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Search Results: 1 - 10 of 176364 matches for " Massimo De Paschale "
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How immigration can change the prevalence of HBV infection in an urban area of Northern Italy
Massimo De Paschale,Maria Teresa Manco,Luisa Belvisi,Carlo Magnani
Microbiology Research , 2011, DOI: 10.4081/mr.2011.e21
Abstract: The introduction of HBV vaccination in Italy has led to a decline in new HBV infections. Increasing immigration over recent years suggests a change in short-term epidemiology of HBV. The aim of this study was to assess the prevalence of HBV infection in the general population living in the catchment area of Legnano Hospital (Northern Italy). In the period 2007-2008, 22,758 inpatients and outpatients were examined for Hepatitis B surface antigen (HBsAg), of whom 1,654 (7.3%) were of foreign origin. Of the 488 patients who were positive for HBsAg (2.1%), 381 (1.8%) were Italian and 107 (6.5%) were born in other countries. In terms of age, the prevalence of HBsAg was significantly higher among non- Italians in every age group (other than those aged >60 and <11 years), and in many of the selected subgroups: the inpatients of some departments (35.4% vs 17.2%), pregnant women (5.3% vs 0.3%), blood donors (4.7% vs 0.1%), and hospital staff (6.4% vs 1.3%). Non- Italians were affected by 16.7% of acute infections and 24.3% of chronic infections; they also accounted for 42.6% of subjects with carrier state, 16.0% of patients with chronic hepatitis, and 12.2% of patients with cirrhosis. In our area, the overall prevalence of HBsAg among Italians is less than 2% (as expected following the introduction of HBV vaccination), but it is significantly higher among patients from areas highly endemic for HBV infection who represent a new reservoir for HBV infection.
Rubella antibody screening during pregnancy in an urban area of Northern Italy
Massimo De Paschale,Maria Teresa Manco,Alessia Paganini,Carlo Agrappi
Infectious Disease Reports , 2012, DOI: 10.4081/idr.2012.e17
Abstract: Various countries have implemented anti-rubella vaccination campaigns with the main aim of preventing congenital infection. In 2003, Italy joined the European WHO programme for the elimination of congenital rubella and issued a special healthcare plan, one of the objectives of which was to reduce the proportion of rubella-susceptible pregnant women to less than 5% by 2005. The aim of this study was to determine the percentage of seronegative pregnant women after the implementation of this plan. Anti-rubella IgG and IgM antibodies were sought in 2385 pregnant women who attended our hospital for serological screening between 1 July 2008 and 30 June 2010. They included 750 women of foreign origin (31.4%). Eight percent of the women were anti-rubella seronegative: 6.2% of the Italians and 11.7% of the non-Italians. Among the women of foreign origin, the percentage of seronegativity ranged from 5.6% of those coming from Eastern Europe to 17.7% of those coming from Latin America. The level of seropositivity among women of Italian origin is high, although the objective of ensuring less than 5% of susceptible pregnant women has not yet been quite reached in our area. However, particular attention needs to be given to women coming from geographical areas characterised by different epidemiologies and vaccination strategies because the percentage of seronegativity is in some cases double that of Italian women.
Incidence and Risk of Cytomegalovirus Infection during Pregnancy in an Urban Area of Northern Italy
Massimo De Paschale,Carlo Agrappi,Maria Teresa Manco,Alessia Paganini,Pierangelo Clerici
Infectious Diseases in Obstetrics and Gynecology , 2009, DOI: 10.1155/2009/206505
Abstract: The fetal consequences of CMV infection make it one of the most serious infections contracted during pregnancy, but the scientific community is divided over the proposed implementation of preventive screening for anti-CMV antibodies. The aim of this study was to assess the incidence and risk of infection during pregnancy in 2817 women who underwent anti-CMV IgG and IgM antibody screening during the period 2005–2007. The prevalence of anti-CMV IgG antibodies was 68.3% (95% CI: 66.6–70.0); the seroconversion rate in the 892 seronegative women was 0.32%; the results of IgG avidity testing revealed an cumulative incidence of 1.4% (95% CI: 0.97–1.83), density incidence of 0.8% (as cases/pregnant woman-trimester) (95% CI: 0.47–1.13), and a risk of infection of 0.5% (95% CI: 0.24–0.76). The screening identified 13 cases of primary infection (84.6% of which occurred in the first trimester of pregnancy). The possibility to identify these cases and consequently to plan appropriate interventions, supports the use of screening during pregnancy, especially in the first trimester when the risk of infection is greater.
