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Search Results: 1 - 10 of 44853 matches for " Michael Epperly "
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Strategies for Discovery of Small Molecule Radiation Protectors and Radiation Mitigators
Joel S. Greenberger,Michael W. Epperly
Frontiers in Oncology , 2012, DOI: 10.3389/fonc.2011.00059
Abstract: Mitochondrial targeted radiation damage protectors (delivered prior to irradiation) and mitigators (delivered after irradiation, but before the appearance of symptoms associated with radiation syndrome) have been a recent focus in drug discovery for (1) normal tissue radiation protection during fractionated radiotherapy, and (2) radiation terrorism counter measures. Several categories of such molecules have been discovered: nitroxide-linked hybrid molecules, including GS-nitroxide, GS-nitric oxide synthase inhibitors, p53/mdm2/mdm4 inhibitors, and pharmaceutical agents including inhibitors of the phosphoinositide-3-kinase pathway and the anti-seizure medicine, carbamazepine. Evaluation of potential new radiation dose modifying molecules to protect normal tissue includes: clonogenic radiation survival curves, assays for apoptosis and DNA repair, and irradiation-induced depletion of antioxidant stores. Studies of organ specific radioprotection and in total body irradiation-induced hematopoietic syndrome in the mouse model for protection/mitigation facilitate rational means by which to move candidate small molecule drugs along the drug discovery pipeline into clinical development.
Antioxidant Approaches to Management of Ionizing Irradiation Injury
Joel Greenberger,Valerian Kagan,Hulya Bayir,Peter Wipf,Michael Epperly
Antioxidants , 2015, DOI: 10.3390/antiox4010082
Abstract: Ionizing irradiation induces acute and chronic injury to tissues and organs. Applications of antioxidant therapies for the management of ionizing irradiation injury fall into three categories: (1) radiation counter measures against total or partial body irradiation; (2) normal tissue protection against acute organ specific ionizing irradiation injury; and (3) prevention of chronic/late radiation tissue and organ injury. The development of antioxidant therapies to ameliorate ionizing irradiation injury began with initial studies on gene therapy using Manganese Superoxide Dismutase (MnSOD) transgene approaches and evolved into applications of small molecule radiation protectors and mitigators. The understanding of the multiple steps in ionizing radiation-induced cellular, tissue, and organ injury, as well as total body effects is required to optimize the use of antioxidant therapies, and to sequence such approaches with targeted therapies for the multiple steps in the irradiation damage response.
FACETS - a Framework for Parallel Coupling of Fusion Components
John R. Cary,Ammar Hakim,Mahmood Miah,Scott Kruger,Alexander Pletzer,Svetlana Shasharina,Srinath Vadlamani,Alexei Pankin,Ronald Cohen,Tom Epperly,Tom Rognlien,Richard Groebner,Satish Balay,Lois McInnes,Hong Zhang
Physics , 2010,
Abstract: Coupling separately developed codes offers an attractive method for increasing the accuracy and fidelity of the computational models. Examples include the earth sciences and fusion integrated modeling. This paper describes the Framework Application for Core-Edge Transport Simulations (FACETS).
Does Child Maltreatment Mediate Family Environment and Psychological Well-Being?  [PDF]
Michael Galea
Psychology (PSYCH) , 2010, DOI: 10.4236/psych.2010.12019
Abstract: This study tried to establish if childhood maltreatment mediates the established relationship between family environ-ment and psychological well-being, in a sample of Maltese university students (N = 312). However, our analysis sug-gested partial mediation only. Moreover, results indicated that abusive families are less loving, socially integrated, organized, and more conflicted. Family environment contributed positively, albeit limited, to cognitive well-being after controlling for child abuse history. In particular, cohesion, do add unique variance to subjective well-being, after controlling for child abuse. This study replicates classic research on the important role that family environment plays in children’s holistic development.
Blended Change Management: Concept and Empirical Investigation of Blending Patterns  [PDF]
Michael REISS
iBusiness (IB) , 2009, DOI: 10.4236/ib.2009.12008
Abstract: In coping with the challenges of revolutionary or evolutionary change processes, change managers do not rely on single tools but on toolboxes containing several domains of tools. The impact of toolboxes on change performance depends both on the complementary inter-domain mix and the intra-domain blending of tools. The patterns of blending are investigated both conceptually and empirically with respect to scope, diversity and coupling of tools. Survey results indicate that blending practices are predominantly determined by rational tool evaluation and by task context.
Single Wire Electrical System  [PDF]
Michael Bank
Engineering (ENG) , 2012, DOI: 10.4236/eng.2012.411092
Abstract: The purpose of this article is to remind of the past and present problems of creating single wire electrical systems. This article presents a new one wire electrical transmission system named B-Line which uses one line only and does not use ground as a second line. The proposed method is to work on all frequencies and on all communication systems including DC systems. It also proposes to work on the concept of the single-pole signal source and single-pole signal load. It illustrates the possibility of cutting the cost of electrical lines and several other advantages in the fields of high frequency communication lines and antennas.
Relationship of nine constants  [PDF]
Michael Snyder
Natural Science (NS) , 2013, DOI: 10.4236/ns.2013.59117

