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Search Results: 1 - 10 of 4980 matches for " Melanie White-Koning "
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Assessing the quality of life of children with mental disorders using a computer-based self-reported generic instrument (KidIQoL)—Quality of life of children with mental disorders  [PDF]
Melanie White-Koning, Hélène Grandjean, Martine Gayral-Taminh, Valérie Lauwers-Cancès, Jean-Philippe Raynaud
Open Journal of Psychiatry (OJPsych) , 2011, DOI: 10.4236/ojpsych.2011.11002
Abstract: OBJECTIVE: To assess the self-reported quality of life (Qol) of children with various mental disorders and compare the scores in this population with those in children without such problems. METHODS: Self- reported Qol was assessed using KidiQoL, a generic computer-based tool with 44 items exploring four domains (Physical and psychological health, Family life, School life and Social and physical environment). The study group consisted of 139 children (111 boys and 28 girls) aged between 6 and 12 years (mean age 9.1 years) referred to an outpatient mental health unit for mental disorders, 29 of whom completed the questionnaire about 2 weeks later in order to assess test-retest reliability. The comparison group consisted of 130 children from the general population, aged 6 to 12 years (mean age 9.0 years) and attending main- stream schools in the same geographical area. RE- SULTS: The test-retest reliability of the instrument was very good with an intraclass correlation coefficient of 0.97 for the total score and above 0.90 in all domains. No significant differences in domain and total scores were observed according to gender or developmental age. Children with developmental disorders or schizophrenia reported significantly lower QoL in the Health domain than children with other types of mental disorders. In all domains and for the total score, the children with mental disorders re- ported significantly lower QoL than the children from the general population; CONCLUSION: KidIQoL has been found suitable and psychometrically valid in children with mental disorders. Its use could help the assessment and adaptation of psychiatric care.
A Molecular Toolbox for Rapid Generation of Viral Vectors to Up- or Down-Regulate Neuronal Gene Expression in vivo
Melanie D. White,Matthew F. Nolan
Frontiers in Molecular Neuroscience , 2011, DOI: 10.3389/fnmol.2011.00008
Abstract: We introduce a molecular toolbox for manipulation of neuronal gene expression in vivo. The toolbox includes promoters, ion channels, optogenetic tools, fluorescent proteins, and intronic artificial microRNAs. The components are easily assembled into adeno-associated virus (AAV) or lentivirus vectors using recombination cloning. We demonstrate assembly of toolbox components into lentivirus and AAV vectors and use these vectors for in vivo expression of inwardly rectifying potassium channels (Kir2.1, Kir3.1, and Kir3.2) and an artificial microRNA targeted against the ion channel HCN1 (HCN1 miRNA). We show that AAV assembled to express HCN1 miRNA produces efficacious and specific in vivo knockdown of HCN1 channels. Comparison of in vivo viral transduction using HCN1 miRNA with mice containing a germ line deletion of HCN1 reveals similar physiological phenotypes in cerebellar Purkinje cells. The easy assembly and re-usability of the toolbox components, together with the ability to up- or down-regulate neuronal gene expression in vivo, may be useful for applications in many areas of neuroscience.
Comparing Simple Quasar Demographics Models
Melanie Veale,Martin White,Charlie Conroy
Physics , 2014, DOI: 10.1093/mnras/stu1821
Abstract: This paper explores several simple model variations for the connections among quasars, galaxies, and dark matter halos for redshifts 1 < z < 6. A key component of these models is that we enforce a self-consistent black hole (BH) history by tracking both BH mass and BH growth rate at all redshifts. We connect objects across redshift with a simple constant-number-density procedure, and choose a fiducial model with a relationship between BH and galaxy growth rates that is linear and evolves in a simple way with redshift. Within this fiducial model, we find the quasar luminosity function (QLF) by calculating an "intrinsic" luminosity based on either the BH mass or BH growth rate, and then choosing a model of quasar variability with either a lognormal or truncated power-law distribution of instantaneous luminosities. This gives four model variations, which we fit to the observed QLF at each redshift. With the best-fit models in hand, we undertake a detailed comparison of the four fiducial models, and explore changes to our fiducial model of the BH-galaxy relationship. Each model variation can successfully fit the observed QLF, the shape of which is generally set by the "intrinsic" luminosity at the faint end and by the scatter due to variability at the bright end. We focus on accounting for the reasons that physically different models can make such similar predictions, and on identifying what observational data or physical arguments are most essential in breaking the degeneracies among models.
Developing an educational framework for the teaching of simulation within nurse education  [PDF]
Melanie Humphreys
Open Journal of Nursing (OJN) , 2013, DOI: 10.4236/ojn.2013.34049
Abstract:

The use of simulations as a teaching and learning tool within health care has increasing importance; simulations are seen as the major teaching method for practicing and assessing developing skills, knowledge, attitudes and meaningful decision-making within the field of nursing. Certainly the utilisations of simulations feature widely within many aspects of health care; a greater understanding of the key conceptual notions will serve to benefit all of those engaged within their application. This literature review has enabled the construction of a conceptual model for the teaching of simulation and can serve to promote the continued positive development of simulations within education. Through a consistent and insightful approach to teaching, dynamic learning will be assured within this very important aspect of engaging the nursing student within the learning process.