Search for Anti-EA(D) Antibodies in Subjects with an “Isolated VCA IgG” Pattern
Massimo De Paschale,Debora Cagnin,Teresa Cerulli,Maria Teresa Manco,Carlo Agrappi,Paola Mirri,Arianna Gatti,Cristina Rescaldani,Pierangelo Clerici
International Journal of Microbiology , 2010, DOI: 10.1155/2010/695104
Abstract: The presence of an “isolated viral capsid antigen (VCA) IgG” pattern in serum is not easy to interpret without the aid of further tests, such as specific immunoblotting or a virus genome search, that often give rise to organisational and economic problems. However, one alternative is to use an enzyme-linked immunosorbent assay (ELISA) to detect anti-early antigen (EA) antibodies, which can be found in about 85% of subjects with acute Epstein-Barr virus (EBV) infections. The purpose of this work was to search for anti-EA(D) antibodies in 130 samples with an isolated VCA IgG pattern at ELISA screening and classified as being indicative of past (102 cases) or acute (28 cases) infection on the basis of the immunoblotting results. Thirty-seven samples (28.5%) were positive for anti-EA(D), of which 25 (89.3%) had been classified by immunoblotting as indicating acute and 12 (11.8%) past EBV infection. This difference was statistically significant (<.01). The results of our search for anti-EA(D) antibodies correctly identified nearly 90% of acute (presence) or past EBV infections (absence). When other tests are not available, the search for anti-EA antibodies may therefore be helpful in diagnosing patients with an isolated VCA IgG pattern at screening tests.
Search for Anti-EA(D) Antibodies in Subjects with an “Isolated VCA IgG” Pattern
Massimo De Paschale,Debora Cagnin,Teresa Cerulli,Maria Teresa Manco,Carlo Agrappi,Paola Mirri,Arianna Gatti,Cristina Rescaldani,Pierangelo Clerici
International Journal of Microbiology , 2010, DOI: 10.1155/2010/695104
Abstract: The presence of an “isolated viral capsid antigen (VCA) IgG” pattern in serum is not easy to interpret without the aid of further tests, such as specific immunoblotting or a virus genome search, that often give rise to organisational and economic problems. However, one alternative is to use an enzyme-linked immunosorbent assay (ELISA) to detect anti-early antigen (EA) antibodies, which can be found in about 85% of subjects with acute Epstein-Barr virus (EBV) infections. The purpose of this work was to search for anti-EA(D) antibodies in 130 samples with an isolated VCA IgG pattern at ELISA screening and classified as being indicative of past (102 cases) or acute (28 cases) infection on the basis of the immunoblotting results. Thirty-seven samples (28.5%) were positive for anti-EA(D), of which 25 (89.3%) had been classified by immunoblotting as indicating acute and 12 (11.8%) past EBV infection. This difference was statistically significant ( ). The results of our search for anti-EA(D) antibodies correctly identified nearly 90% of acute (presence) or past EBV infections (absence). When other tests are not available, the search for anti-EA antibodies may therefore be helpful in diagnosing patients with an isolated VCA IgG pattern at screening tests. 1. Introduction The most common manifestation of primary Epstein-Barr virus (EBV) infection is acute infectious mononucleosis, a self-limited clinical syndrome that most frequently affects adolescents and young adults. Serology is one of the cardinal means of diagnosing EBV infection as antibody search for viral capsid antigen (VCA), nuclear antigen (EBNA), and early antigen (EA) makes it possible to define the status of the infection [1, 2]. The three parameters of VCA IgG, VCA IgM, and EBNA-1 IgG generally make it simple to distinguish acute and past infection in immunocompetent patients [3]. The presence of VCA IgG and VCA IgM in the absence of EBNA-1 IgG is indicative of acute infection, whereas the presence of VCA IgG and EBNA-1 IgG in the absence of VCA IgM is typical of past infection. However, the presence of an isolated VCA IgG pattern may appear in about 8% of all subjects with at least one EBV infection marker [4] and may be difficult to interpret because it can be found in patients with prior infection as well as in those with acute infection. In fact, in some cases, VCA IgM may appear 1-2 weeks after VCA IgG, or for a very short time, or at such a low concentration as to be missed by conventional laboratory tests [5]; furthermore, VCA IgM may persist for a long time after acute infection and still
Nuclear Reprogramming in Mouse Primordial Germ Cells: Epigenetic Contribution
Massimo De Felici
Stem Cells International , 2011, DOI: 10.4061/2011/425863
Abstract: The unique capability of germ cells to give rise to a new organism, allowing the transmission of primary genetic information from generation to generation, depends on their epigenetic reprogramming ability and underlying genomic totipotency. Recent studies have shown that genome-wide epigenetic modifications, referred to as “epigenetic reprogramming”, occur during the development of the gamete precursors termed primordial germ cells (PGCs) in the embryo. This reprogramming is likely to be critical for the germ line development itself and necessary to erase the parental imprinting and setting the base for totipotency intrinsic to this cell lineage. The status of genome acquired during reprogramming and the associated expression of key pluripotency genes render PGCs susceptible to transform into pluripotent stem cells. This may occur in vivo under still undefined condition, and it is likely at the origin of the formation of germ cell tumors. The phenomenon appears to be reproduced under partly defined in vitro culture conditions, when PGCs are transformed into embryonic germ (EG) cells. In the present paper, I will try to summarize the contribution that epigenetic modifications give to nuclear reprogramming in mouse PGCs. 1. Introduction Nuclear reprogramming is generally defined as the process reverting