Through the process of trial and error, four unitless equations made up of nine constants have been found with exact answers. The related constants are the Speed of Light [1], the Planck constant [2], Wien’s displacement constant [3], Avogadro’s number [4], the universal Gravity constant [5], the Ampere constant [6], the Faraday constant [7], the Gas constant [8] and Apery’s constant [9].

The Counterfeit Electronics Problem  [PDF]
Michael Pecht
Open Journal of Social Sciences (JSS) , 2013, DOI: 10.4236/jss.2013.17003

Counterfeit electronics have been reported in a wide range of products, including computers, telecommunications equipment, automobiles, avionics and military systems. Counterfeit electronic products include everything from very inexpensive capacitors and resistors to costly microprocessors to servers. This paper describes the counterfeit electronic products problem, and discusses the implication of counterfeit electronics on the electronic supply chain. We then present counterfeit detection and prevention techniques for electronics.

Irrationality Re-Examined: A Few Comments on the Conjunction Fallacy  [PDF]
Michael Aristidou
Open Journal of Philosophy (OJPP) , 2013, DOI: 10.4236/ojpp.2013.32050
Abstract: In this paper, I argue that the probability model used to infer irrationality for the subjects in the famous Linda problem is not appropriate, and I suggest different approaches based on fuzzy reasoning models. My line of argument is two-fold: 1) If the term “probability” is understood properly (mathematically), then the experimenters used the wrong model. 2) If the term “probability” is understood casually (non- mathematically), then alternative models perhaps should be used to justify the subjects’ responses. The objective is to experiment with new ways of looking at irrationality and raise a discussion regarding the relation between irrationality, reasoning errors and logical models that are used as frameworks to study irrationality.
User-Friendly: Anthropomorphic Devices and Mechanical Behaviour in Japan  [PDF]
Michael Shea
Advances in Anthropology (AA) , 2014, DOI: 10.4236/aa.2014.41006

Anthropomorphic avatars and disembodied voices have become part of everyday life in Japan. From the animated characters that bow after you complete a transaction at an automated teller machine to the phenomenal proliferation of consumer goods bearing cute faces. There is a discernable growing tendency to anthropomorphize machines. These anthropomorphic devices stand in contrast with the somewhat automated nature of many human interactions. Particularly in the behavior required of employees that work in customer service roles, which calls to mind the demand that workers must often behave as machines from which the notion of a robot originates. Based on research conducted at the National Museum of Emerging Science and Innovation in Tokyo, examples not only of how friendliness can be mechanically produced but also of new devices being imbued with functions to demonstrate their friendliness will be critically examined.

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