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Prevalence of Restless Legs Syndrome in Patients Treated with Peritoneal Dialysis: Clinical and Biochemical Characteristics among Patients with and without Restless Legs Syndrome  [PDF]
Selda Korkmaz, Bulent Tokgoz, Sevda Ismailogullari, Ismail Kocyigit, Merva Kocyigit, Ozgur Berkay Aksu, Murat Aksu
Open Journal of Nephrology (OJNeph) , 2013, DOI: 10.4236/ojneph.2013.31008
Abstract: Introduction and Aims:This is a prospective study identifying prevalence of Restless Legs Syndrome (RLS) in patients ongoing peritoneal dialysis (PD) due to end stage renal disease (ESRD) and comparing clinical and biochemical characteristics among patients with and without RLS. Methods: Two hundred ESRD patients who received PD at least six months assessed by neurologist and nephrologist with regards to presence of RLS. Also, clinical and biochemical features of these patients are determined. One hundred and forty four patients were excluded from study because they had other secondary causes of RLS except for ESRD. Results: Thirteen of 56 patients (23.2%) had RLS. The use of vitamin B + folic acid supplements was significantly lower in patients with RLS than in those without RLS (69.2% vs 97.7%; p = 0.008). There was no significant difference between patient groups with and without RLS in terms of age, gender, body mass index, cause of ESRD, peritoneal membrane transport characteristic, smoking, consuming alcohol, use of erythropoietin, duration of PD, hemoglobin, serum calcium, serum phosphorus, serum albumin, levels of serum iron, total iron binding capacity, ferritin, folic acid and vitamin B12, transferrin saturation, weekly Kt/V urea value, and amount of residual urine volume (p > 0.05). Conclusion: RLS is more common among PD patients than general population. Although essential cause is not exactly known, use of folic acid and vitamin B complex decrease the RLS prevalence in this particular patient group.
Unusual Clinical Presentation of Ethylene Glycol Poisoning: Unilateral Facial Nerve Paralysis
Eray Eroglu,Ismail Kocyigit,Sami Bahcebasi,Aydin Unal,Murat Hayri Sipahioglu,Merva Kocyigit,Bulent Tokgoz,Oktay Oymak
Case Reports in Medicine , 2013, DOI: 10.1155/2013/460250
Abstract: Ethylene glycol (EG) may be consumed accidentally or intentionally, usually in the form of antifreeze products or as an ethanol substitute. EG is metabolized to toxic metabolites. These metabolites cause metabolic acidosis with increased anion gap, renal failure, oxaluria, damage to the central nervous system and cranial nerves, and cardiovascular instability. Early initiation of treatment can reduce the mortality and morbidity but different clinical presentations can cause delayed diagnosis and poor prognosis. Herein, we report a case with the atypical presentation of facial paralysis, hematuria, and kidney failure due to EG poisoning which progressed to end stage renal failure and permanent right peripheral facial nerve palsy. 1. Introduction Ethylene glycol (EG) may be consumed accidentally or intentionally, usually in the form of antifreeze products or as an ethanol substitute. It is converted by alcohol dehydrogenase to active metabolites in the liver, and these metabolites cause metabolic acidosis with increased anion gap, renal failure, hypocalcemia, oxaluria, and damage to the central nervous system and cranial nerves [1–3]. Diagnosis of EG poisoning could be a challenge due to altered mental status and lack of poisoning history. While metabolic acidosis with increased anion gap is common, osmolar gap resolves within 24 to 72 hours as the EG is metabolized to toxic metabolites. Early initiation of treatment can reduce the mortality, and morbidity but different presentations especially with delayed cases could be a problem, so patients with acute renal failure require more attention [4]. In cases of renal failure with the suspicion of EG poisoning, kidney biopsy should be considered promptly. Histological examination of renal tissue often reveals widespread necrosis of the tubular epithelium and deposition of a multitude of doubly refractile oxalate crystals in the distal tubules and collecting ducts [5, 6]. Herein, we report a case with the atypical presentation of facial paralysis, hematuria, and kidney failure due to EG poisoning. 2. Case Report A 25-year-old man was admitted to the emergency department of our university hospital with sudden onset of nausea, vomiting, slight mental disability, and abdominal pain. Cardiovascular, respiration, and gastrointestinal system examination findings were normal. The neurological examinations of the cranial nerves and limbs were normal. He was clinically dehydrated. On the first day of his admission, laboratory studies revealed a BUN level of 35?mg/dL, creatinine level of 3.17?mg/dL, calcium level of
Lead Inhibition on Urea Hydrolyzing Microorganisms under Batch Conditions
A. Kilic, H. Kocyigit
Biotechnology & Biotechnological Equipment , 2010, DOI: 10.2478/V10133-010-0079-2
Abstract: Lead, Pb(II), inhibition of microbial calcium precipitation by ureolytic microorganisms was carried out with a glucose containing mineral medium under batch conditions over an incubation period of 120 hours. Substrate removal rate fitted a zero order up to 70th hour and first order kinetic after that time for all samples containing lead concentrations of 0-64 mg/L. The increase of Pb(II) concentrations from 0 to 64 mg/L reduced constant of substrate degradation rate from 10.26 to 4.04 mg glucose/L h, and from 0.027 to 0.005 1/h for zero (k0) and first order kinetic constant (k1), respectively. The Pb(II) at concentration higher than 16 mg/L mainly inhibited both substrate removal and nitrification process. Although nitrification was inhibited at higher concentrations of lead, its inhibition caused precipitation of calcium due to high pH and alkalinity levels in the samples. As a result that a modified Monod inhibition model was applied to BOD data, BOD removal rate inhibited non-competitively. The non-competitive inhibition constants (K1) were 10.4 mg/L for KS, and 37.3 mg/L for Rmax at Pb(II) concentration of 64 mg/L.
