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Search Results: 1 - 10 of 231 matches for " Meike Vogler "
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Targeting BCL2-Proteins for the Treatment of Solid Tumours
Meike Vogler
Advances in Medicine , 2014, DOI: 10.1155/2014/943648
Abstract: Due to their central role in the regulation of apoptosis, the antiapoptotic BCL2-proteins are highly promising targets for the development of novel anticancer treatments. To this end, several strategies have been developed to inhibit BCL2, , BCL-w, and MCL1. While early clinical trials in haematological malignancies demonstrated exciting single-agent activity of BCL2-inhibitors, the response in solid tumours was limited, indicating that, in solid tumours, different strategies have to be developed in order to successfully treat patients with BCL2-inhibitors. In this review, the function of the different antiapoptotic BCL2-proteins and their role in solid tumours will be discussed. In addition, a comprehensive analysis of current small molecules targeting these antiapoptotic BCL2-proteins (e.g., ABT-737, ABT-263, ABT-199, TW-37, sabutoclax, obatoclax, and MIM1) will be provided including a discussion of the results of any clinical trials. This analysis will summarise the potential of BCL2-inhibitors for the treatment of solid tumours and will unravel novel approaches to utilise these inhibitors in clinical applications. 1. Mechanisms of Apoptosis Evasion of cell death or apoptosis is a key hallmark of cancer [1]. Generally, cells can die by apoptosis, a form of programmed cell death, or after acute injury by necrosis and cell lysis, which initiates an inflammatory response. Apoptosis was first described as a unique process associated with typical morphological changes by Carl Vogt as early as 1842 and was named apoptosis in 1972 [2]. It is a common property of multicellular organisms and is present in virtually all cell types throughout the body. Apoptosis plays a fundamental role in physiological processes, especially in mammalian development and the immune system [3, 4]. In addition, apoptosis represents a major barrier to cancer cells that must be circumvented. Therefore, many tumours acquire resistance to apoptosis through a variety of strategies. The most commonly occurring loss of a proapoptotic regulator involves the p53 tumour suppressor gene [5]. In addition to the activation of proapoptotic factors, resistance to apoptosis is often due to upregulation of antiapoptotic factors. Thus, a number of genes that encode components of the apoptotic machinery are directly targeted by activating or inactivating genetic lesions in cancer cells. In many tumours, deregulation of cell death underlies drug resistance and is a major reason for failure of conventional anticancer therapy. Upon activation, apoptosis unfolds in a precisely organised series of steps,
The Numerical Simulation of General Relativistic Shock Waves by a Locally Inertial Godunov Method Featuring Dynamical Time Dilation
Zeke Vogler
Mathematics , 2011, DOI: 10.1098/rspa.2011.0355
Abstract: We introduce what we call a locally inertial Godunov method with dynamical time dilation, and use it to simulate a new one parameter family of general relativistic shock wave solutions of the Einstein equations for a perfect fluid. The forward time solutions resolve the secondary reflected wave (an incoming shock wave) in the Smoller-Temple shock wave model for an explosion into a static singular isothermal sphere. The backward time solutions indicate black hole formation from a smooth underlying solution via collapse associated with an incoming rarefaction wave. As far as we know, this is the first numerical simulation of a fluid dynamical shock wave in general relativity.
Smut fungi (Ustilaginomycetes and Microbotryales, Basidiomycota) in Panama
Piepenbring,Meike;
Revista de Biología Tropical , 2001,
Abstract: this is the first publication dedicated to the diversity of smut fungi in panama bases on field work, the study of herbarium specimens, and referentes taken from literatura. it includes smuts parasitizing cultivated and wild plants. the latter are mostly found in rural vegetation. among the 24 species cites here, 14 species are recorded for the first time for panama. one of them, sporisorium ovarium, is observes for the first time in central america. entyloma spilanthis is found on the host species acmella papposa var. macrophylla (asteraceae) for the first time. entyloma costaricense and entyloma ecuadorense are considered synonyms of entyloma compositarum and entyloma spilanthis respectively. for the new conbination sponsorium panamensis see note at the end of this publication. descriptions of the species are complemented by some illustrations, a checklist, and a key.
