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Search Results: 1 - 10 of 3836 matches for " Mehmet Tolga Dogru "
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Differences in left ventricular structure, functions and elastance in the patients with normotensive blood pressure
Mehmet Tolga Dogru,Emine Tireli,Mahmut Guneri,Atila Iyisoy
Anadolu Kardiyoloji Dergisi , 2008,
Abstract: Objective: We aimed in this study to investigate the differences in left ventricular (LV) structure, function and elastance parameters in the patients with normotensive blood pressure (BP) levels.Methods: A total of 294 normotensive patients (<140/90 mmHg) (135 males, mean age: 45±11 years; 159 females, mean age 38±10 years) were enrolled into the present cross-sectional study. Patients were categorized into three groups according to their BP levels as optimal BP (<120/80 mmHg), normal BP (120-129 / 80-84 mmHg) and high normal BP (129-139 / 84-89 mmHg) groups. We evaluated LV structure and functions by using Doppler echocardiography in all participants. Afterwards we compared the measurements for revealing the echocardiographic differences among the BP groups. In this study, one-way ANOVA Kruskal-Wallis, one-way ANCOVA and partial correlation analysis tests were used for the statistically evaluation of the data. In addition, relative risk ratios (RR) were also calculated for determination of the effects of BP levels to echocardiographic parameters.Results: There were significant statistical differences in left atrial diameter (LA) (p=0.002), transmitral A wave velocity (A) (p=0.002), meridional wall stress (MWS) (p<0.001), pulmonary capillary wedge pressure (PCW) (p=0.029) among BP groups. After the correction of the data for anthropometric measurements, multiple comparisons have shown that only end-systolic (Es) and end-diastolic elastance (Ed) were different between the normal and high-normal BP groups (for Es, p=0.013; for Ed, p=0.007). But it was found that optimal BP group had significant differences in LV structure and function parameters when compared to high normal BP group (for LA, p=0.028; for A, p=0.035; for MWS, p=0.002; for Es, p<0.001; for Ed, p<0.001). Besides, increased RR were detected for increased left atrial diameter index and pulmonary capillary wedge pressure values in high-normal BP group (RR: 1.537, 95% CI (1.197-1.974), p=0.005 and RR: 1.272, 95% CI (1.089-1.485), p=0.032, respectively).Conclusion: Pathologic changes in LV due to increasing BP begin at below-hypertensive BP levels. It could be possible that normal BP stage is the beginning level of these changes.
Elimination of Post-Operative Complications in Penetrating Keratoplasty by Deploying Six Sigma  [PDF]
?brahim ?ahbaz, Mehmet Tolga Taner, üzeyir Tolga ?ahandar, Gamze Ka?an, Engin Erba?
American Journal of Operations Research (AJOR) , 2014, DOI: 10.4236/ajor.2014.44018

This paper shows how a public eye and research hospital in Turkey initiated Six Sigma principles to reduce the number of complications occurring after penetrating keratoplasty surgeries. Data were collected for nine years. To analyse the complications among 55 patients (59 eyes) underwent penetrative keratoplasty, main tools of Six Sigma’s Define-Measure-Analyze-Improve-Control (DMAIC) improvement cycle such as SIPOC table and Failure, Mode and Effect Analysis (FMEA) were implemented. Sources and root causes of eleven types of complications were identified and reported. For a successful penetrating keratoplasty surgery patient’s anatomy, suitability of donor cornea, experience of ophthalmic surgeon, sterilization and hygiene, and performance of the equipment were determined to be the “critical-to-quality” factors. The complication with the highest hazard score was found to be the glaucoma. The process sigma level of the process was measured to be 3.1418. The surgical team concluded that all types of post-operative complications should be significantly reduced by taking the necessary preventive measures.

Unavoidable myomectomy during cesarean section: a case report  [PDF]
Ayse Nur Aksoy, Kemal Tolga Saracoglu, Mehmet Aksoy, Ayten Saracoglu
Health (Health) , 2011, DOI: 10.4236/health.2011.33029
Abstract: Since myomectomy throughout cesarean deliv- ery may lead to hemorrhage and uterinal atony, it is not recommended. But, myomectomy has been reported during cesarean section in recent studies. We presented a patient with large in- tramural myoma who was diagnosed at 34 weeks of pregnancy and operated with an unavoidable cesarean-combined myomectomy. A 33-year-old unpursued primigravida was referred to emer- gency department with abdominal pain and amenorrhea of 34 weeks duration. A sonographic diagnosis of myoma in pregnancy was made. Cesarean section was required for fetal distress and alive 2300 g weighted male infant with Ap- gar score of 6 at one minute, was born. As uterine incision could not be closed because of the myoma, myomectomy was performed dur- ing cesarean section unavoidably. A single 970 g and 15 × 18 cm sized myoma was removed. The physical examinations were unremarkable in the postoperative period. Although there are case series that have demonstrated the safety of myomectomy during cesarean section, we con-cluded that myomectomy during cesarean section is not a safe procedure accept inevitable situa-tions.
