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Search Results: 1 - 10 of 30512 matches for " Mi-Jin Noh "
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Determinants Influencing Consumers’ Trust and Trust Performance of Social Commerce and Moderating Effect of Experience
Sanghyun Kim,Mi-Jin Noh
Information Technology Journal , 2012,
Abstract: The main purpose of this study is to investigate the effects of various antecedents of trust in Social commerce (s-commerce) (reputation, size, information quality and communication) on consumers’ trust. In addition, the study examines the moderating effects of consumers’ s-commerce experience on the relationships between these trust antecedents and trust and the effect of trust on trust performance. The results based on a sample of 466 s-commerce users and structural equation modeling with SmartPLS 2.0 indicate significant effects of all trust antecedents; significant moderating effects of consumers’ s-commerce experience and a positive effect of trust on trust performance and suggest a new theory for IS research. In addition, the results have important implications for s-commerce firms wishing to develop consumers’ trust as well as effective business models.
Effects of Antecedents of Collectivism on Consumers’ Intention to Use Social Commerce
Sanghyun Kim,Mi-Jin Noh,Kyung-Tag Lee
Journal of Applied Sciences , 2012,
Abstract: Social commerce (s-commerce), a subset of electronic commerce (e-commerce), involves social interactions and user contributions and facilitates the online buying and selling of a wide range products and services. Given that s-commerce encourages consumers to share product- and service-related information, it reflects collectivism, not individualism. Using the Technology Acceptance Model (TAM), this study employs the Structural Equation Modeling (SEM) method to investigate a research model incorporating consumers’ preferences, reliance, concern and norm acceptance as antecedents of collectivism. The results of a survey of 365 s-commerce users indicate that preferences, reliance and norm acceptance had significant effects on the perceived usefulness of s-commerce. In addition, the goodness-of-fit results indicate that collectivism and perceived ease of use accounted for 65.7% of the variance in the perceived usefulness of s-commerce. This study contributed to the literature by providing useful insights into the factors influencing consumers’ decision to adopt s-commerce.
Meleagrin, a New FabI Inhibitor from Penicillium chryosogenum with at Least One Additional Mode of Action
Chang Ji Zheng, Mi-Jin Sohn, Sangku Lee, Won-Gon Kim
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0078922
Abstract: Bacterial enoyl-acyl carrier protein reductase (FabI) is a promising novel antibacterial target. We isolated a new class of FabI inhibitor from Penicillium chrysogenum, which produces various antibiotics, the mechanisms of some of them are unknown. The isolated FabI inhibitor was determined to be meleagrin by mass spectroscopy and nuclear magnetic resonance spectral analyses, and its more active and inactive derivatives were chemically prepared. Consistent with their selective inhibition of Staphylococcus aureus FabI, meleagrin and its more active derivatives directly bound to S. aureus FabI in a fluorescence quenching assay, inhibited intracellular fatty acid biosynthesis and growth of S. aureus, and increased the minimum inhibitory concentration for fabI-overexpressing S. aureus. The compounds that were not effective against the FabK isoform, however, inhibited the growth of Streptococcus pneumoniae that contained only the FabK isoform. Additionally no resistant mutant to the compounds was obtained. Importantly, fabK-overexpressing Escherichia coli was not resistant to these compounds, but was resistant to triclosan. These results demonstrate that the compounds inhibited another target in addition to FabI. Thus, meleagrin is a new class of FabI inhibitor with at least one additional mode of action that could have potential for treating multidrug-resistant bacteria.
Heavy metal chemistry in soils received long-term application of organic wastes  [PDF]
Soon-Ik Kwon, Yeon-Ah Jang, Kye-Hoon Kim, Goo-Bok Jung, Min-Kyeong Kim, Hae Hwang, Mi-Jin Chae, Seung-Chang Hong, Kyu-Ho So, Sun-Gang Yun, Kwon-Rae Kim
Journal of Agricultural Chemistry and Environment (JACEN) , 2012, DOI: 10.4236/jacen.2012.11001
Abstract: This study was carried out to understand the long-term effect of organic waste treatment on the fate of heavy metals originated from the organic wastes, together with examination of changes in soil properties. For this, the soils received three different organic wastes (municipal sewage sludge, alcohol fermentation processing sludge, pig manure compost) in three different rates (12.5, 25, 50 ton/ha/yr) for 7 years (1994 - 2000) were used. To see the long-term effect, plant growth study and soil examination were conducted twice in 2000 and 2010, respectively. There was no additional treatment of organic wastes for post ten years after ceasing organic waste treatment for seven years. Soil examination conducted in 2010 showed decreases in soil pH, EC, total nitrogen, organic matter, available phosphorus, exchangeable cations and heavy metal contents in all soils received organic wastes compared to the results obtained in 2000. Speciation of heavy metals in soil through sequential extraction showed that organically bound Cu was the dominant species in all treatment and exchangeable Cu was increased in the plots treated with municipal sewage sludge and alcohol fermentation processing sludge. organically bound Ni increased from 25% - 30% to 32% - 45% in 2010 inall treatment while Pb showed increase in carbonate form in all treatments. Zn existed mainly as sulfide and residual forms, showing increases in organically bound form in all treatment during post ten years.


