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Search Results: 1 - 10 of 26586 matches for " Meijer Martin "
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Involvement of the opportunistic pathogen Aspergillus tubingensis in osteomyelitis of the maxillary bone: a case report
Bathoorn Erik,Escobar Salazar Natalia,Sepehrkhouy Shahrzad,Meijer Martin
BMC Infectious Diseases , 2013, DOI: 10.1186/1471-2334-13-59
Abstract: Background Aspergillus tubingensis is a black Aspergillus belonging to the Aspergillus section Nigri, which includes species that morphologically resemble Aspergillus niger. Recent developments in species determination have resulted in clinical isolates presumed to be Aspergillus niger being reclassified as Aspergillus tubingensis by sequencing. We present a report of a patient with an osteomyelitis of the maxillary bone with a probable invasive Aspergillus tubingensis infection. Case presentation We describe an immune compromised patient suffering from osteomyelitis of the maxillary bone after tooth extraction. The osteomyelitis probably resulted in dentogenic pansinusitis presenting as an acute ethmoiditis. Histologic examination of biopsy samples showed osteomyelitis, and inflammation of the surrounding connective tissue. Cultures of the alveolar wound grew Aspergillus tubingensis. The patient was treated with liposomal amphoterocin B, which was changed to oral treatment with voriconazole based on susceptibility testing (MIC for voriconazole was 1 μg/ml). Conclusion This case shows that Aspergillus tubingensis may have the potential to cause severe invasive infections in immunocompromised hosts. A larger proportion of Aspergillus tubingensis isolates are less susceptible to azoles compared to Aspergillus niger. Therefore, correct species identification and susceptibility testing is crucial for the choice of anti-fungal treatment, screening of azole resistance, and characterization of the pathogenic potential of the various species within Aspergillus section Nigri.
Processes of Science and Art Modeled as a Holoflux of Information Using Toroidal Geometry  [PDF]
Dirk K. F. Meijer
Open Journal of Philosophy (OJPP) , 2018, DOI: 10.4236/ojpp.2018.84026
Abstract: An attempt is made to model the structure of science and art discovery processes in the light of currently defined ideas on the societal flow of knowledge and conservation of information, using the versatile physical concept of toroidal geometry. This should be seen as a heuristic model that is open for further development and evolution. The scientific process, has been often described as a iterative and/or recurrent process. Current models explain the generation of new knowledge on the basis of a number of sequential steps (activities) operating in a circular mode. This model intrinsically assumes this process to be congruent for all individual scientific efforts. Yet, such a model is obviously inadequate to fully describe the whole integral process of scientific discovery as an ongoing interactive process, performed in a cumulative fashion. This implies that any new cycle starts from a different perspective or, optimistically seen, is initiated from a higher level, in a spiral mode, that takes into account the ongoing rise of scientific perspectives. Also, any model that attempts to picture the scientific process, should include potential interactions of concepts or hypotheses, in the sense that concurrently developed concepts may (mutually) influence each other and even may be mixed or superposed or, alternatively, may even result in concept extinction. Science and art progression, both seen as an individual effort and as a historically-based flow of events, is inherently a non-linear or even sometimes a chaotic process, where quite suddenly arising visions can cast a very different light on main-stream scientific thought and/or seem to remove existing barriers in more traditional “habits of the mind”. In contrast to the rather gradual evolution of science, the history of art sometimes even shows complete rejection of preceding conceptualizations and styles. The dynamics of cognition and perception are fruitfully suggested by the rotational dynamics of a torus as a basis for its “self-reflexive” property. Also, the torus exhibits contraction/relaxation loops, in which the torus turns inside out in a vibrating mode, implying strange loop trajectories. This suggests that the toroidal geometry embodies a cognitive twist, relating the “inside” to “outside” of knowledge as with a Möbius strip, a phenomenon that can be seen as the basis for self-consciousness. The torus geometry may also be applied to the art process on the basis of personal
The European economic community and economic assosiation
S. Meijer
Koers : Bulletin for Christian Scholarship , 1959, DOI: 10.4102/koers.v26i12.1720
Abstract: I am grateful to the Afrika-Seminaar of the Potchefstroom University for inviting me to give a talk on the European Economic Community and the Association of the Overseas Countries and Territories.
