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Search Results: 1 - 10 of 12 matches for " Masome Sabetkasaei "
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The effect of amygdala lesion on anterior claustrum kindled seizures in rats
Fariba Zafari,Masome Sabetkasaei,Yousef Sadeghi,Mohammad Mohammad-zade
Physiology and Pharmacology , 2008,
Abstract: Introduction: The claustrum interconnects with the allocortical and neocortical regions and also projects to the hippocampus and the amygdala. .The role of claustrum in the complex partial seizure is not clear. Thus in this study the effect of amygdala lesion on anterior claustrum kindled seizures in rat were investigated. Methods: Male Wistar rats, weighting 250-300 g, were received DC current via a bipolar electrode which is inserted in right basolateral amygdala. A tripolar electrode for stimulation and electroencephalography recording in the right anterior claustrum has been fixed. After a 10 days period of surgical recovery, animals were received kindling stimulation (60Hz, 2s, 1 ms pulse duration) daily, and kindling parameters were measured. In the control group animals did not receive DC current. In the lesion groups (2 groups) animals received DC current both before kindling stimulation and after full kindled statement respectively. Results: Our result showed that amygdala lesion, were capable of delaying claustrum kindling. The delay in kindling was due to an increase in the stimulation trials required to kindle to seizure stages. Furthermore the effect of this lesion on established kindled seizures reduced the severity of claustrum by decrease the stage 5 duration and after discharge duration. Conclusion: amygdale lesion had no effect on the expression of generalized seizures and claustrum play an important role in the propagation of epileptic seizure. Whereas the amygdala has a facilitators role in propagation claustrum kindled seizure.
Effect of Spinal and Systemic Clonidine Administration on the Postoperative Analgesia in Morphine-dependent and Na ve Rats
Masoumeh Sabetkasaei,Leila Rezai Gharai
Iranian Journal of Pharmaceutical Research , 2006,
Abstract: Post operative pain and its control remains one of the most important issues in the field of surgery and health care system. Formalin test has been used as a method for assessing painand analgesia in rats. Systemic and spinally administered clonidine, an α2-adrenergic agonist, is proved to enhance postoperative analgesia. It has also been shown that morphine-dependent rats experience more chronic pain than na ve rats.In this study we have explored the effect of certain doses of i.t. and i.p. clonidine on postoperative pain in morphine-dependent and na ve rats. Rats were addicted by oral morphine. For one group, an intrathecal catheter was inserted 48 hours before surgery. A 1-cm longitudinal incision was made through skin, fascia and muscle of the plantar aspect of the right hind paw. Both morphine-dependent and na ve rats received i.t. (17μg.kg 1) or i.p.(0.7 mg.kg 1) clonidine immediately and 15 minutes befor formalin test, respectively. Then, formalin-induced behaviors were recorded. In both phases of formalin test in morphinedepondent rats, i.p clonidine produced more analgesic effect, compared to i.t. injection(P<0.01). On the other hand i.p. clonidine caused more analgesic effect in phase II of formalin test in morphine-dependent than na ve rats (P<0.05).Clonidine may potentiate the analgesic effect of chronically administered morphine. Also it seems that clonidine acts better in supraspinal level, compared to the spinal level.
Effect of Folic Acid on serum Leptin, Grehlin concentration, and feed intake in male Wistar rats
Mansoor Rezaei,Masoumeh Sabetkasaei,Naser Kalantari,Mahdi Hedayati
Physiology and Pharmacology , 2011,
Abstract: Introduction: There is no comprehensive study on the effect of Folate on food intake; therefore the present study was carried out to determine the effect of Folate supplementation on serum concentrations of Leptin and Grehlin and food intake in male Wistar rats. Methods: The study was carried out for 42 days during which the animals were weighed weekly; their food and water intakes were measured every 48 hours. Serum leptin, ghrelin and insulin were measured using ELISA. Repeated Measures and t-test were done to analyze the data. Results: The amount of water intake in the case group was significantly (p<0.05) higher that the control group, food intake was also higher in the group receiving folate as compared to the control although it did not reach the significance level. The Body weight of the rats receiving the supplement were significantly (p<0.001) higher than the control group. The experimental group had higher serum leptin and lower serum ghrelin levels although not significantly. Serum insulin level was significantly higher in the experimental group (p<0.001). A significant correlation was found between Water and food intake (r=0.9, p<0.001), and between body weight and the food intake (r=0.6, p<0.001). There was a significant correlation between serum insulin level with food intake (r=0.6, p< 0.001) and body weight (r=0.36, p=0.05). Conclusion: Daily folate supplementation for a long period increased body growth and food intake in weaning rats. Since serum ghrelin level was also higher, it is possible that increased weight was related to the other body tissues, rather than adipose tissue.
