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Search Results: 1 - 10 of 225 matches for " Meri Hovsepyan "
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Reduced levels of SCD1 accentuate palmitate-induced stress in insulin-producing β-cells
Kristofer Th?rn, Meri Hovsepyan, Peter Bergsten
Lipids in Health and Disease , 2010, DOI: 10.1186/1476-511x-9-108
Abstract: Insulin-secreting MIN6 cells with reduced levels of SCD1 were established by siRNA mediated knockdown. When fatty acid oxidation was measured, no difference between cells with reduced levels of SCD1 and mock-transfected cells were found. Also, reducing levels of SCD1 did not affect insulin secretion in response to glucose. To investigate how SCD1 knockdown affected cellular mechanisms, differentially regulated proteins were identified by a proteomic approach. Cells with reduced levels of SCD1 had higher levels of ER chaperones and components of the proteasome. The higher amounts did not protect the β-cell from palmitate-induced ER stress and apoptosis. Instead, rise in levels of p-eIF2α and CHOP after palmitate exposure was 2-fold higher in cells with reduced levels of SCD1 compared to mock-transfected cells. Accordingly, apoptosis rose to higher levels after exposure to palmitate in cells with reduced levels of SCD1 compared to mock-transfected cells.In conclusion, reduced levels of SCD1 augment palmitate-induced ER stress and apoptosis in the β-cell, which is an important caveat when considering targeting this enzyme as a treatment of the metabolic syndrome.Stearoyl-CoA desaturases (SCD:s) are a family of endoplasmic reticulum (ER) resident enzymes introducing a Δ9 double-bond in saturated fatty acids, thereby generating their monounsaturated counterparts [1]. In mice, four isoforms of SCD have been characterized, which all catalyze the same reaction but have somewhat different substrate specificities [1]. The physiological role of having multiple isoforms is not fully understood, but the different expression patterns and inducibility indicate exclusive roles for the different isoforms [2]. In humans, only one functional ortholog to mouse SCD has been found [3]. In addition, humans express another SCD isoform, termed hSCD5, which is unique to primates [4]. Much focus has been directed towards the SCD1 isoform, which is ubiquitously expressed in mouse, and the majo
Cryoglobulins as Potential Triggers of Inflammation in Schizophrenia
Andranik Chavushyan,Meri Hovsepyan,Anna Boyajyan
Schizophrenia Research and Treatment , 2013, DOI: 10.1155/2013/125264
Abstract: This case study aimed to investigate effects of type III cryoglobulins isolated from the blood of patients with schizophrenia on the production of proinflammatory cytokines interleukin(IL)-1β, IL-6 and tumor necrosis factor-α (TNF-α), anti-inflammatory cytokine IL-10, and chemotactic cytokines IL-8 and monocyte chemoattractant protein-1 (MCP-1) by peripheral blood mononuclear cells (PBMCs). The experiments were performed in vitro using PBMCs healthy subjects and the blood of patients whit schizoprenia. The enzyme-linked immunosorbent assay and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay were used upon study. The results obtained indicated significant increase ( ) in IL-1β, IL-6, TNF-α, IL-8, and MCP-1 production by cultured PBMCs when incubating for 24 hours with cryoglobulins, beginning from 0.4?mg/mL. The gender difference does not affect the cryoglobulins-induced production of these cytokines by PBMCs. No influence of cryoglobulins on production of IL-10 by PBMCs was observed. Also, it was shown that cryoglobulins in concentration ≤4?mg/mL possessed no cytotoxic effect towards cultured PBMCs. Based upon the results obtained, we concluded that type III cryoglobulins are implicated in schizophrenia-associated alterations in the immune response through induction of the expression of proinflammatory and chemotactic cytokines by PBMCs. 1. Introduction A considerable evidence suggests a role for upregulated immune response in the pathogenesis of schizophrenia (SCZ), since alterations in both the innate and adaptive immunity including autoimmune and inflammatory components were described in this pathology at both central and peripheral levels [1–7]. Moreover, according to a genetic-vascular-inflammatory hypothesis based upon a number of epidemiologic, clinical, and experimental studies, SCZ generates from a damage of the brain microvascular system initiated by genetically induced upregulated inflammatory reactions developed in response to ubiquitous environmental factors [8]. The results of our previous study revealed the detectable blood levels of type III cryoglobulins (Cgs) in SCZ and found the presence of complement activation split products in these complexes [9]. The presence of Cgs in the blood is detected in lymphoproliferative, autoimmune and infectious diseases and considered as a marker of the immune system chronic activation, inflammation, and autoimmune sensitization [10, 11]. Cgs can cause immune complex vacuities by depositing in the blood vessels, bind complement components, activate the complement system, and induce
Proteins altered by elevated levels of palmitate or glucose implicated in impaired glucose-stimulated insulin secretion
E-ri M Sol, Meri Hovsepyan, Peter Bergsten
Proteome Science , 2009, DOI: 10.1186/1477-5956-7-24
