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Search Results: 1 - 10 of 748 matches for " Matti Viluksela "
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Dioxin Induces Genomic Instability in Mouse Embryonic Fibroblasts
Merja Korkalainen, Katriina Huumonen, Jonne Naarala, Matti Viluksela, Jukka Juutilainen
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0037895
Abstract: Ionizing radiation and certain other exposures have been shown to induce genomic instability (GI), i.e., delayed genetic damage observed many cell generations later in the progeny of the exposed cells. The aim of this study was to investigate induction of GI by a nongenotoxic carcinogen, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Mouse embryonic fibroblasts (C3H10T1/2) were exposed to 1, 10 or 100 nM TCDD for 2 days. Micronuclei (MN) and expression of selected cancer-related genes were assayed both immediately and at a delayed point in time (8 days). For comparison, similar experiments were done with cadmium, a known genotoxic agent. TCDD treatment induced an elevated frequency of MN at 8 days, but not directly after the exposure. TCDD-induced alterations in gene expression were also mostly delayed, with more changes observed at 8 days than at 2 days. Exposure to cadmium produced an opposite pattern of responses, with pronounced effects immediately after exposure but no increase in MN and few gene expression changes at 8 days. Although all responses to TCDD alone were delayed, menadione-induced DNA damage (measured by the Comet assay), was found to be increased directly after a 2-day TCDD exposure, indicating that the stability of the genome was compromised already at this time point. The results suggested a flat dose-response relationship consistent with dose-response data reported for radiation-induced GI. These findings indicate that TCDD, although not directly genotoxic, induces GI, which is associated with impaired DNA damage response.
Role of microRNAs and DNA methyltransferases in transmitting induced genomic instability between cell generations
Katriina Huumonen,Merja Korkalainen,Matti Viluksela,Jonne Naarala,Jukka Juutilainen
Frontiers in Public Health , 2014, DOI: 10.3389/fpubh.2014.00139
Abstract: There is limited understanding of how radiation or chemicals induce genomic instability, and how the instability is epigenetically transmitted to the progeny of exposed cells or organisms. Here we measured the expression of microRNAs (miRNAs) and DNA methyltransferases (DNMTs) in murine embryonal fibroblasts exposed to ionizing radiation or 2,3,7,8 -tetrachlorodibenzo-p-dioxin (TCDD), which were previously shown to induce genomic instability in this cell line. Cadmium was used as a reference agent that does not induce genomic instability in our experimental model. Measurements at 8 and 15 days after exposure did not identify any such persistent changes that could be considered as signals transmitting genomic instability to the progeny of exposed cells. However, measurements at 2 days after exposure revealed findings that may reflect initial stages of genomic instability. Changes that were common to TCDD and two doses of radiation (but not to cadmium) included 5 candidate signature miRNAs and general up-regulation of miRNA expression. Expression of DNMT3a, DNMT3b and DNMT2 were suppressed by cadmium but not by TCDD or radiation, consistently with the hypothesis that sufficient expression of DNMTs is necessary in the initial phase of induced genomic instability.
Biological and toxicological effects of non-dioxin-like PCBs
Viluksela Matti,van der Ven Leo TM,Schrenk Dieter,Lilienthal Hellmuth
Acta Veterinaria Scandinavica , 2012, DOI: 10.1186/1751-0147-54-s1-s16
Abstract:
A Novel Hybrid Approach to Estimate Customer Interruption Costs for Industry Sectors  [PDF]
Sinan Kufeoglu, Matti Lehtonen
Engineering (ENG) , 2013, DOI: 10.4236/eng.2013.510A006
Abstract:

The power system infrastructure, operations and market have gone through radical changes for the last couple of decades. The society has become more dependent to the continuous electric power supply and hence the concept of electric power reliability has become more significant. At this point, understanding the economic outcomes of power outages is vital and imperative for both utilities and the customers. There are certain methodologies to understand the costs of power interruptions. This paper suggests a novel hybrid method that comprises of customer surveys and direct analytical methods to reach customer specific, objective and reliable results for the industry sector customers. The paper also brings a statistical approach to censor the zero and extreme responses given via the surveys.