A Comprehensive Evaluation of Eye Surgery Performance by Sigma Quality Level for Eye Care Hospitals in Turkey  [PDF]
?brahim ?ahbaz, Mehmet Tolga Taner, Gamze Ka?an, Engin Erba?
American Journal of Operations Research (AJOR) , 2015, DOI: 10.4236/ajor.2015.55028
Abstract: Sigma Quality Levels are statistical indices that can play an important role in establishment of more reliable and robust surgical processes. This article aims to highlight the value of interpreting sigma levels as a modern means of both the efficiency and success rate of nine different type of eye surgery processes involved. Data were compiled from a comprehensive study of multiple sources—all based on medical practices—carried out in a range of eye care hospitals throughout Turkey. It is found that the eye surgery processes in Turkey operates at an average of 3.4816 sigma level. This corresponds to a DPMO of 23,725 and a yield of approximately 97.63% in 7292 surgeries. Thus, Turkish eye care hospitals have to make significant changes to drive to a 6σ level performance.
Discovering functional interaction patterns in protein-protein interaction networks
Mehmet E Turanalp, Tolga Can
BMC Bioinformatics , 2008, DOI: 10.1186/1471-2105-9-276
Abstract: In this article, we map known functional annotations of proteins onto a PPI network in order to identify frequently occurring interaction patterns in the functional space. We propose a new frequent pattern identification technique, PPISpan, adapted specifically for PPI networks from a well-known frequent subgraph identification method, gSpan. Existing module discovery techniques either look for specific clique-like highly interacting protein clusters or linear paths of interaction. However, our goal is different; instead of single clusters or pathways, we look for recurring functional interaction patterns in arbitrary topologies. We have applied PPISpan on PPI networks of Saccharomyces cerevisiae and identified a number of frequently occurring functional interaction patterns.With the help of PPISpan, recurring functional interaction patterns in an organism's PPI network can be identified. Such an analysis offers a new perspective on the modular organization of PPI networks. The complete list of identified functional interaction patterns is available at http://bioserver.ceng.metu.edu.tr/PPISpan/ webcite.In the last few years, with the advances in high-throughput techniques, like yeast two-hybrid [1,2] and affinity purification coupled with mass spectrometry [3,4], the complete sets of interacting proteins of an increasing number of organisms have been identified [5]. In addition, probabilistic techniques that utilize indirect genomic evidence have provided increased genome coverage by predicting new interactions with multiple supporting evidence [6,7].In parallel with the availability of genome-scale protein networks, various studies have been conducted to analyze these networks in order to understand their topological organization [8-10], identify conserved subnetworks across different species [11,12], discover modules of interaction [13-18], predict functions of uncharacterized proteins [19-21], and improve the accuracy of currently available networks [5,22-26]. In
Filiz Acun Kaya,Nihal Hamamci,Guvenc Basaran,Mehmet Dogru
Journal of International Dental and Medical Research , 2010,
Abstract: During orthodontic treatment, the early response of periodontal tissues to mechanical stressinvolves several metabolic changes that allow tooth movement. The aim of the present study was todetermine tumor necrosis factor alpha (TNF-α), interleukin 1β (IL-1β) and interleukin 8 (IL-8) levelsin GCF in tooth early levelling movement orthodontic treatment.Seventeen patients, 8 female and 9 male individuals (aged: 16-20 years; mean 18.2 ± 1.4years), participated in this study. Each subject underwent a session of professional oral hygieneand received oral hygiene instructions. Three months later, a fixed orthodontic appliance wasplaced. The patients were seen at baseline and between 1-7 days levelling of the teeth.The concentration of TNF-α, IL-1β and IL-8 were shown in Tables 1. There were statisticaldifferences between the observations at the 1-2 day of levelling for TNF-α, IL-1β and IL-8 (p<.05).Orthodontic forced induces rapid release of the TNF-α, 1L-1β and IL 8 levels during toothmovement in gingival crevicular fluid (GCF). The results of this study support the hypothesis thatproinflammatory cytokines play a potent role in bone resorption after the application of orthodonticforce in short time.