Abstract: After culture, cells were protein profiled by SELDI-TOF-MS and 2D-PAGE. Differentially expressed proteins were discovered and identified by peptide mass fingerprinting. Complimentary protein profiles were obtained by the two approaches with SELDI-TOF-MS being more efficient in separating proteins in the low molecular range and 2D-PAGE in the high molecular range. Identified proteins included alpha glucosidase, calmodulin, gars, glucose-6-phosphate dehydrogenase, heterogenous nuclear ribonucleoprotein A3, lon peptidase, nicotineamide adenine dinucleotide hydrogen (NADH) dehydrogenase, phosphoglycerate kinase, proteasome p45, rab2, pyruvate kinase and t-complex protein. The observed glucose-induced differential protein expression pattern indicates enhanced glucose metabolism, defense against reactive oxygen species, enhanced protein translation, folding and degradation and decreased insulin granular formation and trafficking. Palmitate-induced changes could be related to altered exocytosis.The identified altered proteins indicate mechanism important for altered β-cell function in T2DM.Reduced insulin secretory capacity and loss of mass of the pancreatic β-cells are hallmarks in the development of type 2 diabetes mellitus (T2DM) [1,2]. The aberrant insulin secretory characteristics have been linked to exposure of the cells to prolonged periods of elevated glucose and fatty acid levels [3]. The secretory alterations depend on what fatty acid is present during exposure and include enhanced secretion at basal glucose concentrations and/or lowered insulin levels at elevated glucose concentrations [3,4]. These alterations lead to reduced or even abolished glucose-stimulated insulin secretion (GSIS). In addition, β-cell mass is reduced by the combined elevation of glucose and fatty acids [5]. The fatty acid palmitate has especially negative effects on both β-cell function and mass via different mechanisms [4,6-10]. Despite these efforts to define causes responsible for the a
Residual Control Rights, Transferable Returns, and Their Implications for Ownership Structure  [PDF]
Meri Melkonyan
Modern Economy (ME) , 2013, DOI: 10.4236/me.2013.45039
Abstract:

The paper examines the consolidation problem in a model characterized by non-contractible, relationship specific investments, transferable and non-transferable payoffs, and ex post actions that are chosen after the uncertainty in the model is realized. We determine the relationship between the optimal ownership structure and the nature of the relationship specific investments and ex post actions and the degree to which payoffs are transferable with ownership.

The Effect on Growth of a Tax Shift between Land Value Taxes and Income Taxes in Denmark  [PDF]
Philip Allan, Gohar Hovsepyan
Modern Economy (ME) , 2019, DOI: 10.4236/me.2019.108119
Abstract: A land value tax (LVT) is different from a property tax in that it only taxes the underlying land, not the structure built on top of it. LVT is recognized by economists across the political spectrum, as the only tax raising significant revenue which theoretically does not diminish economic activity (and even increases it). This is in part because land is fixed and supply, and cannot be moved when taxed. An LVT instead encourages development of the land. This paper maps the ratio of LVT to other taxes in Denmark over time, and assesses its effect on economic growth. We can conclude that just as in theory, empirical evidence in the case of Denmark also shows positive results with regards to economic growth.
THE ANALYSIS OF THE CREATIVITY AND DECION MAKING ABILITIEES OF UNIVERSITY STUDENTS ACCORDING TO SOME VARIABLES
Meri? ERASLAN
Beden Egitimi ve Spor Bilimleri Dergisi , 2012,
Abstract: In this study it was aimed to analyze the creativity and decision making abilities of chess sportsmen according to gender, department and NPD (National Power Degree) score. For this reason, 107 university chess sportsmen of whom are 81 male 26 female have participated to research and The Creativity Scale (Kirton, 1976) and Melbourne Decision Making scale I- II (Man and Ark, 1998) have been used in this study. The creativity abilities of chess sportsmen have been analyzed via ANOVA test for department, and T Test for gender and NPD score. The decision making abilities have been tested via single optioned MANOVA analysis for the three variables. At the end of this study a meaningful discrepancy couldn’t be found for the variables gender (t(105)=1.013, P>0.05), NPD score t(105)=1.060, P>0.05) and department (f(1,235)=0,501, P>0.05) for creativity abilities of students. However, while it has been reached to meaningful results for the purpose of gender they are attentive, prudent and sub-dimension of panic (Wilks Lambda λ=.887; F (4,102)=3.253;P≤0.05), and for the purpose of department they are prudent (F (2,104)=3.235; P≤0.05), meaningful results could not be ascertained for NPD score (Wilks Lambda λ=.987;F (4,102)=0.329; P>0.05). As a result it can be said that the creativity abilities of chess sportsmen do not change according to gender, department and NPD score. In terms of decision making, it can be claimed that while males are more attentive, females are quick for solution, and the students from social and human sciences hold over their decisions than the students of technical sciences, and the experience is not an effective tool In terms of decision making.