The study of the neuroprotective effects of curcumin, against homocysteine intracerebroventricular injection –induced cognition impairment and oxidative stress in the rat
Masoumeh Sabetkasaei,amin ataie,Abbas Haghparast,Akbar Hajizadeh Moghaddam
Physiology and Pharmacology , 2009,
Abstract: Introduction: Aging is the major risk factor for neurodegenerative diseases and oxidative stress is involved in the pathophysiology of these diseases. Oxidative stress can induce neuronal damages and modulate intracellular signaling, ultimately leading to neuronal death by apoptosis or necrosis. Methods: In this study, we investigated the possible antioxidant and neuroprotective properties of the polyphenolic antioxidant compound, Curcumin against homocysteine (Hcy) neurotoxicity. Curcumin (5, 15, 45 mg/kg) was injected intraperitonealy once daily for a period of 10 days beginning 5 days prior to Hcy (0.2 μmol/μl) intracerebroventricular injection in rats. Biochemical and behavioral studies, including passive avoidance learning and locomotor activity tests were studied 24 h after the last curcumin or its vehicle injection. Also Histopathological studies and cell dencity in different regions of hippocampus was investigated. Results: Hcy could induce lipid peroxidation and increase MDA and SOA levels in rats' brain. Additionally, Hcy impaired memory retention in passive avoidance learning test. However, Curcumin treatment decreased MDA and SOA levels significantly as well as improved learning and memory in rats. Histopathological analysis also indicated that Hcy could decrease hippocampus cell count and Curcumin inhibited this toxic effect. Conclusion: These results suggest that Hcy may induce lipid peroxidation in rats' brain and decrease hippocampus cells. Also polyphenol treatment (Curcumin) has the ability to improve learning and memory deficits by protecting the nervous system against Oxidative stress. Keywords: Homocysteine, Curcumin, Lipid peroxidation, Oxidative Stress
An investigation of the neuroprotective effects of Curcumin in a model of Homocysteine - induced oxidative stress in the rat’s brain
A Ataie,M Sabetkasaei,A Haghparast,A Hajizadeh Moghaddam
DARU : Journal of Pharmaceutical Sciences , 2010,
Abstract: "n "nBackground and the purpose of the study: Aging is the major risk factor for neurodegenerative diseases and oxidative stress is involved in the pathophysiology of them. Oxidative stress can induce neuronal damages and modulate intracellular signaling, ultimately leading to neuronal death by apoptosis or necrosis. In this study, the possible antioxidant and neuroprotective properties of the natural polyphenolic antioxidant compound, curcumin against homocysteine (Hcy) neurotoxicity was investigated. "nMethods: Curcumin (5, 15, 45 mg/kg) was injected intraperitonealy (i.p.) once daily for a period of 10 days beginning 5 days prior to Hcy (0.2 μmol/μl) intracerebroventricular (i.c.v) injection in rats. Biochemical and behavioral studies, including passive avoidance learning and locomotor activity tests were studied 24 hrs after the last curcumin or its vehicle injection. The cell density of hippocampus layers and apoptosis in rats' hippocampi by immunohistochical methods were also studied. Results and major conclusion:Results indicated that Hcy could induce lipid peroxidation and increase Malondialdehyde (MDA) and Super Oxide Anion (SOA) levels in rat's brain.Additionally, Hcy impaired memory retention in passive avoidance learning test. However, curcumin decreased MDA and SOA levels significantly and improved learning and memory in rats. On the other hand Hcy could induce cell death and apoptosis in rats' hippocampi which was inhibited by curcumin. These results suggest that Hcy may induce lipid peroxidation in rat's brain. and polyphenol treatment (curcumin) improves learning and memory deficits by protecting the nervous system against Oxidative stress.