Tolga ?zdemirk?ran,ümit Tahtac?,Mehmet ?elebisoy
Marmara Medical Journal , 2009,
Abstract: Orbital apex syndrome is characterized by the involvement of the 2,3,4 and 6th cranial nerves with the paralysis of ophtalmic branch of the 5th cranial nerve due to inflammatory, infectious, neoplastic, travmatic, vascular and sometimes iatrogenic reasons in the ophtalmic canal region. Biopsy from the resposible lesion can guide the tretment and it may be very informative.Altough the hemangiomas are the most common primary tumor of the orbit, cavernous hemangiomas as a cause of the ‘Orbital apex syndrome’ is very uncommon. Orbital Magnetic Resonance Imaging (MRI) is a very useful tool to detect the mass lesion in the orbit and for the distinctive diagnosis. Morbidity can be decresed with the early diagnosis and early surgical teratment.
Development of a Six Sigma Infrastructure for Trabeculectomy Process  [PDF]
Can ?ztürker, ?brahim ?ahbaz, Zeynep Karaaras? ?ztürker, Mehmet Tolga Taner, ?ükrü Bayraktar, Gamze Ka?an
American Journal of Operations Research (AJOR) , 2014, DOI: 10.4236/ajor.2014.44024
Abstract: The aim of this article is to show how an eye clinic of a Turkish public hospital initiated Six Sigma principles to reduce the number of complications encountered during and after trabeculectomy surgeries. Data were collected for ten years. To analyse the process, main tools of Six Sigma’s Define-Measure-Analyze-Improve-Control (DMAIC) improvement cycle such as SIPOC Table, Failure, Mode and Effect Analysis were implemented. Sources and root causes of ten types of complications were identified and reported. Patient’s eye anatomy, experience of ophthalmic surgeon, quality of surgical equipment, quality and type of suture, and experience of staff were identified to be Critical-to-Quality (CTQ) factors for a successful surgery. The most frequently occurring complication was found to be hypotony. The process sigma level of the process was measured to be 3.1391. The surgical team concluded that ten complications (out of twelve) should be significantly reduced by taking the necessary preventative measures.
Congenital Frontal Mature Dermoid Cyst: A Case Report  [PDF]
Mehmet Hakan Seyithanoglu, Kazim Dogan, Meliha Gundag, Serdar Cevik, Seref Ozturk, Tolga Turan Dundar
Open Journal of Modern Neurosurgery (OJMN) , 2014, DOI: 10.4236/ojmn.2014.44032
Abstract: Dermoid cysts are uncommon congenital or acquired developmental cystic malformations that were usually seen in the midline of frontal region and the anterior fontanel. Congenital forms develop from the remnants of the epithelium or ectodermal membranous bone growth line. We report here a case of a congenital frontal dermoid cyst that should be considered in the differential diagnosis of lipoma and neurofibroma. Dermoid cysts should be considered in the differential diagnosis of all nodular cyst-like lesions in the head and neck region. Early recognition and accurate diagnosis by means of Computerized Tomography scan or Magnetic Resonance Imaging facilitate successful treatment.
The Use of Neuronavigation with Vasular Microdoppler in Transsphenoidal Pituitary Surgery  [PDF]
Mehmet Hakan Seyithanoglu, Serkan Kitis, Meliha Gundag Papaker, Fatih Calis, Tolga Turan Dundar, Serdar Cevik
Open Journal of Modern Neurosurgery (OJMN) , 2016, DOI: 10.4236/ojmn.2016.61009
Abstract: Object: To evaluate the use of neuronavigation with vascular micro-doppler in transsphenoidal pituitary surgery. Methods: 141 cases having done transsphenoidal pituitary surgery are evaluated from 2005 to 2014. Fluoroscopy was used in 69 cases and vascular micro-doppler with neuronavigation were used in 72 cases. Results: Transsphenoidal surgery has a lot of risks due to sella’s deep location, and position of the carotid artery and the optic nerve. Clasically the fluoroscopy and microscopic anatomical markers were used in order to minimize the risk of carotid artery and optic nerve damage. Additional devices such as neuronavigation and vascular micro-doppler are needed to decrease the morbidity and mortality arising from these injuries. Conclusion: Neurovascular complications such as carotid artery and optic nerve injuries owing to disorientation in transsphenoidal surgery will reduce the use of neuronavigation with vascular micro-doppler.
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