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Search Results: 1 - 10 of 10157 matches for " Matiana; Moreno-Macías "
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Morbilidad infantil por causas respiratorias y su relación con la contaminación atmosférica en Ciudad Juárez, Chihuahua, México
Hernández-Cadena,Leticia; Barraza-Villarreal,Albino; Ramírez-Aguilar,Matiana; Moreno-Macías,Hortencia; Miller,Paul; Carbajal-Arroyo,Luz Aurora; Romieu,Isabelle;
Salud Pública de México , 2007, DOI: 10.1590/S0036-36342007000100005
Abstract: objective: to assess the impact of atmospheric pollutants on the respiratory health of children of different age groups in juarez city, chihuahua, mexico. material and methods: data on emergency room visits between 1997 and 2001 for respiratory diseases in children less than 17 years old were obtained from hospitals in the juarez city belonging to the mexican social security institute (imss). diseases were classified into three groups according to icd 9th and 10th codes: a) upper respiratory diseases, b) lower respiratory diseases, and c) asthma attacks. this information was stratified by age group (<=5 years and >5 years). daily air pollution data (ozone and pm10) and weather conditions were obtained from the monitoring network system in juarez city. statistical analysis was carried out using a generalized additive model assuming a poisson distribution. results: ozone concentrations, but not pm10, were statistically associated with emergency room visits for respiratory diseases, mainly among children 5 years old or younger. in this group, an increase of 20 ppb 1-hr maximum for ozone was associated with an increase of 8.3% in the number of emergency room visits for upper respiratory diseases, with a 3-day exposure lag; and an increase of 12.7% in the number of emergency room visits for lower respiratory diseases when considering a 4-day exposure lag in a maximum 8-hr mobile average. the largest effect for the complete sample and for the group 6 to 16 years of age was observed for 3-day lag (5.1% for an increase of 20 ppb 1-hr maximum for ozone). for the 6 to16 year old group we did not find a significant effect. conclusion: the wide range of risk is quite important and might represent a substantial cost for the health system as well as for the society. our results emphasize the need to implement preventive and control measures for air pollution and avoid the worsening of the present situation.
Validez en el registro del pico espiratorio máximo de ni?os asmáticos de la Ciudad de México
Jiménez-Millán,Diana; Ramírez-Aguilar,Matiana; Moreno-Macías,Hortensia; Barraza-Villarreal,Albino; del Río-Navarro,Blanca Estela; Romieu,Isabelle;
Salud Pública de México , 2007, DOI: 10.1590/S0036-36342007000300003
Abstract: objective: to determine the concordance between maximum peak expiratory flow records (pefr) reported by the parents of asthmatic children and the electronic values stored by the airwatch device (pefe). material and methods: records of pef measurements between october 1998 and 1999 were obtained from 42 asthmatic children 5 to 15 years of age recruited at the hospital infantil de mexico federico gomez, in mexico city. parents recorded the maximum value in the health diary. spearman correlation was calculated between pefe and pefr and a mixed-effects logistic model was used. results: the correlation between pefe and pefr was r=0.96 (p<0.05) among children with a diagnosis of moderate or severe asthma and r=0.40 (p<0.05) among children diagnosed with mild asthma. follow-up time, asthma severity, gender and age of the child and their interactions were predictors of the differences between pefe and pefr. conclusions: parents of children with moderate or severe asthma from 6 to 8 years of age report pef values with greater accuracy during follow-up than others.
Assessment of personal exposure to ozone in asthmatic children residing in Mexico City
Ramírez-Aguilar,Matiana; Barraza-Villarreal,Albino; Moreno-Macías,Hortensia; Winer,Arthur M; Cicero-Fernández,Pablo; Vélez-Márquez,Ma. Guadalupe Doris; Cortez-Lugo,Marlene; Sienra-Monge,Juan José; Romieu,Isabelle;
Salud Pública de México , 2008, DOI: 10.1590/S0036-36342008000100013
Abstract: objective: a study was conducted to evaluate personal ozone exposure (o3p) among asthmatic children residing in mexico city. material and methods: a total of 158 chil-dren were recruited from december 1998 to april 2000. on average, three o3p measurements were obtained per child using passive badges. time-activity patterns were recorded in a diary. daily ambient ozone measurements (o3a) were obtained from the fixed station, according to children?s residence. levels of o3a and ozone, weighted by time spent in different micro-environments (o3w), were used as independent variables in order to model o3p concentrations using a mixed-effects model. results: mean o3p was 7.8 ppb. the main variables in the model were: time spent indoors, distance between residence and fixed station, follow-up group, and two interaction terms (overall r2=0.50, p<0.05). conclusions: the o3w concentrations can be used as a proxy for o3p, taking into account time-activity patterns and the place of residence of asthmatic mexican children.
