OALib Journal期刊

ISSN: 2333-9721




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匹配条件: “Masoud Gharib” ,找到相关结果约1246条。
In vitro and in vivo activities of ticarcillin-loaded nanoliposomes with different surface charges against Pseudomonas aeruginosa (ATCC 29248)
Amir Gharib, Zohreh Faezizadeh, Masoud Godarzee
DARU Journal of Pharmaceutical Sciences , 2012, DOI: 10.1186/2008-2231-20-41
Abstract: Ticarcillin-loaded nanoliposomes with positive, negative and neutral surface charges were prepared by extrusion method. Ticarcillin encapsulation efficacies for different formulations were measured by HPLC method. Minimum inhibitory concentration (MIC) of ticarcillin nanoliposomal forms against strain ATCC 29248 were determined by broth dilution method. The killing rate of Pseudomonas aeruginosa was exposed to various concentrations of ticarcillin in free and nanoliposomal forms were analyzed. Ultimately, in vivo therapeutic efficacy of nanoliposomes in burned mice skin infected with strain ATCC 29248 was investigated.The encapsulation efficacies for ticarcillin-loaded cationic nanoliposomes were significantly higher (76%?±?0.17) than those of neutral (55%?±?0.14) and anionic (43%?±?0.14) nanoliposomes. The MIC of free, cationic, neutral and anionic nanoliposomal forms of ticarcillin against ATCC 29248 were to 24, 3, 6 and 48 mg/L, respectively. The killing rates of ticarcillin-loaded cationic nanoliposomes were higher than those of free and other drug formulations. Treatment by ticarcillin-loaded nanoliposomes with positive, neutral and negative surface charges resulted in almost 100, 60 and 20% survival rates, respectively.Our data suggested that cationic ticarcillin-loaded nanoliposomes because of high effectiveness would be a good choice to treatment of Pseudomonas aeruginosa infections.Pseudomonas aeruginosa is an opportunistic pathogen causing severe, acute and chronic nosocomial infections in hospitals, especially burn units [1]. Since P. aeruginosa can rapidly disseminate from the burn wound sites into the blood stream the clinical outcome in these patients can lead to sepsis, which is often fatal [2]. The major problem associated with Pseudomonas infection is resistance to conventional antibiotics. Therefore, there is the compelling need to develop novel drug delivery to overcome this resistance [3]. Ticarcillin is an antibiotic belonging to the carboxypeni
Effect of modified constraint induced movement therapy on weight bearing and protective extension in children with hemiplegic cerebral palsy
Masoud Gharib,Sayed Ali Hosseyni,Nazila Akbar Fahimmi,Masoud Salehi
Behbood , 2012,
Abstract: Background: Constraint induced movement therapy is one of the new therapeutic interventions that limits the performance of intact upper limb with increased use of the affected limb. Aim of this study was to investigate the effects of modified constraint induced movement therapy on weight bearing & protective extension in children with hemiplegic cerebral palsy.Methods: 21 hemiplegic children were selected and randomly divided into experimental and control groups. Common Practices of Occupational Therapy applied for 6 weeks in both groups equally and test group received constrain induced movement therapy for three hours every day. Weight-bearing and protective extension was measured based on quality of test skills of upper limbs (QUEST). Data analyzed using appropriated statistical methods. Results: 11 children in the experimental group (7 girls, 4 boys) with mean age 47.2 ± 55.5 months and 10 children in the control group (5 girls, 5 boys) with mean age 19.2 ± 10.5) months were studied. No significant difference observed before and after six weeks intervention between two groups (P>0.05). There was a significant change before and after six weeks intervention in both subscales (P<0.05).Conclusion: This study showed that modified constraint induced movement therapy may affect weight bearing, but has no effect on the protective extension.
Survey of special needs in physically disabled people: A qualitative research
Ali Farhoudian,Leila Soleimaninia,Masoud Gharib,Mohammad Hassan Farhadi
Pajouhan Scientific Journal , 2013,
Abstract: Introduction: After sanction of "the rights of disabled people convention" United Nations Organization have been stressed more on dealing with this group's needs. Therewith, most of countries in the world have been committed in this field. Therefore with consideration of importance of identifying the needs in disabled people and making policies for them, this study conducted in order to identify the special needs in physically disabled people.Material and Methods: This article is a part of a qualitative research with grounded theory method. 15 physically disabled people of Tehran were selected through a purposeful sampling participated in study. The main method for collecting data was semi-structured interview that continued until theoretical saturation of information. Data was analyzed with Strauss & Corbin coding manner or continued comparison and the assessor's viewpoints method is used for validity promotion of data.Results: Totally, most important domains of special needs in disabled group were: family and relatives, education, movement and transportation, building and places (houses and public places), social participation and occupation, treatment and rehabilitation services, and people's attitude toward their problems.Conclusion: The results indicated that for promoting social participation and function independency in disabled people, should be emphasis on "equality of opportunities" in society rather than "disability". Thus, public systems and services should be available equally for all, such as physical environments and places, housing, transport system, educational and vocational opportunities, and socio-cultural life like equipments for sport and amusement. Then, physically disabled people can reach to a life with more quality and same with others.
