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Search Results: 1 - 10 of 298451 matches for " Mathew J. Gregoski "
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Differential Impact of Stress Reduction Programs upon Ambulatory Blood Pressure among African American Adolescents: Influences of Endothelin-1 Gene and Chronic Stress Exposure
Mathew J. Gregoski,Vernon A. Barnes,Martha S. Tingen,Yanbin Dong,Haidong Zhu,Frank A. Treiber
International Journal of Hypertension , 2012, DOI: 10.1155/2012/510291
Abstract: Stress-activated gene × environment interactions may contribute to individual variability in blood pressure reductions from behavioral interventions. We investigated effects of endothelin-1 (ET-1) LYS198ASN SNP and discriminatory stress exposure upon impact of 12-week behavioral interventions upon ambulatory BP (ABP) among 162 prehypertensive African American adolescents. Following genotyping, completion of questionnaire battery, and 24-hour ABP monitoring, participants were randomized to health education control (HEC), life skills training (LST), or breathing awareness meditation (BAM). Postintervention ABP was obtained. Significant three-way interactions on ABP changes indicated that among ET-1 SNP carriers, the only group to show reductions was BAM from low chronic stress environments. Among ET-1 SNP noncarriers, under low chronic stress exposure, all approaches worked, especially BAM. Among high stress exposure noncarriers, only BAM resulted in reductions. If these preliminary findings are replicated via ancillary analyses of archival databases and then via efficacy trials, selection of behavioral prescriptions for prehypertensives will be edging closer to being guided by individual's underlying genetic and environmental factors incorporating the healthcare model of personalized preventive medicine.
Differential Impact of Stress Reduction Programs upon Ambulatory Blood Pressure among African American Adolescents: Influences of Endothelin-1 Gene and Chronic Stress Exposure
Mathew J. Gregoski,Vernon A. Barnes,Martha S. Tingen,Yanbin Dong,Haidong Zhu,Frank A. Treiber
International Journal of Hypertension , 2012, DOI: 10.1155/2012/510291
Abstract: Stress-activated gene × environment interactions may contribute to individual variability in blood pressure reductions from behavioral interventions. We investigated effects of endothelin-1 (ET-1) LYS198ASN SNP and discriminatory stress exposure upon impact of 12-week behavioral interventions upon ambulatory BP (ABP) among 162 prehypertensive African American adolescents. Following genotyping, completion of questionnaire battery, and 24-hour ABP monitoring, participants were randomized to health education control (HEC), life skills training (LST), or breathing awareness meditation (BAM). Postintervention ABP was obtained. Significant three-way interactions on ABP changes indicated that among ET-1 SNP carriers, the only group to show reductions was BAM from low chronic stress environments. Among ET-1 SNP noncarriers, under low chronic stress exposure, all approaches worked, especially BAM. Among high stress exposure noncarriers, only BAM resulted in reductions. If these preliminary findings are replicated via ancillary analyses of archival databases and then via efficacy trials, selection of behavioral prescriptions for prehypertensives will be edging closer to being guided by individual's underlying genetic and environmental factors incorporating the healthcare model of personalized preventive medicine. 1. Introduction Essential hypertension (EH) is a major risk factor for cardiovascular disease (CVD), and EH incidence among youth is increasing [1]. African Americans (AAs) experience a higher prevalence, earlier onset, and greater severity of EH-related complications than other ethnic groups [2]. From late childhood onward, AAs display increased levels of resting and ambulatory blood pressure (ABP) compared to other ethnic groups [3–5]. BP levels are monotonically associated with future CVD morbidity and mortality [6]. Stage I prehypertensive adults (i.e., SBP/DBP 121–129/81–84?mmHg) have a 40% increased risk and adults with stage II prehypertension (i.e., SBP/DBP 130–139/85–89?mmHg) are twice as likely to develop CVD compared to those with optimal BP (<120/<80?mmHg) [6–8]. BP percentile ranking tracks from late childhood into adulthood [9–11] placing AA adolescents with BP between the 50th and 95th percentiles for age and sex at an increased risk of future EH and CVD development [9]. EH, like other multifactorial chronic diseases, results from a complex interplay between an individual’s genetic underpinnings, lifestyle behaviors, psychosocial factors, and exposures to various environmental toxins. Over time, this dynamic interplay eventuates in adverse
Development and Validation of a Smartphone Heart Rate Acquisition Application for Health Promotion and Wellness Telehealth Applications