Ozone exposure, vitamin C intake, and genetic susceptibility of asthmatic children in Mexico City: a cohort study
Moreno-Macías Hortensia,Dockery Douglas W,Schwartz Joel,Gold Diane R
Respiratory Research , 2013, DOI: 10.1186/1465-9921-14-14
Abstract: Background We previously reported that asthmatic children with GSTM1 null genotype may be more susceptible to the acute effect of ozone on the small airways and might benefit from antioxidant supplementation. This study aims to assess the acute effect of ozone on lung function (FEF25-75) in asthmatic children according to dietary intake of vitamin C and the number of putative risk alleles in three antioxidant genes: GSTM1, GSTP1 (rs1695), and NQO1 (rs1800566). Methods 257 asthmatic children from two cohort studies conducted in Mexico City were included. Stratified linear mixed models with random intercepts and random slopes on ozone were used. Potential confounding by ethnicity was assessed. Analyses were conducted under single gene and genotype score approaches. Results The change in FEF25-75 per interquartile range (60 ppb) of ozone in persistent asthmatic children with low vitamin C intake and GSTM1 null was 91.2 ml/s (p = 0.06). Persistent asthmatic children with 4 to 6 risk alleles and low vitamin C intake showed an average decrement in FEF25-75 of 97.2 ml/s per 60 ppb of ozone (p = 0.03). In contrast in children with 1 to 3 risk alleles, acute effects of ozone on FEF25-75 did not differ by vitamin C intake. Conclusions Our results provide further evidence that asthmatic children predicted to have compromised antioxidant defense by virtue of genetic susceptibility combined with deficient antioxidant intake may be at increased risk of adverse effects of ozone on pulmonary function.
Breast-feeding practices in Mexico: results from the Second National Nutrition Survey 1999
González-Cossío Teresa,Moreno-Macías Hortensia,Rivera Juan A,Villalpando Salvador
Salud Pública de México , 2003,
Abstract: OBJECTIVE: To assess breast-feeding (BF) practices and determinants of exclusive BF (EBF) <4 and <6 months (mo) among women and infants <23 mo in the NNS-1999. MATERIAL AND METHODS: BF practices from the day and night before the interview were ascertained, and median duration estimated. Determinants of EBF<4 and <6 mo were analysed by logistic regression models for complex surveys. RESULTS: Prevalence of EBF<4 mo was 25.7%, and of <6 mo 20.3%. The overall rate of continued BF (second year) was 30.9%, median duration of BF 9 mo, and the national proportion of children ever breast-fed 92.3%. The probability (p) of EBF<4 mo was determined by infant age and sex, by maternal socio-economic level (SEL) and ethnicity, and by the interaction between infant sex and SEL. The pEBF<6 mo was determined by infant age and length, by maternal ethnicity, and employment. CONCLUSIONS: EBF rates and duration are low in Mexico and have improved only slightly in the last 20 y. Infant and maternal characteristics determine the pEBF. If improvements in infant health are a national priority, aggressive interventions to promote and protect BF are urgently needed in Mexico, as well as formal evaluation of current initiatives.
Efecto del ambiente rural sobre la prevalencia de rinitis alérgica en escolares de Mexicali, Baja California, México
B?cker,Claudia; Barraza-Villarreal,Albino; Moreno-Macías,Hortensia; Escamilla-Nú?ez,Consuelo; Romieu,Isabelle;
Revista Panamericana de Salud Pública , 2009, DOI: 10.1590/S1020-49892009000500008
Abstract: objectives: to assess the prevalence of allergic rhinitis symptoms among schoolchildren in mexicali, baja california, mexico, and determine what impact a rural environment might have on this condition. methods: a population-based, cross-sectional study using a standardized questionnaire administered to a random sample of 2 087 schoolchildren 6-7 years of age (1 078 girls and 1 009 boys) living in the city of mexicali, baja california, mexico. the study analyzed associations between exposure variables and personal and family health history, and two dependent variables-nasal symptoms and nasal and ocular symptoms, in the absence of a cold or flu-using odd ratios (or) and 95% confidence intervals (95%ci). the study took place in february-july 2004 and followed the methodology of the international study of asthma and allergies in childhood (isaac). results: the general prevalence of nasal symptoms and nasal and ocular symptoms was 25.0% and 10.5%, respectively. the boys and girls who had ever lived on a farm or in a rural area had a lower probability, adjusted for confounding variables, of presenting nasal symptoms (or = 0.43; 95%ci: 0.24-0.77), or nasal and ocular symptoms (or = 0.39; 95%ci: 0.16-0.93). conclusions: in the study population, exposure to a rural environment in early childhood decreased the risk of developing allergic rhinitis, regardless of a family history of asthma.
Breast-feeding practices in Mexico: results from the Second National Nutrition Survey 1999
González-Cossío,Teresa; Moreno-Macías,Hortensia; Rivera,Juan A; Villalpando,Salvador; Shamah-Levy,Teresa; Monterrubio,Eric A; Hernández-Gardu?o,Adolfo;
Salud Pública de México , 2003, DOI: 10.1590/S0036-36342003001000004
Abstract: objective: to assess breast-feeding (bf) practices and determinants of exclusive bf (ebf) <4 and <6 months (mo) among women and infants <23 mo in the nns-1999. material and methods: bf practices from the day and night before the interview were ascertained, and median duration estimated. determinants of ebf<4 and <6 mo were analysed by logistic regression models for complex surveys. results: prevalence of ebf<4 mo was 25.7%, and of <6 mo 20.3%. the overall rate of continued bf (second year) was 30.9%, median duration of bf 9 mo, and the national proportion of children ever breast-fed 92.3%. the probability (p) of ebf<4 mo was determined by infant age and sex, by maternal socio-economic level (sel) and ethnicity, and by the interaction between infant sex and sel. the pebf<6 mo was determined by infant age and length, by maternal ethnicity, and employment. conclusions: ebf rates and duration are low in mexico and have improved only slightly in the last 20 y. infant and maternal characteristics determine the pebf. if improvements in infant health are a national priority, aggressive interventions to promote and protect bf are urgently needed in mexico, as well as formal evaluation of current initiatives.
