Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99


Any time

2020 ( 1 )

2019 ( 24 )

2018 ( 33 )

2017 ( 35 )

Custom range...

Search Results: 1 - 10 of 15909 matches for " Matthew Miller "
All listed articles are free for downloading (OA Articles)
Page 1 /15909
Display every page Item
Human Macrophages Utilize the Podosome Formin FMNL1 for Adhesion and Migration  [PDF]
Matthew R. Miller, Scott D. Blystone
CellBio (CellBio) , 2015, DOI: 10.4236/cellbio.2015.41001
Abstract: Macrophages play a crucial role in detecting, regulating, and resolving immune crises, requiring migration through complex extracellular matrices. Unwarranted macrophage inflammatory activity potentiates kidney disease, rheumatoid arthritis, and transplant rejection. Proper remodeling of the actin cytoskeleton, especially at adhesion structures, is essential to the translocation of macrophages. Macrophages form actin-rich adhesions termed “podosomes”, giving them the capacity to make contacts with the substratum for traction through interstitial tissues. Macrophages express multiple formins, including FMNL1, Dia1, and Fhod1, with potential to impact actin remodeling involved in migration. Formins are a family of proteins that are best known for modifying the actin cytoskeleton via nucleation, elongation, bundling, and/or severing actin filaments. In this study we demonstrate that the formin FMNL1 is a key regulator of podosomes and is required for normal macrophage migration. Additionally, this is the first study to demonstrate defects in primary human cell migration resulting from specific formin silencing. Pharmacologic inhibition of all formin activity results in a significant decrease in podosome formation and normal macrophage migration. Furthermore, targeted suppression of FMNL1 results in decreases in macrophage migration similar to inhibition of all expressed macrophage formins. These novel findings suggest FMNL1 as a possible chemotherapeutic target to hinder macrophage migration, which could offer an innovative method for limiting unnecessary macrophage-mediated inflammation. We hypothesize that formins are required in podosome actin dynamics to support macrophage migration.
An Urgent Need to Restrict Access to Pesticides Based on Human Lethality
Matthew Miller ,Kavi Bhalla
PLOS Medicine , 2010, DOI: 10.1371/journal.pmed.1000358
Report from the Biennial Scientific Meeting of the Australasian Section of the American Oil Chemists Society (AAOCS) Held in Adelaide, November 2011
Matthew R. Miller
Nutrients , 2012, DOI: 10.3390/nu4050372
Abstract: The Australasian section of the American Oil Chemists Society (AAOCS) held their biennial meeting in Adelaide, Australia on 8–11 November 2011. Over 70 scientists, researchers and industry representatives gathered for three days of talks and discussions on lipid related topics. A highlight was the hot topic symposium on the new olive oil standard being introduced in Australia. Paul Miller, Australian Olives Association, gave a compelling address on why the standard was needed. He demonstrated that the increase in price and demand for high quality olive oils has led to products falsely or misleadingly labelled. Furthermore, the genetic and seasonal variation in minor components of olive oil has led to misclassifications. An extensive scientific and political process in Australia and overseas led to development of this new standard. Dr. Leandro Ravetti, Mordern Olives, demonstrated the development of two new methods, for analysis of pyropheophytins and diacylglycerols, are good indicators of modification by deodorisation of oils and show excellent correlation with organoleptic assessment with aging/degradation of extra virgin olive oils. Professor Rod Mailer finished this session with studies of actual adulteration cases in Australia and overseas, further highlighting the need for this new standard. [...]
The Structure of the Milky Way's Hot Gas Halo
Matthew Miller,Joel Bregman
Physics , 2013, DOI: 10.1088/0004-637X/770/2/118
Abstract: The Milky Way's million degree gaseous halo contains a considerable amount of mass that, depending on its structural properties, can be a significant mass component. In order to analyze the structure of the Galactic halo, we use XMM-Newton Reflection Grating Spectrometer archival data and measure OVII K alpha absorption-line strengths toward 26 active galactic nuclei, LMC X-3, and two Galactic sources (4U 1820-30 and X1735-444). We assume a beta-model as the underlying gas density profile and find best-fit parameters of n_o = 0.46^{+0.74}_{-0.35} cm^-3, r_c = 0.35^{+0.29}_{-0.27} kpc, and beta = 0.71^{+0.13}_{-0.14}. These parameters result in halo masses ranging between M(18 kpc) = 7.5^{+22.0}_{-4.6} x 10^8 M_sun and M(200 kpc) = 3.8^{+6.0}_{-0.5} x 10^{10} M_sun assuming a gas metallicity of Z = 0.3 Z_sun, which are consistent with current theoretical and observational work. The maximum baryon fraction from our halo model of f_b = 0.07^{+0.03}_{-0.01} is significantly smaller than the universal value of f_b = 0.171, implying the mass contained in the Galactic halo accounts for 10% - 50% of the missing baryons in the Milky Way. We also discuss our model in the context of several Milky Way observables, including ram pressure stripping in dwarf spheroidal galaxies, the observed X-ray emission measure in the 0.5 - 2 keV band, the Milky Way's star formation rate, spatial and thermal properties of cooler gas (~10^5 K) and the observed Fermi bubbles toward the Galactic center. Although the metallicity of the halo gas is a large uncertainty in our analysis, we place a lower limit on the halo gas between the Sun and the Large Magellanic Cloud (LMC). We find that Z >~ 0.2 Z_sun based on the pulsar dispersion measure toward the LMC.
