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Search Results: 1 - 10 of 44892 matches for " Michael Gruss "
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Alterations of Amino Acids and Monoamine Metabolism in Male Fmr1 Knockout Mice: A Putative Animal Model of the Human Fragile X Mental Retardation Syndrome
Michael Gruss,Katharina Braun
Neural Plasticity , 2001, DOI: 10.1155/np.2001.285
Abstract: The Fragile X syndrome, a common form of mental retardation in humans, is caused by silencing the fragile X mental retardation (FMR1) geneleading to the absence of the encoded fragile X mental retardation protein 1 (FMRP). We describe morphological and behavioral abnormalities for both affected humans and Fmr1 knockout mice, a putative animal model for the human Fragile X syndrome. The aim of the present study was to identify possible neurochemical abnormalities in Fmr1 knockout mice, with particular focus on neurotransmission. Significant region-specific differences: of basal neurotransmitter and metabolite levels were found between wildtype and Fmr1 knockout animals, predominantly in juveniles (post-natal days 28 to 31). Adults (postnatal days 209 to 221) showed only few abnormalities as compared with the wildtype. In juvenile knockout mice, aspartate and taurine were especially increased in cortical regions, striatum, hippocampus, cerebellum, and brainstem. In addition, juveniles showed an altered balance between excitatory and inhibitory amino acids in the caudal cortex, hippocampus, and brainstem. We detected very few differences in monoamine turnover in both age stages. The results presented here provide the first evidence that lack of FMRP expression in FMRP knockout mice is accompanied by age-dependent, region-specific alterations in neurotransmission.
Sepsis-Induced Degradation of Endothelial Glycocalix
Michael Henrich,Marco Gruss,Markus A. Weigand
The Scientific World Journal , 2010, DOI: 10.1100/tsw.2010.88
Konservative Therapie der Stuhlinkontinenz
Gruss HJ
Journal für Urologie und Urogyn?kologie , 2004,
Black Holes in Ho?ava Gravity with Higher Derivative Magnetic Terms
Eyal Gruss
Physics , 2010, DOI: 10.1088/0264-9381/28/8/085007
Abstract: We consider Horava gravity coupled to Maxwell and higher derivative magnetic terms. We construct static spherically symmetric black hole solutions in the low-energy approximation. We calculate the horizon locations and temperatures in the near-extremal limit, for asymptotically flat and (anti-)de Sitter spaces. We also construct a detailed balanced version of the theory, for which we find projectable and non-projectable, non-perturbative solutions.
A Suggestion for a Teleological Interpretation of Quantum Mechanics
Eyal Gruss
Physics , 2000,
Abstract: We suggest solving the measurement problem by postulating the existence of a special future final boundary condition for the universe. Although this is an extension of the way boundary conditions are usually chosen (in terrestrial laboratories), it is our only deviation from standard quantum mechanics. Using two state vectors, or the "two-state", to describe completely the state of systems of interest, we analyze ideal and "weak" measurements, and show the consistency of our scheme. If the final state of a measuring device is assigned to be one of the possible outcomes of the measurement, an effective reduction is observed after an ideal measurement process. For final conditions chosen with an appropriate distribution, the predictions of standard quantum mechanics may be reconstructed, thus eliminating probability from the description of any single measurement. The interpretation attained, the Teleological Interpretation, is an ontological one; it is local and deterministic. Other special assumptions in the choice of the final boundary condition may explain certain unaccounted for phenomena, or even supply a mechanism for essential free will. In this context we believe that a new conception of time should be adopted.
Moderate hypoxia influences excitability and blocks dendrotoxin sensitive K+ currents in rat primary sensory neurones
Marco Gruss, Giovanni Ettorre, Annette Stehr, Michael Henrich, Gunter Hempelmann, Andreas Scholz
Molecular Pain , 2006, DOI: 10.1186/1744-8069-2-12
Abstract: Therefore we investigated the influence of moderate hypoxia (27.0 ± 1.5 mmHg) on action potentials, excitability and ionic conductances of small neurones in a slice preparation of DRGs of young rats. The neurones responded within a few minutes non-uniformly to moderate hypoxia: changes of excitability could be assigned to decreased outward currents in most of the neurones (77%) whereas a smaller group (23%) displayed increased outward currents in Ringer solution. We were able to attribute most of the reduction in outward-current to a voltage-gated K+ current which activated at potentials positive to -50 mV and was sensitive to 50 nM α-dendrotoxin (DTX). Other toxins that inhibit subtypes of voltage gated K+ channels, such as margatoxin (MgTX), dendrotoxin-K (DTX-K), r-tityustoxin Kα (TsTX-K) and r-agitoxin (AgTX-2) failed to prevent the hypoxia induced reduction. Therefore we could not assign the hypoxia sensitive K+ current to one homomeric KV channel type in sensory neurones. Functionally this K+ current blockade might underlie the increased action potential (AP) duration in these neurones. Altogether these results, might explain the functional impairment of peripheral neurones under moderate hypoxia.In the last years the knowledge about the effects of hypoxia on different organ systems showed a remarkable increase. Most efforts were made to understand the actions of hypoxia in the central nervous system, in the regulation of blood flow, in the sensing of oxygen levels in chemoreceptors of the carotid body and the neuroepithelial bodies of the lung (see [1-3] for reviews).Besides the manifold effects of chronic hypoxia on gene-regulation and gene-expression, mechanisms leading to long-term changes and adaptation of cell metabolism [2], it has been established that acute hypoxia modulates the activity of a wide range of different ion channels. Modulation of Ca2+ channels [4,5], Na+ channels [6,7] and especially K+ channels [8-12] have been described to be oxygen se