Mathew J. Gregoski,Martina Mueller,Alexey Vertegel,Aleksey Shaporev,Brenda B. Jackson,Ronja M. Frenzel,Sara M. Sprehn,Frank A. Treiber
International Journal of Telemedicine and Applications , 2012, DOI: 10.1155/2012/696324
Abstract: Objective. Current generation smartphones' video camera technologies enable photoplethysmographic (PPG) acquisition and heart rate (HR) measurement. The study objective was to develop an Android application and compare HRs derived from a Motorola Droid to electrocardiograph (ECG) and Nonin 9560BT pulse oximeter readings during various movement-free tasks. Materials and Methods. HRs were collected simultaneously from 14 subjects, ages 20 to 58, healthy or with clinical conditions, using the 3 devices during 5-minute periods while at rest, reading aloud under observation, and playing a video game. Correlation between the 3 devices was determined, and Bland-Altman plots for all possible pairs of devices across all conditions assessed agreement. Results. Across conditions, all device pairs showed high correlations. Bland-Altman plots further revealed the Droid as a valid measure for HR acquisition. Across all conditions, the Droid compared to ECG, 95% of the data points (differences between devices) fell within the limits of agreement. Conclusion. The Android application provides valid HRs at varying levels of movement free mental/perceptual motor exertion. Lack of electrode patches or wireless sensor telemetric straps make it advantageous for use in mobile-cell-phone-delivered health promotion and wellness programs. Further validation is needed to determine its applicability while engaging in physical movement-related activities. 1. Introduction Many cellular phones now possess high-speed data transmission capabilities (e.g., 3G, 4G) and have embedded microprocessors (e.g., Bluetooth, ANT) with the capability to wirelessly connect to external devices. As a result, cell phones offer several advantages over desktop or laptop computers in telemonitoring-related applications such as higher population penetration, increased privacy, lower cost to purchase, easier ability to transport, and overall increased personal convenience of use [1, 2]. Cell phones are widely used in telemonitoring serving as a conduit for receiving biohealth information from portable medical devices (e.g., blood pressure, glucose and pulse oximeter monitors, weight scales) and mobile sensors (e.g., physical activity; accelerometer counts, heart rate, respiration rate, pulse pressure via chest- or armbands, and wireless electrodes). Once cell phones have received the pertinent information, it is microprocessed, encrypted, and the data packets are transferred to some form of localized or web-based server for secondary processing. At the server level, the data packets are organized into a
BluetoothTM Enabled Acceleration Tracking (BEAT) mHealth System: Validation and Proof of Concept for Real-Time Monitoring of Physical Activity  [PDF]
Aleksey Shaporev, Mathew Gregoski, Vladimir Reukov, Teresa Kelechi, David Morgan Kwartowitz, Frank Treiber, Alexey Vertegel
E-Health Telecommunication Systems and Networks (ETSN) , 2013, DOI: 10.4236/etsn.2013.23007
Abstract: Physical activity is critical to improve the condition of patients with chronic leg and foot ulcers, especially those who are obese and experienced multiple co-morbid conditions. Unfortunately, these individuals are unable to engage in guideline based physical activity (PA) programs. A prototype of BluetoothTM enabled acceleration tracking (BEAT) mHealth system was developed and manufactured for remote monitoring and stimulation of adherence to PA in deconditioned patients. The system consists of a miniature accelerometer-based sensor, smartphone application, and a network service. Validation testing showed high reliability and reproducibility of the BEAT sensors. Pilot study with human subjects demonstrated high accuracy of the BEAT system in recognition of different exercises and calculating overall outcomes of PA. Taken together, these results indicate that BEAT system could become a valuable tool for realtime monitoring of PA in deconditioned patients.

 

Airway safety for patients receiving intraventricular sodium nitroprusside therapy
Mathew J
Neurology India , 2003,
Abstract:
A rare variation of the biceps brachi muscle
Paval J,Mathew J
Indian Journal of Plastic Surgery , 2006,
Abstract: Biceps brachii muscle is very variable. Biceps may be composed of one to five heads. Although the variations in the origin are plenty, there are a very few cases reported on the variations in the insertion of the biceps brachii muscle. In this report we present a variant biceps brachii muscle which gives an abnormal muscle fasciculus from its medial side which continues as a narrow tendinous slip and is inserted in to the medial supracondylar ridge of humerus. We discuss in this report, the possible median nerve entrapment due to the presence of such a variation.
