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Evaluation of Distributive Frequency of Oral Contraceptive Pills Consumption in Women with Cerebrovascular Events Admitted in Farshchian Hospital of Hamadan between 1997-2007
Mehrdokht Mazdeh
Journal of Fasa University of Medical Sciences , 2011,
Abstract: Background & Objectives: Although there is no prolonged time elapsed from propagation of oral contraceptive pills (OCP), case reports demonstrated occurrence of pulmonary embolism and cerebral infarction in women using these pills. Present study was done to specify distributive frequency of oral contraceptive pills consumption in women with cerebrovascular events admitted in Farshchian hospital of Hamadan between 1997 to 2007. Materials & Methods: Every woman with cerebrovascular events during years 1997-2007 who was admitted in Farshchian hospital of Hamadan and her dossier was present in archive of hospital, were carefully checked and those who hadn’t exclusion criteria, were include in this study, a total of 1587 of them with respect to their Characteristics such as type of cerebrovascular event, age, type of oral contraceptive pill and duration of pill use were extracted from patient dossier and registered in respective checklist. Results: 24.1% of patient used oral contraceptive pill and 76.9% of patients were non users. Mean age of OCP users and non users were 45 years. Mean duration of pill use among these patients was 33 months. In assessing type of vascular events, in the group OCP users 73.1% and non users 66.4% had ischemic stroke.Which was statistically significant. In the group OCP users 24.6% and non users 29.1% were hemorrhagic stroke.. Also in the group OCP users 2.3% and non users 4.5% were affected sagital sinuses thrombosis that showed no significant difference. Among OCP users 85% of the patients used OCP, LD and 15% of the patients OCP, HD. Conclusion: The present study showed, the ischemic stroke rate of the patients with OCP consumption were significantly more than those of non users.
Comparison of Serum Levels of Magnesium and Potassium in Stroke Patient and Healthy Controls
Mehrdokht Mazdeh,Saadat Torabian
Journal of Fasa University of Medical Sciences , 2011,
Abstract: Background & Objectives: CVA (cerebrovascular accident) is the most common debilitating disease. Studies show that magnesium and potassium have significant neuroprotective effects. The aim of this study is evaluation of serum levels of potassium and magnesium in stroke patients. Materials & Methods: In this case study, 70 stroke patients were entered in following manner. For a patient, a questionnaire include: age, sex, and kind of stroke was provided and then, in which the serum levels of magnesium and potassium were entered. These levels were compared with those of control group (70 people) whose individuals were sexual and age wise identical and results from these were analyzed with statistical test, t-test. Results: From 70 patients who were entered in this study, 39 (55.7%) individuals were male and 31 (44.3%) female. The mean age of case group was 72.11±10.76. The mean serum level of magnesium and potassium in case group was 1.89±0.25meq/L and 3.81±0.26 meq/L respectively and in control group was 1.95±0.46 meq/L and 3.9±0.41 meq/L that showed the mean serum level of magnesium and potassium in CVA patients was lower than control group, and only about serum level K is significant (P=0.004) Conclusion: The serum level of magnesium and potassium in stroke patients is lower than control group.
Efficacy of Doxycycline as Add-on to Interferon Beta-1a in Treatment of Multiple Sclerosis
Mehrdokht Mazdeh,Ahmad Reza Mobaien
Iranian Journal of Neurology , 2012,
Abstract: Background:Available evidence shows that tetracycline family has cellular and molecular mechanisms to protect neurons and oligodendrocytes by modulating matrix metalloproteinases. We tried to compare the effectiveness of intramuscular and subcutaneous interferon beta-1a (INF-β1a) in combination with oral doxycycline among patient with relapsing remitting multiple sclerosis (RRMS)and secondary progressive multiple sclerosis (SPMS).Methods:A double-blind clinical trial study was conducted at Hamedan University of Medical and Health Sciences in Iran. Sixty patients with definite diagnosis of RRMS or SPMS were treated with doxycycline and 44 μg subcutaneous IFN-β1a three times a week or 30 μg intramuscular IFN-β1a once a week for six months. Neurologic examinations were performed monthly until the end of the treatment. Changes in expanded disability status scale (EDSS) scores, brainmagnetic resonance images (MRIs), and frequency of receiving corticosteroid pulse were evaluated before and after the treatment.Results:Women constituted 88.3% of the participants. The mean age of the patients was 32 years. The mean EDSS scores reduced from 4.5 to 3.0. Based on the frequency of receiving corticosteroid pulse, relapse rate decreased from 3.2 to 0.8. MRI showed that the number, volume,and activity of the lesions decreased among 13.3% of theparticipants, increased among 15%, and remained persistent among 71.7%.Conclusion:Combination of doxycycline and IFN-β1a can decrease relapse rate and improve EDSS scores in patients with RRMS and SPMS. However, it does not affect MRI changes.Furthercontrolled clinical trials on greater number of patients with MS are needed to evaluate the efficacy of combination therapy.