Passive Avoidance Training and Recall are Associated With Increased Glutamate Levels in the Intermediate Medial Hyperstriatum Ventrale of the Day-Old Chick
Jonathan N. Daisley,Michael Gruss,Steven P. R. Rose,Katharina Braun
Neural Plasticity , 1998, DOI: 10.1155/np.1998.53
Interaction-induced conducting-nonconducting transition of ultra-cold atoms in 1D optical lattices
Chih-Chun Chien,Daniel Gruss,Massimiliano Di Ventra,Michael Zwolak
Physics , 2012, DOI: 10.1088/1367-2630/15/6/063026
Abstract: The study of time-dependent, many-body transport phenomena is increasingly within reach of ultra-cold atom experiments. We show that the introduction of spatially inhomogeneous interactions, e.g., generated by optically-controlled collisions, induce negative differential conductance in the transport of atoms in 1D optical lattices. Specifically, we simulate the dynamics of interacting fermionic atoms via a micro-canonical transport formalism within both mean-field and a higher-order approximation, as well as with time-dependent DMRG. For weakly repulsive interactions, a quasi steady-state atomic current develops that is similar to the situation occurring for electronic systems subject to an external voltage bias. At the mean-field level, we find that this atomic current is robust against the details of how the interaction is switched on. Further, a conducting-to-nonconducting transition exists when the interaction imbalance exceeds some threshold from both our approximate and time-dependent DMRG simulations. This transition is preceded by the atomic equivalent of negative differential conductivity observed in transport across solid-state structures.
Reverse Engineering Intel DRAM Addressing and Exploitation
Peter Pessl,Daniel Gruss,Clémentine Maurice,Michael Schwarz,Stefan Mangard
Computer Science , 2015,
Abstract: In this paper, we present a method to reverse engineer DRAM addressing functions based on a physical bus probing. Second, we present an automatic and generic method to reverse engineer DRAM addressing functions merely from performing a timing attack. This timing attack can be performed on any system without privileges and even in virtual machines to derive information about the mapping to physical DRAM channels, ranks and banks. We reversed the complex adressing functions on a diverse set of Intel processors and DRAM configurations. Our work enables side-channel attacks and covert channels based on inner-bank row conflicts and overlaps. Thus, our attack does not exploit the CPU as a shared resource, but only the DRAM that might even be shared across multiple CPUs. We demonstrate the power of such attacks by implementing a high speed covert channel that achieves transmission rates of up to 1.5Mb/s, which is three orders of magnitude faster than current covert channels on main memory. Finally, we show how our results can be used to increase the efficiency of the Rowhammer attack significantly by reducing the search space by a factor of up to 16384.
La pintura mural hispano-musulmana. Tradición o innovación?
Rallo Gruss, Carmen
Al-Qantara : Revista de Estudios Arabes , 2003,
Abstract: It is generally thought that in Western Europe and at the end of the medieval period, tempera paint with oil as a medium was applied to dry plaster walls because the Roman technique for painting on wet plaster (al fresco) had been forgotten. Texts such as the Libro dell'Arte by Cennino Cennini discuss the recovery of the fresco technique by some of the founding painters of the Italian Renaissance, such as Giotto. From Renaissance Italy, it is argued, the technique expanded to the rest of Europe. However, in medieval Hispanic monuments with Islamic iconography there is evidence of painted fresco decoration dated prior to the fifteenth century. This paper studies the sources of this technical tradition by analysing examples of Iberian, Roman, Islamic, Mudéjar and Morisco mural painting. El convencimiento de que a finales de la Edad Media las paredes eran decoradas con pintura al seco, realizada con temple, más o menos graso, olvidando la técnica de pintura al fresco utilizada habitualmente por los romanos, es algo admitido para toda la Europa Occidental. Textos como el Libro dell′Arte de Cennino Cennini nos hablan de su recuperación por los iniciadores del Renacimiento italiano como el Giotto; desde allí se expandirá la técnica a todos los países europeos. Sin embargo, en los monumentos hispanos con iconografía de tradición islámica se siguen realizando decoraciones al fresco hasta el siglo XV. En busca de explicaciones a esta excepción, en este artículo se buscan las fuentes de esa tradición técnica, analizando ejemplos de pintura mural ibera, romana, islámica y de lo morisco o mudéjar. El estudio se centra en los materiales utilizados, incluso con analítica de laboratorio, en paralelo con los motivos estilísticos que se encuentran en cada época.
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