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Search Results: 1 - 10 of 1351 matches for " Matthieu; Chevalier "
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Antibiotic Transport in Resistant Bacteria: Synchrotron UV Fluorescence Microscopy to Determine Antibiotic Accumulation with Single Cell Resolution
Slávka Ka??áková, Laure Maigre, Jacqueline Chevalier, Matthieu Réfrégiers, Jean-Marie Pagès
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0038624
Abstract: A molecular definition of the mechanism conferring bacterial multidrug resistance is clinically crucial and today methods for quantitative determination of the uptake of antimicrobial agents with single cell resolution are missing. Using the naturally occurring fluorescence of antibacterial agents after deep ultraviolet (DUV) excitation, we developed a method to non-invasively monitor the quinolones uptake in single bacteria. Our approach is based on a DUV fluorescence microscope coupled to a synchrotron beamline providing tuneable excitation from 200 to 600 nm. A full spectrum was acquired at each pixel of the image, to study the DUV excited fluorescence emitted from quinolones within single bacteria. Measuring spectra allowed us to separate the antibiotic fluorescence from the autofluorescence contribution. By performing spectroscopic analysis, the quantification of the antibiotic signal was possible. To our knowledge, this is the first time that the intracellular accumulation of a clinical antibitiotic could be determined and discussed in relation with the level of drug susceptibility for a multiresistant strain. This method is especially important to follow the behavior of quinolone molecules at individual cell level, to quantify the intracellular concentration of the antibiotic and develop new strategies to combat the dissemination of MDR-bacteria. In addition, this original approach also indicates the heterogeneity of bacterial population when the same strain is under environmental stress like antibiotic attack.
Biomarkers and atrial fibrillation: A new paradigm for assessing the progression of left atrial endocardial remodelling  [PDF]
Philippe Chevalier, Alina Scridon
Open Journal of Clinical Diagnostics (OJCD) , 2012, DOI: 10.4236/ojcd.2012.22004
Abstract: Atrial fibrillation is a heterogeneous disorder that is usually characterized by paroxysmal onset, particularly in patients without structural heart disease. Defining biological markers of atrial remodelling would help identify patients at high risk who would benefit most from prophylactic treatment and careful monitoring. Biomarkers of atrial fibrillation progression would be helpful for following patients that present with asymptomatic atrial fibrillation. Notably, the roles of such markers in the pathophysiology of atrial fibrillation must be determined. Some markers may indicate the presence, complications or progression of the disease, while others may be involved in key pathological processes and thus represent novel therapeutic targets. Although a number of markers have been reported as potential predictors of paroxysmal atrial fibrillation progression towards persistent arrhythmia, their usefulness and clinical value need further validation. This report reviews several newly identified markers of atrial fibrillation progression.
Grounding the Human Body Improves Facial Blood Flow Regulation: Results of a Randomized, Placebo Controlled Pilot Study  [PDF]
Gaétan Chevalier
Journal of Cosmetics, Dermatological Sciences and Applications (JCDSA) , 2014, DOI: 10.4236/jcdsa.2014.45039
Abstract:

Earthing (grounding) refers to bringing the human body in direct contact with the negative electric charge of the earth’s surface by barefoot exposure outdoors or using special conductive indoor systems that are connected to the Earth. To determine if earthing improves facial blood circulation/flow, a double-blind study was designed with forty subjects either grounded or sham-grounded (27 grounded subjects and 13 sham-grounded subjects acting as controls) for at least one hour in a comfortable recliner chair equipped with conductive mat, pillow, and patches. The grounding systems were either grounded or sham-grounded via a wire to the ground port (third hole) of a power outlet. A Laser Speckle Contrast Imaging camera was used to continuously record changes in facial blood flow non-invasively. Facial blood flow regulation clearly improved among grounded— but not sham-grounded—subjects. The results demonstrate, for the first time, that even one-hour contact with the earth restores blood flow regulation to the face suggesting enhanced skin tissue repair and improved facial appearance with possible implications for overall health. Further studies, using larger comparison groups, longer monitoring times, and more measuring methods, are warranted in order to confirm the novel influence of the Earth as a protector of skin health and appearance.

Grounding the Human Body during Yoga Exercise with a Grounded Yoga Mat Reduces Blood Viscosity  [PDF]
Richard Brown, Gaétan Chevalier
Open Journal of Preventive Medicine (OJPM) , 2015, DOI: 10.4236/ojpm.2015.54019
Abstract: Objective: Research continues to show that being connected to the earth can increase the potential of the body to scavenge free radicals. This study examined the effect of just one hour of grounding on blood viscosity while subjects participated in gentle yoga exercises designed to initiate minor inflammation. Design: In this double blind model, twenty-eight (28) subjects met at the Bowerman Sports Medicine Clinic on the campus of the University of Oregon and were grounded to the earth via contact with a grounded yoga mat or were sham-grounded. Ten yoga exercises were repeated five times over a one-hour period. Blood was taken pre and post exercise and analyzed for blood viscosity using a scanning capillary viscometer. Results: Subjects connected to the earth significantly reduced their post exercise systolic blood viscosity (p = 0.03) and diastolic blood viscosity (p = 0.03). Conclusion: Grounding has the ability to affect exercise induced inflammation, thereby reducing blood viscosity.