The Therapeutic Effect of Avonex, Rebif and Betaferon on EDSS and Relapse in Multiple Sclerosis: A Comparative Study
Mehrdokht Mazdeh,Saeed Afzali,Mahmood Reza Jaafari
Acta Medica Iranica , 2010,
Abstract: We aimed to compare the therapeutic effect of Avonex (Av), Betaferon (Be) & Rebif (Re) on the Expanded Disability Status Scale (EDSS) in Multiple Sclerosis (MS). Ninety patients referring to Farshchian Hospital were entered in this study. The patients were divided into three equal groups: group 1 received Av, group 2 received Re and group 3 received Be, and after 24 months, comparison was done by calculating primary and final EDSS and the relapse rate. For comparison of the primary and final EDSS in each group, the relapse rate between the groups and side effects between the drugs, the paired samples t.test, the One-Way ANOVA test and the Pearson- chi-square were used. Average age was 31.11 ± 8.62 years, 80% being female. Comparison of the average primary and final EDSS using the paired samples t.test showed a significant statistical difference (P < 0.05). Motor and visual disturbances (respectively 68.3% and 60.3%) were the most common signs and relapsing- remitting form was the most common form (42.1%).The average EDSS change of groups Av, Be and Re was respectively, 1.28 (29.76%), 1.30(24.30%) and 1.26 (26.63%), showing no significant statistical difference in reducing EDSS. Groups Av and Be, showed no significant statistical difference in the average relapse rate before and after treatment, but in group Re there was a significant difference (P < 0.05). Treatment with these drugs reduces motor disability, with no significant difference between them. Also in comparison, Re has a greater effect in reducing the relapse rate, but again with no significant statistical difference among them.
A report of multiple sclerosis patients treated by CinnoVex in Iran
Masood Etemadifar,Mehrdokht Mazdeh,Hamid Reza Torabi,Majid Ghaffarpour
Tehran University Medical Journal , 2010,
Abstract: "n Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} Background: Recent studies present a high prevalence of multiple sclerosis (MS) in Iran. Treatment with interferon is now the first choice in management of MS. CinnoVexTM (an interferon beta 1-a) is available in Iran, with achievement of the technology of producing beta interferon. The aim of the present study is to evaluate the efficacy and safety of CinnoVexTM in a national study named CINA study."n"nMethods: This study was conducted from 2007 to 2008 in cities of Tehran, Isfahan, Mashhad, Tabriz, and Shiraz. Patients with relapsing/remitting MS with 16-50 years of age and EDSS of <4 received CinnoVexTM (30μg/week, IM) after diagnosis by a neurologist. EDSS, drug side effects, and frequency of relapse were evaluated for one year in four 3-month visits."n"nResults: A total of 1050 patients entered the study. Complete data were collected from 627 (60%) patients. Mean age was 30.7±8.6 year and 514 (82%) were female. The most common onset presentations were sensory symptoms (44%). Changes of EDSS through the study showed a significant decrease in the last 3-month of evaluation (p<0.05). Drug side effects were observed in 47%, 50%, 61%, and 61.4% (p>0.05) and relapse was occurred in 13.4%, 15.7%, 16.9%, and 2.4% of the patients in the first, second, third, and forth evaluation visits (p=0.001), respectively."n"nConclusion: CinnoVexTM prevents progression and improves clinical course of MS. The conventional side effects of beta interferon therapy, however, are observed with CinnoVexTM.
Calculation of stroke risk in persons above 55 years old without history of stroke who referred to health centers in Hamadan on 2012
Mehrdokht Mazdeh,Hamid Sadeghibidar,Mehdi Beyramijam,Farzaneh Esnaashari
Pajouhan Scientific Journal , 2013,
Abstract: Introduction: Cerebrovascular accidents are the third leading cause of mortality and the most important cause of morbidity in adults in the most of the world. Multiple factors such as Socioeconomic, lifestyle, environmental and genetic factors may be the cause of stroke risk differences in our community. This study was designed to evaluate the Stroke Risk Factor in persons above 55 years old without history of Stroke who referred to Health Centers in Hamadan on 2012.Material and Methods: In a Descriptive- Analytical study, 300 person above 55 years without history of stroke who referred to Health centers of Hamadan were selected (randomly),with regarded of inclusion and exclusion criteria and after explaining the research and its purposes, their permission was obtained. Their demographic data (such as age, gender), history of heart disease, hypertension and drug reception for it, diabetes, hyperlipidemia, smoking were filled in questionnaire. One EKG was performed (about the atrial fibrillation and signs of left ventricular hypertrophy).then data were analyzed and average tenth year stroke risk with use the Prof. Donald Smith software (stroke risk calculator) calculated.Results: The mean age, risk factors and systolic blood pressure in men and women were: 68.62±10006y, 2.16±1.33 and 129.05±18.71mmHg. History of diabetes mellitus, hyperlipidemia, smoking, hypertension(HTN), drug reception for HTN, drug reception in persons with history of HTN, SBP≥140mmHg, drug reception in persons with SBP≥140mmHg,Cardiovascular disease, atrial fibrillation(AF rhythm) and signs of left ventricular hypertrophy(LVH)in EKG have frequency: 19066%, 28%, 19%, 42023%, 34%, 29%, 59077%, 20033%, 3033%, 8033% respectively. The mean calculated stroke risk was for tenth year 10071%.This risk was 11074% in men and 9052% in women population.Conclusion: It’s can be concluded that with regard to transition of socioeconomic and community especially aging and international experience of epidemiologic transition, stroke risk factors and consecutive stroke risk in Hamadan as a small sample of a developing country are rapidly increasing . Its hope that experiences obtained in developed countries applied in preventive programs and healthy planning.