Comparing the Effect of Adding Olanzapine Versus Perphenazine on Maintenance Treatment of Bipolar Type 1
Ahmad Fakhri,Hatam Boostani,Abbas Pezeshki,Masome Nazari Nasab
Jundishapur Scientific Medical Journal , 2012,
Abstract: Background and Objective: Bipolar disorder is one of the most common psychiatric disorder in community. bipolar is an important disorder because of its prevalence and serious complications such as suicide, substance abuse, loss of well being and function, this study was investigated to determine the efficacy of adding perphenazine versus olanzapin in maintenance treatment of bipolar.Subjects and Methods: this study is an interventional study on 40 bipolar patients (16-50 years old) referred to Golestan hospital psychiatric clinic in 2011. Duration of the study was 8 weeks. Severity of mania was assessed with YMRS at 0,3,6 weeks.The data was analized by using SPSS.Results: In both groups symptoms were significantly improved at the end of study (p=0.000, p=0.001).Young mania rating scale between two groups was not significantly different (p=0.2).Conclusion: Because of small sample size, short duration of study and adding anti psychotic drugs on mood stabilizer, further future works shoude be considered.
Nurses' and patients' viewpoints regarding quality of nursing care in the teaching hospitals of Semnan University of Medical Sciences, 2009
Masome Neishabory,Nayere Raeisdana,Raheb Ghorbani,Tahere Sadeghi
Koomesh , 2011,
Abstract: Introduction: Nursing care is an essential component of health services. Patient's health and improvement depends on the quality of nursing care. Nurses and patients views as well as their active participation for making decision have an important role in quality of services, so it must be regarded as a principle. The purpose of this research was to study nurses' and patients' viewpoints regarding quality of nursing care in teaching hospital of Semnan (Iran). Materials and Methods: In this descriptive-comparative study, 52 nurses and 300 patients from internal, surgical, gynecology and pediatric wards of Fatemieh and Amir Hospitals were selected by systematic sampling. Nursing care quality was assessed in psychotic, social and communicative aspects using a Quality Patient Care Scale questioner. The questioner had 41 questions with 3 answer choices (rarely, occasionally and usually) that marked from 1 to 3. Mean scores were calculated for all subjects and then were categorized in undesirable (less than 1.5), low desirable (1.5-2.49) and desirable (2.5-5) groups. Results: 31.6 % of patients and 92.6% of nurses evaluated psychotic-social aspect of care quality as desirable. The desirability percent for communicative aspect of care quality was 24.7% in patients and 56.8% in nurses. There was a significant statistical difference between patients and nurses views in both aspects (P<0.001). In psychosocial aspect, 73.5% of patients expressed that nurses do not introduce themselves and 77.9% of them expressed that nurses rarely introduce new patients to other patients. In communicative aspect, 42.5% of patients declared that they ensured about their secrets rarely. Conclusion: Nurses' and patients' viewpoints on quality of nursing care were different because of their various experiences and insight. Thus, re-evaluation of the quality standards of nursing care based on client approach, choosing some strategies to increase nurse-patient communication and considering psycho-social patients needs seems to be a necessity.
The Study of Relationship between Coping with Pain Experiences (Migraines) and Happiness
Azizi, masome,Nour-Mohammad Yaghoubi,Alemeh Keikha
Modern Applied Science , 2011, DOI: 10.5539/mas.v5n4p63
Abstract: The purpose of present research is reviewing the relationship between coping strategies of headache and happiness so the method of copying strategies of headache and happiness. So the methodology of research is descriptive – measured statistical society of research included those students of Zabol University who have migraine headache. For selected statistical sample, caucus sampling method was used and 120 people were choose as statistical sample which included 67 boys and 53 girls. To collect information, were used Oxfords happiness questionnaire and checking strategies of migraine headache questionnaires of migraine headache questionnaire. Analysis of data was done in two statistical methods, descriptive statistics included frequency distribution, determination of mean. Standard deviation, drawing table, …. In information statistics, pierson correlation test and independent T test were used for analyzing data. The results of research indicate that, there is meaning correlation between varieties of checking strategies of headache and happiness. Also these are meaning fullness difference between create a disaster, soliloquy and reinterpretation among boy and girls students.