Genetic Modification of the Soybean to Enhance the β-Carotene Content through Seed-Specific Expression
Mi-Jin Kim, Jae Kwang Kim, Hye Jeong Kim, Jung Hun Pak, Jai-Heon Lee, Doh-Hoon Kim, Hong Kyu Choi, Ho Won Jung, Jeong-Dong Lee, Young-Soo Chung, Sun-Hwa Ha
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0048287
Abstract: The carotenoid biosynthetic pathway was genetically manipulated using the recombinant PAC (Phytoene synthase-2A-Carotene desaturase) gene in Korean soybean (Glycine max L. cv. Kwangan). The PAC gene was linked to either the β-conglycinin (β) or CaMV-35S (35S) promoter to generate β-PAC and 35S-PAC constructs, respectively. A total of 37 transgenic lines (19 for β-PAC and 18 for 35S-PAC) were obtained through Agrobacterium-mediated transformation using the modified half-seed method. The multi-copy insertion of the transgene was determined by genomic Southern blot analysis. Four lines for β-PAC were selected by visual inspection to confirm an orange endosperm, which was not found in the seeds of the 35S-PAC lines. The strong expression of PAC gene was detected in the seeds of the β-PAC lines and in the leaves of the 35S-PAC lines by RT-PCR and qRT-PCR analyses, suggesting that these two different promoters function distinctively. HPLC analysis of the seeds and leaves of the T2 generation plants revealed that the best line among the β-PAC transgenic seeds accumulated 146 μg/g of total carotenoids (approximately 62-fold higher than non-transgenic seeds), of which 112 μg/g (77%) was β-carotene. In contrast, the level and composition of the leaf carotenoids showed little difference between transgenic and non-transgenic soybean plants. We have therefore demonstrated the production of a high β-carotene soybean through the seed-specific overexpression of two carotenoid biosynthetic genes, Capsicum phytoene synthase and Pantoea carotene desaturase. This nutritional enhancement of soybean seeds through the elevation of the provitamin A content to produce biofortified food may have practical health benefits in the future in both humans and livestock.
Genome-wide expression patterns associated with oncogenesis and sarcomatous transdifferentation of cholangiocarcinoma
Min-A Seol, In-Sun Chu, Mi-Jin Lee, Goung-Ran Yu, Xiang-Dan Cui, Baik-Hwan Cho, Eun-Kyung Ahn, Sun-Hee Leem, In-Hee Kim, Dae-Ghon Kim
BMC Cancer , 2011, DOI: 10.1186/1471-2407-11-78
Abstract: Genes that were differentially expressed between CC cell lines or tissues and cultured normal biliary epithelial (NBE) cells were identified using DNA microarray technology. Expressions were validated in human CC tissues and cells.Using unsupervised hierarchical clustering analysis of the cell line and tissue samples, we identified a set of 342 commonly regulated (>2-fold change) genes. Of these, 53, including tumor-related genes, were upregulated, and 289, including tumor suppressor genes, were downregulated (<0.5 fold change). Expression of SPP1, EFNB2, E2F2, IRX3, PTTG1, PPARγ, KRT17, UCHL1, IGFBP7 and SPARC proteins was immunohistochemically verified in human and hamster CC tissues. Additional unsupervised hierarchical clustering analysis of sarcomatoid CC cells compared to three adenocarcinomatous CC cell lines revealed 292 differentially upregulated genes (>4-fold change), and 267 differentially downregulated genes (<0.25 fold change). The expression of 12 proteins was validated in the CC cell lines by immunoblot analysis and immunohistochemical staining. Of the proteins analyzed, we found upregulation of the expression of the epithelial-mesenchymal transition (EMT)-related proteins VIM and TWIST1, and restoration of the methylation-silenced proteins LDHB, BNIP3, UCHL1, and NPTX2 during sarcomatoid transdifferentiation of CC.The deregulation of oncogenes, tumor suppressor genes, and methylation-related genes may be useful in identifying molecular targets for CC diagnosis and prognosis.Cholangiocarcinoma (CC) is a highly lethal adenocarcinoma arising from bile duct epithelial cells. CC accounts for approximately 15% of the total liver cancer cases worldwide, and its incidence is rising [1,2]. The prognosis for CC is quite poor because of difficulties in early diagnosis, and relative resistance of the tumors to chemotherapy [3,4]. At the time of diagnosis, approximately 70% of CC patients have an occult metastasis or advanced local disease that precludes curativ