Review: Gabriele Lucius-Hoene & Arnulf Deppermann (2002). Rekonstruktion narrativer Identit t. Ein Arbeitsbuch zur Analyse narrativer Interviews Review: Gabriele Lucius-Hoene & Arnulf Deppermann (2002). Rekonstruktion narrativer Identit t. Ein Arbeitsbuch zur Analyse narrativer Interviews [The Reconstruction of Narrative Identity. A Guide to the Analysis of Narrative Interviews] Rese a: Gabriele Lucius-Hoene & Arnulf Deppermann (2002). Rekonstruktion narrativer Identit t. Ein Arbeitsbuch zur Analyse narrati
Meike Schwabe
Forum : Qualitative Social Research , 2003,
Abstract: Das narrative Interview stellt seit langem ein beliebtes und wichtiges Instrument in der qualitativen Sozialforschung dar. Gabriele LUCIUS-HOENE und Arnulf DEPPERMANN verbinden das narrative Interview in diesem Band mit dem Konzept der narrativen Identit t: Autobiographisches Erz hlen wird so als N hrboden aufgefasst, auf dem Identit tskonstruktionen entstehen und zugleich dargestellt werden. Aufgrund der Fülle und Vielfalt auch neuerer identit tsorientierter Forschungsfragen legen die Autoren in diesem Band ein methodisch reflektiertes und flexibles Auswertungsinstrumentarium vor, das speziell auf solche Fragen ausgerichtet ist. Hierbei beziehen sie Erkenntnisse aus der Erz hl- und Gespr chsforschung sowie der diskursiven Psychologie mit ein. In der Form eines Arbeitsbuchs stellen sie forschungspraktische Fragen und analytische Verfahren zusammen und wenden sich damit in erster Linie an qualitativ Forschende, die sich für Identit tsarbeit in verbaler Interaktion interessieren. In gleichem Ma e nützlich erscheint es aber auch für alle, die eine reflektierte Zusammenstellung von Forschungsergebnissen aus verschiedenen diskursiven Disziplinen suchen. URN: urn:nbn:de:0114-fqs030354 The narrative interview has developed into an important instrument in qualitative research. In this guide book, Gabriele LUCIUS-HOENE and Arnulf DEPPERMANN consistently link the narrative interview to the reconstruction of narrative identities: they regard autobiographical narratives as the soil in which identity constructions are simultaneously developed and presented. Due to the growing number and diversity of research focused on questions of identity and biography in the last few years, the authors compile a set of instruments for the analytical reconstruction of such identity work, which is methodologically reflected as well as flexible in its application. In order to do so, they draw on findings of such fields as narrative psychology, conversation analysis and narrative analysis. Because the book is designed as a study book, it particularly addresses those in qualitative research who are interested in identity work within verbal interaction. Furthermore, it offers a reflective collection of research findings of various discursive disciplines. URN: urn:nbn:de:0114-fqs030354 La entrevista narrativa se ha desarrollado como un instrumento importante en la investigación cualitativa. En este libro guía, Gabriele LUCIUS-HOENE y Arnulf DEPPERMANN vinculan consistentemente la entrevista narrativa con la reconstrucción de identidades narrativas: consideran las narrativas autobiográfic
Smut fungi (Ustilaginomycetes and Microbotryales, Basidiomycota) in Panama
Meike Piepenbring
Revista de Biología Tropical , 2001,
Abstract: This is the first publication dedicated to the diversity of smut fungi in Panama bases on field work, the study of herbarium specimens, and referentes taken from literatura. It includes smuts parasitizing cultivated and wild plants. The latter are mostly found in rural vegetation. Among the 24 species cites here, 14 species are recorded for the first time for Panama. One of them, Sporisorium ovarium, is observes for the first time in Central America. Entyloma spilanthis is found on the host species Acmella papposa var. macrophylla (Asteraceae) for the first time. Entyloma costaricense and Entyloma ecuadorense are considered synonyms of Entyloma compositarum and Entyloma spilanthis respectively. For the new conbination Sponsorium panamensis see note at the end of this publication. Descriptions of the species are complemented by some illustrations, a checklist, and a key. Esta es la primera publicación dedicada a la diversidad de carbones en Panamá. Tiene su base en trabajo de campo, estudio de especímenes herborizados y referencias de la literatura. Se incluyen carbones patógenos de plantas cultivadas y silvestres. Las últimas se encontraron sobre todo en zonas rurales. Entre las 24 especies citadas en este estudio, 14 especies son primeros registros para Panamá y una de éstas, Sporisorium ovarium, para América Central. Se encontró Entyloma spilanthis por primera vez en la planta hospedera Acmella papposa var.macrophylla (Asteraceac). Entyloma costaricense y Entyloma ecuadorense son sinónimos de Entyloma compositarum y Entyloma spilanthis respectivamente. "Sphacelotheca" panamensis es una especie dudosa. Se complementan las descripciones de las especies con algunas ilustraciones, una lista de especies y una clave.