The Effect of Aerobic Exercise on Cardiopulmonary System in Children
Dilek Sevimli,Fuat Kocyigit
TAF Preventive Medicine Bulletin , 2009,
Abstract: AIM: The purpose of this study is to investigate the changes in cardiopulmonary system stimulated by aerobic exercise in different age group of children and to find out in which age group aerobic exercise is more effective. METHOD: Totally, 76 children participated in this study. Ages of the participants ranged between 11 17, and mean age was 14.08±0.65. Participants were divided into three groups according to their age range. There were 23 in the first and second and 30 participants in the third group, (15 17), (13 14) and 30 (11 12) respectively. Each of the groups then was divided into two parts one of which was experimental and the other was control group. During 8 weeks, a training programme based on doing aerobic exercise lasting one hour 3 days a week was performed in the experimental groups. Before and after training, EKG, spirometer, blood pressure, heart rate, PWC 170 test of the participants, which was the data collection method, were recorded. The results obtained were compared through t test method of SPSS. RESULTS: The results revealed a decrease in the systolic blood pressure and in the heart rate of those who did exercise as opposed to those who did not do exercise in Group I. In addition, R wave height in V6 of exercise group showed a statistically significant increase. As for second group, it was determined that the R/S, at V1 derivation obtained from the participants who did exercise showed a statistically decrease as compared to those of the participants who did not do exercise. In the third group, no changes were observed in the systolic blood pressure the heart rate, R wave height in V6 and R/S although the measures of PWC 170 test, VC and FVC obtained from all training groups made a significant increase when compared to those of control groups. CONCLUSION: The results of this study revealed that of the three groups the 15 17 age group was affected mostly by the aerobic exercise on kardiyopulmoner sytem. The results suggest that the exercises performed with this group affected the participants positively, which should be taken into consideration for further research. [TAF Prev Med Bull. 2009; 8(2): 125-130]
Resolution analysis of imaging with $\ell_1$ optimization
Liliana Borcea,Ilker Kocyigit
Mathematics , 2015,
Abstract: We study array imaging of a sparse scene of point-like sources or scatterers in a homogeneous medium. For source imaging the sensors in the array are receivers that collect measurements of the wave field. For imaging scatterers the array probes the medium with waves and records the echoes. In either case the image formation is stated as a sparsity promoting $\ell_1$ optimization problem, and the goal of the paper is to quantify the resolution. We consider both narrow-band and broad-band imaging, and a geometric setup with a small array. We take first the case of the unknowns lying on the imaging grid, and derive resolution limits that depend on the sparsity of the scene. Then we consider the general case with the unknowns at arbitrary locations. The analysis is based on estimates of the cumulative mutual coherence and a related concept, which we call interaction coefficient. It complements recent results in compressed sensing by deriving deterministic resolution limits that account for worse case scenarios in terms of locations of the unknowns in the imaging region, and also by interpreting the results in some cases where uniqueness of the solution does not hold. We demonstrate the theoretical predictions with numerical simulations.
On the Convex Hulls of Self-Affine Fractals
Ibrahim Kirat,Ilker Kocyigit
Mathematics , 2015,
Abstract: Suppose that the set ${\mathcal{T}}= \{T_1, T_2,...,T_q \} $ of real $n\times n$ matrices has joint spectral radius less than $1$. Then for any digit set $ D= \{d_1, \cdots, d_q\} \subset {\Bbb R}^n$, there exists a unique nonempty compact set $F=F({\mathcal{T}},D)$ satisfying $ F = \bigcup _{j =1}^q T_j(F + d_j)$, which is called a self-affine fractal. We consider an existing criterion for the convex hull of $F$ to be a polytope, which is due to Kirat and Kocyigit. In this note, we strengthen our criterion for the case $T_1=T_2=\cdots =T_q $. More specifically, we give an upper bound for the number of steps needed for deciding whether the convex hull of $F$ is a polytope or not. This improves our earlier result on the topic.