The Possible Utopia: A Gift of Hope and Reason for Action—Changing the Course of History!  [PDF]
Patricia Rodiles, José ángel Chevalier
Open Journal of Leadership (OJL) , 2015, DOI: 10.4236/ojl.2015.42005
Abstract: Today, the world’s current state reflects how we are living in a critical and chaotic time which brings multiple and challenging problems in social, economic, ecological and cultural aspects among many others. However, for women and men of good will, who yearn for a better, more human, and more solidary world, it is very encouraging that, despite this sad reality, there is a “possible utopia” that would change the course of history. But everybody asks themselves: How can we face a challenge of this magnitude? What path should we follow? Will man be able to change his mind and heart to do so? Will man have the faith, spirit and strength required? Will humanity be able to transform its creations of death into structures of life? What story should be built from now on to the future? It is an enormous and extremely complex task to have a better world, but if we are not willing to start, here and now, where and when will it be? And if we do not, who will? In this sense, Einstein and Edmund Burke challenge us as humanity, with their great motivating and appropriate statements: “If you want different results, do not do always the same” (as cited in Davidovich, Nikolay, Laugerman, & Commodore, 2010: p. 23) and “For evil to triumph [on earth] it is enough that good men do nothing” (as cited in Bartlett, 1968: p. 454; Kirk, 2009: p. 204; Landau, 2006: p. 222). Now, more than ever, it is the best time to start. Without a doubt, it is a monumental challenge, but also a “unique opportunity” that demands the availability of men and women, bold and brave, in order to unite their wills, to make possible the impossible, because our future as humanity is truly at stake.
"Shopping" à la fran?aise: approvisionnement alimentaire et sociabilité
Chevalier, Sophie;
Horizontes Antropológicos , 2007, DOI: 10.1590/S0104-71832007000200004
Abstract: l'auteur décrit les pratiques d'approvisionnement alimentaire des habitants de trois villes fran?aises, paris, lyon et besan?on, en les contrastant avec des banlieusards. elle montre que ces citadins des centres villes fréquentent les commerces alimentaires de proximité l'analyse de ces pratiques révèlent que c'est la dimension sociale qui est la plus importante à examiner pour comprendre ces pratiques d'approvisionnement, en lien avec la sociabilité de quartier. c'est la possibilité de créer des liens personnalisés entre commer?ant et client, et "d'être un client reconnu comme habitant d'un quartier". les commerces "font" la vie de quartier pour la plupart des interlocuteurs des centres villes étudiés. il existe donc à la fois une sociabilité et une socialisation autour de l'activité d'approvisionnement: "faire ses courses" crée du lien social.
Intérieurs domestiques urbains en France et en Angleterre
Chevalier, Sophie;
Horizontes Antropológicos , 2000, DOI: 10.1590/S0104-71832000000100006
Abstract: cette article concerne une recherche comparative portant sur l'analyse des processus d'appropriation d'objets produits en série dans des ménages de la banlieue parisienne et de londres. nous proposons tout d'abord une analyse des décors domestiques fran?ais et anglais en dégageant leurs caractéristiques communes et leurs spécificités particulières. ensuite, nous montrons à travers plusieurs exemples, comment cette construction de l'univers domestique repose sur des processus d'appropriation des objets qui permettent l'expression des identités collectives et individuelles. l'analyse des pratiques et de discours autour des objets domestiques permet de comprendre la fa?on dont ils peuvent matérialiser différentes dimensions de la vie des ménages, comme les rapports de couple, la structure familiale, l'ancrage géographique, etc. nous observons alors des contrastes entre fran?ais et anglais qui ne prennent sens que si on les ramène à un cadre culturel et social spécifique, dans une dynamique historique.
Uma sociedade em mudan?a: antropologia de uma "transi??o" na Bulgária
Chevalier, Sophie;
Horizontes Antropológicos , 2001, DOI: 10.1590/S0104-71832001000100003
Abstract: este artigo trata da transi??o econ?mica e política na bulgária. a autora pretende compreender as experiências individuais dos habitantes de uma pequena cidade - em nível local - e ao mesmo tempo as transforma??es históricas do país. ela constrói quatro "espa?os" conceituais que s?o quatro esferas de intercambio (parentesco; mercado; estado; europa). examina suas situa??es no espa?o (rural e urbano), as rela??es sociais em cada uma destas esferas, e as identidades invocadas pelas pessoas. por fim, descreve as conseqüências econ?micas e políticas da irrup??o de uma nova esfera, a europa.
Les révisions bibliques carolingiennes
Chevalier,Caroline;
Temas medievales , 2006,
Abstract: the author of this article analyzes the history of the vulgata bible within the general context of cultural renovation and religious reform which took place during the carolingian renaissance when, so she explains, one of the main problems was the difficulty to possess a reliable version of the bible. after briefly examining the biblical revisions of maudramne, the manuscripts known as group of ada, as well as the one by angilram, she procedes to an in depth analysis of the important revisions by alcuin and theodulf.
Faire ses courses en voisin
Sophie Chevalier
Métropoles , 2007,
Abstract: Les échanges marchands et la circulation des marchandises, entre la sphère du privé – l’habitat – et la sphère publique – l’environnement urbain de proximité –, permettent de comprendre comment des habitants s’inscrivent dans un espace et comment ils construisent leurs rapports à leur quartier. Si les relations marchandes engendrent des champs de rapports sociaux spécifiques comme l’a montré Michèle de La Pradelle (1996, 2002), de même les pratiques d’approvisionnement participent de la socia...
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