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Search Results: 1 - 10 of 144434 matches for " Mayur B. Kurade "
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Differential fate of metabolism of a disperse dye by microorganisms Galactomyces geotrichum and Brevibacillus laterosporus and their consortium GG-BL
Tatoba R Waghmode,Mayur B Kurade,Anuradha N Kagalkar,Sanjay P Govindwar,
Tatoba R. Waghmode
,Mayur B. Kurade,Anuradha N. Kagalkar,Sanjay P. Govindwar

环境科学学报(英文版) , 2012,
Abstract: The present work aims to evaluate Brown 3 REL degrading potential of developed microbial consortium GG-BL using two microbial cultures, Galactomyces geotrichum MTCC 1360 (GG) and Brevibacillus laterosporus MTCC 2298 (BL). Microbial consortium GG-BL showed 100% decolorization of a dye Brown 3 REL, while individually G. geotrichum MTCC 1360 and B. laterosporus MTCC 2298 showed 26% and 86% decolorization under aerobic condition (shaking) respectively. Measurements of biochemical oxygen demand (BOD) (76%) and chemical oxygen demand (COD) (68%) were done after decolorization by consortium GG-BL. No induction in activities of oxidoreductive enzymes found in G. geotrichum while B. laterosporus showed induction of veratryl alcohol oxidase, Nicotineamide adenine dinucleotide-dichlorophenol indophenol (NADH-DCIP) reductase and riboflavin reductase indicating their role in dye metabolism. Consortium GG-BL showed induction in the activities of laccase, veratryl alcohol oxidase, tyrosinase, NADH-DCIP reductase and riboflavin reductase. Two different sets of induced enzymes from G. geotrichum and B. laterosporus work together in consortium GG-BL resulting in faster degradation of dye. The degradation of Brown 3 REL was analyzed using high performance thin layer chromatography (HPTLC), high performance liquid chromatography (HPLC), Fourier transform infrared spectroscopy (FT-IR) and gas chromatography mass spectroscopy (GC-MS). Phytotoxicity study revealed that metabolites formed after degradation was significantly less toxic in nature.
PULSATILE DRUG DELIVERY: A REVIEW
MAYUR SUTHAR
International Journal of Pharmaceutical Research and Bio-Science , 2012,
Abstract: Pulsatile drug delivery systems are gaining a lot of interest now days. These systems are designed according to the circadian rhythm of the body. These systems deliver the drug at specific time as per the pathophysiological need of the disease, resulting in improved patient compliance and therapeutic efficacy. Pulsatile delivery, which is meant as the liberation of drugs following programmed lag phases, has drawn increasing interest, especially in view of emerging chronotherapeutic approaches. Pulsatile drug delivery shows potential benefits for the diseases which show circadian rhythms like rheumatoid arthritis, cardiovascular diseases, asthma, peptic ulcer, allergic rhinitis.
Skin scraping and a potassium hydroxide mount
Kurade Sachin,Amladi Sangeeta,Miskeen Autar
Indian Journal of Dermatology, Venereology and Leprology , 2006,
Abstract:
RP-HPLC estimation of ramipril and telmisartan in tablets
Kurade V,Pai M,Gude R
Indian Journal of Pharmaceutical Sciences , 2009,
Abstract: A rapid high performance liquid chromatographic method has been developed and validated for the estimation of ramipril and telmisartan simultaneously in combined dosage form. A Genesis C18 column having dimensions of 4.6x250 mm and particle size of 5 μm in isocratic mode, with mobile phase containing a mixture of 0.01 M potassium dihydrogen phosphate buffer (adjusted to pH 3.4 using orthophosphoric acid): methanol:acetonitrile (15:15:70 v/v/v) was used. The mobile phase was pumped at a flow rate of 1.0 ml/min and the eluents were monitored at 210 nm. The selected chromatographic conditions were found to effectively separate ramipril (R t : 3.68 min) and telmisartan (R t : 4.98 min) having a resolution of 3.84. The method was validated in terms of linearity, accuracy, precision, specificity, limit of detection and limit of quantitation. Linearity for ramipril and telmisartan were found in the range of 3.5-6.5 μg/ml and 28.0-52.0 μg/ml, respectively. The percentage recoveries for ramipril and telmisartan ranged from 99.09-101.64% and 99.45-100.99%, respectively. The limit of detection and the limit of quantitation for ramipril was found to be 0.5 μg/ml and 1.5 μg/ml respectively and for telmisartan was found to be 1.5 μg/ml and 3.0 μg/ml, respectively. The method was found to be robust and can be successfully used to determine the drug content of marketed formulations.