The Study of Quality of Life in Aphasic Stroke Patients in University- Medical Centers of Hamedan
M Mazdeh
Qom University of Medical Sciences Journal , 2012,
Abstract: Background and Objectives As clinical improvement of patients surviving stroke is frequently incomplete and is followed by residual neurologic deficit, evaluation of the consequent function of these patients in three respects i.e; physical, social and emotional, which are considered as quality of life is useful in decision making for health care providers. Since few studies have been carried out in this regard, the aim of the present study was to obtain the average life quality score in four levels in aphasic stroke patients and comparing it with the quality of life score of the healthy population which is 5. Methods This study was a descriptive-cross sectional research carried out on 105 aphasic stroke patients referring to medical centers in Hamadan, Iran. Their diagnoses were confirmed by clinical and radiological findings. These patients were eligible for the study and had survived the stroke for at least six months. Sampling was non randomized and goal-oriented. Dependent variables included psychological, communicational, energy and physical status of the patients measured quantitatively. Data were gathered using the SAQOL-39 questionnaire. Results In this study the female population (58.1%) was greater than the male. The greater number of the aphasic patients (42%) was between 71 to 85 years old and the smallest number (6.7%) was between 39 to 50 years old. The greatest average score of life quality in the studied patients was related to the psychological state (2.17), while the smallest was related to the energy state (1.49). Average score of the life quality in the total population of the studied patients was calculated to be (1.88). Conclusion The findings of the present study can lead to special supportive measures with the aim of improving life quality in aphasic stroke patients. We suggest that life quality of the patient after stroke should be compared to his/her own quality of life before stroke. Because there is no special service for care providers of stroke patients, an international program should be planned so that by reducing stress, they could have a better relation with the patients.
The Study of Quality of Life in Aphasic Stroke Patients in University- Medical Centers of Hamedan
M. Mazdeh,A. Yaghobi
Qom University of Medical Sciences Journal , 2009,
Abstract: Background and ObjectivesAs clinical improvement of patients surviving stroke is frequently incomplete and is followed by residual neurologic deficit, evaluation of the consequent function of these patients in three respects i.e; physical, social and emotional, which are considered as quality of life is useful in decision making for health care providers. Since few studies have been carried out in this regard, the aim of the present study was to obtain the average life quality score in four levels in aphasic stroke patients and comparing it with the quality of life score of the healthy population which is 5.Methods This study was a descriptive-cross sectional research carried out on 105 aphasic stroke patients referring to medical centers in Hamadan, Iran. Their diagnoses were confirmed by clinical and radiological findings. These patients were eligible for the study and had survived the stroke for at least six months. Sampling was non randomized and goal-oriented. Dependent variables included psychological, communicational, energy and physical status of the patients measured quantitatively. Data were gathered using the SAQOL-39 questionnaire.Results In this study the female population (58.1%) was greater than the male. The greater number of the aphasic patients (42%) was between 71 to 85 years old and the smallest number (6.7%) was between 39 to 50 years old. The greatest average score of life quality in the studied patients was related to the psychological state (2.17), while the smallest was related to the energy state (1.49). Average score of the life quality in the total population of the studied patients was calculated to be (1.88).ConclusionThe findings of the present study can lead to special supportive measures with the aim of improving life quality in aphasic stroke patients. We suggest that life quality of the patient after stroke should be compared to his/her own quality of life before stroke. Because there is no special service for care providers of stroke patients, an international program should be planned so that by reducing stress, they could have a better relation with the patients.Keywords: Life Quality; Stroke; Aphasia.
Cost of hemodialysis in Iran
Mahdavi-Mazdeh Mitra
Saudi Journal of Kidney Diseases and Transplantation , 2009,
Abstract:
Volatile constituents of essential oils isolated from flowers and leaves of Eupatorium cannabinum L. from Iran
Mehdi Mirza,Mehrdokht Najafpour Navaei,Mohammad Dini
Iranian Journal of Pharmaceutical Research , 2006,
Abstract: Hydro-distilled volatile oils from the flowers and leaves of Eupatorium cannabinum L.which gathered in Touchal on Mountain Alborz (Tehran province) in Iran were investigated mainly by a combination of GC and GC/MS. Thirty-nine components were identified in the oils. The main constituents of the essential oils in flowers and leaves were germacrene D (27.3%, 37.1%), gemacrene B (12.4%, 11.7%) and β-caryophyllene (8.6%, 10.1%). Although the main components of all the oils are similar, their percentages are different.
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