A Tertiary Twist to the Transglutaminase Tale
Frits Koning
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.0050337
Abstract:
Novo nascimento crist?o: uma nova identidade? Convers?o, etnicidade e cidadania na Indonésia
Koning, Juliette;
Religi?o & Sociedade , 2008, DOI: 10.1590/S0100-85872008000100003
Abstract: the current upsurge of pentecostal-charismatic christianity in asia and the participation of ethnic chinese therein, raise the question whether the adherence to charismatic belief has become part of an ethnic chinese 'identity'. in the context of a more general discussion on the global appeal of charismatic christianity, this paper zooms in on the situation in indonesia a country where the majority population is muslim. the aim is to come to an understanding of the manner in which the new born christian chinese in this study give meaning to their conversion experiences.
A Tertiary Twist to the Transglutaminase Tale
Frits Koning
PLOS Biology , 2007, DOI: 10.1371/journal.pbio.0050337
Abstract:
Epigenetic Repression of p16INK4A by Latent Epstein-Barr Virus Requires the Interaction of EBNA3A and EBNA3C with CtBP
Lenka Skalska equal contributor,Robert E. White equal contributor,Melanie Franz,Michaela Ruhmann,Martin J. Allday
PLOS Pathogens , 2010, DOI: 10.1371/journal.ppat.1000951
Abstract: As an inhibitor of cyclin-dependent kinases, p16INK4A is an important tumour suppressor and inducer of cellular senescence that is often inactivated during the development of cancer by promoter DNA methylation. Using newly established lymphoblastoid cell lines (LCLs) expressing a conditional EBNA3C from recombinant EBV, we demonstrate that EBNA3C inactivation initiates chromatin remodelling that resets the epigenetic status of p16INK4A to permit transcriptional activation: the polycomb-associated repressive H3K27me3 histone modification is substantially reduced, while the activation-related mark H3K4me3 is modestly increased. Activation of EBNA3C reverses the distribution of these epigenetic marks, represses p16INK4A transcription and allows proliferation. LCLs lacking EBNA3A express relatively high levels of p16INK4A and have a similar pattern of histone modifications on p16INK4A as produced by the inactivation of EBNA3C. Since binding to the co-repressor of transcription CtBP has been linked to the oncogenic activity of EBNA3A and EBNA3C, we established LCLs with recombinant viruses encoding EBNA3A- and/or EBNA3C-mutants that no longer bind CtBP. These novel LCLs have revealed that the chromatin remodelling and epigenetic repression of p16INK4A requires the interaction of both EBNA3A and EBNA3C with CtBP. The repression of p16INK4A by latent EBV will not only overcome senescence in infected B cells, but may also pave the way for p16INK4A DNA methylation during B cell lymphomagenesis.
Behavioral phenotypes of impulsivity related to the ANKK1 gene are independent of an acute stressor
Melanie J White, C Phillip Morris, Bruce R Lawford, Ross Young
Behavioral and Brain Functions , 2008, DOI: 10.1186/1744-9081-4-54
Abstract: TaqIA genotyping was conducted on 72 healthy young adults who were randomly allocated to either an acute psychosocial stress or relaxation induction condition. Behavioral phenotypes of impulsivity were measured using a card-sorting index of reinforcement sensitivity and computerized response inhibition and delay discounting tasks.Separate analyses of variance revealed associations between the A1 allele and two laboratory measures of impulsivity. The presence of the TaqIA allele (A1+) was associated with slower card-sorting in the presence of small financial reinforcers, but was overcome in a second administration after either a five-minute rest or psychosocial stress induction. A1+ participants also demonstrated significantly poorer response inhibition and faster response times on a computerized stop inhibition task, independent of acute stress exposure.These findings indicate the A1 allele is associated with an endophenotype comprising both a "rash impulsive" behavioral style and reinforcement-related learning deficits. These effects are independent of stress.The phenotypes of multiple psychiatric disorders involve features of impulsivity including attention deficit hyperactivity disorder (ADHD), bipolar disorder, mania, bulimia nervosa, several personality disorders, schizophrenia and substance dependence [1]. Impulsivity is also implicated in several forms of aggression and violence, sexual impulsivity, binge eating, obesity, self-harm and suicidal behavior [2]. As such, the study of factors that may contribute to impulsivity is fundamental to understanding and treating maladaptive human behavior.Dopamine is integral to leading theories of an impulsive personality phenotype [3,4] and plays a crucial role in brain reinforcement circuits [2,5]. Personality theories of impulsivity also consistently emphasize the role of genetics, reflecting evidence from twin studies of high heritability on self-report measures, including sensation seeking (55% [6]), novelty seeking
Extended Model of Stock Price Behaviour  [PDF]
Nico Koning, Daniel T. Cassidy, Rachid Ouyed
Journal of Mathematical Finance (JMF) , 2018, DOI: 10.4236/jmf.2018.81001
Abstract: We have developed an extended model for stock price behaviour that is able to accommodate fat-tailed distributions with support as large as \"\" . The “homogeneously saturated” (HS) model avoids exponential price changes for large fluctuations by means of a saturation parameter. In the limit where the saturation parameter is zero, the standard model of stock price behaviour (i.e., geometric Brownian motion) is recovered. We compare simulated stock price series generated for both the standard and HS model for the DJIA and five random stocks from the NYSE and NASDAQ exchanges. We find that in all cases, the HS model provides a better fit to the observed price series than the standard model. This has implications to many areas of finance including the Black-Scholes formula for option pricing.
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