Zwischen Skepsis und Ann herung - Island und die Europ ische Union
Meike Stommer
Nordeuropaforum , 2007,
Abstract: Iceland is the only Nordic country which has never applied for membership of the EU. The Icelandic political elite has successfully kept the issue out of the mainstream political discussion. But their actions have not been in line with the political discourse: during the last few decades Iceland has established closer ties to European integration and the EU and, due to decisions made by the political elite, is deeply involved in the processes of European integration. This paper examines the steps which Iceland has taken towards European integration since World War II. The attitudes of the politicalelite, of certain organized groups as well as of the population in general are presented and the reasons for Iceland’s reserved attitude towards the EU are discussed.
Compared Evaluation of Botulinum Toxin A and a Cosmetic Antiperspirant in the Treatment of Focal Axillary Hyperhidrosis  [PDF]
Meike Streker,Stefanie Lübberding,Martina Kerscher
Journal of Cosmetics, Dermatological Sciences and Applications (JCDSA) , 2013, DOI: 10.4236/jcdsa.2013.33029
Abstract: Background: Primary focal hyperhidrosis can significantly reduce quality of life. Therefore a lot of treatment options in a range of conservative, physical and surgical techniques are available. Objective: To assess the efficacy of an antiperspirant containing aluminum chloride compared to a Botulinumtoxin A treatment for patients with primary focal hyperhidrosis. Methods and material: In this randomized, single-center, half-side trail, a clinical score was done by patients and physician to evaluate the severity of hyperhidrosis. Gravimetric tests were performed to gather the amount of sweat per unit of time. Furthermore the efficacy was determined using a four point questionnaire. Skin irritation was assessed by measuring pH value and transepidermal water loss. Results: A total of 22 patients were enrolled. Two weeks after baseline the hyperhidrosis level was significantly reduced (BTX-A: ﹣92.9%, AL: 66.7%). In addition both treatment options induced a significant reduction of sweat production (BTX-A: ﹣80.8%, AL: 68.8%). Please change in: Patients evaluated good resp, very good efficacy for both treatment options at day 28. pH value and TEWL never left physiological range. Conclusion: Both botulinum toxin A treatment and an antiperspirant containing aluminum chloride in the evaluated galenic formulation are an effective and safe treatment option for axillary focal hyperhidrosis.