the nucleus of a differentiated cell to a pluripotent or totipotent state. The formation in culture of embryonic stem (ES) or epiblast embryonic stem (EpiES) cells from the inner cell mass (ICM) of the blastocyst or the epiblast of postgastrulating embryo, respectively, of embryonic germ (EG) cells from primordial germ cells and more recently of induced pluripotent stem (iPS) cells from differentiated somatic cells are examples of nuclear reprogramming in vitro. As far as I know, in mammals, physiological nuclear reprogramming leading to totipotency occurs only at the onset of embryogenesis when the genome of the zygote and subsequently of the early blastomeres acquires totipotency. This reprogramming requires a genome status of gametes that originates from early processes of nuclear reprogramming occurring at the beginning of gametogenesis in the primordial germ cells (PGCs), the embryonic precursors of the gametes. The identification of the timing and the underlying molecular mechanisms of this early process in PGCs offers precious information not only about gametogenesis and reproduction, but also on the secretes of stemness and clues for a number of pathologies including cancer development. Nuclear reprogramming involves a variety of genetic and
La crisis de los sub-primes, el impasse neoliberal y los commons
Angelis, Massimo De;
Argumentos (México, D.F.) , 2010,
Abstract: marx studied the reproduction of the commons which he defined as social reproduction, to the extent that this takes place in the capitalist form. the cycles of neoliberalism and production of commons are interdependent and the social forces which speak for capital are well aware of that. in marxian analysis of capital there is the presence of capital's "other"; that which is "the outside", exactly there in the forge of capitalist production. this is the dialectic of capital which aims to recover class struggle, "the outside", as a function of its own "development". what does this disquisition on the role of reproduction and "the outside" of capital have to do with the sub-primes crisis? as usuall the crises of capital illuminate the contradictions of the specific historical forms of capitalist development, that is to say, the recovery of that which is outside of capital. thus, recurring crises are moments of a mechanism for the enclosure and disciplining of social work which is continuous, exactly because the conflict between opposing value forms and practices are continuous.
LA CRISIS DE LOS SUB-PRIMES, el impase neoliberal y los commons
Massimo De Angelis
Argumentos (México, D.F.) , 2010,
Abstract: Marx estudió la reproducción de los bienes comunales (commons), aquello que define como la reproducción social, en la medida en que ésta se realiza en la forma capitalista. Los dos ciclos (de neoliberalismo y producción de lo común) son interdependientes y las fuerzas sociales que hablan por el capital lo saben muy bien. En el análisis marxiano del capital existe la presencia del otro-del-capital, del afuera del capital, exactamente ahí, en la fragua de la producción capitalista. Esta es la dialéctica del capital que pretende recuperar la lucha, el "afuera del capital", en función del propio "desarrollo". Qué tiene que ver esta disquisición sobre el papel de la reproducción y el "afuera" del capital con la reciente crisis de los sub-primes? Por lo general, las crisis del capital iluminan las contradicciones de las formas históricas específicas del desarrollo capitalista, es decir, de la recuperación del afuera del capital. Las crisis recurrentes son entonces momentos de un mecanismo de cercamiento y disciplina del trabajo social que es continuo, exactamente porque continuo es el conflicto entre formas y prácticas de valor opuestas.
Two Fractal Regimes of the Soil Hydraulic Properties  [PDF]
Samuele De Bartolo, Carmine Fallico, Gerardo Severino, Massimo Veltri
Applied Mathematics (AM) , 2014, DOI: 10.4236/am.2014.512170
Abstract: A fractal analysis of the soil retention and hydraulic conductivity curves is presented. The retention process is modeled by a two fractal regimes: one pertaining to high water content values, and another accounting for the low water content data. This significantly improves the physical insight of the retention process as compared with the case of one-fractal models. The fractal dimensions characterizing the two regimes are estimated by fitting the retention curve model upon real data, and subsequently they are used to determine the hydraulic conductivity which for the retention curve models of Mualem and Burdine, is obtained in closed form. The reliability of the model is tested against independent conductivity data collected in a field-scale campaign.
Assessing and mapping groundwater vulnerability to contamination: The Italian “combined” approach
Massimo Civita,Marina De Maio
Geofísica internacional , 2004,
Abstract: Early in the eighties the Italian scientific community, together with institutional decision-makers, realized the urgency of protecting environmental resources. The VAZAR1 project was set up in 1984, as part of the GNDCI-CNR2 scientific context, Research Line, 4 “Aquifer Vulnerability Assessment”. Groundwater contamination was examined in this project. The Italian approach to assessing and mapping groundwater vulnerability to contamination is based on: a) the GNDCI Basic Method, a HCS type approach that can be used for any type of Italian hydrogeologic situation, even where there is a limited number of data. A unified legend and symbols are also defined for each hydrogeologic level. b) The SINTACS method, a PCSM developed for use prevalently in areas with a good data base coverage. The methodological approach described in this paper now makes up the Italian standard in Italian Law (152/993) ratified in the national guide lines produced by ANPA, the Italian National Agency for Environment Protection.
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