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Economic Station-Centered Network and Invisible Collaboration: A Cyclic vs. Semi-Cyclic View  [PDF]
Masayuki Matsui
Theoretical Economics Letters (TEL) , 2012, DOI: 10.4236/tel.2012.23063
Abstract: By our past review, this paper will verify the hypothesis that the autonomous (invisible) body balancing would be better under changeable demand speed and a leading principle in the collaborative networks. This hypothesis was first utilized in the Conveyor-Serviced Production System (CSP System) with cycle time by a Station-Centered Approach to the physical networks. Recently, we are ascertaining this hypothesis in cost/profit balancing under demand speed (invisible hand) at the economic body chain networks. Generally, it becomes simpler at series (cyclic) type, but would not be so at parallel (semi-cyclic) type. Throughout this paper, we will point out the principle of autonomous (invisible) body ba-lancing by demand speed (cycle time), and would extend to a parallel (semi-cyclic) supply chain by the Station-Centered Approach. This thing would bring the invisible merit that the profit maximization occurs at the relative cost balancing of each enterprise in a series-parallel body network.
The Invisible Body-Balancing Economics: A Medium Approach  [PDF]
Masayuki Matsui
Theoretical Economics Letters (TEL) , 2015, DOI: 10.4236/tel.2015.51010
Abstract: Our global world is under the variety of individual bodies on the division of work. This paper would consider the invisible body-balancing network and economics by a medium approach. This medium approach originated from the Newsboy problem, and would be attained by the invisible hand of market (demand) speed at Chameleon’s criteria. First, our new treatment and condition to balancing are given. Next, a few trial cases are discussed and verified at the series type.
A Theory of Modern Economic Growth toward Sharing Society  [PDF]
Masayuki Matsui
Theoretical Economics Letters (TEL) , 2018, DOI: 10.4236/tel.2018.84045
Abstract: Since Industrial Revolution and the division of labor, the wealth of nations is more and more increasing. Although the smaller division of labor is better in GDP, but mass production with larger lot (quantity) is better since Fordism and the division of quantity (lot-size Q, 0<Q<) is well-known to be worse in manufacturing, for the sake of the larger set-up with penalty. This paper presents the progressive discipline for the contradiction on modern economic growth in the lot-sizing scheme. The theory would govern over from mass-production (larger Q), mid-lot (EOQ) and disparities (smaller Q), toward next to sharing equilibrium (0<Q<1). Especially, the Nash’s condition for the case of Q < 1 could be obtained by the duality of flow line vs. job shop. This theoretical review would give the further wealthy development to the gap-wider society of artifacts in the future, and point out that the shared society too could be balanced on the base of the harmonic mean under Industrial-financial capitalism.
Treatment for Depression with Chronic Neck Pain Completely Cured in 94.2% of Patients Following Neck Muscle Treatment  [PDF]
Takayoshi Matsui, Toshiro Fujimoto
Neuroscience & Medicine (NM) , 2011, DOI: 10.4236/nm.2011.22011
Abstract: We report three patients with cervical neuromuscular syndrome (CNMS) who followed similar courses. Autonomic imbalance may occur following neck muscle pain, and a wide variety of somatic symptoms including headache and vertigo appear and a generalized poor condition may continue for long periods. If many such somatic symptoms persist for months to years, symptoms of depression are exacerbated. The patients end up in psychiatric clinics, where they are diagnosed with depression, but they do not respond to antidepressants. Thus, they continue to suffer for many years. These patients eventually were completely cured with the resolution of neck pain by neck muscle treatment, using two types of special low-frequency therapy equipment, far-infrared radiation and acupuncture. When treatment for the neck muscles is initiated, symptoms of depression are quickly relieved, and diverse somatic symptoms disappear one after another as neck muscle tension is gradually alleviated (the number of abnormal neck muscle checkpoints decreases). Such a course suggests that neck muscle tension and chronic pain are closely related to depression. Neck muscle-related depression due to CNMS clearly differs from psychiatric conditions such as major and bipolar depression. In patients with neck muscle-related depression, symptoms of depression are not accompanied by ungrounded anxiety, a sense of emptiness, apathy, or self-rejection. Neck muscle abnormalities leading to CNMS are caused by head injury, whiplash injury, and a prolonged forward-bent-posture due to using a personal computer, playing computer games, texting, and engaging in machine-paced work such as assembly-line operation.
