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Search Results: 1 - 10 of 591 matches for " Megumi Kawamoto "
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A novel transferrin receptor-targeted hybrid peptide disintegrates cancer cell membrane to induce rapid killing of cancer cells
Megumi Kawamoto, Tomohisa Horibe, Masayuki Kohno, Koji Kawakami
BMC Cancer , 2011, DOI: 10.1186/1471-2407-11-359
Abstract: In vitro: We assessed the cytotoxicity of TfR-lytic hybrid peptide for 12 cancer and 2 normal cell lines. The specificity for TfR is demonstrated by competitive assay using TfR antibody and siRNA. In addition, we performed analysis of confocal fluorescence microscopy and apoptosis assay by Annexin-V binding, caspase activity, and JC-1 staining to assess the change in mitochondria membrane potential. In vivo: TfR-lytic was administered intravenously in an athymic mice model with MDA-MB-231 cells. After three weeks tumor sections were histologically analyzed.The TfR-lytic hybrid peptide showed cytotoxic activity in 12 cancer cell lines, with IC50 values as low as 4.0-9.3 μM. Normal cells were less sensitive to this molecule, with IC50 values > 50 μM. Competition assay using TfR antibody and knockdown of this receptor by siRNA confirmed the specificity of the TfR-lytic hybrid peptide. In addition, it was revealed that this molecule can disintegrate the cell membrane of T47D cancer cells just in 10 min, to effectively kill these cells and induce approximately 80% apoptotic cell death but not in normal cells. The intravenous administration of TfR-lytic peptide in the athymic mice model significantly inhibited tumor progression.TfR-lytic peptide might provide a potent and selective anticancer therapy for patients.The transferrin receptor (TfR) is a cell-membrane-associated glycoprotein involved in the cellular uptake of iron and the regulation of cell growth [1]. Iron is a required cofactor of heme and nonheme proteins involved in a variety of cellular processes including metabolism and DNA synthesis [2,3]. Therefore, various studies have shown elevated levels of TfR expression on cancer cells when compared with their normal counterparts [4-13]. Bladder-transitional cell carcinomas, breast cancer, glioma, lung adenocarcinoma, chronic lymphocytic leukemia, and non-Hodgkin's lymphoma also showed increased TfR expression that correlated with tumor grade and stage or prognosi
Rejection Sensitivity, Self-Efficacy, and Learning Strategy: Mediating and Moderating the Role of Basic Needs Satisfaction  [PDF]
Miki Terada, Taishi Kawamoto
Psychology (PSYCH) , 2017, DOI: 10.4236/psych.2017.83028
Abstract: Rejection sensitive people often experience interpersonal difficulties, resulting in dissatisfaction with their need for relatedness. However, whether they are satisfied with their autonomy and competence, or experience difficulties from these factors other than in interpersonal relationships, remains largely unexplored. This study examined the influence of rejection sensitivity and need satisfaction (autonomy, competence, and relatedness) on learning strategy and self-efficacy. We found that competence satisfaction mediates the relationship between rejection sensitivity and self-efficacy. In addition, hierarchical regression analysis revealed a significant three-way interaction of rejection sensitivity, autonomy, and competence satisfaction with learning strategy. Competence satisfaction has a positive effect when individuals have low rejection sensitivity and are satisfied with autonomy need, whereas autonomy satisfaction has a positive effect when individuals have high rejection sensitivity and are dissatisfied with their competence levels. This suggests that autonomy and competence satisfaction levels are important for the understanding of psychological difficulties in rejection sensitive individuals.
Relevance of Visual, Auditory, and Olfactory Cues in Pet Dogs’ Awareness of Humans  [PDF]
Megumi Fukuzawa, Marina Watanabe
Open Journal of Animal Sciences (OJAS) , 2017, DOI: 10.4236/ojas.2017.73023
Abstract: Many studies have looked at how dogs respond to human communicative information. Here, we examined which human communicative factors were important in influencing dogs’ responses. Eleven healthy pet dogs with no apparent aggressive behaviour toward people were recruited. Five sensory conditions (all cues presented; either a visual, an auditory, or an olfactory cue presented; no cues presented) were provided three times randomly to each dog during the tests. All tests were video recorded, and both the dogs’ behaviour and time taken to reach the person when she presented each of the sensory cue conditions were observed. Total rates of reaching the person were as follows: 97.0% (all cues), 87.9% (auditory cues), 84.4% (visual cues), 84.4% (olfactory cues), and 69.7% (no cues). The time taken for the dog to notice the person in the box and then obtain a reward from her differed among the five conditions: all cues (6.00 ± 0.32 s) and visual cues (6.02 ± 0.91 s) were significantly faster than auditory cues (18.56 ± 9.57 s) and no cues (26.55 ± 11.72 s). Thus the type of information input was important in recognition of the person by the dogs and influenced the dogs’ response times; visual cues appeared advantageous in confirming the person’s presence.
