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OALib Journal期刊

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Revolt and Remember: How the Shimshal Nature Trust Develops and Sustains Social-Ecological Resilience in Northern Pakistan
Mehjabeen Abidi-Habib,Anna Lawrence
Ecology and Society , 2007,
Abstract: The Shimshal Nature Trust is an indigenous institution rooted in a thriving and dynamic culture that links the local ecology and society. It has deployed identity, traditional knowledge, science, and institutional innovation to adapt to outside challenges without destroying local commons management. This paper reviews scholarly debate on natural resource management and uses resilience theory to examine this complex adaptive system. Two disturbances to Shimshal resilience prompted by a national park and a new road are traced. Shimshali responses include social processes of learning, knowledge systems, and renewal. Ways in which adaptive renewal cycles involve Revolt, a short, fast reaction, and Remember, a larger, slower cascade, are put in perspective. Simple and powerful qualities that guide change are highlighted. We conclude that the Shimshal Nature Trust creates a resilient interface between the outside and inside worlds. Government, donors, and academics can participate in contextualized action-learning cycles that result in more informed and negotiated contributions to local institutions for commons management.
RVM Based Human Fall Analysis for Video Surveillance Applications
B.Yogameena,G. Deepika,J. Mehjabeen
Research Journal of Applied Sciences, Engineering and Technology , 2012,
Abstract: For the safety of the elderly people, developed countries need to establish new healthcare systems to ensure their safety at home. Computer vision and video surveillance provides a promising solution to analyze personal behavior and detect certain unusual events such as falls. The main fall detection problem is to recognize a fall among all the daily life activities, especially sitting down and crouching down activities which have similar characteristics to falls (especially a large vertical velocity). In this study, a method is proposed to detect falls by analyzing human shape deformation during a video sequence. In this study, Relevance Vector Machine (RVM) is used to detect the fall of an individual based on the results obtained from torso angle through skeletonization. Experimental results on benchmark datasets demonstrate that the proposed algorithm is efficient. Further it is computationally inexpensive.
REVIEW ARTICLE – Intravenous paracetamol in pediatrics: A global perspective
Muzammil Irshad, MBBS,Mehjabeen Malik, MBBS,Aamir Furqan, MBBS
Anaesthesia, Pain & Intensive Care , 2012,
Abstract: Intravenous (IV) Paracetamol is an excellent post operative analgesic and antipyretic in children. Efficacy and tolerability of IV Propacetamol have been established in pediatric practice. It is believed that paracetamol works by inhibiting cyclooxygenase-2 (COX-2) enzymes. Studies bring to light that therapeutic doses of IV acetaminophen are effective and tolerable in children with least chances of hepatotoxicity. However, overdose toxicity has been reported in children and drug induced hypotension in febrile critically ill patients. Therapeutic doses according to body weight of neonates and children can be administered in hospital settings. Special education of health care staff regarding precise dose and solution is necessary to assess the role of IV paracetamol preparation in pediatric practice.
NOVEL INVESTIGATIONS ON THUJA OCCIDENTALIS EXTRACT ON RABBIT HEMATOLOGICAL AND BIOCHEMICAL PARAMETERS
Mansoor Ahmad,Farah-Saeed,Mehjabeen,Noor Jahan
International Research Journal of Pharmacy , 2013, DOI: 10.7897/2230-8407.04326
Abstract: Thuja occidentalis (family: Cupressaceae) has been used as antiseptic, expectorant, diuretic and in the treatment of cancer and removal of kidney stones in different systems of medicine. The present studies were carried out on T. occidentalis leaves extract to evaluate the hematological and biochemical effects on rabbits. The animals were divided in to control (A and B) and treated (C and D) male and female groups (n=5). There was a slight decrease in Hemoglobin, Red blood cell count and Hematocrit/Packed cell volume values, while a significant increase in platelet count was observed in male and female treated groups. However, slight increase in total leukocyte count value in male treated group and decrease count with female treated group was also observed. Urea, Creatine phospho kinase, Creatine phospho kinase iso-enzyme, Direct Bilirubin, Gamma-glutamyl transpeptidase, Cholesterol and Albumin/Globulin ratio values were elevated in male treated group. While Phosphorus, Uric acid, Lactate dehydrogenase, Serum glutamic oxaloacetic transaminase, serum glutamic-pyruvic transaminase, Alkaline Phosphatase, Cholesterol, Triglycerides, High density lipoprotein, Low density lipoprotein, Very-low-density lipoprotein, Globulin and Blood Glucose values were found low. In female treated group almost same results were observed like male treated group except that hypoglycemic effect was more pronounced in female treated group. These findings suggested that when results of hematological and biochemical parameters of test groups (C & D) were compared with their respective controls (A & B), significant changes were observed which contributes towards the diversified therapeutic effect of T. occidentalis.