Intramuscular Olanzapine – a UK case series of early cases
Chris J Bushe, Mark Taylor, Mathew Mathew
Annals of General Psychiatry , 2007, DOI: 10.1186/1744-859x-6-11
Abstract: We report on an early unselected case series of 7 patients who received IM olanzapine in routine clinical practice settings in the UK. In this case series, olanzapine IM was generally effective, and no adverse events were reported. Adjunctive benzodiazepines were given concomitantly in 1 of the 7 subjects. This is relevant as concomitant benzodiazepines are not recommended for a minimum of 1 hour post IM olanzapine administration. PANSS-EC data was collected in 2 of the 7 subjects.Although patients had greater severity of psychosis than clinical trial patients there were no unexpected findings. In addition the PANSS-EC scale is a scale that may be useful in assessing the efficacy of IM antipsychotics in routine clinical practice.During recent years more attention has been shown to rapid tranquilisation for the treatment of acute agitation in schizophrenia and bipolar disorder and the potential problems associated with it [1,2]. The majority of patients that require rapid tranquilisation have some form of serious psychosis and may also have physical problems such as biochemical disturbances and dehydration [3,4]For many years the standard treatments used were droperidol and lorazepam [2]. Concerns over QTc prolongation led to cessation of use of droperidol in the UK [5] along with awareness that QTc prolongation could be more severe in patients administered intramuscular typical medications [1]. Droperidol usage is no longer permitted in the UK [5] and has been replaced in most instances by haloperidol. However, the use of intramuscular haloperidol is also well recognised to be associated with acute dystonic reactions and other extrapyramidal side effects [6,7].Since Feb 2004 intramuscular olanzapine has been available in the UK and Europe and was the first licensed atypical available in Europe as a short acting intramuscular formulation. Clinical trials suggested low rates of occurrence for any QTc prolongation and acute dystonic reactions [1,7,8]. There were no dif
Critical illness neuropathy
Vijayan J,Alexander Mathew
Indian Journal of Critical Care Medicine , 2005,
Abstract: The neuromuscular syndrome of acute limb and respiratory weakness that commonly accompanies patients with multi-organ failure and sepsis constitutes critical illness polyneuropathy. It is a major cause of difficulty in weaning off the patient from the ventilator after respiratory and cardiac causes have been excluded. It is usually an axonal motor-sensory polyneuropathy, and is usually associated with or accompanied with a coma producing septic encephalopathy. The neuropathy is usually not apparent until the patient′s encephalopathy has peaked, and may be noted only when the brain dysfunction is resolving. Patients usually have a protracted hospital course complicated by multi-organ failure and the systemic inflammatory response syndrome. Elevated serum glucose levels and reduced albumin are risk factors for nerve dysfunction, as is prolonged intensive care unit stay. Polyneuropathy may develop after only one week of the systemic inflammatory response syndrome, but the frequency tends to correlate with the duration of the severe illness.
Antioxidant activity of Pseudarthria viscida
Mathew Gincy,Sasikumar J
Indian Journal of Pharmaceutical Sciences , 2007,
Abstract: Antioxidant activity of the crude methanol extract of Pseudarthria viscida (L) Wight and Arn. stem and root was performed by1,1-diphenyl-2-picrylhydrozyl (DPPH) radical quenching assay and reducing power test models. Both stem and root extracts exhibited potential antioxidant activity in both the assays.
An Examination of Transformational Leadership among Graduating Baccalaureate Nursing Students and Practicing Nurses  [PDF]
Lizy Mathew
Open Journal of Nursing (OJN) , 2014, DOI: 10.4236/ojn.2014.411079
Abstract: Leadership skills are essential among nurses to address the challenges faced by the nursing profession. This quantitative comparative study examined five components of transformational leadership skills as outlined by Kouzes and Posner among graduating baccalaureate nursing students and practicing nurses [1]. Five leadership components were used to examine if differences existed among the groups studied. The results indicated significant differences for modeling the way, inspiring a shared vision, enabling others to act, and encouraging the heart. The study revealed that nursing students graduating from generic and accelerated programs have inferior leadership skills compared to nurses in clinical practice. The results may be useful in leadership training of nursing students through collaborative practices between practice settings and nursing schools to improve patient safety.
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