Needs assessment of rehabilitation specialists for training in child development (0-8 years old)
Roshanak Vameghi,Firoozeh Sajedi,Masoud Gharib,Enayatollah Bakhshi
Pajouhan Scientific Journal , 2013,
Abstract: Introduction: This study intends to determine the needs assessment of rehabilitation specialists for training in child development (0-8 years old).Material and Methods: This study is a cross -sectional, descriptive- analytic. At the first, a questionnaire was made for the assessment of the knowledge and skills of the specialists that work in the rehabilitation team of the children with developmental disorders (occupational therapy, speech therapy, physiotherapy, technical orthopedics, preschool children education, audiometry, social working and psychology of children with special needs). The content and face validity and reliability of the questionnaire were determined. Then 400 rehabilitation specialists fill in the questionnaires. After data collection and analysis, the needs of these specialists were determined.Results: The Cronbach's Alpha of questionnaire was 0.93, which was good. One hundred and four persons (43.2%) knew the most necessity to skill increasing in normal children development indexes as the first priority. Sixty-four persons (26.1%) knew the most necessity in primary prevention methods from developmental disorders as the second priority and 66 persons (27.2%) knew the methods of early detection and intervention in developmental disorders as the third priority. One hundred and twenty five persons (45.1%) knew the most necessity to knowledge increasing in normal children development indexes as the first priority. Seventy- six persons (27.4%) knew the most necessity to the methods of early detection and intervention in developmental disorders as the second priority and 74 persons (26.2%) knew the primary prevention methods from developmental disorders as the third priority.Conclusion: It is necessary to plan and perform training of the different rehabilitation specialists for increasing the knowledge and skills in children development themes that they have sensed as the most necessities.
Travelling Wave Solutions of Kaup-Kupershmidt Equation Which Describes Pseudo Spherical Surfaces  [PDF]
G. M. Gharib
Applied Mathematics (AM) , 2015, DOI: 10.4236/am.2015.61016
Abstract: In this paper I introduce the geometric notion of a differential system describing surfaces of a constant negative curvature and describe a family of pseudo-spherical surface for Kaup-Ku-pershmidt Equation with constant Gaussian curvature 1. I obtained new soliton solutions for Kaup-Kupershmidt Equation by using the modified sine-cosine method.
Nonlinear Multiple Model Predictive Control of Solution Polymerization of Methyl Methacrylate  [PDF]
Masoud Abbaszadeh
Intelligent Control and Automation (ICA) , 2011, DOI: 10.4236/ica.2011.23027
Abstract: A sequential linearized model based predictive controller is designed using the DMC algorithm to control the temperature of a batch MMA polymerization process. Using the mechanistic model of the polymerization, a parametric transfer function is derived to relate the reactor temperature to the power of the heaters. Then, a multiple model predictive control approach is taken in to track a desired temperature trajectory.The coefficients of the multiple transfer functions are calculated along the selected temperature trajectory by sequential linearization and the model is validated experimentally. The controller performance is studied on a small scale batch reactor.
Comparison of Acidic and Polymeric Agents in Synthesis of TiO2 Nanoparticles via a Modified Sol-Gel Method  [PDF]
Masoud Karimipour
World Journal of Nano Science and Engineering (WJNSE) , 2013, DOI: 10.4236/wjnse.2013.33012
TiO2 nano particles were synthesized in Rutile and Anatase phases by sol-gel method using two kind of complex agents, acidic (Citric Acid) and organic complex agent (acetyl acetone) at 400°C, 500°C, 650°C sintering temperatures. The structural analysis by XRD diffraction confirmed phase formation of titanium oxide. Particles sizes were determined by using Scherrer formula. TEM was employed to confirm nano particles formation. The size of nano particles as well as Phase formation can be controlled by the type of complex agent and sintering temperature. Acetyl Acetone causes a more crystalline structure and more uniformity of size distribution in 400°C sintering temperatures. Moreover, it results in obtaining single phase TiO2 nanoparticles at 400°C and 650°C sintering temperature. On the other hand, at high sintering temperature, the particles obtained from polymeric agent tend to agglomerate larger in size than the acidic product.