Het wankele voetstuk van de professional
Rietje Meijer
Journal of Social Intervention : Theory and Practice , 2008,
Abstract: The Scientific Council for Government Policies in the Netherlands recommends in its report (2004) that the professional is assigned a more important role in social services. In this article, the author analyses which conditions regarding the quality of the professional should be fulfilled to put this recommendation into effect. First, the rather weak position and autonomy of social workers deserves to be supported and strengthened, both by the government and by professionals themselves. Second, while the importance of a substantial job content and of knowledge development is widely acclaimed, in practice content and knowledge still have to be improved. The author states that this could be realized by creating a stronger developmental climate within organisations. Third, of the personal characteristics of ‘top’ social workers, motivation, an orientation toward development and cooperation, involvement in clients, autonomy, the ability to critically reflect on one’s professional behaviour and being able to establish an public image in the local environment seem to be the most important characteristics to create a successful professional practice.
P.W. van der Veur, The lion and the gadfly. Dutch colonialism and the spirit of E. F. E. Douwes Dekker
Hans Meijer
BMGN : Low Countries Historical Review , 2008,
'Op de drempel tussen twee werelden'. A.H.J. Lovink, de laatste landvoogd van Indonesi
H. Meijer
BMGN : Low Countries Historical Review , 1999,
B. Bouman, Ieder voor zich en de Republiek voor ons allen. De logistiek achter de Indonesische revolutie 1945-1950
Hans Meijer
BMGN : Low Countries Historical Review , 2008,
'Geschiedenis is nu eenmaal altijd politiek.' De studie-Drooglever als symptoom van de moeizame omgang van Nederland met het koloniaal verleden en de complexe relatie met Indonesi . Discussie over Een daad van vrije keuze
H. Meijer
BMGN : Low Countries Historical Review , 2007,
Abstract: ‘History is by definition political’. The Drooglever study as a symptom of the uneasy relationship the Netherlands has with its colonial past and its complex relationship with Indonesia In December 1999, the Dutch Minister of Foreign Affairs, J.J. van Aartsen, complied with a request from parliament for an historical study into the referendum held in 1969 among the Papua population in the former Dutch New Guinea. The outcome of this ‘Act of Free Choice’ was manipulated and resulted in the territory becoming a permanent part of Indonesia, which is what Indonesia had coveted all along. The decision to carry out the study angered the Indonesian government and resulted in a deterioration of the already fragile bilateral relations between both countries. When Drooglever’s findings were published the Balkenende II (2003-2006) cabinet was confronted with a dilemma: how could it do justice to the study carried out by the historian P. J. Drooglever on the one hand, yet try to repair the political damage to its relations with Indonesia on the other. In the context of the complex Dutch-Indonesian relationship in general this article not only deals with Van Aartsen’s motives for accepting this controversial research, but also explains why Indonesia reacted as it did and outlines how the Balkenende government tried to deal with this thorny issue.
F.H. Peters, Vervlogen verwachtingen. De teloorgang van Nieuw-Guinea in 1961-1962
H. Meijer
BMGN : Low Countries Historical Review , 2011,
Fumonisin and Ochratoxin Production in Industrial Aspergillus niger Strains
Jens C. Frisvad, Thomas O. Larsen, Ulf Thrane, Martin Meijer, Janos Varga, Robert A. Samson, Kristian F. Nielsen
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0023496
Abstract: Aspergillus niger is perhaps the most important fungus used in biotechnology, and is also one of the most commonly encountered fungi contaminating foods and feedstuffs, and occurring in soil and indoor environments. Many of its industrial applications have been given GRAS status (generally regarded as safe). However, A. niger has the potential to produce two groups of potentially carcinogenic mycotoxins: fumonisins and ochratoxins. In this study all available industrial and many non-industrial strains of A. niger (180 strains) as well as 228 strains from 17 related black Aspergillus species were examined for mycotoxin production. None of the related 17 species of black Aspergilli produced fumonisins. Fumonisins (B2, B4, and B6) were detected in 81% of A. niger, and ochratoxin A in 17%, while 10% of the strains produced both mycotoxins. Among the industrial strains the same ratios were 83%, 33% and 26% respectively. Some of the most frequently used strains in industry NRRL 337, 3112 and 3122 produced both toxins and several strains used for citric acid production were among the best producers of fumonisins in pure agar culture. Most strains used for other biotechnological processes also produced fumonisins. Strains optimized through random mutagenesis usually maintained their mycotoxin production capability. Toxigenic strains were also able to produce the toxins on media suggested for citric acid production with most of the toxins found in the biomass, thereby questioning the use of the remaining biomass as animal feed. In conclusion it is recommended to use strains of A. niger with inactive or inactivated gene clusters for fumonisins and ochratoxins, or to choose isolates for biotechnological uses in related non-toxigenic species such as A. tubingensis, A. brasiliensis, A vadensis or A. acidus, which neither produce fumonisins nor ochratoxins.
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