Length control of an optical resonator using second-order transverse modes
John Miller,Matthew Evans
Physics , 2014, DOI: 10.1364/OL.39.002495
Abstract: We present the analysis of an unorthodox technique for locking a laser to a resonant optical cavity. Error signals are derived from the interference between the fundamental cavity mode and higher-order spatial modes of order two excited by mode mismatch. This scheme is simple, inexpensive and, in contrast to similar techniques, first-order-insensitive to beam jitter. After mitigating sources of technical noise, performance is fundamentally limited by quantum shot-noise.
Edge colored hypergraphic arrangements
Matthew Miller,Max Wakefield
Mathematics , 2009,
Abstract: A subspace arrangement defined by intersections of hyperplanes of the braid arrangement can be encoded by an edge colored hypergraph. It turns out that the characteristic polynomial of this type of subspace arrangement is given by a generalized chromatic polynomial of the associated edge colored hypergraph. The main result of this paper supplies a sufficient condition for the existence of non-trivial Massey products of the subspace arrangements complex complement. This is accomplished by studying a spectral sequence associated to the Lie coalgebras of Sinha and Walter.
Elliptic flow from final state interactions in the distorted-wave emission-function model
Matthew Luzum,Gerald A. Miller
Physics , 2008, DOI: 10.1103/PhysRevC.79.024902
Abstract: The effect of final state interactions on the elliptic flow coefficient measured in relativistic heavy ion collisions is investigated within the DWEF formalism established by Miller and Cramer [Phys. Rev. Lett. 94, 102302 (2005), J. Phys. G34, 703 (2007), Phys. Rev. C78, 054905 (2008)]. It is found that the optical potential previously found to give the best fit of particle multiplicity and Hanbury Brown and Twiss radii in RHIC events has a moderate effect on the resulting elliptic flow coefficient v_2. This indicates that final state interactions should be taken into account to confidently predict v_2 to better than ~20% accuracy.
Limits with braid arrangements
Matthew S. Miller,Max Wakefield
Mathematics , 2012,
Abstract: We define a monoid structure on the set of $k$-equal arrangements and use this structure to define limits of braid arrangements. We compute the cohomology of the associated limits of rational models of the arrangements complex complements. We collect these complexes together into one complex by creating a new differential and product on their direct sum and show that the resulting complex is exact.
On the Betti numbers of some Gorenstein ideals
Matthew Miller,Rafael H. Villarreal
Mathematics , 1994,
Abstract: Assume $R$ is a polynomial ring over a field and $I$ is a homogeneous Gorenstein ideal of codimension $g\ge3$ and initial degree $p\ge2$. We prove that the number of minimal generators $\nu(I_p)$ of $I$ that are in degree $p$ is bounded above by $\nu_0={p+g-1\choose g-1}-{p+g-3\choose g-1}$, which is the number of minimal generators of the defining ideal of the extremal Gorenstein algebra of codimension $g$ and initial degree $p$. Further, $I$ is itself extremal if $\nu(I_p)=\nu_0$.
Host Searching and Aggregation Activity of Recently Fed and Unfed Bed Bugs (Cimex lectularius L.)
Matthew D. Reis,Dini M. Miller
Insects , 2011, DOI: 10.3390/insects2020186
Abstract: Groups of starved, virgin adult male or female bed bugs were stimulated to search for a host by the presence of a heated artificial feeder. Some of the bed bug groups were allowed to obtain a blood meal and some were not. After the removal of the feeder, bed bugs were observed throughout the scotophase to record their searching and aggregation behavior. Groups of male and female bed bugs that were unable to obtain a blood meal continued to search in the arena for the majority of the scotophase. Bed bugs that were able to obtain a blood meal returned to their shelter to aggregate 30 min after feeding. Overall, the proportion of bed bugs aggregating in shelters during the scotophase was significantly greater for those that had fed successfully than those that had not. However, all bed bugs, regardless of feeding status, began to return to shelters to aggregate 2 h prior to the photophase.
Page 1 /15909
Display every page Item

Copyright © 2008-2017 Open Access Library. All rights reserved.