Effect of Using Stone Cutting Slurry Waste (Al-Khamkha) on the Compaction Characteristics of Jerash Cohesive Soil  [PDF]
Talal Masoud
Open Journal of Civil Engineering (OJCE) , 2015, DOI: 10.4236/ojce.2015.52021
Abstract: The aim of this research is to study the effect of using (Al-KHAMKHA) is stone cutting slurry waste local name in JORDAN on the unit weight and moisture content of Jerash cohesive soil Al-Khamkha which is the local name of the stone cutting slurry waste which is produced during the cutting operation, This water carries large amounts of stone powder, which leads to complex nature of environmental problem so these waste material needs to be utilized meaningfully in economic way. The degree of compaction of a soil is measured in terms of its dry unit weight Al-Khamkha mixed with Jerash cohesive soil at different amount ranges from 0%, 5%, 10%, 15%, up to 50% and compaction characteristics of Jerash cohesive soil without and with different amount of Al-Khamkha was studied. This investigation show that as the amount of Al-Khamkha increase from 0% to 15%, the dry unit weight of Jerash cohesive soil increase from 14.4 KN/m3 at 0% of Al-Khamkha to 16.5 KN/m3 at 15% and after that .any increase of Al-Khamkha decrease the dry unit weight. On the other hand, the optimum water content of the Jerash cohesive soil was increases with increasing the percentage of Al-Khamkha on the cohesive soil.
Investigation of the Stability of Oxadiasole and Their Analogs Using Quantum Mechanics Computation  [PDF]
Masoud Karimi
Computational Chemistry (CC) , 2016, DOI: 10.4236/cc.2016.41002
Abstract: This study aimed at investigating factors affecting the stability as well as structural properties of different Oxadiasole and Thiadiasole isomers based on theoretical level B3LYP/6-311+G**, Nuclear Magnetic Resonance (NMR), and Nucleus-independent Chemical Shift (NICS). Qualitative relationships between relative stabilities of 1,2,3-Oxadiazole, 1,2,4-Oxadiazole, 1,2,5-Oxadiazole and 1,3,4-Oxadiazole were obtained. Aromatic stabilization energy (ASE), aromatic ring current (NICS), HUMO-LUMO gaps, electro-negativity (X), hardness (η), softness (S), electro-philicity (ω) and structural parameters were also calculated in the same theoretical level. The results show that 1,3,4-Oxadiazole is more stable than 1,2,3-Oxadiazole, 1,2,4-Oxadiazole and 1,2,5-Oxadiazole. Unlike the trends observed in Oxadiazoles, 1,2,5-Thiadiazole isomer is more stable than other corresponding Isomers.
Effects of Kombucha on oxidative stress induced nephrotoxicity in rats
Ola Gharib
Chinese Medicine , 2009, DOI: 10.1186/1749-8546-4-23
Abstract: Twenty male albino rats were divided into four groups: (1) the control group treated with vehicle, (2) Kombucha (KT)-treated group, (3) TCE-treated group and (4) KT/TCE-treated group. Kidney lipid peroxidation, glutathione content, nitric oxide (NO) and total blood free radical concentrations were evaluated. Serum urea, creatinine level, gamma-glutamyl transferase (GGT) and lactate dehydrogenase (LDH) activities were also measured.TCE administration increased the malondiahyde (MDA) and NO contents in kidney, urea and creatinine concentrations in serum, total free radical level in blood and GGT and LDH activities in serum, whereas it decreased the glutathione (GSH) level in kidney homogenate. KT administration significantly improved lipid peroxidation and oxidative stress induced by TCE.The present study indicates that Kombucha may repair damage caused by environmental pollutants such as TCE and may be beneficial to patient suffering from renal impairment.Kombucha is a sour beverage prepared from the fermentation of black tea and sugar with a symbiotic culture of acetic acid bacteria and yeasts such as Bacterium xylinum, Bacterium xylinoides, Bacterium gluconicum, Saccharomyces ludwigii, Saccharomyces apiculatus varieties, Schizosaccaromyces pombe, Acetobacter ketogenum, Torula varieties, Pichia fermantans and other yeasts reported to have potential health effects [1]. Fermentation and oxidation processes of Kombucha microorganisms produce a wide range of organic acids, vitamins and enzymes. Research indicated that Kombucha improved resistance against cancer, prevented cardiovascular diseases, promoted digestion, stimulated immunity and reduced inflammation [2].Glucuronic acid is one of the organic acids produced during fermentation process in Kombucha and may improve oxidative metabolism [3]. Trichloroethylene (TCE) is a major environmental contaminant and an occupational concern due to its widespread industrial use [4]. An animal carcinogen, TCE is nephrotoxic and

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