Compared Evaluation of Botulinum Toxin A and a Cosmetic Antiperspirant in the Treatment of Focal Axillary Hyperhidrosis  [PDF]
Meike Streker, Stefanie Lübberding, Martina Kerscher
Journal of Cosmetics, Dermatological Sciences and Applications (JCDSA) , 2013, DOI: 10.4236/jcdsa.2013.33029
Abstract:

Background: Primary focal hyperhidrosis can significantly reduce quality of life. Therefore a lot of treatment options in a range of conservative, physical and surgical techniques are available. Objective: To assess the efficacy of an antiperspirant containing aluminum chloride compared to a Botulinumtoxin A treatment for patients with primary focal hyperhidrosis. Methods and material: In this randomized, single-center, half-side trail, a clinical score was done by patients and physician to evaluate the severity of hyperhidrosis. Gravimetric tests were performed to gather the amount of sweat per unit of time. Furthermore the efficacy was determined using a four point questionnaire. Skin irritation was assessed by measuring pH value and transepidermal water loss. Results: A total of 22 patients were enrolled. Two weeks after baseline the hyperhidrosis level was significantly reduced (BTX-A: 92.9%, AL: 66.7%). In addition both treatment options induced a significant reduction of sweat production (BTX-A: 80.8%, AL: 68.8%). Please change in: Patients evaluated good resp, very good efficacy for both treatment options at day 28. pH value and TEWL never left physiological range. Conclusion: Both botulinum toxin A treatment and an antiperspirant containing aluminum chloride in the evaluated galenic formulation are an effective and safe treatment option for axillary focal hyperhidrosis.

The potential of generics policies: more room for exploitation–PPRI Conference Report
Sabine Vogler, PhD
Generics and Biosimilars Initiative Journal , 2012,
Abstract: Introduction: This Conference Report aims to provide an overview of key results, messages and conclusions of the Pharmaceutical Pricing and Reimbursement Information (PPRI) Conference with regard to generics.Method: The PPRI Conference, organized by the World Health Organization (WHO) Collaborating Centre for Pharmaceutical Pricing and Reimbursement Policies, took place in Vienna, Austria, on 29 and 30 September 2011, with keynote talks, presentations of policies and research results, poster sessions and panel discussions.Results: Several presentations and discussions addressed the topic of generics (64% of all invited contributions, 46% of the accepted abstracts). European and non-European countries use incentives to promote generics as part of their pharmaceutical policy. Budgetary pressure on policymakers has created a sense of urgency to encourage measures to increase generics uptake (i.e. achieve a higher generics market share). There are considerable differences between the prices of originators and (lowest) generic medicines. Presentations included case studies on how to enhance generics uptake.Conclusion: Although policies on generics were not a specific programme strand of the conference, this was a recurring theme throughout. An important lesson from the conference was that the full potential of policies on generics has yet to be fully exploited. Generics uptake could be improved by a more consistent implementation of generics policies.
The impact of pharmaceutical pricing and reimbursement policies on generics uptake: implementation of policy options on generics in 29 European countries─an overview
Sabine Vogler, PhD
Generics and Biosimilars Initiative Journal , 2012,
Abstract: Introduction: To describe pharmaceutical pricing and reimbursement systems in 29 European countries with regard to medicines, particularly generics, and their possible impact on generics uptake.Method: Data collection on pharmaceutical pricing and reimbursement policies with the staff of competent authorities.Results: In most European countries the prices of medicines are controlled at the stage of manufacture (ex-factory price) or wholesale. Usually, price control systems target reimbursable medicines, and the prices of reimbursable generics are regulated. Sixteen of the 29 countries surveyed in this study apply a policy of generic price linkage, i.e. setting the price of the generic medicines at a specific percentage lower than that of the originator. Twenty-two of the surveyed countries run a reference price system, i.e. a reimbursement policy based on clusters of identical or similar medicines for which a fixed amount of reimbursement is granted. Most countries cluster medicines with the same active ingredient, and only a few countries have opted for broader reference groups, thus allowing more interchangeability between choice of medicines and higher savings on costs. Demand-side measures such as generics substitution and/or prescribing by the international non-proprietary name are in place in nearly all the countries surveyed. These are usually not mandatory for the stakeholders concerned.Conclusion: As many pharmaceutical policies tend to address reimbursable medicines, generics fall under the scope of these measures. European countries apply a mix of specific measures to promote generics uptake. There appears to be room for improvement regarding the enforcement of some policies.
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