PROJECTION OF PENETRATION OF THE BROKER IN HOME BRAZILIAN CAPITAL MARKET THROUGH LINEAR, GOMPERTZ AND FISHER – PRY MODELS PROJE O DA PENETRA O DO HOME BROKER NO MERCADO DE CAPITAIS BRASILEIRO ATRAVéS DOS MODELOS LINEAR, FISHER-PRY E GOMPERTZ
Carlos Kawamoto
Future Studies Research Journal : Trends and Strategies , 2010, DOI: 10.7444/future.v2i1.46
Abstract: This paper aims to discuss the theories of internationalization and competitiveness, the positioning of a Brazilian company from agribusiness industry, exporting meat and food that has become a major global player in this industry JBS - Friboi. This company has been internationalized very fast in recent years and become a global leader in beef production, the second to the production of chicken meat and third largest producer of pork in the U.S. (JBS, 2010). The case is emblematic of JBS when analyzed under the concept of Porter's diamond applied to Brazil. This company gained scale and competitiveness with the access to natural resources of prodution (condition factor), but now it is necessary for maintenance its leading position, it requires a strategy grounded in innovation beyond just scale and operational excellence). Este artigo tem como objetivo discutir à luz das teorias de internacionaliza o e competitividade, o posicionamento de uma empresa genuinamente brasileira exportadora de carnes e alimentos que se tornou um grande player global nessa indústria a JBS – Friboi que possui hoje 140 unidades de produ o no mundo e mais de 120 mil colaboradores. Esta empresa que se internacionalizou de forma muito veloz nos últimos anos, se tornou líder global na produ o de carne bovina, segundo maior produtor de carne de frango e terceiro maior produtor de carne suína nos EUA (JBS, 2010). O caso da JBS é emblemático quando analisado sob o conceito do diamante de Porter aplicado ao Brasil. As vantagens advindas dos recursos naturais no Brasil ajudaram a criar o expertise da JBS, e das demais empresas do setor, culminando na sua lideran a neste mercado e criando escala para concorrer no exterior. A empresa ganhou escala e competitividade com a vantagem da produ o pecuária em recursos naturais (condi o de fatores), mas se sup e que para a manuten o da sua posi o de lideran a é necessária uma estratégia pautada em inova o que transcenda apenas o aumento da escala e excelência operacional.
CALIBRA O DO MODELO SEMI-COMPENSATóRIO DE ESCOLHA MODAL
Eiji Kawamoto
Transportes , 2010,
Abstract: Dois s o os objetivos deste trabalho: o primeiro e apresentar uma maneira de calibrar o modelo Semi-compensatório do comportamento de escolha do usuário de transporte de passageiros, e o segundo, relatar um resultado preliminar de calibra o. Esse novo modelo foi concebido e desenvolvido a partir do pressuposto de que a escolha do meio de locomo o se faz através da avalia o das utilidades intrínsecas das alternativas disponíveis e das utilidades atribuídas às quantias que se "desembolsam" em cada alternativa. A forma n o convencional do modelo (n o-compensatório e determinístico) requereu a concep o e o desenvolvimento de um processo para a sua calibra o: uma aplica o da técnica de maximiza o da verossimilhan a. Esse processo foi aplicado a dados referentes a um grupo de 95 pessoas (50 funcionários da Escola de Engenharia de S o Carlos-USP e 45 funcionários do DER-SP, Regional de Campinas). O resultado da calibra o mostrou-se satisfatório, pois aproximadamente 85% das escolhas preditas pelo modelo calibrado coincidiram com as escolhas realizadas pelo grupo estudado. Abstract: There are two objectives in this paper: the first one is to present an alternative way to calibrate travel behaviour models with semi-compensatory structures; the second one is to analyse some preliminary results of a calibration exercise. This new model has been developed based upon the following assumption: the choice of transport mode is made on the basis of the assessment of the intrinsic utilities of available transport alternatives and the utilities attached to the amount of money needed to travel in each of these alternatives. The non-conventional structure of the model (non-compensatory and deterministic) has required the conception and development of a calibration process: an application of the maximum likelihood estimation technique. This process has been applied to a data base which consisted of information obtained from a group of 95 users (50 of them were staff of the S o Carlos Engineering School and the remaining were staff of the S o Paulo State Highway Department). The calibration result was considered satisfactory as approximately 85% of the choices predicted by the model has coincided with the observed ones.