Consumo de alimentos y asma en ni?os escolares de Cuernavaca
Gutiérrez-Delgado,Rosa Inés; Barraza-Villarreal,Albino; Escamilla-Nú?ez,María Consuelo; Solano-González,Maritsa; Moreno-Macías,Hortensia; Romieu,Isabelle;
Salud Pública de México , 2009, DOI: 10.1590/S0036-36342009000300010
Abstract: objective:to evaluate the relation between diet and the development of asthma and allergic rhinitis in schoolchildren from cuernavaca, morelos, mexico. material and methods:we apply the isaac's questionnaire in 5460 schoolchildren from 6 to 8 and 11-14-year-old of elementary level selected in random form. six groups of food were formed using a hierarchic clusters analysis and the association was evaluated using logistic regression models. results:the consumption of fast food had an adverse effect for current wheezing (or=1.82; ci95%=1.16-2.87) and the consumption of tidbits for more than three episodes of wheezing (or=2.26; ci95%=1.04-4.95) and nasal symptoms without cold, or=1.35 (ic95%;1.06-1.71). conclusions:this study provides evidence that the diet plays a very important role since the high consumption of fast food and tidbits increased the risk of asthma and rhinitis symptoms.
Overweight and obesity in school children aged 5 to 11 years participating in food assistance programs in Mexico
Cuevas-Nasu,Lucía; Hernández-Prado,Bernardo; Shamah-Levy,Teresa; Monterrubio,Eric A; Morales-Ruan,María del Carmen; Moreno-Macías,Lidia B;
Salud Pública de México , 2009, DOI: 10.1590/S0036-36342009001000018
Abstract: objective: to determine the association between overweight and obesity among mexican school-aged children and participation in the liconsa milk and the school breakfast food assistance programs. material and methods: data from 15 003 school-aged children included in the mexican national health and nutrition survey 2006 (ensanut 2006) were analyzed. information on body mass index (bmi) and participation in food assistance programs was obtained. descriptive analyses were conducted and logistic regression models were adjusted. results: prevalence of overweight and obesity was 17.3% and 9%, respectively. no significant association between overweight and obesity and participation in liconsa was found. among school-aged children in the middle socioeconomic status quintile, those enrolled in the school breakfast program were more likely to be overweight than those not enrolled (or= 1.6, 95% ci 1.1, 2.3). conclusions: we found no association between the liconsa and the school breakfast programs and overweight or obesity in school-aged children.
Safety and Efficacy of Racotumomab-Alum Vaccine as Second-Line Therapy for Advanced Non-Small Cell Lung Cancer  [PDF]
Eduardo Santiesteban, Leslie Perez, Sailyn Alfonso, Elia Neninger, Soraida Acosta, Yoana Flores, Maurenis Hernandez, Carmen Viada, Robin García, Meylán Cepeda, Daymys Estevez, Yoisbel Moreno, Amparo Macías
International Journal of Clinical Medicine (IJCM) , 2014, DOI: 10.4236/ijcm.2014.514113
Abstract:

Despite extensive clinical research in non-small cell lung cancer (NSCLC), overall survival is still poor. Racotumomab-alum is an anti-idiotypic cancer vaccine that targets NeuGcGM3 tumor associated ganglioside. The aim of this study was to evaluate safety and efficacy of racotumomab-alum in advanced NSCLC patients with progressive disease. This expanded access program included 86 histologically confirmed NSCLC patients, 18 years or older age, with advanced disease and without therapeutic option, with ECOG performance status ≤3, adequate organ functions and signed informed consent. The primary endpoint was overall survival and toxicity was measure assessed treatment-related toxicity according CTCAEv3. The study was approved by ethical review boards of participant institutions. Racotumomab-alum treatment consisted in 5 biweekly intradermal doses (1 mg/mL) during the induction phase of treatment (2 months). The maintenance phase consisted in monthly re-immunizations until unacceptable toxicity or PS worsening. The median overall survival time of all patients treated with racotumomab-alum was 8.96 months. The survival rates at 12 and 24 months were 42.8% and 28.0%, respectively. Patients that completed the induction phase of treatment (five doses or more) reached a median OS of 12.1 months. The most common adverse events were injection site reaction, bone pain, cough and asthenia. Racotumomab-alum cancer vaccine could be considered an effective and safe treatment option as second-line therapy for advanced NSCLC. Further clinical studies should be conducted to confirm this result.

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