Dinucleotide repeat polymorphism in Fms-like tyrosine kinase-1 (Flt-1) gene is not associated with preeclampsia
Shin-Young Kim, Ji-Hyae Lim, Jae-Hyug Yang, Moon-Young Kim, Jung-Yeol Han, Hyun-Kyong Ahn, Jun-Seek Choi, So-Yeon Park, Mi-Jin Kim, Hyun-Mee Ryu
BMC Medical Genetics , 2008, DOI: 10.1186/1471-2350-9-68
Abstract: The number of the d(TG)n repeats was analyzed in 170 patients with preeclampsia and in 202 normotensive pregnancies. The region containing the dinucleotide repeat polymorphism of the Flt-1 gene was amplified by polymerase chain reaction (PCR) from the DNA samples and was analyzed by direct PCR sequencing.We found 10 alleles of the dinucleotide repeat polymorphism and designated these as allele*12 (A1) through allele*23 (A12) according to the number of the TG repeats, from 12 to 23. The frequency of the 14-repeat allele (A3) was most abundant (63.82% in preeclampsia and 69.06% in controls), followed by the 21-repeat allele (A10; 28.53% in preeclampsia and 23.76% in controls). There was no significant difference in the allele frequency between patients with preeclampsia and normal controls. The most common genotype in preeclamptic and normotensive pregnancies was heterozygous (TG)14/(TG)21 (41.76%) and homozygous (TG)14/(TG)14 (45.05%), respectively. However, the genotype frequencies were not significantly different between preeclamptic patients and controls.This is the first study to characterize the dinucleotide repeat polymorphism of the Flt-1 gene in patients with preeclampsia. We found no differences in the allele or genotype frequencies between patients with preeclampsia and normal pregnancies. Although limited by a relatively small sample size, our study suggests that the d(TG)n repeat polymorphism of the Flt-1 gene is not associated with the development of preeclampsia in Korean pregnant women.Preeclampsia, a pregnancy-specific syndrome affecting about 5% to 10% of all pregnancies, is characterized by hypertension and proteinuria after 20 weeks of gestation. It is a major cause of maternal and perinatal morbidity and mortality and occurs only in the presence of a placenta and remits dramatically after the placenta has been delivered. The underlying pathogenetic mechanisms of this maternal syndrome are much debated with the current hypotheses including inflamma
Genome-Wide Association Study Identifies HLA-DP as a Susceptibility Gene for Pediatric Asthma in Asian Populations
Emiko Noguchi ,Hiromi Sakamoto,Tomomitsu Hirota,Kaori Ochiai,Yoshimasa Imoto,Masafumi Sakashita,Fumitake Kurosaka,Akira Akasawa,Shigemi Yoshihara,Noriko Kanno,Yumi Yamada,Naoki Shimojo,Yoichi Kohno,Yoichi Suzuki,Mi-Jin Kang,Ji-Won Kwon,Soo-Jong Hong,Ken Inoue,Yu-ichi Goto,Fumio Yamashita,Takashi Asada,Hiroshi Hirose,Ikuo Saito,Shigeharu Fujieda,Nobuyuki Hizawa,Toru Sakamoto,Hironori Masuko,Yusuke Nakamura,Ichiro Nomura,Mayumi Tamari,Tadao Arinami,Teruhiko Yoshida,Hirohisa Saito,Kenji Matsumoto
PLOS Genetics , 2011, DOI: 10.1371/journal.pgen.1002170
Abstract: Asthma is a complex phenotype influenced by genetic and environmental factors. We conducted a genome-wide association study (GWAS) with 938 Japanese pediatric asthma patients and 2,376 controls. Single-nucleotide polymorphisms (SNPs) showing strong associations (P<1×10?8) in GWAS were further genotyped in an independent Japanese samples (818 cases and 1,032 controls) and in Korean samples (835 cases and 421 controls). SNP rs987870, located between HLA-DPA1 and HLA-DPB1, was consistently associated with pediatric asthma in 3 independent populations (Pcombined = 2.3×10?10, odds ratio [OR] = 1.40). HLA-DP allele analysis showed that DPA1*0201 and DPB1*0901, which were in strong linkage disequilibrium, were strongly associated with pediatric asthma (DPA1*0201: P = 5.5×10?10, OR = 1.52, and DPB1*0901: P = 2.0×10?7, OR = 1.49). Our findings show that genetic variants in the HLA-DP locus are associated with the risk of pediatric asthma in Asian populations.