The Profitability of Banking Sector in Republic of Macedonia
Meri Boshkoska
International Journal of Economics and Finance , 2013, DOI: 10.5539/ijef.v5n3p143
Abstract: The banking sector has a dominant role in the process of mediating and dispersing the finances of the economical subject with suffice towards the ones with a deficit. Although it is well known fact that the banking sector plays the major role in the enhancing and developing of a country’s economy, it is evident that this sector is under big influence of the changes within the financial environment-regarding the situation of the capital market on a global scale. If the banking sector functions efficiently, give loans to support the enterprises, it leads to bigger consumption-meaning that for the population of the country the banking sector is highly valued and trusted. The paper examines the structure and the profitability of the banking sector in Republic of Macedonia comparing with the banking sectors of some countries in the region.
Some remarks on the Cantor pairing function SOME REMARKS ON THE CANTOR PAIRING FUNCTION
Meri Lisi
Le Matematiche , 2007,
Abstract: In this paper, some results and generalizations about the Cantor pairing function are given. In particular, it is investigated a very compact expression for the n-degree generalized Cantor pairing function (g.C.p.f., for short), that permits to obtain n tupling functions which have the characteristics to be n-degree polynomials with rational coefficients. A recursive formula for the n-degree g.C.p.f. is also provided. In this paper, some results and generalizations about the Cantor pairing function are given. In particular, it is investigated a very compact expression for the n-degree generalized Cantor pairing function (g.C.p.f., for short), that permits to obtain n tupling functions which have the characteristics to be n-degree polynomials with rational coef cients. A recursive formula for the n-degree g.C.p.f. is also provided.
Adicciones y complicidades: placer, cuerpo y lenguaje o la osadía narrativa de Flavia Company
Torras, Meri
Arbor : Ciencia, Pensamiento y Cultura , 2006, DOI: 10.3989/arbor.2006.i721.57
Abstract: This article focuses on the fiction work of the Argentine- Catalan-Spanish author Flavia Company (1963) and makes a further analysis on the forms and the genres of the literary tradition, specially focusing in the text Dame Placer (1999) (give me pleasure). Areading of this novel is proposed in a thematic-formal dialog between this particular work and some other own and alien literary works along with the transformation of the epistolary tradition of the heroines, seduced and abandoned. The accurate work of the author describing the passion in the text anatomy is also emphasized along with the search for the readers’ complicity through the counter-character of the narrator. Este artículo se centra en la obra narrativa de la autora argentino-catalana-espa ola Flavia Company (1963) y analiza el uso experimental de las formas y los géneros de la tradición literaria, centrándose fundamentalmente en el texto Dame placer (1999). Se propone una lectura de esta novela en diálogo temático-formal con otras obras literarias—propias y ajenas—, así como transformación de la tradición epistolar de las heroínas literarias seducidas y abandonadas. Igualmente, se pone de manifiesto la cuidadosa labor de la autora para escribir la pasión en la anatomía del texto así como la búsqueda de la complicidad lectora, a través de la contrafigura de la narrataria.
Excitations of photon-number states in Kerr nonlinear resonator at finite temperatures
G. H. Hovsepyan,G. Yu. Kryuchkyan
Physics , 2014, DOI: 10.1140/epjd/e2015-50738-y
Abstract: We investigate temperature reservoir effects in a lossy Kerr nonlinear resonator considering selective excitation of ooscillatory mode driven by a sequence of Gaussian pulses. In this way, we analyze time-dependent populations of photon-number states and quantum statistics on the base of second-order photon correlation function in one-photon and two-photon transitions. The effects coming from thermal reservoirs are interesting for performing more realistic approach to generate Fock states and for study phenomena connecting quantum engineering and temperature. We also study the role of pulse-shaping effects during selective excitation.
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