An Interactive Fuzzy Satisficing Method for Multiobjective Stochastic Integer Programming with Simple Recourse  [PDF]
Masatoshi Sakawa, Takeshi Matsui
Applied Mathematics (AM) , 2012, DOI: 10.4236/am.2012.330180
Abstract: This paper considers multiobjective integer programming problems involving random variables in constraints. Using the concept of simple recourse, the formulated multiobjective stochastic simple recourse problems are transformed into deterministic ones. For solving transformed deterministic problems efficiently, we also introduce genetic algorithms with double strings for nonlinear integer programming problems. Taking into account vagueness of judgments of the decision maker, an interactive fuzzy satisficing method is presented. In the proposed interactive method, after determineing the fuzzy goals of the decision maker, a satisficing solution for the decision maker is derived efficiently by updating the reference membership levels of the decision maker. An illustrative numerical example is provided to demonstrate the feasibility and efficiency of the proposed method.
Interactive Fuzzy Programming for Random Fuzzy Two-Level Integer Programming Problems through Fractile Criteria with Possibility  [PDF]
Masatoshi Sakawa, Takeshi Matsui
Applied Mathematics (AM) , 2013, DOI: 10.4236/am.2013.48A006

This paper considers two-level integer programming problems involving random fuzzy variables with cooperative behavior of the decision makers. Considering the probabilities that the decision makers’ objective function values are smaller than or equal to target variables, fuzzy goals of the decision makers are introduced. Using the fractile criteria to optimize the target variables under the condition that the degrees of possibility with respect to the attained probabilities are greater than or equal to certain permissible levels, the original random fuzzy two-level integer programming problems are reduced to deterministic ones. Through the introduction of genetic algorithms with double strings for nonlinear integer programming problems, interactive fuzzy programming to derive a satisfactory solution for the decision maker at the upper level in consideration of the cooperative relation between decision makers is presented. An illustrative numerical example demonstrates the feasibility and efficiency of the proposed method.

Adherence with Drug Therapy in Pregnancy
Doreen Matsui
Obstetrics and Gynecology International , 2012, DOI: 10.1155/2012/796590
Abstract: Available information suggests that nonadherence with medication is a common problem in pregnant women. Not taking prescribed drugs may have potentially negative consequences as patients may not achieve their therapeutic goal. In addition to the many factors that may influence medication-taking behaviour in the general population, unique challenges are encountered in pregnant women as both maternal health and fetal well-being must be considered. On the one hand, pregnant women may be motivated to keep their underlying disease under control, while, on the other hand, fear and anxiety regarding the potential harmful effects of their medication on their unborn child may result in poor adherence with needed medication. Providing evidence-based information, ideally preconceptually, regarding the effects of their medication during pregnancy may be important in avoiding misperceptions that lead to nonadherence. 1. Introduction Advances in drug therapy have resulted in efficacious treatments being available for many acute and chronic medical conditions; however, it is well recognized that “Drugs don’t work in patients who don’t take them” [1]. The WHO defines adherence, a term which is often used interchangeably with compliance, as the extent to which a person’s behaviour-taking medication, following a diet, and/or executing lifestyle changes, corresponds with agreed recommendations from a health care provider [2]. Unfortunately, nonadherence with medication regimens is not uncommon with the potential negative consequences of failure to achieve the desired treatment goal. Many factors may play a role in whether patients comply with their therapy and pregnancy may present unique challenges as fetal well-being must also be considered in addition to maternal health. This paper will provide a brief overview of medication adherence in general and then will focus on some of the issues related to medication-taking behaviour during pregnancy. 2. Overview of Medication Adherence Nonadherence with drug therapy may take many forms with delayed or omitted doses being the most common errors. Discontinuation of medication administration prior to completion of the course is also common. Adherence is generally measured over a specified period of time and often reported as the percentage of the prescribed doses of medication actually taken by the patient [3]. In a meta-analysis of 569 studies, reported adherence to medical treatment ranged from 4.6% to 100% with a median of 76% and an overall average of 75.2% [4]. Drug compliance may be of particular concern with chronic
Predicting survival outcomes using subsets of significant genes in prognostic marker studies with microarrays
Shigeyuki Matsui
BMC Bioinformatics , 2006, DOI: 10.1186/1471-2105-7-156