A Wittig-olefination–Claisen-rearrangement approach to the 3-methylquinoline-4-carbaldehyde synthesis
Mukund G. Kulkarni,Mayur P. Desai,Deekshaputra R. Birhade,Yunus B. Shaikh
Beilstein Journal of Organic Chemistry , 2012, DOI: 10.3762/bjoc.8.197
Abstract: Efficient syntheses are described for the synthetically important 3-methylquinoline-4-carbaldehydes 6a–h from o-nitrobenzaldehydes 1a–h employing a Wittig-olefination–Claisen-rearrangement protocol. The Wittig reaction of o-nitrobenzaldehydes with crotyloxymethylene triphenylphosphorane afforded crotyl vinyl ethers 2a–h, which on heating under reflux in xylene underwent Claisen rearrangement to give 4-pentenals 3a–h. Protection of the aldehyde group of the 4-pentenals as acetals 4a–h and subsequent oxidative cleavage of the terminal olefin furnished nitroaldehydes 5a–h. Reductive cyclization of these nitroaldehydes yielded the required 3-methylquinoline-4-carbaldehydes 6a–h in excellent yields. Therefore, an efficient method was developed for the preparation of 3-methylquinoline-4-carbaldehydes from o-nitrobenzaldehydes in a simple five-step procedure.
Decreasing adrenergic or sympathetic hyperactivity after severe traumatic brain injury using propranolol and clonidine (DASH After TBI Study): study protocol for a randomized controlled trial
Patel Mayur B,McKenna John W,Alvarez JoAnn M,Sugiura Ayaka
Trials , 2012, DOI: 10.1186/1745-6215-13-177
Abstract: Background Severe TBI, defined as a Glasgow Coma Scale ≤ 8, increases intracranial pressure and activates the sympathetic nervous system. Sympathetic hyperactivity after TBI manifests as catecholamine excess, hypertension, abnormal heart rate variability, and agitation, and is associated with poor neuropsychological outcome. Propranolol and clonidine are centrally acting drugs that may decrease sympathetic outflow, brain edema, and agitation. However, there is no prospective randomized evidence available demonstrating the feasibility, outcome benefits, and safety for adrenergic blockade after TBI. Methods/Design The DASH after TBI study is an actively accruing, single-center, randomized, double-blinded, placebo-controlled, two-arm trial, where one group receives centrally acting sympatholytic drugs, propranolol (1 mg intravenously every 6 h for 7 days) and clonidine (0.1 mg per tube every 12 h for 7 days), and the other group, double placebo, within 48 h of severe TBI. The study uses a weighted adaptive minimization randomization with categories of age and Marshall head CT classification. Feasibility will be assessed by ability to provide a neuroradiology read for randomization, by treatment contamination, and by treatment compliance. The primary endpoint is reduction in plasma norepinephrine level as measured on day 8. Secondary endpoints include comprehensive plasma and urine catecholamine levels, heart rate variability, arrhythmia occurrence, infections, agitation measures using the Richmond Agitation-Sedation Scale and Agitated Behavior scale, medication use (anti-hypertensive, sedative, analgesic, and antipsychotic), coma-free days, ventilator-free days, length of stay, and mortality. Neuropsychological outcomes will be measured at hospital discharge and at 3 and 12 months. The domains tested will include global executive function, memory, processing speed, visual-spatial, and behavior. Other assessments include the Extended Glasgow Outcome Scale and Quality of Life after Brain Injury scale. Safety parameters evaluated will include cardiac complications. Discussion The DASH After TBI Study is the first randomized, double-blinded, placebo-controlled trial powered to determine feasibility and investigate safety and outcomes associated with adrenergic blockade in patients with severe TBI. If the study results in positive trends, this could provide pilot evidence for a larger multicenter randomized clinical trial. If there is no effect of therapy, this trial would still provide a robust prospective description of sympathetic hyperactivity afte
Mechanical and Abrasive Wear Behavior of Metal Sulphide Lubricant Filled Epoxy Composites
M. Sudheer,N. Karthik Madhyastha,M. Kewin Amanna,B. Jonthan,K. Mayur Jayaprakash
ISRN Polymer Science , 2013, DOI: 10.1155/2013/242450
Abstract: The present work reveals the effect of the addition of commercial MoS2 (10?wt%) particles on mechanical and two-body abrasive wear behavior of epoxy with/without glass fiber mat reinforcement. The composites were fabricated using casting and simple hand lay-up techniques followed by compression molding. The mechanical properties such as density, hardness, tensile, and flexural properties were determined as per ASTM standards. The abrasive wear testing was carried out using pin-on-disc wear tester for different loads and abrading distances at constant speed of 1?m/s. A significant reduction in wear loss and specific wear rate was noticed after the incorporation of MoS2 filler allowing less wear of matrix during abrasion which in turn facilitated lower fiber damage. However the incorporation of MoS2 particles had a detrimental effect on most of the mechanical properties of the composites. The worn surface features were investigated through scanning electron microscopy (SEM) in order to investigate the wear mechanisms. 