Vehicles, Replicators, and Intercellular Movement of Genetic Information: Evolutionary Dissection of a Bacterial Cell
Matti Jalasvuori
International Journal of Evolutionary Biology , 2012, DOI: 10.1155/2012/874153
Abstract: Prokaryotic biosphere is vastly diverse in many respects. Any given bacterial cell may harbor in different combinations viruses, plasmids, transposons, and other genetic elements along with their chromosome(s). These agents interact in complex environments in various ways causing multitude of phenotypic effects on their hosting cells. In this discussion I perform a dissection for a bacterial cell in order to simplify the diversity into components that may help approach the ocean of details in evolving microbial worlds. The cell itself is separated from all the genetic replicators that use the cell vehicle for preservation and propagation. I introduce a classification that groups different replicators according to their horizontal movement potential between cells and according to their effects on the fitness of their present host cells. The classification is used to discuss and improve the means by which we approach general evolutionary tendencies in microbial communities. Moreover, the classification is utilized as a tool to help formulating evolutionary hypotheses and to discuss emerging bacterial pathogens as well as to promote understanding on the average phenotypes of different replicators in general. It is also discussed that any given biosphere comprising prokaryotic cell vehicles and genetic replicators may naturally evolve to have horizontally moving replicators of various types. 1. Introduction Viruses that infect prokaryotic cells are known to be enormously diverse in terms of genetic information [1, 2]. Most novel viral isolates are likely to have at least some genes that have no homologues among any of the previously known genes, including those in the genomes of related viruses [3]. Yet, there has been a dispute whether or not new genes may actually emerge in viruses [3]. Viruses are dependent on cellular resources such as nucleotides, amino acids, and lipids for producing more viruses; therefore it seems justified to ask whether they also use cellular genes for their genetic information. Yet, when viral genes are compared to other genes in databases, it often appears that they have no cellular counterparts [2]. Where then do these viral genes come from? Have they been acquired from a cellular host that we simply have not sequenced before? Or alternatively, are the cellular genes perhaps just evolving rapidly in viral genomes so that their common ancestry with the host genes can no longer be derived? Or perhaps, is it indeed possible that new genes actually emerge in viruses themselves? Forterre and Prangishvili from Pasteur Institute
The Marketplace Variables in Successful and Unsuccessful NPD Projects in Technology Intensive Companies
Haverila,Matti;
Journal of technology management & innovation , 2010, DOI: 10.4067/S0718-27242010000400010
Abstract: we present an exploratory investigation of how managers conceptualize and perceive 'marketplace' variables in successful and unsuccessful new product development (npd) projects, and explore the role that marketplace variables play in differentiating between successful and unsuccessful npd outcomes. limitations and future research directions are also discussed. our findings indicate that managers perceive the marketplace in multiple ways during the npd process and also that differences exist in metric equivalence across successful and unsuccessful npd projects. also, although half of the marketplace variables are positively related to npd success, managers in finnish technology companies appear to attach higher relative importance to market attractiveness rather than market competitiveness variables. marketplace variables appear to be less important than in the korean and chinese samples, and much more important than in the canadian sample in the mishra et al. study (1996), and similarly much more important than in the cooper study (1979b).
Review of Carole A. George (2008) User-Centred Library Websites: Usability Evaluation Methods.
Matti Pekuri
Libreas : Library Ideas , 2009,
Abstract:
SIOG (International Society of Geriatric Oncology) recommendations for anthracycline use in the elderly
Matti Aapro
Hematology Reports , 2011, DOI: 10.4081/hr.2011.s3.e6
Abstract: A taskforce of the International Society of Geriatric Oncology (SIOG) has recently submitted recommendations on the use of anthracyclines in elderly patients. Despite the aging of the population and the high proportion of elderly individuals in the population of patients with non-Hodgkin’s lymphoma, the development of specialist expertise in the treatment of elderly patients with cancer is relatively recent. Treatment of the elderly is complex because they are a highly heterogeneous population, with large variations in health status, comorbidities and life expectancy. In addition, these patients are generally more susceptible than young patients to the cardiotoxic effects of anthracyclines. Strategies for assessing elderly patients with cancer, reducing the risk of congestive heart failure, and assessing the cardiotoxic effects of treatments are discussed. In addition, a summary of the SIOG recommendations is presented.
Du an Coti and the European institute: Bridging the gap
Joutsen Matti
Temida , 2012, DOI: 10.2298/tem1202031j
Abstract: The paper describes the context in which the European Institute, on its establishment, identified Professor Du an Coti as the ideal candidate to serve on its Advisory Board and an internationally oriented criminal justice practitioner and criminologist, so that the Board could bridge the gap between East and West, and academia and practice. Professor Du an Coti served on the Board with distinction.
In Search of Explanations: from Why-questions to Shakespearean Questions
Matti Sintonen
Philosophica , 1993,
Abstract:
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