The mercury forms in soil and their ecological importance
Merva Milan,Zaic Ján
Acta Montanistica Slovaca , 1997,
Abstract: Ecological and hygienic importance of mercury to environment results from its physical and chemical properties. At temperatures usual for the temperate climatic zone, the mercury is a liquid metal with relatively high tension of saturated vapours. Interaction of these vapours with a solid phase is realised predominantly by physical forces on the phase interface through the mediation of the adsorption mechanism. Contamination of the soil occurs and the soil consequently becomes an emitter of mercury since the processes of physical adsorption and desorption in the environment are reversible processes. On three examples the authors demonstrate the manifestations of physical adsorption and desorption on the soil samples and point out the relevant part of this contamination mechanism in the entire soil contamination. From the point of view of a possible separation of individual contributions to the solid phase contamination, either of anthropogeneous or natural origin, the authors recommend to use the recording of a thermodesorption curve for defining three regions characterizing the origin, or forms of mercury and its bound to the solid phase. Authors state that the current analytical methods for determining the mercury concentration in a solid phase provide an information on the so called entire mercury in it but do not distinguish individual mercury forms. From an ecological as well as hygienical point of view, the mercury content in a solid phase reveals more important from the physical adsorption, as it is the mercury form which is very mobil and interactive in respect of the other components of the environment.
Resorption of a Sequestrated Cervical Disc
Kocyigit A,Kocyigit A,Manisali M,Akalin E
Indian Journal of Physical Medicine and Rehabilitation , 2010,
Abstract: In literature cervical disc extrusions are considered bymost neurosurgeons a definitive indication for surgery.This approach may stem from a fear of disc fragmentmigration with neurological deterioration. We report arare case of cervical disc sequestration with a seldomprognosis which resolved spontaneously in a 2 monthfollow up on magnetic resonance imaging, emphasizingthe efficacy and applicability of conservative treatmentin cervical disc herniations. Even with the basicconservative treatment methods we observed theprominent decrease in symptoms and spontaneous totalresorption of the sequestrated fragment. Conservativetreatment in sequestrated cervical discs with noneurological deficit can be an alternative therapeuticapproach with the guidence of MRI.
A Case of Pituitary Hemorrhage Following Cardiopulmonary Bypass Surgery  [PDF]
Ozgen Ilgaz Kocyigit, Serdar Kabatas, Erdinc Civelek, Ezgi Tuncay, Oguz Omay, Tufan Cansever, Ayda Turkoz
Surgical Science (SS) , 2011, DOI: 10.4236/ss.2011.23034
Abstract: A 68-year-old female patient with previous history of transsphenoidal hypophysectomy operation underwent three-vessel coronary artery bypass graft (CABG) surgery for extensive coronary artery disease. Preoperative neurological examination revealed sequelae visual loss at right temporal visual field. Follow-up Magnetic Resonance Imaging studies showed a residual hypophyseal tumor tissue extending to suprasellar area. No additional pathology was detected in the early postoperative cranial control CT, but aggravation of visual field defect was determined. Coincidently, cranial magnetic resonance imaging (MRI) showed hemorrhage into the tumor tissue. We decided to follow-up the patient who exhibited no additional symptoms and was discharged well on the fifth day due to the signs of resolution of hemorrhage. Follow-up controls of the patient at sixth and twelfth months demonstrated normal hormone levels without any additional clinical complaints. We present preoperative assessment, perioperative anesthesia management, and postoperative clinical follow-up of a patient with a residual hypophyseal tumor.
A molecular-based fast method to determine the extent of DNA damages in higher plants and fungi
M Dikilitas, A Kocyigit, F Yigit
African Journal of Biotechnology , 2009,
Abstract: Comet assay also called ‘single cell gel electrophoresis is a technique for the detection of DNA damage and repair at the level of single cells, which is one of the most advanced techniques introduced to the agricultural sciences in recent years. The assay is one of the most popular tests of DNA damage detection (e.g. single and double-strand breaks, oxidative-induced base damage and DNA-DNA/DNAprotein cross linking) by electrophoresis. The assay is very sensitive, rapid, easy to handle, noninvasive, visual and inexpensive compared to most conventional techniques to detect DNA damage, there is also little amount of cell samples required and it is applicable for most eukaryotic cells, thus, it has rapidly gained importance in the fields of genetic toxicology, medicine, environmental studies and agriculture. Isolated DNA from cells are embedded in a thin agarose gel on a microscope slide and unwound in a suitable buffer and exposed to a weak electric field to attract broken, negatively-charged DNA towards the anode. After electrophoresis, migrated DNA fragments stained with a fluorescent dye would resemble a shape of a comet observed by a fluorescence microscopy. The extent of comet-like shapes would indicate the level of DNA damage in cells. The intensity of comet tail relative to the head would also reflect the extent of DNA damage in numerical.
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