Fractal Structure of Quantum Gravity in Two Dimensions
Noboru Kawamoto
Physics , 1993,
Abstract: Recent numerical results on the fractal structure of two-dimensional quantum gravity coupled to $c=-2$ matter are reviewed. Analytic derivation of the fractal dimensions based on the Liouville theory and diffusion equation is also discussed. Excellent agreements between the numerical and theoretical results are obtained. Some problems on the non-universal nature of the fractal structure in the continuum limit are pointed out. ============================================================================ This is a review paper on \lq\lq Fractal Structure of Quantum Gravity in Two Dimension. Talk given at Nishinomiya-Yukawa Simposium, Nov. 1992. Figures are available from the author directly as hard copies.
Non-String Pursuit towards Unified Model on the Lattice
Noboru Kawamoto
Physics , 1999, DOI: 10.1143/PTPS.134.84
Abstract: Non-standard overview on the possible formulation towards a unified model on the lattice is presented. It is based on the generalized gauge theory which is formulated by differential forms and thus expected to fit in a simplicial manifold. We first review suggestive known results towards this direction. As a small step of concrete realization of the program, we propose a lattice Chern-Simons gravity theory which leads to the Chern-Simons gravity in the continuum limit via Ponzano-Regge model. We then summarize the quantization procedure of the generalized gauge theory and apply the formulation to the generalized topological Yang-Mills action with instanton gauge fixing. We find N=2 super Yang-Mills theory with Dirac-K{\"a}hler fermions which are generated from ghosts via twisting mechanism. The Weinberg-Salam model is formulated by the generalized Yang-Mills action which includes Connes's non-commutative geometry formulation as a particular case. In the end a possible scenario to realize the program is proposed. The formulations given here are by far incomplete towards the final goal yet include hopeful evidences. This summary of the overview is the extended version of the talk given at Nishinomiya-Yukawa memorial symposium (Nishinomiya-city Japan, Nov. 1998).
Microscopic analysis of the microscopic reversibility in quantum systems
Tatsuro Kawamoto
Physics , 2011, DOI: 10.1088/1742-5468/2011/11/P11019
Abstract: We investigate the robustness of the microscopic reversibility in open quantum systems which is discussed by Monnai [arXiv:1106.1982 (2011)]. We derive an exact relation between the forward transition probability and the reversed transition probability in the case of a general measurement basis. We show that the microscopic reversibility acquires some corrections in general and discuss the physical meaning of the corrections. Under certain processes, some of the correction terms vanish and we numerically confirmed that the remaining correction term becomes negligible; the microscopic reversibility almost holds even when the local system cannot be regarded as macroscopic.
Electroweak data and Standard Model Fit Results
T. Kawamoto
Physics , 2001,
Abstract: Most recent tests of the Standard Model of the electroweak interaction are reported using data from the four LEP experiments ALEPH, DELPHI, L3 and OPAL, the SLD experiment at SLC, the Tevatron ppbar experiments CDF and D0, and the NuTeV neutrino experiment. Consistency of the Standard Model is studied. The value of the Higgs mass is inferred from a global fit.
A stochastic model of the tweet diffusion on the Twitter network
Tatsuro Kawamoto
Computer Science , 2012, DOI: 10.1016/j.physa.2013.03.048
Abstract: We introduce a stochastic model which describes diffusions of tweets on the Twitter network. By dividing the followers into generations, we describe the dynamics of the tweet diffusion as a random multiplicative process. We confirm our model by directly observing the statistics of the multiplicative factors in the Twitter data.
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