stent versus the zotarolimus-eluting stent in a consecutive cohort of patients at a tertiary medical center Original Research (1989) Total Article Views Authors: Shammas NW, Shammas GA , Nader E, Jerin M, Mrad L, Marogil P, Henn C, Dvorak A, Chintalapani A, Meriner S Published Date April 2012 Volume 2012:8 Pages 205 - 211 DOI: http://dx.doi.org/10.2147/VHRM.S30122 Received: 22 January 2012 Accepted: 09 March 2012 Published: 11 April 2012 Nicolas W Shammas, Gail A Shammas, Elie Nader, Michael Jerin, Luay Mrad, Peter Marogil, Courtney Henn, Alex Dvorak, Archana Chintalapani, Susan Meriner Midwest Cardiovascular Research Foundation, Davenport, IA, USA Background: In this study we compared the outcomes of the everolimus-eluting stent (EES) versus the zotarolimus-eluting stent (ZES) in patients treated at a tertiary medical center, with up to one year of follow-up. Methods: Unselected consecutive patients were retrospectively recruited following stenting with the ZES (n = 197) or EES (n = 190). The first 100 consecutive patients in each cohort underwent syntax scoring. The primary endpoint of the study was target vessel failure, defined as the combined endpoint of cardiac death, non-fatal myocardial infarction, or target vessel revascularization. Secondary endpoints included target lesion revascularization, target lesion failure, acute stent thrombosis, total death, cardiac death, and non-fatal myocardial infarction. Results: The two groups were similar, including for Syntax scores (19.6 ± 12.8 versus 20.6 ± 13.6), number of stents per patient (2.9 ± 1.9 versus 2.9 ± 2.1), and cardiovascular risk factors. By one year, the primary outcome occurred in 20.8% EES versus 26.7% ZES (P = 0.19) patients. The secondary endpoints were as follows: target lesion revascularization (8.9% versus 20.6%, P = 0.003), target vessel revascularization (18.9% versus 25.6%, P = 0.142), definite and probable stent thrombosis (0% versus 2.5%), non-fatal myocardial infarction (2.7% versus 3.6%), and mortality (3.2% versus 5.1%) for the EES versus the ZES, respectively. Conclusion: EES had similar target vessel failure to ZES, but superior target lesion revascularization and target lesion failure at one year of follow-up in an unselected cohort of patients.
Does Child Maltreatment Mediate Family Environment and Psychological Well-Being?  [PDF]
Michael Galea
Psychology (PSYCH) , 2010, DOI: 10.4236/psych.2010.12019
Abstract: This study tried to establish if childhood maltreatment mediates the established relationship between family environ-ment and psychological well-being, in a sample of Maltese university students (N = 312). However, our analysis sug-gested partial mediation only. Moreover, results indicated that abusive families are less loving, socially integrated, organized, and more conflicted. Family environment contributed positively, albeit limited, to cognitive well-being after controlling for child abuse history. In particular, cohesion, do add unique variance to subjective well-being, after controlling for child abuse. This study replicates classic research on the important role that family environment plays in children’s holistic development.
Blended Change Management: Concept and Empirical Investigation of Blending Patterns  [PDF]
Michael REISS
iBusiness (IB) , 2009, DOI: 10.4236/ib.2009.12008
Abstract: In coping with the challenges of revolutionary or evolutionary change processes, change managers do not rely on single tools but on toolboxes containing several domains of tools. The impact of toolboxes on change performance depends both on the complementary inter-domain mix and the intra-domain blending of tools. The patterns of blending are investigated both conceptually and empirically with respect to scope, diversity and coupling of tools. Survey results indicate that blending practices are predominantly determined by rational tool evaluation and by task context.
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