Identification of potential targets in Staphylococcus aureus N315 using computer aided protein data analysis
Mehjabeen Hossain,Dil Umme Salma Chowdhury,Jacy Farhana,Mohammed Touaha Akbar
Bioinformation , 2013,
Abstract: Staphylococcus aureus is a gram positive bacterium, responsible for both community-acquired and hospital-acquired infection, resulting in a mortality rate of 39%. 43.2% resistance to methicilin and emerging resistance to Fluroquinolone and Oxazolidinone, have evoked the necessity of the establishment of alternative and effective therapeutic approach to treat this bacteria. In this computational study, various database and online software are used to determine some specific targets of Staphylococcus aureus N315 other than those used by Penicillin, Quinolone and Oxazolidinone. For this purpose, among 302 essential proteins, 101 non-homologous proteins were accrued and 64 proteins which are unique in several metabolic pathways of S. aureus were isolated by using metabolic pathway analysis tools. Furthermore, 7 essentially unique enzymes involved in exclusive metabolic pathways were revealed by this research, which can be potential drug target. Along with these important enzymes, 15 non-homologous proteins located on membrane were identified, which can play a vital role as potential therapeutic targets for the future researchers.
Antimicrobial screening of selected flora of Pakistan
Zia-Ul-Haq M.,Ahmad Mansoor,Mehjabeen,Jehan Noor
Archives of Biological Sciences , 2011, DOI: 10.2298/abs1103691z
Abstract: Ethanolic extracts of Ferula assafoetida resin, Grewia asiatica leaves, Ipomoea hederacea seeds, Lepidium sativum seeds, Nigella sativa seeds and Terminalia chebula fruits were tested in vitro for their antibacterial and antifungal activities. The antibacterial study performed against eight bacterial species viz., Escherichia coli, Citrobacter, Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella typhi, Micrococcus luteus, Proteus mirabilis and Bacillus subtilis indicated that the investigated plants have potent activity against all the tested microorganisms. The antifungal activity of these extracts was performed against nine fungal strains, viz., Aspergillus parasiticus, Aspergillus niger, Yersinia aldovae, Candida albicans, Aspergillus effusus, Fusarium solani, Macrophomina phaseolina, Saccharomyces cerevisiae and Trichophyton rubrum. The extracts showed moderate as well as significant activity against the different fungal strains.
Antidiabetic Activity of Vinca rosea Extracts in Alloxan-Induced Diabetic Rats
Mohammed Fazil Ahmed,Syed Mohammed Kazim,Syed Safiullah Ghori,Syeda Sughra Mehjabeen,Shaik Rasheed Ahmed,Shaik Mehboob Ali,Mohammed Ibrahim
International Journal of Endocrinology , 2010, DOI: 10.1155/2010/841090
Abstract: The present study was carried out to evaluate the antidiabetic activity of Vinca rosea methanolic whole plant extracts in alloxan induced diabetic rats for 14 days. The methanolic whole plant extract at high dose (500?mg/kg) exhibited significant anti-hyperglycemic activity than whole plant extract at low dose (300?mg/kg) in diabetic rats. The methanolic extracts also showed improvement in parameters like body weight and lipid profile as well as regeneration of -cells of pancreas in diabetic rats. Histopathological studies reinforce the healing of pancreas, by methanolic Vinca rosea extracts, as a possible mechanism of their antidiabetic activity. 1. Introduction Diabetes mellitus is one of the common metabolic disorders with micro-and macrovascular complications that results in significant morbidity and mortality. It is considered as one of the five leading causes of death in the world [1, 2]. In modern medicine no satisfactory effective therapy is still available to cure diabetes mellitus [3]. There is increasing demand by patients to use natural products with antidiabetic activity due to side effects associated with the use of insulin and oral hypoglycemic agents [4–6]. There are numerous traditional medicinal plants reported to have hypoglycemic properties such as Allium sativum (Garlic), Azadirachta indica (Neem), Vinca rosea (Nayantara), Trigonella foenum (Fenugreek), Momordica charantia (Bitter ground), Ocimum santum (Tulsi). Many of these are less effective in lowering glucose levels in severe diabetes. Vinca rosea (C. roseus) Linn. (Apocynaceae) is an herbaceous subshrub also known as Madagascar periwinkle, Vinca rosea, or Lchnera rosea worldwide. It is cultivated mainly for its alkaloids, which are having anticancer activities [7]. The two classes of active compounds in Vinca are alkaloids and tannins. Catharanthus roseus produces more than 100 monoterpenoids indole alkaloids (TIA) in different organs [8]. The leaves and stems are the sources of dimeric alkaloids, vinacristine and vinblastine that are indispensable cancer drugs, while roots have antihypertensive, ajmalicine and serpentine [9]. The leaves are used traditionally in various regions of the world including India, West Indies as well as Nigeria to control diabetes [10]. The leaves have been known to contain 150 useful alkaloids among other pharmacologically active compounds. Significant antihyperglycemic and hypotensive activity of the leaf extracts (hydroalcoholic or dichloromethane-methanol) have been reported in laboratory animals [11]. Fresh leaf juice of C. roseus has been
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