Additive Effect between IL-13 Polymorphism and Cesarean Section Delivery/Prenatal Antibiotics Use on Atopic Dermatitis: A Birth Cohort Study (COCOA)
So-Yeon Lee, Jinho Yu, Kang-Mo Ahn, Kyung Won Kim, Youn Ho Shin, Kyung-shin Lee, Seo Ah Hong, Young-ho Jung, Eun Lee, Song-I Yang, Ju-hee Seo, Ji-Won Kwon, Byoung-Ju Kim, Hyo-Bin Kim, Woo-Kyung Kim, Dae Jin Song, Gwang Cheon Jang, Jung Yeon Shim, Soo-Young Lee, Ja-Young Kwon, Suk-Joo Choi, Kyung-Ju Lee, Hee Jin Park, Hye-Sung Won, Ho-Sung Yoo, Mi-Jin Kang, Hyung-Young Kim, Soo-Jong Hong
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0096603
Abstract: Background Although cesarean delivery and prenatal exposure to antibiotics are likely to affect the gut microbiome in infancy, their effect on the development of atopic dermatitis (AD) in infancy is unclear. The influence of individual genotypes on these relationships is also unclear. To evaluate with a prospective birth cohort study whether cesarean section, prenatal exposure to antibiotics, and susceptible genotypes act additively to promote the development of AD in infancy. Methods The Cohort for Childhood of Asthma and Allergic Diseases (COCOA) was selected from the general Korean population. A pediatric allergist assessed 412 infants for the presence of AD at 1 year of age. Their cord blood DNA was subjected to interleukin (IL)-13 (rs20541) and cluster-of-differentiation (CD)14 (rs2569190) genotype analysis. Results The combination of cesarean delivery and prenatal exposure to antibiotics associated significantly and positively with AD (adjusted odds ratio, 5.70; 95% CI, 1.19–27.3). The association between cesarean delivery and AD was significantly modified by parental history of allergic diseases or risk-associated IL-13 (rs20541) and CD14 (rs2569190) genotypes. There was a trend of interaction between IL-13 (rs20541) and delivery mode with respect to the subsequent risk of AD. (P for interaction = 0.039) Infants who were exposed prenatally to antibiotics and were born by cesarean delivery had a lower total microbiota diversity in stool samples at 6 months of age than the control group. As the number of these risk factors increased, the AD risk rose (trend p<0.05). Conclusion Cesarean delivery and prenatal antibiotic exposure may affect the gut microbiota, which may in turn influence the risk of AD in infants. These relationships may be shaped by the genetic predisposition.
Evaluation of Methane Yield on Mesophilic-Dry Anaerobic Digestion of Piggery Manure Mixed with Chaff for Agricultural Area  [PDF]
Dong-Heui Kwak, Mi-Sug Kim, Jae-Seung Kim, Young-Youl Oh, Soon-Ok Noh, Byung-Ok So, Su-Young Jung, Su-Jin Jung, Soo-Wan Chae
Advances in Chemical Engineering and Science (ACES) , 2013, DOI: 10.4236/aces.2013.34029
Abstract: A mesophilic-dry anaerobic digestion process is valid in treating high-concentration substrates containing low moisture content. It has merits of lower wastewater discharge and lower heat capacity required in maintaining reactor temperature as compared with a thermophilic-wet anaerobic digestion process. In fact, chaff can be easily obtained in farming areas and used as a mixture substrate as one of bulking agents for controlling moisture and supplying carbon. For this reason, this study applies the chaff to improve livestock manure, which contains high moisture content and is discharged from domestic pig farms. This study aims at verifying its feasibility for improving methane production efficiency on a basis of BMP (Biochemical Methane Potential) assay obtained through a series of experiments. Finding results were methane gas production and gas production per volatile solid (VS) added, and methane gas production among biogas production were increased as the chaff added in the piggery manure was increased. According to experimental results for improving the methane production efficiency, mixture of the chaff and the piggery manure played an important role in controlling the moisture content and improving the methane gas production rate, and also verified its feasibility in the mesophilic-dry anaerobic digestion process indicating relatively less difficulty for operation and management.
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