1. Introduction In recent times, there has been a remarkable growth in large-scale production of fiber and/or filler-reinforced polymer matrix composites for engineering applications [1]. Among various types of fiber reinforcements, namely, short, long (unidirectionally reinforced UD composites), fabric (bidirectionally reinforced BD composites), and the combinations of fabrics or long fibers in various directions (multidirectionally reinforced), BD reinforcement offers a unique solution to ever increasing demands on advanced materials in terms of better performance and ease in processing. Thermoset epoxy resins are extensively studied as a matrix material as they exhibits low shrinkage, higher mechanical properties, easy fabrication, excellent chemical and moisture resistance, good wettability, and good electrical characteristics [2]. One of the well-known reinforcement for polymers is glass fibers. Glass fibers have very high strength and high stiffness. It has been found that size and volume fraction of the fibers/fillers play an important role to improve the mechanical properties such as stiffness and strength. Polymer composites are extensively used in the tribosituations where resistance to abrasive wear is an extremely important criterion. Typical examples are chute liners, conveyor aids, vanes, gears, for pumps handling industrial fluids, sewage and abrasive contaminated water, and so forth. [3]. Polymers filled with solid lubricant (SL) have been extensively studied because of the increasing industrial and material applications.
Electric-field-induced turbulent energy cascade in an oil-in-oil emulsion
Atul Varshney,Mayur Sathe,Shankar Ghosh,Anand Yethiraj,S. Bhattacharya,J. B. Joshi
Physics , 2014,
Abstract: We observe electro-hydrodynamically driven turbulent flows at low Reynolds numbers in a two-fluid emulsion consisting of micron-scale droplets. In the presence of electric fields, the droplets produce interacting hydrodynamic flows which result in a dynamical organization at a spatial scale much larger than the size of the individual droplets. We characterize the dynamics associated with these structures by both video imaging and a simultaneous, in situ, measurement of the time variation of the bulk Reynolds stress with a rheometer. The results display scale invariance in the energy spectra in both space and time.
A Markov Jump Process for More Efficient Hamiltonian Monte Carlo
Andrew B. Berger,Mayur Mudigonda,Michael R. DeWeese,Jascha Sohl-Dickstein
Statistics , 2015,
Abstract: In most sampling algorithms, including Hamiltonian Monte Carlo, transition rates between states correspond to the probability of making a transition in a single time step, and are constrained to be less than or equal to 1. We derive a Hamiltonian Monte Carlo algorithm using a continuous time Markov jump process, and are thus able to escape this constraint. Transition rates in a Markov jump process need only be non-negative. We demonstrate that the new algorithm leads to improved mixing for several example problems, both by evaluating the spectral gap of the Markov operator, and by computing autocorrelation as a function of compute time. We release the algorithm as an open source Python package.
Balloon Mitral Valvuloplasty in Rheumatic Double Orifice Mitral Valve  [PDF]
Mayur Jain, Neerav Panchani, No Bansal, Bhanu Duggal
World Journal of Cardiovascular Diseases (WJCD) , 2015, DOI: 10.4236/wjcd.2015.510033
Abstract: We are reporting four cases of acquired double orifice mitral valve (DOMV) of rheumatic etiology (rare) presenting as significant mitral stenosis (MS) treated successfully by percutaneous intervention. All four patients are young (3 males, 1 female) who presented with dyspnea of Newyork heart association (NYHA) class II with mean duration of 1.3 years. Typical clinical findings of MS were present in all. Echocardiography confirmed the diagnosis of moderate to severe MS of rheumatic etiology with double orifice of mitral valve of Trowitzsch incomplete bridge variety [1], giving appearance of two equal (like a pair of spectacles in one patient) or unequal size orifices (in three patients) in parasternal short axis view. Color Doppler examination revealed separate jets originating from each orifice, determined severity of the lesion and evaluated the eligibility for balloon mitral valvuloplasty (BMV). BMV was carried out under transeosophagial echo (TEE) guidance (for perfect septal puncture and crossing the separate orifices) using Inoue balloon of appropriate size (in accordance with patient’s height) with intention to break central fibrous strand converting into a single orifice. All four patients underwent successful BMV (clinical & ECHO criteria) after dilating the separate orifices (except case 4) but the fibrous strand could not be broken. Hence, this study shows that good results can be obtained in acquired double orifice mitral valve with significant MS with BMV even without breaking the fibrous strand. Considering rarity of isolated DOMV cases and rheumatic etiology being very rare, this report of four rheumatic acquired DOMV cases with successful BMV done with good result is significant.
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