Abstract: We develop a methodology for predicting survival outcomes using subsets of significant genes in prognostic marker studies with microarrays. Key components in this methodology include building prediction models, assessing predictive performance of prediction models, and assessing significance of prediction results. As particular specifications, we assume Cox proportional hazard models with a compound covariate. For assessing predictive accuracy, we propose to use the cross-validated log partial likelihood. To assess significance of prediction results, we apply permutation procedures in cross-validated prediction. As an additional key component peculiar to prognostic prediction, we also consider incorporation of standard prognostic factors. The methodology is evaluated using both simulated and real data.The developed methodology for prognostic prediction using a subset of significant genes can provide new insights based on predictive capability, possibly incorporating standard prognostic factors, in selecting a fraction of relevant genes for subsequent studies.Genetic markers hold great promise for refining our ability to establish precise prognostic prediction for diseases. The development of comprehensive, gene expression microarray technology has allowed the selection of relevant marker genes from a large pool of candidate genes in early-phased, developmental prognostic marker studies for various cancers including diffuse large B-cell lymphoma [1], follicular lymphoma [2], acute myeloid leukemia [3], lung adenocarcinoma [4], and metastatic kidney cancer [5]. The selected genes will be further investigated in subsequent studies using technically simpler, but more reliable assays such as multiplexed quantitative reverse-transcriptase polymerase chain reaction (RT-PCR) in formalin-fixed, paraffin-embedded tissue sections for routine clinical use [6,7]. Accordingly, the primary task in early-phased prognostic marker studies with microarrays would be to select a small f
Medication adherence issues in patients: focus on cost
Matsui D
Clinical Audit , 2013, DOI: http://dx.doi.org/10.2147/CA.S30125
Abstract: ication adherence issues in patients: focus on cost Review (490) Total Article Views Authors: Matsui D Published Date March 2013 Volume 2013:5 Pages 33 - 42 DOI: http://dx.doi.org/10.2147/CA.S30125 Received: 09 November 2012 Accepted: 11 January 2013 Published: 11 March 2013 Doreen Matsui Department of Pediatrics and Medicine, University of Western Ontario, London, Ontario, Canada; Children's Hospital, London Health Sciences Centre, London, Ontario, Canada; Children's Health Research Institute, London, Ontario, Canada Abstract: Advances in drug therapy have resulted in efficacious treatments being available; however, the benefit may be lost if prescribed medications are not taken properly. Unfortunately, poor medication adherence is common and widespread, affecting all age groups and disease conditions. Adherence is a factor in health outcomes of pharmacotherapy with possible failure to achieve therapeutic goals and worsening of illness. Higher health care costs may result from more frequent physician and emergency department visits and increased hospitalization rates. The cost of medications may play a role in whether patients do or do not take their medication with increased cost sharing leading to poorer adherence with prescription drugs. Given the possible adverse consequences of nonadherence, interventions to improve medication-taking behavior are encouraged although not consistently successful. Surprisingly, there is relatively little information on the cost-effectiveness of these interventions and more methodologically sound research is needed in this area. Alternative strategies that have been proposed are value-based insurance design and the use of financial incentives, although the former has not been widely accepted, and the latter is ethically controversial. This article reviews some of the main issues with regards to adherence with drug therapy including some of the cost implications of less than optimal medication adherence.
Water Ethics for First Nations and Biodiversity in Western Canada
Kenichi Matsui
International Indigenous Policy Journal , 2012,
Abstract: The increasing division of academic disciplines and bureaucracy has led to the compartmentalization of knowledge on water security, biodiversity, Indigenous rights, and traditional ecological knowledge policy. The attempt to re-establish links among these issues in academic studies can shed light on integrated watergovernance and the establishment of water ethics. In order to facilitate this effort, this paper discusses three propositions: (1) the establishment of strong legal and ethical frameworks is needed; (2) policymakers and scientists alike need to recognize links between biodiversity and water security; and (3) they need to improvecross-cultural understanding and communication in using the traditional knowledge of Indigenous peoples and local people. This article examines these issues in Western Canada (British Columbia, Alberta, Saskatchewan, and Manitoba) because this region has invited cross-cultural and inter-jurisdictional conflicts since the twentieth century.
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