Effect of Hexanic and Alcoholic Extracts of Fenugreek Seed in Male Diabetic Rats
Mahmood Abedinzade,Iraj Nikokar,Sima Nasri,Masome Jamal Omidi
Zahedan Journal of Research in Medical Sciences , 2013,
Abstract: Background: Diabetes mellitus is recognized with severe complications. Many herbal medicines have been recommended for treatment of diabetes problem. In this study, the effect of hexanic and alcoholic extracts of fenugreek (Trigonella-foenum graecum) on serum parameters was investigated in normal and streptozotocin-induced diabetic rats. Materials and Methods: This experimental study was carried out in 2011 at paramedical school of Guilan University of Medical Sciences, 48 male Sprague Dawley rats (230-300 gram) were divided into six groups: control, type 1 diabetic, and 2 diabetic groups that receive alcoholic extract and 2 groups receive hexanic extract of fenugreek (100, 200 mg/kg body weight) intraperitonealy for 28 days. For diabetes induction, streptozotocin (60 mg/kg/ intraperitonealy) was used. Blood glucose, total cholesterol, triglyceride (TG), urea, creatinine, uric acid, AST and ALT level was measured. Data were analyzed with spss software 16 and One Way ANOVAs and Tukey test. p<0.05 was statistically significant. Results: fenugreek extract inhibit weight loss especially in diabetic groups that receive hexanic extract (p=0.006). blood glucose, total cholesterol, TG, urea, creatinin, uric acid, AST and ALT level was reduced significantly in diabetics groups that receive fenugreek extract (p=0.001). This effect was stronger in groups that receive Hexanic extractConclusion: Fenugreek is a good candidate for reduction of diabetic complications.
Association Between Atherosclerosis in Carotid Artery and Elastic Modulus of Brachial Artery
Tavvos Rahmani-Cherati,Manijhe Mokhtari-Dizaji,Masome Gity
Journal of Tehran University Heart Center , 2007,
Abstract: Background: Common carotid arterial stiffness can be assessed during carotid arterial ultrasonography, but its association with brachial stiffness, a well-defined cardiovascular risk factor, has not been clarified. The aim of this study was to examine the relationship between common carotid artery and brachial artery stiffness. Methods: The static pressure-strain elastic modulus of the common carotid and brachial arteries were evaluated in 40 men with 15 healthy carotids, 15 mild carotid stenoses, and 10 severe carotid stenoses, by B-mode and Doppler ultrasonography. The local elastic modulus was estimated by the measurement of the arterial strain; the static pressure was also measured based on the peak-systolic and end-diastolic velocity in each artery.Results: The elastic modulus of the right common carotid artery (RCCA) and right brachial artery (RBA) increased linearly with the growth of atherosclerosis from 1772±566 Pa and 2639±1096 Pa for the normal subjects to 6168±1026 Pa and 5587±1592 Pa for the severe stenosis group, respectively. In the three groups; healthy, mild stenosis, and severe stenosis; there was a significant difference in the elastic modulus of the right common carotid artery between the groups and also for the right brachial artery, separately (p-value<0.05). The Pearson correlation analysis showed a significant correlation between the elastic modulus of the right common carotid artery and the elastic modulus of the right brachial artery.Conclusion: The brachial artery elastic modulus is associated with the common carotid elastic modulus. This study showed that atherosclerosis was a generalized process that might involve the entire vasculature. An evaluation of the elastic modulus of the RBA, however, showed that there were fundamental differences in the dynamic behavior of the brachial artery when compared to elastic arteries, such as the common carotid artery.
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